Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells

Journal of Lipid Research

Volumn 37, Issue 1, 1996, Pages 148-158

  Mark, Michael ^a   Müller, Peter ^a   Maier, Roland ^a   Eisele, Bernhard ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

2,3 monoepoxysqualene; 2,3; 22,23 diepoxysqualene; 24,25 epoxylanosterol; HMG CoA reductase; lanosterol; oxysterols; squalene oxidase

Indexed keywords

4 CHLORO N [4 (4 DIMETHYLAMINOMETHYLPHENYL)CYCLOHEXYL] N METHYLBENZAMIDE; ANTILIPEMIC AGENT; BIBX 79; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LANOSTEROL SYNTHASE; LANOSTEROL SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL SYNTHESIS; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; PRIORITY JOURNAL;

ANTILIPEMIC AGENTS; BENZAMIDES; CHOLESTEROL; CYCLOHEXYLAMINES; ENZYME INHIBITORS; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INTRAMOLECULAR TRANSFERASES; ISOMERASES; LIVER; LOVASTATIN; SIMVASTATIN; SQUALENE; TUMOR CELLS, CULTURED;

EID: 0030064188     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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