Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies

Journal of Medicinal Chemistry

Volumn 48, Issue 20, 2005, Pages 6220-6228

  Soulier, Jean Louis ^a   Russo, Olivier ^a   Giner, Mireille ^a   Rivail, Lucie ^a   Berthouze, Magali ^b   Ongeri, Sandrine ^a   Maigret, Bernard ^c   Fischmeister, Rodolphe ^b   Lezoualc'h, Frank ^b   Sicsic, Sames ^a   Berque Bestel, Isabelle ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c NANCY UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (1 PIPERIDINYL)ETHYL ESTER; CYCLIC AMP; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GLIA CELL; NONHUMAN; PROTEIN FUNCTION; RAT; STRUCTURE ANALYSIS;

ADENOSINE MONOPHOSPHATE; AMINOBENZOIC ACIDS; ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; PIPERIDINES; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN, 5-HT4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444449975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050234z     Document Type: Article

References (27)

1. Bulenger, S. M., S.; Bouvier, M. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol. Sci. 2005, in press.
2. Breitwieser, G. G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling. Circ. Res. 2004, 94, 17-27.
3. Bai, M. Dimerization of G-protein-coupled receptors: roles in signal transduction. Cell. Signal. 2004, 16, 175-186.
4. Milligan, G. Oligomerization of G-protein-coupled receptors. J. Cell. Sci. 2001, 114, 1265-1271.
5. Hansen, J. L. Sheikh, S. P. Functional consequences of 7TM receptor dimerization. Eur. J. Pharm. Sci. 2004, 23, 301-317.
6. 4 receptors in living cells. FEBS Lett. 2005, in press.
7. 4 Receptor Ligands: Applications and New Prospects. J. Med. Chem. 2003, 46, 319-344.
8. 4 receptor regulates secretion of non-amyloidogenic precursor protein. J. Biol. Chem. 2001, 276, 44881-44888.
9. 4 receptors: a novel therapeutic target for Alzheimer's disease? Curr. Alzheimer Res. 2004, 1, 79-86.
10. Portoghese, P. S. 2000 Alfred Burger Award Address in Medicinal Chemistry. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes. J. Med. Chem. 2001, 44, 3758-3758.
11. Bhushan, R. G.; Sharma, S. K.; Xie, Z.; Daniels, D. J.; Portoghese, P. S. A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers. J. Med. Chem. 2004, 47, 2969-2972.
12. 4 receptors. Br. J. Pharmacol. 2004, 143, 361-370.
13. Vakser, I. A. Protein docking for low-resolution structures. Protein Eng. 1995, 8, 371-377.
14. Vakser, I. A. Evaluation of GRAMM low-resolution docking methodology on the hemagglutinin-antibody complex. Proteins 1997, Suppl 1, 226-230.
15. Vakser, I. A.; Jiang, S. Strategies for modeling the interactions of transmembrane helices of G protein-coupled receptors by geometric complementarity using the GRAMM computer algorithm. Methods Enzymol. 2002, 343, 313-328.
16. Guo, W.; Shi, L.; Javitch, J. A. The fourth transmembrane segments forms the interface oh the dopamine D2 receptor homodimer. J. Biol. Chem. 2003, 278, 4385-4388.
17. Klco, J. M.; Lassere, T. B.; Baranski, T. J. C5a receptor oligomerization. I. Bisulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J. Biol. Chem. 2003, 278, 35345-35353.
18. Fotiadis, D.; Liang, Y.; Filipek, S.; Sapertstein, D. A.; Engel, A.; Palczewski, K. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett. 2004, 564, 281-288.
19. Overton, M. C.; Chinault, S. L.; Blumer, K. J. Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor. J. Biol. Chem. 2003, 278, 49369-49377.
20. 4 receptors. J. Med. Chem. 1997, 40, 608-621.
21. 4 receptors. J. Med. Chem. 2003, 46, 2606-2620.
22. Roy, B. C.; Hormas, D.; Mallik, S. Synthesis of new, pyrene-containing metal, chelating lipids and sensing of cupric ions. Org. Lett. 2003, 5, 11-14.
23. Diaz, H. K., J. W. The synthesis of dibenzofuran based diacics and amino acids designed to nucleate parallel and antiparallel beta-sheat formation. Tetrahedron Lett. 1991, 32, 5725-5728.
24. Rathod, K. T.; Patel, P. M.; Patel, S. K.; Patel, K. C. Synthesis and physico chemical properties based on s-triazine. Ultra Sci. 1999, 11, 36-41.
25. Leydet, A.; Barragan, V.; Boyer, B.; Montera, J. L.; Roque, J. P. et al. Polyanion inhibitors of human immunodeficiency virus and other viruses. 5. Telomerized anionic surfactants derived from amino acids. J. Med. Chem. 1997, 40, 342-349.
26. 4 receptor isoforms. J. Med. Chem. 2000, 43, 3761-3769.
27. Kawanishi, Y.; Ishihara, S.; Takahashi, K.; Tsushima, T.; Hagishita, S.; Ishikawa, M.; Ishihara, Y. Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist. Chem. Pharm. Bull. 1997, 45 (1), 116-124.