Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Journal of Translational Medicine

Volumn 6, Issue , 2008, Pages

  DiBlasio Smith, Elizabeth A ^a   Arai, Maya ^a   Quinet, Elaine M ^a   Evans, Mark J ^a   Kornaga, Tad ^a   Basso, Michael D ^a   Chen, Liang ^a   Feingold, Irene ^a   Halpern, Anita R ^a   Liu, Qiang Yuan ^a   Nambi, Ponnal ^a   Savio, Dawn ^a   Wang, Shuguang ^a   Mounts, William M ^a   Isler, Jennifer A ^a   Slager, Anna M ^a   Burczynski, Michael E ^a   Dorner, Andrew J ^a   LaVallie, Edward R ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ABC TRANSPORTER A1; ABC TRANSPORTER G1; BIOLOGICAL MARKER; CELL NUCLEUS RECEPTOR; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LXR 623; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WAY 252623; ABC TRANSPORTER; CELL RECEPTOR; DNA BINDING PROTEIN; HYPOCHOLESTEROLEMIC AGENT; LIVER X RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EXPOSURE; EX VIVO STUDY; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MONKEY; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; T LYMPHOCYTE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD CELL; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MONONUCLEAR CELL; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; BLOOD CELLS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTES, MONONUCLEAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 55349087953     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-6-59     Document Type: Article

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