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Volumn 17, Issue 9, 2013, Pages 1029-1038

Oxysterol receptors and their therapeutic applications in cancer conditions

Author keywords

Cancer therapy; Cholesterol homeostasis; Liver X receptors; Oxysterols

Indexed keywords

BETA CATENIN; CASPASE 3; CHEMOKINE RECEPTOR CCR7; LIVER X RECEPTOR; OXYSTEROL; PROTEIN BAX;

EID: 84882649891     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.820708     Document Type: Review
Times cited : (34)

References (100)
  • 2
    • 37649021073 scopus 로고    scopus 로고
    • Oxysterols: Novel biologic roles for the 21st century
    • Javitt NB. Oxysterols: novel biologic roles for the 21st century. Steroids 2008;73:149-57
    • (2008) Steroids , vol.73 , pp. 149-157
    • Javitt, N.B.1
  • 3
    • 0342316532 scopus 로고    scopus 로고
    • Oxysterols: Modulators of cholesterol metabolism and other processes
    • Schroepfer GJ. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000;80:361-554
    • (2000) Physiol Rev , vol.80 , pp. 361-554
    • Schroepfer, G.J.1
  • 4
    • 0022345543 scopus 로고
    • Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes
    • Rooney MW, Yachnin S, Kucuk O, et al. Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes. Biochim Biophys Acta 1985;820:33-9
    • (1985) Biochim Biophys Acta , vol.820 , pp. 33-39
    • Rooney, M.W.1    Yachnin, S.2    Kucuk, O.3
  • 5
    • 0026518303 scopus 로고
    • Inhibition of NK cell-mediated cytotoxicity by oxysterols
    • Kucuk O, Stoner-Picking J, Yachnin S, et al. Inhibition of NK cell-mediated cytotoxicity by oxysterols. Cell Immunol 1992;139:541-9
    • (1992) Cell Immunol , vol.139 , pp. 541-549
    • Kucuk, O.1    Stoner-Picking, J.2    Yachnin, S.3
  • 6
    • 57049189735 scopus 로고    scopus 로고
    • Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin e inhibitable events associated with 7-ketocholesterol- induced apoptosis
    • Vejux A, Guyot S, Montange T, et al. Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. J Nutr Biochem 2009;20:45-61
    • (2009) J Nutr Biochem , vol.20 , pp. 45-61
    • Vejux, A.1    Guyot, S.2    Montange, T.3
  • 7
    • 0025932955 scopus 로고
    • Membrane-related oxysterol function: Preliminary results on the modification of protein kinase C activity and substrate phosphorylation by 7 beta, 25-dihydroxycholesterol
    • Moog C, Deloulme JC, Baudier J, et al. Membrane-related oxysterol function: preliminary results on the modification of protein kinase C activity and substrate phosphorylation by 7 beta, 25-dihydroxycholesterol. Biochimie 1991;73:1321-6
    • (1991) Biochimie , vol.73 , pp. 1321-1326
    • Moog, C.1    Deloulme, J.C.2    Baudier, J.3
  • 8
    • 79952202599 scopus 로고    scopus 로고
    • 7-ketocholesterol inhibits Na, K-ATPase activity by decreasing expression of its a1-subunit and membrane fluidity in human endothelial cells
    • Duran MJ, Pierre SV, Lesnik P, et al. 7-ketocholesterol inhibits Na, K-ATPase activity by decreasing expression of its a1-subunit and membrane fluidity in human endothelial cells. Cell Mol Biol (Noisy-le-grand) 2010;56(Suppl): OL1434-41
    • (2010) Cell Mol Biol (Noisy-le-grand) , vol.56 , Issue.SUPPL.
    • Duran, M.J.1    Pierre, S.V.2    Lesnik, P.3
  • 9
    • 84884311634 scopus 로고    scopus 로고
    • Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes
    • doi: 10.1016/j.bcp.2013.02.028
    • Ragot K, Mackrill JJ, Zarrouk A, et al. Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. Biochem Pharmacol 2013;doi:10.1016/j.bcp.2013.02.028
    • (2013) Biochem Pharmacol
    • Ragot, K.1    Mackrill, J.J.2    Zarrouk, A.3
  • 11
    • 0035976936 scopus 로고    scopus 로고
    • The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols
    • Janowski BA, Shan B, Russell DW. The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 2001;276:45408-16
    • (2001) J Biol Chem , vol.276 , pp. 45408-45416
    • Janowski, B.A.1    Shan, B.2    Russell, D.W.3
  • 12
    • 0030064188 scopus 로고    scopus 로고
    • Effects of a novel 2, 3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells
    • Mark M, Muller P, Maier R, et al. Effects of a novel 2, 3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res 1996;37:148-58
    • (1996) J Lipid Res , vol.37 , pp. 148-158
    • Mark, M.1    Muller, P.2    Maier, R.3
  • 13
    • 33744788672 scopus 로고    scopus 로고
    • Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
    • Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci USA 2006;103:8408-13
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8408-8413
    • Corcoran, R.B.1    Scott, M.P.2
  • 14
    • 34247844371 scopus 로고    scopus 로고
    • Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
    • Dwyer JR, Sever N, Carlson M, et al. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem 2007;282:8959-68
    • (2007) J Biol Chem , vol.282 , pp. 8959-8968
    • Dwyer, J.R.1    Sever, N.2    Carlson, M.3
  • 15
    • 0036733753 scopus 로고    scopus 로고
    • Cholesterol modification of Hedgehog family proteins
    • Jeong J, McMahon AP. Cholesterol modification of Hedgehog family proteins. J Clin Invest 2002;110:591-6
    • (2002) J Clin Invest , vol.110 , pp. 591-596
    • Jeong, J.1    McMahon, A.P.2
  • 16
    • 38149069055 scopus 로고    scopus 로고
    • Purified npc1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein
    • Infante RE, Abi-Mosleh L, Radhakrishnan A, et al. Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J Biol Chem 2008;283:1052-63
    • (2008) J Biol Chem , vol.283 , pp. 1052-1063
    • Infante, R.E.1    Abi-Mosleh, L.2    Radhakrishnan, A.3
  • 17
    • 38149068309 scopus 로고    scopus 로고
    • Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop
    • Infante RE, Radhakrishnan A, Abi-Mosleh L, et al. Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem 2008;283:1064-7518.
    • (2008) J Biol Chem , vol.283 , pp. 1064-7518
    • Infante, R.E.1    Radhakrishnan, A.2    Abi-Mosleh, L.3
  • 18
    • 38949137379 scopus 로고    scopus 로고
    • Characteristics of oxysterol binding proteins
    • Yan D, Olkkonen VM. Characteristics of oxysterol binding proteins. Int Rev Cytol 2008;265:253-85
    • (2008) Int Rev Cytol , vol.265 , pp. 253-285
    • Yan, D.1    Olkkonen, V.M.2
  • 19
    • 77953243855 scopus 로고    scopus 로고
    • A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)
    • Wang Y, Kumar N, Crumbley C, et al. A second class of nuclear receptors for oxysterols: regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta 2010;1801:917-23
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 917-923
    • Wang, Y.1    Kumar, N.2    Crumbley, C.3
  • 20
    • 54549090146 scopus 로고    scopus 로고
    • The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno-and endobiotic gene regulation
    • Wada T, Kang HS, Jetten AM, et al. The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno-and endobiotic gene regulation. Exp Biol Med (Maywood) 2008;233:1191-201
    • (2008) Exp Biol Med (Maywood) , vol.233 , pp. 1191-1201
    • Wada, T.1    Kang, H.S.2    Jetten, A.M.3
  • 21
    • 33645127044 scopus 로고    scopus 로고
    • Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor
    • Deng R, Yang D, Yang J, et al. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. J Pharmacol Exp Ther 2006;317:317-25
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 317-325
    • Deng, R.1    Yang, D.2    Yang, J.3
  • 22
    • 1642457373 scopus 로고    scopus 로고
    • CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor
    • Shenoy SD, Spencer TA, Mercer-Haines NA, et al. CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. Drug Metab Dispos 2004;32:66-71
    • (2004) Drug Metab Dispos , vol.32 , pp. 66-71
    • Shenoy, S.D.1    Spencer, T.A.2    Mercer-Haines, N.A.3
  • 23
    • 33748793667 scopus 로고    scopus 로고
    • Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann-Pick C disease
    • Langmade SJ, Gale SE, Frolov A, et al. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci USA 2006;103:13807-12
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13807-13812
    • Langmade, S.J.1    Gale, S.E.2    Frolov, A.3
  • 24
    • 65649132754 scopus 로고    scopus 로고
    • 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR
    • Trousson A, Bernard S, Petit PX, et al. 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR. J Neurochem 2009;109:945-58
    • (2009) J Neurochem , vol.109 , pp. 945-958
    • Trousson, A.1    Bernard, S.2    Petit, P.X.3
  • 25
    • 34948820661 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
    • Umetani M, Domoto H, Gormley AK, et al. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med 2007;13:1185-92
    • (2007) Nat Med , vol.13 , pp. 1185-1192
    • Umetani, M.1    Domoto, H.2    Gormley, A.K.3
  • 26
    • 38049008502 scopus 로고    scopus 로고
    • 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
    • DuSell CD, Umetani M, Shaul PW, et al. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol 2008;22:65-77
    • (2008) Mol Endocrinol , vol.22 , pp. 65-77
    • Dusell, C.D.1    Umetani, M.2    Shaul, P.W.3
  • 27
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski BA, Willy PJ, Devi TR, et al. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996;383:728-31
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3
  • 28
    • 14444285707 scopus 로고    scopus 로고
    • Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
    • Lehmann JM, Kliewer SA, Moore LB, et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 1997;272:3137-40
    • (1997) J Biol Chem , vol.272 , pp. 3137-3140
    • Lehmann, J.M.1    Kliewer, S.A.2    Moore, L.B.3
  • 29
    • 0033524420 scopus 로고    scopus 로고
    • Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
    • Janowski BA, Grogan MJ, Jones SA, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci USA 1999;96:266-71
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 266-271
    • Janowski, B.A.1    Grogan, M.J.2    Jones, S.A.3
  • 30
    • 78651354102 scopus 로고    scopus 로고
    • Targeting liver X receptors in human health: Deadlock or promising trail?
    • Viennois E, Pommier AJ, Mouzat K, et al. Targeting liver X receptors in human health: deadlock or promising trail? Expert Opin Ther Targets 2011;15:219-32
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 219-232
    • Viennois, E.1    Pommier, A.J.2    Mouzat, K.3
  • 31
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • Repa JJ, Mangelsdorf DJ. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 2000;16:459-81
    • (2000) Annu Rev Cell Dev Biol , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 32
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet DJ, Turley SD, Ma W, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1998;93:693-704
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3
  • 33
    • 0034284918 scopus 로고    scopus 로고
    • Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    • Repa JJ, Turley SD, Lobaccaro JA, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000;289:1524-9
    • (2000) Science , vol.289 , pp. 1524-1529
    • Repa, J.J.1    Turley, S.D.2    Lobaccaro, J.A.3
  • 34
    • 0034669171 scopus 로고    scopus 로고
    • Role of LXRs in control of lipogenesis
    • Schultz JR, Tu H, Luk A, et al. Role of LXRs in control of lipogenesis. Genes Dev 2000;14:2831-8
    • (2000) Genes Dev , vol.14 , pp. 2831-2838
    • Schultz, J.R.1    Tu, H.2    Luk, A.3
  • 35
    • 0037046543 scopus 로고    scopus 로고
    • Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines
    • Collins JL, Fivush AM, Watson MA, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 2002;45:1963-6
    • (2002) J Med Chem , vol.45 , pp. 1963-1966
    • Collins, J.L.1    Fivush, A.M.2    Watson, M.A.3
  • 36
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • Repa JJ, Liang G, Ou J, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000;14:2819-30
    • (2000) Genes Dev , vol.14 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3
  • 37
    • 0034710965 scopus 로고    scopus 로고
    • Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
    • Venkateswaran A, Laffitte BA, Joseph SB, et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci USA 2000;97:12097-102
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12097-12102
    • Venkateswaran, A.1    Laffitte, B.A.2    Joseph, S.B.3
  • 39
    • 2542427448 scopus 로고    scopus 로고
    • Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice
    • Wu JE, Basso F, Shamburek RD, et al. Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. J Biol Chem 2004;279:22913-25
    • (2004) J Biol Chem , vol.279 , pp. 22913-22925
    • Wu, J.E.1    Basso, F.2    Shamburek, R.D.3
  • 40
    • 0038614979 scopus 로고    scopus 로고
    • Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
    • Yu L, York J, Von Bergmann K, et al. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem 2003;278:15565-70
    • (2003) J Biol Chem , vol.278 , pp. 15565-15570
    • Yu, L.1    York, J.2    Von Bergmann, K.3
  • 41
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    • Repa JJ, Berge KE, Pomajzl C, et al. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 2002;277:18793-800
    • (2002) J Biol Chem , vol.277 , pp. 18793-18800
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3
  • 42
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    • Zelcer N, Hong C, Boyadjian R, et al. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 2009;325:100-4
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3
  • 43
    • 33745824191 scopus 로고    scopus 로고
    • Liver X receptors regulate adrenal cholesterol balance
    • Cummins CL, Volle DH, Zhang Y, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest 2006;116:1902-12
    • (2006) J Clin Invest , vol.116 , pp. 1902-1912
    • Cummins, C.L.1    Volle, D.H.2    Zhang, Y.3
  • 44
    • 34250805279 scopus 로고    scopus 로고
    • Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility
    • Volle DH, Mouzat K, Duggavathi R, et al. Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility. Mol Endocrinol 2007;21:1014-27
    • (2007) Mol Endocrinol , vol.21 , pp. 1014-1027
    • Volle, D.H.1    Mouzat, K.2    Duggavathi, R.3
  • 45
    • 47949088159 scopus 로고    scopus 로고
    • Androgen deprivation by activating the liver X receptor
    • Lee JH, Gong H, Khadem S, et al. Androgen deprivation by activating the liver X receptor. Endocrinology 2008;149:3778-88
    • (2008) Endocrinology , vol.149 , pp. 3778-3788
    • Lee, J.H.1    Gong, H.2    Khadem, S.3
  • 46
    • 0037965630 scopus 로고    scopus 로고
    • Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
    • Laffitte BA, Chao LC, Li J, et al. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 2003;100:5419-24
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5419-5424
    • Laffitte, B.A.1    Chao, L.C.2    Li, J.3
  • 47
    • 0348111308 scopus 로고    scopus 로고
    • Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha
    • Dalen KT, Ulven SM, et al. Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J Biol Chem 2003;278:48283-91
    • (2003) J Biol Chem , vol.278 , pp. 48283-48291
    • Dalen, K.T.1    Ulven, S.M.2
  • 48
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis the carbohydrate-response element-binding protein is a target gene of LXR
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 2007;282:743-51
    • (2007) J Biol Chem , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 49
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • Joseph SB, Castrillo A, Laffitte BA, et al. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 2003;9:213-19
    • (2003) Nat Med , vol.9 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3
  • 50
    • 0242361567 scopus 로고    scopus 로고
    • Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism
    • Castrillo A, Joseph SB, Vaidya SA, et al. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell 2003;12:805-1651.
    • (2003) Mol Cell , vol.12 , pp. 805-1651
    • Castrillo, A.1    Joseph, S.B.2    Vaidya, S.A.3
  • 51
    • 77958533169 scopus 로고    scopus 로고
    • Antiproliferative effect of LXR agonists T0901317 and 22 (R)-hydroxycholesterol on multiple human cancer cell lines
    • Chuu C-P, Lin H-P. Antiproliferative effect of LXR agonists T0901317 and 22 (R)-hydroxycholesterol on multiple human cancer cell lines. Anticancer Res 2010;30:3643-8
    • (2010) Anticancer Res , vol.30 , pp. 3643-3648
    • Chuu, C.-P.1    Lin, H.-P.2
  • 52
    • 79952281538 scopus 로고    scopus 로고
    • LXR-A selectively reprogrammes cancer cells to enter into apoptosis
    • Mehrotra A, Kaul D, Joshi K. LXR-A selectively reprogrammes cancer cells to enter into apoptosis. Mol Cell Biochem 2011;349:41-55
    • (2011) Mol Cell Biochem , vol.349 , pp. 41-55
    • Mehrotra, A.1    Kaul, D.2    Joshi, K.3
  • 53
    • 84874922871 scopus 로고    scopus 로고
    • Lack of liver x receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell
    • Dufour J, Pommier A, Alves G, et al. Lack of liver x receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS One 2013;8:e58876
    • (2013) PLoS One , vol.8
    • Dufour, J.1    Pommier, A.2    Alves, G.3
  • 54
    • 84865530278 scopus 로고    scopus 로고
    • Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2
    • Noghero A, Perino A, Seano G, et al. Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2. Arterioscler Thromb Vasc Biol 2012;32:2280-8
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2280-2288
    • Noghero, A.1    Perino, A.2    Seano, G.3
  • 55
    • 38449120272 scopus 로고    scopus 로고
    • The association between statins and cancer incidence in a veterans population
    • Farwell WR, Scranton RE, Lawler EV, et al. The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst 2008;100:134-9
    • (2008) J Natl Cancer Inst , vol.100 , pp. 134-139
    • Farwell, W.R.1    Scranton, R.E.2    Lawler, E.V.3
  • 56
    • 57249095662 scopus 로고    scopus 로고
    • Suppression of beta-catenin signaling by liver X receptor ligands
    • Uno S, Endo K, Jeong Y, et al. Suppression of beta-catenin signaling by liver X receptor ligands. Biochem Pharmacol 2009;77:186-95
    • (2009) Biochem Pharmacol , vol.77 , pp. 186-195
    • Uno, S.1    Endo, K.2    Jeong, Y.3
  • 57
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 58
    • 84886306802 scopus 로고    scopus 로고
    • The oxysterol receptors LXRa and LXRb suppress proliferation in the colon
    • doi: 10.1002/mc.21924
    • Vedin L-L, Gustafsson J-A, Steffensen KR. The oxysterol receptors LXRa and LXRb suppress proliferation in the colon. Mol Carcinog 2012;doi:10.1002/mc. 21924
    • (2012) Mol Carcinog
    • Vedin, L.-L.1    J-A, G.2    Steffensen, K.R.3
  • 59
    • 84878343697 scopus 로고    scopus 로고
    • Receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice
    • doi: 10.1053/j.gastro.2013.02.00560
    • Lo Sasso GL, Bovenga F, Murzilli S, et al.Liver X. Receptors Inhibit Proliferation of Human Colorectal Cancer Cells and Growth of Intestinal Tumors in Mice. Gastroenterology 2013;doi:10.1053/j.gastro.2013.02.00560.
    • (2013) Gastroenterology
    • Lo Sasso, G.L.1    Bovenga, F.2    Murzilli, S.3    Liver, X.4
  • 60
    • 52249113756 scopus 로고    scopus 로고
    • Impact of statin therapy on survival in epithelial ovarian cancer
    • Elmore RG, Ioffe Y, Scoles DR, et al. Impact of statin therapy on survival in epithelial ovarian cancer. Gynecol Oncol 2008;111:102-5
    • (2008) Gynecol Oncol , vol.111 , pp. 102-105
    • Elmore, R.G.1    Ioffe, Y.2    Scoles, D.R.3
  • 61
    • 70749157037 scopus 로고    scopus 로고
    • Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
    • Scoles DR, Xu X, Wang H, et al. Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein. Gynecol Oncol 2010;116:109-16
    • (2010) Gynecol Oncol , vol.116 , pp. 109-116
    • Scoles, D.R.1    Xu, X.2    Wang, H.3
  • 62
    • 77954067003 scopus 로고    scopus 로고
    • Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells
    • Rough JJ, Monroy MA, Yerrum S, et al. Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. J Ovarian Res 2010;3:13
    • (2010) J Ovarian Res , vol.3 , pp. 13
    • Rough, J.J.1    Monroy, M.A.2    Yerrum, S.3
  • 63
    • 0034908972 scopus 로고    scopus 로고
    • Phase i pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug
    • Alberts DS, Hallum AV III, Stratton-Custis M, et al. Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug. Clin Cancer Res 2001;7:1246-50
    • (2001) Clin Cancer Res , vol.7 , pp. 1246-1250
    • Alberts, D.S.1    Hallum, A.V.2    Stratton-Custis, M.3
  • 64
    • 84863229699 scopus 로고    scopus 로고
    • T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected]
    • Miller DH, Fischer AK, Chu KF, et al. T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected]. Int J Gynecol Cancer 2011;21:1350-6
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 1350-1356
    • Miller, D.H.1    Fischer, A.K.2    Chu, K.F.3
  • 65
    • 29944446607 scopus 로고    scopus 로고
    • Statins and cancer risk: A meta-analysis
    • Dale KM, Coleman CI, Henyan NN, et al. Statins and cancer risk: a meta-analysis. JAMA 2006;295:74-80
    • (2006) JAMA , vol.295 , pp. 74-80
    • Dale, K.M.1    Coleman, C.I.2    Henyan, N.N.3
  • 66
    • 4243078496 scopus 로고    scopus 로고
    • The nuclear oxysterol receptor LXRalpha is expressed in the normal human breast and in breast cancer
    • Vigushin DM, Dong Y, Inman L, et al. The nuclear oxysterol receptor LXRalpha is expressed in the normal human breast and in breast cancer. Med Oncol 2004;21:123-31
    • (2004) Med Oncol , vol.21 , pp. 123-131
    • Vigushin, D.M.1    Dong, Y.2    Inman, L.3
  • 67
    • 7444259771 scopus 로고    scopus 로고
    • Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells
    • Fukuchi J, Kokontis JM, Hiipakka RA, et al. Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells. Cancer Res 2004;64:7686-968.
    • (2004) Cancer Res , vol.64 , pp. 7686-7968
    • Fukuchi, J.1    Kokontis, J.M.2    Hiipakka, R.A.3
  • 68
    • 84865701098 scopus 로고    scopus 로고
    • LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: Relation to proliferation and apoptosis
    • El Roz A, Bard J-M, Huvelin J-M, et al. LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. Anticancer Res 2012;32:3007-13
    • (2012) Anticancer Res , vol.32 , pp. 3007-3013
    • El Roz, A.1    Bard, J.-M.2    Huvelin, J.-M.3
  • 69
    • 64349083106 scopus 로고    scopus 로고
    • The oxysterol receptor LXR inhibits proliferation of human breast cancer cells
    • Vedin L-L, Lewandowski SA, Parini P, et al. The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis 2009;30:575-9
    • (2009) Carcinogenesis , vol.30 , pp. 575-579
    • Vedin, L.-L.1    Lewandowski, S.A.2    Parini, P.3
  • 70
    • 34547475143 scopus 로고    scopus 로고
    • Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor
    • Gong H, Guo P, Zhai Y, et al. Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol 2007;21:1781-90
    • (2007) Mol Endocrinol , vol.21 , pp. 1781-1790
    • Gong, H.1    Guo, P.2    Zhai, Y.3
  • 71
    • 0035572863 scopus 로고    scopus 로고
    • Epidemiology and molecular pathology of gallbladder cancer
    • Lazcano-Ponce EC, Miquel JF, Munoz N, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin 2001;51:349-64
    • (2001) CA Cancer J Clin , vol.51 , pp. 349-364
    • Lazcano-Ponce, E.C.1    Miquel, J.F.2    Munoz, N.3
  • 72
    • 77957047251 scopus 로고    scopus 로고
    • Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/-female mice
    • Gabbi C, Kim H-J, Barros R, et al. Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/-female mice. Proc Natl Acad Sci USA 2010;107:14763-873.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14763-14873
    • Gabbi, C.1    Kim, H.-J.2    Barros, R.3
  • 73
    • 84881135704 scopus 로고    scopus 로고
    • LXR, prostate cancer and cholesterol: The Good, the Bad and the Ugly
    • De Boussac H, Pommier AJ, Dufour J, et al. LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly. Am J Cancer Res 2013;3:58-69
    • (2013) Am J Cancer Res , vol.3 , pp. 58-69
    • De Boussac, H.1    Pommier, A.J.2    Dufour, J.3
  • 74
    • 7444235550 scopus 로고    scopus 로고
    • Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells
    • Fukuchi J, Hiipakka RA, Kokontis JM, et al. Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells. Cancer Res 2004;64:7682-5
    • (2004) Cancer Res , vol.64 , pp. 7682-7685
    • Fukuchi, J.1    Hiipakka, R.A.2    Kokontis, J.M.3
  • 75
    • 33746176754 scopus 로고    scopus 로고
    • Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
    • Chuu CP, Hiipakka RA, Kokontis JM, et al. Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Cancer Res 2006;66:6482-6
    • (2006) Cancer Res , vol.66 , pp. 6482-6486
    • Chuu, C.P.1    Hiipakka, R.A.2    Kokontis, J.M.3
  • 76
    • 84862737436 scopus 로고    scopus 로고
    • Lxra regulates the androgen response in prostate epithelium
    • Viennois E, Esposito T, Dufour J, et al. Lxra regulates the androgen response in prostate epithelium. Endocrinology 2012;153:3211-23
    • (2012) Endocrinology , vol.153 , pp. 3211-3223
    • Viennois, E.1    Esposito, T.2    Dufour, J.3
  • 77
    • 77952242043 scopus 로고    scopus 로고
    • Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells
    • Pommier AJ, Alves G, Viennois E, et al. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene 2010;29:2712-23
    • (2010) Oncogene , vol.29 , pp. 2712-2723
    • Pommier, A.J.1    Alves, G.2    Viennois, E.3
  • 79
    • 84878481495 scopus 로고    scopus 로고
    • Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice
    • Pommier AJC, Dufour J, Alves G, et al. Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice. PLoS Genet 2013;9:e100348380.
    • (2013) PLoS Genet , vol.9
    • Ajc, P.1    Dufour, J.2    Alves, G.3
  • 80
    • 84866696143 scopus 로고    scopus 로고
    • An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent81 Moschetta A. Nuclear receptor LXR as a novel therapeutic antitumoral target inglioblastoma
    • Guo D, Reinitz F, Youssef M, et al. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent81. Moschetta A. Nuclear receptor LXR as a novel therapeutic antitumoral target inglioblastoma. Cancer Discov 2011;1:381-2
    • (2011) Cancer Discov , vol.1 , pp. 381-382
    • Guo, D.1    Reinitz, F.2    Youssef, M.3
  • 81
    • 70350724700 scopus 로고    scopus 로고
    • Liver x receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes
    • Geyeregger R, Shehata M, Zeyda M, et al. Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes. J Leukoc Biol 2009;86:1039-48
    • (2009) J Leukoc Biol , vol.86 , pp. 1039-1048
    • Geyeregger, R.1    Shehata, M.2    Zeyda, M.3
  • 82
    • 73849096869 scopus 로고    scopus 로고
    • Tumor-mediated liver x receptor-alpha activation inhibits cc chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
    • Villablanca EJ, Raccosta L, Zhou D, et al. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med 2010;16:98-10584.
    • (2010) Nat Med , vol.16 , pp. 98-10584
    • Villablanca, E.J.1    Raccosta, L.2    Zhou, D.3
  • 83
    • 84857139806 scopus 로고    scopus 로고
    • Selective liver X receptor modulators (SLiMs): What use in human health?
    • Viennois E, Mouzat K, Dufour J, et al. Selective liver X receptor modulators (SLiMs): what use in human health? Mol Cell Endocrinol 2012;351:129-41
    • (2012) Mol Cell Endocrinol , vol.351 , pp. 129-141
    • Viennois, E.1    Mouzat, K.2    Dufour, J.3
  • 84
    • 55349087953 scopus 로고    scopus 로고
    • Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
    • DiBlasio-Smith EA, Arai M, Quinet EM, et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J Transl Med 2008;6:59
    • (2008) J Transl Med , vol.6 , pp. 59
    • Diblasio-Smith, E.A.1    Arai, M.2    Quinet, E.M.3
  • 85
    • 67049144914 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants
    • Katz A, Udata C, Ott E, et al. Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants. J Clin Pharmacol 2009;49:643-987.
    • (2009) J Clin Pharmacol , vol.49 , pp. 643-987
    • Katz, A.1    Udata, C.2    Ott, E.3
  • 86
    • 0141481039 scopus 로고    scopus 로고
    • Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist
    • Kaneko E, Matsuda M, Yamada Y, et al. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. J Biol Chem 2003;278:36091-8
    • (2003) J Biol Chem , vol.278 , pp. 36091-36098
    • Kaneko, E.1    Matsuda, M.2    Yamada, Y.3
  • 87
    • 77950911589 scopus 로고    scopus 로고
    • Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo
    • Yasuda T, Grillot D, Billheimer JT, et al. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol 2010;30:781-6
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 781-786
    • Yasuda, T.1    Grillot, D.2    Billheimer, J.T.3
  • 89
    • 0042346382 scopus 로고    scopus 로고
    • Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion
    • Sun Y, Yao J, Kim T-W, et al. Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem 2003;278:27688-94
    • (2003) J Biol Chem , vol.278 , pp. 27688-27694
    • Sun, Y.1    Yao, J.2    Kim, T.-W.3
  • 90
    • 14244255485 scopus 로고    scopus 로고
    • The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease
    • Koldamova RP, Lefterov IM, Staufenbiel M, et al. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem 2005;280:4079-88
    • (2005) J Biol Chem , vol.280 , pp. 4079-4088
    • Koldamova, R.P.1    Lefterov, I.M.2    Staufenbiel, M.3
  • 91
    • 34547531201 scopus 로고    scopus 로고
    • Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
    • Zelcer N, Khanlou N, Clare R, et al. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci USA 2007;104:10601-6
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10601-10606
    • Zelcer, N.1    Khanlou, N.2    Clare, R.3
  • 92
    • 80051472136 scopus 로고    scopus 로고
    • Oxysterols as biomarkers in neurodegenerative diseases
    • Leoni V, Caccia C. Oxysterols as biomarkers in neurodegenerative diseases. Chem Phys Lipids 2011;164:515-24
    • (2011) Chem Phys Lipids , vol.164 , pp. 515-524
    • Leoni, V.1    Caccia, C.2
  • 93
    • 0037108819 scopus 로고    scopus 로고
    • Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration
    • Wang L, Schuster GU, Hultenby K, et al. Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci USA 2002;99:13878-83
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13878-13883
    • Wang, L.1    Schuster, G.U.2    Hultenby, K.3
  • 94
    • 79959938167 scopus 로고    scopus 로고
    • Interplay between LXR and Wnt/bcatenin signaling in the negative regulation of peripheral myelin genes by oxysterols
    • Makoukji J, Shackleford G, Meffre D, et al. Interplay between LXR and Wnt/bcatenin signaling in the negative regulation of peripheral myelin genes by oxysterols. J Neurosci 2011;31:9620-9
    • (2011) J Neurosci , vol.31 , pp. 9620-9629
    • Makoukji, J.1    Shackleford, G.2    Meffre, D.3
  • 95
    • 33847078808 scopus 로고    scopus 로고
    • Role of the nuclear receptors for oxysterols LXRs in steroidogenic tissues: Beyond the 'foie gras', the steroids and sex?
    • Volle DH, Lobaccaro JM. Role of the nuclear receptors for oxysterols LXRs in steroidogenic tissues: beyond the 'foie gras', the steroids and sex? Mol Cell Endocrinol 2007;265-266:183-9
    • (2007) Mol Cell Endocrinol , vol.265-266 , pp. 183-189
    • Volle, D.H.1    Lobaccaro, J.M.2
  • 96
    • 67649645087 scopus 로고    scopus 로고
    • Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice
    • Mouzat K, Volat F, Baron S, et al. Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. Endocrinology 2009;150:3369-75
    • (2009) Endocrinology , vol.150 , pp. 3369-3375
    • Mouzat, K.1    Volat, F.2    Baron, S.3
  • 97
    • 84862282169 scopus 로고    scopus 로고
    • Review of salvage therapy for biochemically recurrent prostate cancer: The role of imaging and rationale for systemic salvage targeted anti-prostate-specific membrane antigen radioimmunotherapy
    • Kosuri S, Akhtar NH, Smith M, et al. Review of salvage therapy for biochemically recurrent prostate cancer: the role of imaging and rationale for systemic salvage targeted anti-prostate-specific membrane antigen radioimmunotherapy. Adv Urol 2012;2012:921674
    • (2012) Adv Urol , vol.2012 , pp. 921674
    • Kosuri, S.1    Akhtar, N.H.2    Smith, M.3
  • 98
    • 77956292811 scopus 로고    scopus 로고
    • The role of HER2 in cancer therapy and targeted drug delivery
    • Tai W, Mahato R, Cheng K. The role of HER2 in cancer therapy and targeted drug delivery. J Control Release 2010;146:264-75
    • (2010) J Control Release , vol.146 , pp. 264-275
    • Tai, W.1    Mahato, R.2    Cheng, K.3
  • 99
    • 2942520109 scopus 로고    scopus 로고
    • Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin) conjugated polyethylenimine
    • Chiu S-J, Ueno NT, Lee RJ. Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin) conjugated polyethylenimine. J Control Release 2004;97:357-69
    • (2004) J Control Release , vol.97 , pp. 357-369
    • Chiu, S.-J.1    Ueno, N.T.2    Lee, R.J.3
  • 100
    • 0036554863 scopus 로고    scopus 로고
    • Anti-HER2 immunoliposomes: Enhanced efficacy attributable to targeted delivery
    • Park JW, Hong K, Kirpotin DB, et al. Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Clin Cancer Res 2002;8:1172-81
    • (2002) Clin Cancer Res , vol.8 , pp. 1172-1181
    • Park, J.W.1    Hong, K.2    Kirpotin, D.B.3


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