메뉴 건너뛰기




Volumn 144, Issue 7, 2013, Pages

Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice

Author keywords

Adenoma; Mouse Model; NR1H3 NR1H2; Nuclear Receptor

Indexed keywords

ADENOVIRUS VECTOR; AZOXYMETHANE; CHOLESTEROL; DEXTRAN SULFATE; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA;

EID: 84878343697     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.02.005     Document Type: Article
Times cited : (88)

References (41)
  • 1
    • 34247869042 scopus 로고    scopus 로고
    • The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas
    • E. Giovannucci, D. Michaud The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas Gastroenterology 132 2007 2208 2225
    • (2007) Gastroenterology , vol.132 , pp. 2208-2225
    • Giovannucci, E.1    Michaud, D.2
  • 2
    • 77954645899 scopus 로고    scopus 로고
    • Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    • Y. Yasuda, M. Shimizu, Y. Shirakami Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice Cancer Sci 101 2010 1701 1707
    • (2010) Cancer Sci , vol.101 , pp. 1701-1707
    • Yasuda, Y.1    Shimizu, M.2    Shirakami, Y.3
  • 3
    • 0021257629 scopus 로고
    • Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol synthesis and esterification during the first cell cycle of liver regeneration
    • A. Trentalance, S. Leoni, M.T. Mangiantini Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol synthesis and esterification during the first cell cycle of liver regeneration Biochim Biophys Acta 794 1984 142 151
    • (1984) Biochim Biophys Acta , vol.794 , pp. 142-151
    • Trentalance, A.1    Leoni, S.2    Mangiantini, M.T.3
  • 4
    • 0016206178 scopus 로고
    • Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol
    • M.S. Brown, J.L. Goldstein Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol J Biol Chem 249 1974 7306 7314
    • (1974) J Biol Chem , vol.249 , pp. 7306-7314
    • Brown, M.S.1    Goldstein, J.L.2
  • 5
    • 0019135838 scopus 로고
    • Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth
    • M.S. Brown, J.L. Goldstein Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth J Lipid Res 21 1980 505 517
    • (1980) J Lipid Res , vol.21 , pp. 505-517
    • Brown, M.S.1    Goldstein, J.L.2
  • 6
    • 0018746012 scopus 로고
    • Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor
    • J.L. Goldstein, J.A. Helgeson, M.S. Brown Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor J Biol Chem 254 1979 5403 5409
    • (1979) J Biol Chem , vol.254 , pp. 5403-5409
    • Goldstein, J.L.1    Helgeson, J.A.2    Brown, M.S.3
  • 7
    • 33746872856 scopus 로고    scopus 로고
    • Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice
    • M.V. Swamy, J.M. Patlolla, V.E. Steele Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice Cancer Res 66 2006 7370 7377
    • (2006) Cancer Res , vol.66 , pp. 7370-7377
    • Swamy, M.V.1    Patlolla, J.M.2    Steele, V.E.3
  • 8
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • B.A. Janowski, P.J. Willy, T.R. Devi An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3
  • 9
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • D.J. Mangelsdorf, C. Thummel, M. Beato The nuclear receptor superfamily: the second decade Cell 83 1995 835 839
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3
  • 10
    • 44449138033 scopus 로고    scopus 로고
    • Nuclear receptors, intestinal architecture and colon cancer: An intriguing link
    • I. D'Errico, A. Moschetta Nuclear receptors, intestinal architecture and colon cancer: an intriguing link Cell Mol Life Sci 65 2008 1523 1543
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1523-1543
    • D'Errico, I.1    Moschetta, A.2
  • 11
    • 7444259771 scopus 로고    scopus 로고
    • Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells
    • J. Fukuchi, J.M. Kokontis, R.A. Hiipakka Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells Cancer Res 64 2004 7686 7689
    • (2004) Cancer Res , vol.64 , pp. 7686-7689
    • Fukuchi, J.1    Kokontis, J.M.2    Hiipakka, R.A.3
  • 12
    • 33746176754 scopus 로고    scopus 로고
    • Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
    • C.P. Chuu, R.A. Hiipakka, J.M. Kokontis Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist Cancer Res 66 2006 6482 6486
    • (2006) Cancer Res , vol.66 , pp. 6482-6486
    • Chuu, C.P.1    Hiipakka, R.A.2    Kokontis, J.M.3
  • 13
    • 77952242043 scopus 로고    scopus 로고
    • Liver X receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells
    • A.J. Pommier, G. Alves, E. Viennois Liver X receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells Oncogene 29 2010 2712 2723
    • (2010) Oncogene , vol.29 , pp. 2712-2723
    • Pommier, A.J.1    Alves, G.2    Viennois, E.3
  • 14
    • 64349083106 scopus 로고    scopus 로고
    • The oxysterol receptor LXR inhibits proliferation of human breast cancer cells
    • L.L. Vedin, S.A. Lewandowski, P. Parini The oxysterol receptor LXR inhibits proliferation of human breast cancer cells Carcinogenesis 30 2009 575 579
    • (2009) Carcinogenesis , vol.30 , pp. 575-579
    • Vedin, L.L.1    Lewandowski, S.A.2    Parini, P.3
  • 15
    • 57249095662 scopus 로고    scopus 로고
    • Suppression of beta-catenin signaling by liver X receptor ligands
    • S. Uno, K. Endo, Y. Jeong Suppression of beta-catenin signaling by liver X receptor ligands Biochem Pharmacol 77 2009 186 195
    • (2009) Biochem Pharmacol , vol.77 , pp. 186-195
    • Uno, S.1    Endo, K.2    Jeong, Y.3
  • 16
    • 70749157037 scopus 로고    scopus 로고
    • Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
    • D.R. Scoles, X. Xu, H. Wang Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein Gynecol Oncol 116 2010 109 116
    • (2010) Gynecol Oncol , vol.116 , pp. 109-116
    • Scoles, D.R.1    Xu, X.2    Wang, H.3
  • 17
    • 70350724700 scopus 로고    scopus 로고
    • Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes
    • R. Geyeregger, M. Shehata, M. Zeyda Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes J Leukoc Biol 86 2009 1039 1048
    • (2009) J Leukoc Biol , vol.86 , pp. 1039-1048
    • Geyeregger, R.1    Shehata, M.2    Zeyda, M.3
  • 18
    • 0034595292 scopus 로고    scopus 로고
    • Targeted disruption of Skp2 results in accumulation of cyclin e and p27(Kip1), polyploidy and centrosome overduplication
    • K. Nakayama, H. Nagahama, Y.A. Minamishima Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication EMBO J 19 2000 2069 2081
    • (2000) EMBO J , vol.19 , pp. 2069-2081
    • Nakayama, K.1    Nagahama, H.2    Minamishima, Y.A.3
  • 19
    • 21644487430 scopus 로고    scopus 로고
    • Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries
    • F. Blaschke, O. Leppanen, Y. Takata Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries Circ Res 95 2004 e110 e123
    • (2004) Circ Res , vol.95
    • Blaschke, F.1    Leppanen, O.2    Takata, Y.3
  • 20
    • 46149098344 scopus 로고    scopus 로고
    • LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    • S.J. Bensinger, M.N. Bradley, S.B. Joseph LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 134 2008 97 111
    • (2008) Cell , vol.134 , pp. 97-111
    • Bensinger, S.J.1    Bradley, M.N.2    Joseph, S.B.3
  • 21
    • 33845587711 scopus 로고    scopus 로고
    • Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice
    • W. Chen, G. Chen, D.L. Head Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice Cell Metab 5 2007 73 79
    • (2007) Cell Metab , vol.5 , pp. 73-79
    • Chen, W.1    Chen, G.2    Head, D.L.3
  • 22
    • 77950597894 scopus 로고    scopus 로고
    • Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes
    • G. Lo Sasso, N. Celli, M. Caboni Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes Hepatology 51 2010 1334 1344
    • (2010) Hepatology , vol.51 , pp. 1334-1344
    • Lo Sasso, G.1    Celli, N.2    Caboni, M.3
  • 23
    • 78651346813 scopus 로고    scopus 로고
    • Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis
    • G. Lo Sasso, S. Murzilli, L. Salvatore Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis Cell Metab 12 2010 187 193
    • (2010) Cell Metab , vol.12 , pp. 187-193
    • Lo Sasso, G.1    Murzilli, S.2    Salvatore, L.3
  • 24
    • 57149118460 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
    • S. Modica, S. Murzilli, L. Salvatore Nuclear bile acid receptor FXR protects against intestinal tumorigenesis Cancer Res 68 2008 9589 9594
    • (2008) Cancer Res , vol.68 , pp. 9589-9594
    • Modica, S.1    Murzilli, S.2    Salvatore, L.3
  • 25
    • 38849171267 scopus 로고    scopus 로고
    • Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    • B.K. Popivanova, K. Kitamura, Y. Wu Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis J Clin Invest 118 2008 560 570
    • (2008) J Clin Invest , vol.118 , pp. 560-570
    • Popivanova, B.K.1    Kitamura, K.2    Wu, Y.3
  • 26
    • 0020025385 scopus 로고
    • Effects of sodium butyrate, a new pharmacological agent, on cells in culture
    • J. Kruh Effects of sodium butyrate, a new pharmacological agent, on cells in culture Mol Cell Biochem 42 1982 65 82
    • (1982) Mol Cell Biochem , vol.42 , pp. 65-82
    • Kruh, J.1
  • 27
    • 0027970153 scopus 로고
    • Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells
    • P.C. Schroy, A.K. Rustgi, E. Ikonomu Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells J Cell Physiol 161 1994 111 123
    • (1994) J Cell Physiol , vol.161 , pp. 111-123
    • Schroy, P.C.1    Rustgi, A.K.2    Ikonomu, E.3
  • 28
    • 0038206426 scopus 로고    scopus 로고
    • Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation
    • D. Kucerova, J. Stokrova, J. Korb Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation Int J Mol Med 10 2002 779 784
    • (2002) Int J Mol Med , vol.10 , pp. 779-784
    • Kucerova, D.1    Stokrova, J.2    Korb, J.3
  • 29
    • 68849100416 scopus 로고    scopus 로고
    • Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours Regulation by intestine-specific transcription factor CDX2
    • S. Modica, A. Morgano, L. Salvatore Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours Regulation by intestine-specific transcription factor CDX2 Gut 58 2009 1250 1259
    • (2009) Gut , vol.58 , pp. 1250-1259
    • Modica, S.1    Morgano, A.2    Salvatore, L.3
  • 30
    • 33947367803 scopus 로고    scopus 로고
    • Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin secreting cells
    • W. Wente, M.B. Brenner, H. Zitzer Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin secreting cells Endocrinology 148 2007 1843 1849
    • (2007) Endocrinology , vol.148 , pp. 1843-1849
    • Wente, W.1    Brenner, M.B.2    Zitzer, H.3
  • 31
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • E.R. Fearon, B. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 32
    • 75449115416 scopus 로고    scopus 로고
    • The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors
    • S. Modica, F. Gofflot, S. Murzilli The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors Gastroenterology 138 2010 636 648
    • (2010) Gastroenterology , vol.138 , pp. 636-648
    • Modica, S.1    Gofflot, F.2    Murzilli, S.3
  • 33
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • L.K. Su, K.W. Kinzler, B. Vogelstein Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene Science 256 1992 668 670
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3
  • 34
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • K.W. Kinzler, M.C. Nilbert, L.K. Su Identification of FAP locus genes from chromosome 5q21 Science 253 1991 661 665
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.K.3
  • 35
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • T.C. He, A.B. Sparks, C. Rago Identification of c-MYC as a target of the APC pathway Science 281 1998 1509 1512
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 36
    • 84861101004 scopus 로고    scopus 로고
    • An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway
    • D. Guo, F. Reinitz, M. Youssef An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway Cancer Discov 1 2011 442 456
    • (2011) Cancer Discov , vol.1 , pp. 442-456
    • Guo, D.1    Reinitz, F.2    Youssef, M.3
  • 37
    • 84866696143 scopus 로고    scopus 로고
    • Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma
    • A. Moschetta Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma Cancer Discov 1 2011 381 382
    • (2011) Cancer Discov , vol.1 , pp. 381-382
    • Moschetta, A.1
  • 38
    • 28844439793 scopus 로고    scopus 로고
    • Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?
    • D.J. Mulholland, S. Dedhar, G.A. Coetzee Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 26 2005 898 915
    • (2005) Endocr Rev , vol.26 , pp. 898-915
    • Mulholland, D.J.1    Dedhar, S.2    Coetzee, G.A.3
  • 39
    • 84886312094 scopus 로고    scopus 로고
    • The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon
    • Epub ahead of print
    • L.L. Vedin, J.A. Gustafsson, K.R. Steffensen The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon Mol Carcinog 2012 May 18 Epub ahead of print
    • (2012) Mol Carcinog
    • Vedin, L.L.1    Gustafsson, J.A.2    Steffensen, K.R.3
  • 40
    • 0037031856 scopus 로고    scopus 로고
    • Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    • B.B. Madison, L. Dunbar, X.T. Qiao Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine J Biol Chem 277 2002 33275 33283
    • (2002) J Biol Chem , vol.277 , pp. 33275-33283
    • Madison, B.B.1    Dunbar, L.2    Qiao, X.T.3
  • 41
    • 77951784373 scopus 로고    scopus 로고
    • Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis
    • E. Kress, S. Skah, M. Sirakov Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis Gastroenterology 138 2010 1863 1874
    • (2010) Gastroenterology , vol.138 , pp. 1863-1874
    • Kress, E.1    Skah, S.2    Sirakov, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.