N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A novel, exceptionally selective, potent δ opioid receptor agonist with oral bioavailability and its analogues

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3895-3905

  Wei, Z Y ^a   Brown, W ^a   Takasaki, B ^a   Plobeck, N ^a   Delorme, D ^a,b   Zhou, F ^a   Yang, H ^a   Jones, P ^a   Gawell, L ^a   Gagnon, H ^a   Schmidt, R ^a   Yue, S Y ^a   Walpole, C ^a   Payza, K ^a   St Onge, S ^a   Labarre, M ^a   Godbout, C ^a   Jakob, A ^a   Butterworth, J ^a   Kamassah, A ^a   Morin, P E ^a   Projean, D ^a   Ducharme, J ^a   Roberts, E ^a,c   more..

^a ASTRAZENECA   (United Kingdom)

^b METHYLGENE INC   (Canada)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; ALKENE DERIVATIVE; BENZHYDRYL DERIVATIVE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N,N DIETHYL 4 (PHENYLPIPERIDIN 4 YLIDENEMETHYL)BENZAMIDE; OIL; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; BIOLOGICAL AVAILABILITY; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, MOLECULAR; PIPERAZINES; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRANSFECTION;

EID: 0034687241     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000229p     Document Type: Article

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