LXR-α selectively reprogrammes cancer cells to enter into apoptosis

Molecular and Cellular Biochemistry

Volumn 349, Issue 1-2, 2011, Pages 41-55

  Mehrotra, Aanchal ^a   Kaul, Deepak ^a   Joshi, Kusum ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

AATF; Apoptosis; LXR ; T cell leukemia; Withaferin A

Indexed keywords

PROTEIN BCL 2; PROTEINASE ACTIVATED RECEPTOR 4; WITHAFERIN A;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; GENE; GENETIC CODE; HUMAN; HUMAN CELL; LXR ALPHA GENE; REGULATORY MECHANISM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; HYDROXYCHOLESTEROLS; LIGANDS; NEOPLASMS; ORPHAN NUCLEAR RECEPTORS; PROTEIN BINDING; RESPONSE ELEMENTS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; WITHANOLIDES;

EID: 79952281538     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0659-3     Document Type: Article

References (22)

1. JH Webb 1901 Cancer, its nature and treatment Lancet ii 976 10.1016/S0140-6736(01)73258-8
2. C White 1909 On the occurrence of crystals in tumours J Pathol Bacteriol 13 3 10 10.1002/path.1700130103
3. F Balkwill A Mantovani 2000 Inflammation and cancer: back to Virchow? Lancet 357 539 545 10.1016/S0140-6736(00)04046-0 (Pubitemid 32173595)
4. K Michael 2006 NF-kB and cancer: mechanisms and targets Mol Carcinog 45 355 361 10.1002/mc.20217 (Pubitemid 43865841)
5. M Karin Y Cao FR Greten ZW Li 2002 NF-kB in cancer: from innocent bystander to major culprit Nat Rev Cancer 2 301 310 1:CAS:528: DC%2BD38XivFGqt7k%3D 10.1038/nrc780 12001991 (Pubitemid 37328783)
6. TD Gilmore 2003 The Re1/NF-kB/IkB signal transduction pathway and cancer Cancer Treat Res 115 241 265 1:CAS:528:DC%2BD3sXnt12gsL8%3D 10.1007/0-306-48158- 8-10 12613200
7. SB Joseph A Castrillo BA Laffitte DJ Mangelsdorf P Tontonoz 2003 Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat Med 9 213 219 1:CAS:528:DC%2BD3sXotlSgsw%3D%3D 10.1038/nm820 12524534 (Pubitemid 36227724)
8. JJ Repa G Liang J Ou Y Bashmakov JM Lobaccaro I Shimomura B Shan MS Brown JL Goldstein DJ Mangelsdorf 2000 Regulation of mouse sterol regulatory element- binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR alpha and LXR beta Genes Dev 14 2819 2830 1:CAS:528:DC%2BD3cXos1ehsLs%3D 10.1101/gad.844900 11090130
9. VP Dave D Kaul Y Sharma R Bhattacharya 2009 Functional genomics of blood cellular LXR-a gene in human coronary heart disease J Mol Cell Cardiol 46 536 544 1:CAS:528:DC%2BD1MXivVenurk%3D 10.1016/j.yjmcc.2008.12.020 19211025
10. R Maitra MA Porter S Huang BP Gilmour 2009 Inhibition of NF-kappaB by the natural product Withaferin A in cellular models of cystic fibrosis inflammation J Inflamm 6 15 10.1186/1476-9255-6-15 10.1186/1476-9255-6-15
11. C Mandal A Dutta A Mallick S Chandra L Misra RS Sangwan 2008 Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade Apoptosis 13 1450 1464 1:CAS:528:DC%2BD1cXhtlylu7vP 10.1007/s10495-008-0271-0 18987975
12. D Kaul A Mehrotra 2007 Functional characterization of AATF transcriptome in human leukemic cells Mol Cell Biochem 297 215 220 1:CAS:528: DC%2BD2sXjtVSqs7s%3D 10.1007/s11010-006-9317-1 17006618 (Pubitemid 46443545)
13. A Mehrotra K Joshi D Kaul 2010 E2F-1 RNomics is critical for reprogramming of cancer cells to quiescent state Int J Cancer 127 4 849 858 1:CAS:528:DC%2BC3cXnvFKru70%3D 20013804
14. LC Mishra BB Singh S Dagenais 2000 Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review Altern Med Rev 5 334 346 1:STN:280:DC%2BD3cvls1amsw%3D%3D 10956379 (Pubitemid 30660827)
15. JR Schultz H Tu A Luk JJ Repa JC Medina L Li S Schwendner S Wang M Thoolen DJ Mangelsdorf KD Lustig B Shan 2000 Role of LXRs in control of lipogenesis Genes Dev 14 2831 2838 1:CAS:528:DC%2BD3cXos1ehsLg%3D 10.1101/gad.850400 11090131
16. D Kaul PK Anand 2003 Regulation of PPAR-gamma gene in human promyelocytic HL-60 cell line Leuk Res 27 683 686 1:CAS:528:DC%2BD3sXksValurY%3D 10.1016/S0145-2126(02)00279-5 12801525 (Pubitemid 36683256)
17. P Chomczynski N Sacchi 1987 Single step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction Anal Biochem 162 156 159 1:CAS:528:DyaL2sXitFSns7Y%3D 10.1016/0003-2697(87)90021-2 2440339 (Pubitemid 17064313)
18. F Blaschke O Leppanen Y Takata E Caglayan J Liu MC Fishbein K Kappert KI Nakayama AR Collins E Fleck WA Hsueh RE Law D Bruemmer 2004 Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries Circ Res 95 e110 e123 1:CAS:528:DC%2BD2cXhtVensrjN 10.1161/01.RES.0000150368.56660.4f 15539633
19. V Lise-Lotte AL Sebastian P Paolo G Jan-Ake KR Steffensen 2009 The oxysterol receptor LXR inhibits proliferation of human breast cancer cells Carcinogenesis 30 575 579 10.1093/carcin/bgp029 10.1093/carcin/bgp029
20. BA Janowski PJ Willy TR Devi JR Falck DJ Mangelsdorf 1996 An oxysterol signalling pathway mediated by the nuclear receptor LXR-α Nature 383 728 731 1:CAS:528:DyaK28XmsVGns78%3D 10.1038/383728a0 8878485 (Pubitemid 26360651)
21. LD Engstrom AS Youkilis JL Gorelick D Zhen V Ackley CA Petroff LQ Benson MR Coon X Zhu SM Hanash DS Wechsler 2004 Mxi-1, an alternatively transcribed Mxi-1 isoform is overexpressed in glioblastomas Neoplasia 6 660 673 1:CAS:528:DC%2BD2cXhtVShu77E 10.1593/neo.04244 15548375 (Pubitemid 39411102)
22. QB Linda RC Melissa MK Leslie CH Grace A Amod K Sarnaik DS Weschler 1999 Expression of Mxi1, a myc antagonist, is regulated by Sp1 and AP2 J Biol Chem 274 28794 28802 10.1074/jbc.274.40.28794 (Pubitemid 29473015)