Oxysterols as biomarkers in neurodegenerative diseases

Chemistry and Physics of Lipids

Volumn 164, Issue 6, 2011, Pages 515-524

  Leoni, Valerio ^a   Caccia, Claudio ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

ABC A1; Biomarker; Dementia; LXR; Oxysterols

Indexed keywords

24S HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; BIOLOGICAL MARKER; CHOLESTEROL DERIVATIVE; OXYSTEROL; TAU PROTEIN; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; CEREBROSPINAL FLUID; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; DEGENERATIVE DISEASE; HOMEOSTASIS; HUMAN; HUNTINGTON CHOREA; MEMORY; MULTIPLE SCLEROSIS; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION; PRIORITY JOURNAL; REVIEW;

ANIMALS; BIOLOGICAL MARKERS; CHOLESTEROL; HUMANS; NEURODEGENERATIVE DISEASES; OXIDATION-REDUCTION;

EID: 80051472136     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2011.04.002     Document Type: Review

References (108)

1. K. Abildayeva, P.J. Jansen, V. Hirsch-Reinshagen, V.W. Bloks, A.H. Bakker, F.C. Ramaekers, J. de Vente, A.K. Groen, C.L. Wellington, F. Kuipers, and M. Mulder 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux J. Biol. Chem. 281 2006 12799 12808 (Pubitemid 43855372)
2. E.H. Aylward Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease Brain Res. Bull. 72 2007 152 158 (Pubitemid 46367460)
3. F. Bagnato, N. Jeffreis, N.D. Richert, R.D. Stone, J.M. Ohayon, H. McFarland, and J.A. Frank Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years Brain 126 2003 1782 1789 (Pubitemid 36917337)
4. K. Blennow, A. Wallin, P. Fredman, I. Karlsson, C.G. Gottfries, and L. Svennerholm Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors Acta Neurol. Scand. 81 1990 323 326 (Pubitemid 20174132)
5. I. Björkhem Crossing the barrier, oxysterols as cholesterol transporters and metabolic modulators in the brain J. Intern. Med. 260 2006 493 508 (Pubitemid 44772369)
6. I. Björkhem, A. Cedazo-Minguez, V. Leoni, and S. Meaney Oxysterols and neurodegenerative diseases Mol. Aspects Med. 30 2009 171 179
7. I. Björkhem, V. Leoni, and S. Meaney Genetic connections between neurological disorders and cholesterol metabolism J. Lipid Res. 51 2010 2489 2503
8. I. Björkhem, and S. Meaney Brain cholesterol: long secret life behind a barrier Arterioscl. Thromb. Vasc. Biol. 24 2004 806 815 (Pubitemid 38620856)
9. K. Blennow, H. Hampel, M. Weiner, and H. Zetterberg Cerebrospinal fluid and plasma biomarkers in Alzheimer disease Nat. Rev. Neurol. 6 2010 131 144
10. K. Blennow, M.J. de Leon, and H. Zetterberg Alzheimer disease Lancet 368 2006 387 403
11. K. Blennow, A. Wallin, H. Agren, C. Spenger, J. Siegfried, and E. Vanmechelen Tau protein in cerebrospinal fluid, a biochemical marker for axonal degeneration in Alzheimer disease? Mol. Chem. Neuropathol. 26 1995 231 245 (Pubitemid 26002016)
12. S. Bodovitz, and W.L. Klein Cholesterol modulates α-secretase cleavage of amyloid precursor protein J. Biol. Chem. 271 1996 4436 4440
13. N. Bogdanovic, L. Bretillon, E.G. Lund, U. Diczfalusy, L. Lannfelt, B. Winblad, D.W. Russell, and I. Björkhem On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells Neurosci. Lett. 314 2001 45 48 (Pubitemid 33043802)
14. L. Bretillon, D. Lütjohann, L. Stahle, T. Widhe, L. Bindl, G. Eggersten, U. Diczfalusy, and I. Bjorkhem Plasma levels of 24S- hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface J. Lipid Res. 41 2000 840 845 (Pubitemid 30314140)
15. L. Bretillon, O. Siden, L.O. Wahlund, D. Lütjohann, L. Minthon, M. Crisby, J. Hillert, G.C. Groth, U. Diczfalusy, and I. Björkhem Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases Neurosci. Lett. 293 2000 87 90
16. A.J. Brown, and W. Jessup Oxysterols, sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
17. J. Brown, C. Theisler, S. Silberman, D. Magnuson, N. Gottardi-Littell, J.M. Lee, D. Yager, J. Crowley, K. Sambamurti, M.M. Rahman, A.B. Reiss, C.B. Eckman, and B. Wolozin Differential expression of cholesterol hydroxylases in Alzheimer's disease J. Biol. Chem. 279 2004 34674 34681 (Pubitemid 39318097)
18. G. Bu Apolipoprotein E and its receptors in Alzheimer's disease, pathways, pathogenesis and therapy Nat. Rev. Neurosci. 10 2009 333 344
19. K. Buerger, M. Ewers, T. Pirttilä, R. Zinkowski, I. Alafuzoff, S.J. Teipel, J. DeBernardis, D. Kerkman, C. McCulloch, H. Soininen, and H. Hampel CSF phosphorylated Tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease Brain 129 2006 3035 3041 (Pubitemid 44684523)
20. I. Burkard, A. von Eckardstein, G. Waeber, P. Vollenweider, and K.M. Rentsch Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers Atherosclerosis 194 2007 71 78 (Pubitemid 47464309)
21. A. Cifelli, M. Arridge, P. Jezzard, M.M. Esiri, J. Palace, and P.M. Matthews Thalamic neurodegeneration in multiple sclerosis Ann. Neurol. 52 2002 650 653 (Pubitemid 35246871)
22. V. Danylaité Karrenbauer, V. Leoni, E.T. Lim, G. Giovannoni, G.T. Ingle, J. Sastre-Garriga, A.J. Thompson, W. Rashid, G. Davies, J. Hillert, D.H. Miller, I. Björkhem, and T. Masterman Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis Clin. Neurol. Neurosurg. 108 2006 456 460 (Pubitemid 43744509)
23. J.M. Dietschy, and S.D. Turley Thematic review series, brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal J. Lipid Res. 45 2004 1375 1397 (Pubitemid 39022664)
24. D. Famer, S. Meaney, M. Mousavi, I. Björkhem, and M. Crisby Regulation of α-and β-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the α-secretase pathway Biochem. Biophys. Res. Commun. 359 2007 46 50 (Pubitemid 46844819)
25. N.C. Fox, R.I. Scahill, W.R. Crum, and M.N. Rossor Correlation between rates of brain atrophy and cognitive decline in AD Neurology 52 1999 1687 1689 (Pubitemid 29220648)
26. E.R. Frears, D.J. Stephens, C.E. Walters, H. Davies, and B.M. Austen The role of cholesterol in the biosynthesis of beta-amyloid Neuroreport 10 1999 1699 1705
27. M. Futter, H. Schoenmakers, O. Sadiq, K. Chatterjee, and D.C. Rubinsztein Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors J. Med. Genet. 46 2009 438 446
28. T.F. Gendron, and L. Petruccelli The role of Tau in neurodegeneration Mol. Neurodegener. 4 2009 13 32
29. J.M. Gil, and A.C. Rego Mechanisms of neurodegeneration in Huntington's disease Eur. J. Neurosci. 27 2008 2803 2820 (Pubitemid 351832229)
30. C. Goizet, A. Boukhris, A. Durr, C. Beetz, J. Truchetto, C. Tesson, M. Tsaousidou, S. Forlani, L. Guyant-Marechal, B. Fontaine, J. Guimaraes, B. Isidor, O. Chazouilleres, D. Wendum, D. Grid, F. Chevy, P.F. Chinnery, P. Coutinho, J.P. Azulay, I. Feki, F. Mochel, C. Wolf, C. Mhiri, A. Crosby, A. Brice, and G. Stevanin CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5 Brain 132 2009 1589 1600
31. M. Heverin, N. Bogdanovic, D. Lütjohann, T. Bayer, I. Pikuleva, L. Bretillon, U. Diczfalusy, B. Winblad, and I. Björkhem Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease J. Lipid Res. 45 2004 186 193 (Pubitemid 38180529)
32. M. Heverin, S. Meaney, D. Lütjohann, U. Diczfalusy, J. Wahren, and I. Björkhem Crossing the barrier, net flux of 27-hydroxycholesterol into the human brain J. Lipid Res. 46 2005 1047 1052
33. D.S. Howland, S.P. Trusko, M.J. Savage, A.G. Reaume, D.M. Lang, J.D. Hirsch, N. Maeda, R. Siman, B.D. Greenberg, R.W. Scott, and D.G. Flood Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol J. Biol. Chem. 273 1998 16576 16582 (Pubitemid 28311445)
34. Y. Huang, X.Q. Liu, T. Wyss-Coray, W.J. Brecht, D.A. Sanan, and R.W. Mahley Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons Proc. Natl. Acad. Sci. U S A 98 2001 8838 8843 (Pubitemid 32678114)
35. L. Iuliano, R. Monticolo, G. Straface, I. Spoletini, W. Gianni, C. Caltagirone, P. Boss, and G. Spalletta Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease J. Alzheimers Dis. 21 2010 1383 1392
36. C.R. Jack Jr., D.S. Knopman, W.J. Jagust, L.M. Shaw, P.S. Aisen, M.W. Weiner, R.C. Petersen, and J.Q. Trojanowski Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade Lancet Neurol. 9 2010 119 128
37. C.R. Jack Jr., V.J. Lowe, S.D. Weigand, H.J. Wiste, M.L. Senjem, D.S. Knopman, M.M. Shiung, J.L. Gunter, B.F. Boeve, B.J. Kemp, M. Weiner, R.C. Petersen Alzheimer's Disease Neuroimaging Initiative Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease, implications for sequence of pathological events in Alzheimer's disease Brain 132 2009 1355 1365
38. C.R. Jack Jr., R.C. Petersen, Y. Xu, P.C. O'Brien, G.E. Smith, R.J. Ivnik, E.G. Tangalos, and E. Kokmen Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease Neurology 51 1998 993 999 (Pubitemid 28473390)
39. A.G. Kermode, P.S. Tofts, A.J. Thompson, D.G. MacManus, P. Rudge, B.E. Kendall, D.P. Kingsley, I.F. Moseley, E.P. du Boulay, and W.I. McDonald Heterogenity of blood-brain barrier changes in multiple sclerosis, an MRI study with gadolinium-DTPA enhancement Neurology 40 1990 229 235 (Pubitemid 20099429)
40. W.S. Kim, A.S. Rahamanto, A. Kamili, K.A. Rye, I.C. Guillemin, W. Jessup, A.F. Hill, and B. Garner Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to Apoliporptien E discs and suppression of amyloid-beta peptide generation J. Biol. Chem. 282 2007 2851 2861 (Pubitemid 47084333)
41. M. Kivipelto, and A. Solomon Cholesterol as a risk factor for Alzheimer's disease - epidemiological evidence Acta Neurol. Scand. Suppl. 185 2006 50 57 (Pubitemid 44015225)
42. H. Kolsch, R. Heun, A. Kerksiek, K.V. Bergmann, W. Maier, and D. Lutjohann Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients Neurosci. Lett. 368 2004 303 308 (Pubitemid 39214973)
43. J. Koschack, D. Lütjohann, C. Schmidt-Samoa, and E. Irle Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals Neurobiol. Aging 30 2009 898 902
44. T.J. Kotti, D.M. Ramirez, B.E. Pfeiffer, K.M. Huber, and D.W. Russell Brain cholesterol turnover required for geranylgeraniol production and learning in mice Proc. Natl. Acad. Sci. U. S. A. 103 2006 3869 3874 (Pubitemid 43376647)
45. A.R. Koudinov, and N.V. Koudinova Essential role for cholesterol in synaptic plasticity and neuronal degeneration FASEB J. 15 2001 1858 1860
46. M.A. Lee, S. Smith, J. Palace, S. Narayann, N. Silver, L. Minicucci, M. Filippi, D.H. Miller, D.L. Arnold, and P.M. Matthews Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis, evidence for distinct mechanism of lesion genesis? Brain 122 1999 1261 1270 (Pubitemid 29324847)
47. V. Leoni, D. Lütjohann, and T. Mastermann Levels of 7-oxocholesterol in cerebrospinal fluid in patients with multiple sclerosis are more than a thousand times lower than reported J. Lipid Res. 46 2005 191 195 (Pubitemid 40271081)
48. V. Leoni, C. Mariotti, S.J. Tabrizi, M. Valenza, E.J. Wild, S.M. Henley, N.Z. Hobbs, M.L. Mandelli, M. Grisoli, I. Björkhem, E. Cattaneo, and S. Di Donato Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease Brain 131 2008 2851 2859
49. V. Leoni, T. Masterman, U. Diczfalusy, G. De Luca, J. Hillert, and I. Björkhem Changes in human plasma levels of 24S-hydroxycholesterol during progression of multiple sclerosis Neurosci. Lett. 331 2002 163 166
50. V. Leoni, T. Masterman, P. Patel, S. Meaney, U. Diczfalusy, and I. Björkhem Side-chain oxidised oxysterols in cerebrospinal fluid and integrity of blood-brain barrier J. Lipid Res. 44 2003 793 799 (Pubitemid 37279681)
51. V. Leoni, T. Mastermann, F.S. Mousavi, B. Wretlind, L.O. Wahlund, U. Diczfalusy, J. Hillert, and I. Björkhem Diagnostic use of cerebral and extracerebral oxysterols Clin. Chem. Lab. Med. 42 2004 186 191 (Pubitemid 38401447)
52. Leoni, V., 2005b. On the Possible use of oxysterols for the diagnosis and evaluation of patients with neurological and neurodegenerative diseases. Karolinska Institutet, Stockholm. ISBN 91-7140-255-1.
53. V. Leoni, M. Shafaati, A. Salomon, M. Kivipelto, I. Bjorkhem, and L.O. Wahlund Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment? Neurosci. Lett. 397 2006 83 87 (Pubitemid 43340464)
54. V. Leoni, C. Mariotti, L. Nanetti, E. Salvatore, F. Squitieri, A.R. Bentivoglio, M. Bandettini Del Poggio, S. Piacentini, D. Monza, M. Valenza, E. Cattaneo, and S. Di Donato Whole body cholesterol metabolism is impaired in Huntington's disease Neurosci. Lett. 2011 Mar 21
55. Y. Liu, D.A. Peterson, and D. Schubert Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis Proc. Natl. Acad. Sci. U. S. A. 95 1998 13266 13271 (Pubitemid 28509560)
56. E.G. Lund, J.M. Guileyardo, and D.W. Russell cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain Proc. Natl. Acad. Sci. U. S. A. 6 1999 7238 7243 (Pubitemid 29299645)
57. D. Lütjohann, O. Breuer, G. Ahlborg, I. Nennesmo,. Siden, U. Diczfalusy, and I. Björkhem Cholesterol homeostasis in human brain, evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation Proc. Natl. Acad. Sci. U. S. A. 93 1996 9799 9804 (Pubitemid 26296689)
58. D. Lütjohann, A. Papassotiropoulos, I. Björkhem, S. Locatelli, M. Bagli, R.D. Oehring, U. Schlegel, F. Jessen, M.L. Rao, K. von Bergmann, and R. Heun Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients J. Lipid Res. 41 2000 195 198 (Pubitemid 30117859)
59. L. Mateos, F.X. Gil-Bea, M.M. Ismail, V. Leoni, B. Wimblad, I. Björkhem, and A. Cedazo-Minguez Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease J. Alzheimers Dis. February 2011 (PubMed PMID: 21297254)
60. W.I. McDonald, A. Compston, G. Edan, D. Goodkin, H.P. Hartung, F.D. Lublin, H.F. McFarland, D.W. Paty, C.H. Polman, S.C. Reingold, M. Sandberg-Wollheim, W. Sibley, A. Thompson, S. van den Noort, B.Y. Weinshenker, and J.S. Wolinsky Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis Ann. Neurol. 50 2001 121 127
61. B. McGuinness, J. O'Hare, D. Craig, R. Bullock, R. Malouf, and P. Passmore Statins for the treatment of dementia Cochrane Database Syst. Rev. 8 2010 CD007514 (Review)
62. S. Meaney, M. Heverin, U. Panzenboeck, L. Ekström, M. Axelsson, U. Andersson, U. Diczfalusy, I. Pikuleva, J. Wahren, W. Sattler, and I. Björkhem Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid J. Lipid Res. 48 2007 944 951 (Pubitemid 46557899)
63. D.H. Miller, F. Barkhof, J.A. Frank, G.J. Parker, and A.J. Thompson Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance Brain 125 2002 1676 1695
64. A.M. Nicholson, and A. Ferreira Increased membrane cholesterol might render ature hippocampal neurons more suceptable to B-amyloid-induced calpain activation and Tau toxicity J. Neurosci. 29 2009 4640 4651
65. J.N. Noseworthy, C. Lucchinetti, M. Rodriguez, and B.G. Weinshenker Multiple sclerosis N. Eng. J. Med. 343 2000 938 952
66. Y. Ohyama, S. Meaney, M. Heverin, L. Ekström, A. Brafman, M. Shafir, U. Andersson, M. Olin, G. Eggertsen, U. Diczfalusy, E. Feinstein, and I. Björkhem Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes J. Biol. Chem. 281 2006 3810 3820 (Pubitemid 43847805)
67. A. Papassotiropoulos, D. Lütjohann, M. Bagli, S. Locatelli, F. Jessen, R. Buschfort, U. Ptok, I. Björkhem, K. von Bergmann, and R. Heun 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia J. Psychiatr. Res. 36 2002 27 32 (Pubitemid 34037845)
68. A. Papassotiropoulos, D. Lütjohann, M. Bagli, S. Locatelli, F. Jessen, M.L. Rao, W. Maier, I. Björkhem, K. von Bergmann, and R. Heun Plasma 24S-hydroxycholesterol, a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease Neuroreport 11 2000 1959 1962
69. J.S. Paulsen, D.R. Langbehn, J.C. Stout, E. Aylward, C.A. Ross, M. Nance, M. Guttman, S. Johnson, M. MacDonald, L.J. Beglinger, K. Duff, E. Kayson, K. Biglan, I. Shoulson, D. Oakes, M. Hayden Predict-HD Investigators and Coordinators of the Huntington Study Group Detection of Huntington's disease decades before diagnosis, the Predict-HD study J. Neurol. Neurosurg. Psychiatry 79 2008 874 880
70. F.W. Pfrieger Outsourcing in the brain, do neurons depend on cholesterol delivery by astrocytes? Bioessays 25 2003 72 78 (Pubitemid 36093328)
71. E. Posse de Chaves, and V. Narayanaswami Apolipoprotein E and cholesterol in aging and disease in the brain Future Lipidol. 3 2008 505 530
72. J.R. Prasanthi, A. Huls, S. Thomasson, A. Thompson, E. Schommer, and O. Ghribi Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells Mol. Neurodegener. 4 2009 1
73. L. Puglielli, R.E. Tanzi, and D.M. Kovacs Alzheimer's disease: the cholesterol connection Nat. Neurosci. 6 2003 345 351 (Pubitemid 36373979)
74. H.D. Rosas, A.K. Liu, S. Hersch, M. Glessner, R.J. Ferrante, D.H. Salat, A. van der Kouwe, B.G. Jenkins, A.M. Dale, and B. Fischl Regional and progressive thinning of the cortical ribbon in Huntington's disease Neurology 58 2002 695 701 (Pubitemid 34211546)
75. D.W. Russell The enzymes, regulation, and genetics of bile acid synthesis Annu. Rev. Biochem. 72 2003 137 174 (Pubitemid 36930444)
76. D.W. Russell, R.W. Halford, D.M. Ramirez, R. Shah, and T. Kotti Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain Annu. Rev. Biochem. 78 2009 1017 1040
77. A.M. Saunders, W.J. Strittmatter, D. Schmechel, P.H. George-Hyslop, M.A. Pericak-Vance, S.H. Joo, B.L. Rosi, J.F. Gusella, D.R. Crapper-MacLachlan, and M.J. Alberts Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease Neurology 43 1993 1467 1472 (Pubitemid 23230526)
78. P. Schönknecht, D. Lütjohann, J. Pantel, H. Bardenheuer, T. Hartmann, K. von Bergmann, K. Beyreuther, and J. Schröder Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls Neurosci. Lett. 324 2002 83 85 (Pubitemid 34442684)
79. R. Schüle, E. Brandt, K.N. Karle, M. Tsaousidou, S. Klebe, S. Klimpe, M. Auer-Grumbach, A.H. Crosby, C.A. Hubner, L. Schols, T. Deufel, and C. Beetz Analysis of CYP7B1 in non-consanguineous cases of hereditary spastic paraplegia Neurogenetics 10 2009 97 104
80. R. Schüle, T. Siddique, H.X. Deng, Y. Yang, S. Donkervoort, M. Hansson, R.E. Madrid, N. Siddique, L. Schöls, and I. Björkhem Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis J. Lipid Res. 51 2010 819 823
81. A. Serrano-Pozo, G.L. Vega, D. Lütjohann, J.J. Locascio, M.K. Tennis, A. Deng, A. Atri, B.T. Hyman, M.C. Irizarry, and J.H. Growdon Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers Alzheimer Dis. Assoc. Disord. 24 2010 220 226
82. M. Shafaati, A. Solomon, M. Kivipelto, I. Björkhem, and V. Leoni Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders Neurosci. Lett. 425 2007 78 82 (Pubitemid 47410361)
83. M. Simons, P. Keller, B. DeStrooper, K. Beyreuther, C.G. Dotti, and K. Simons Cholesterol depletion inhibits the generation of b-amyloid in hippocampal neurons Proc. Natl. Acad. Sci. U. S. A. 95 1998 6460 6464 (Pubitemid 28249035)
84. A. Solomon, V. Leoni, M. Kivipelto, A. Besga, A.R. Oksengrd, P. Julin, L. Svensson, L.O. Wahlund, N. Andreasen, B. Winblad, H. Soininen, and I. Björkhem Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease Neurosci. Lett. 462 2009 89 93
85. W.J. Strittmatter, K.H. Weisgraber, M. Goedert, A.M. Saunders, D. Huang, E.H. Corder, L.M. Dong, R. Jakes, M.J. Alberts, J.R. Gilbert, S.H. Han, C. Hulette, G. Einstein, D.E. Schmechel, M.A. Pericak-Vance, and A.D. Roses Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype Exp Neurol 125 1994 163 171 (Pubitemid 24076094)
86. S.J. Tabrizi, D.R. Langbehn, B.R. Leavitt, R.A. Roos, A. Durr, D. Craufurd, C. Kennard, S.L. Hicks, N.C. Fox, R.I. Scahill, B. Borowsky, A.J. Tobin, H.D. Rosas, H. Johnson, R. Reilmann, B. Landwehrmeyer, J.C. Stout TRACK-HD investigators Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study, cross-sectional analysis of baseline data Lancet Neurol. 8 2009 791 801
87. C.E. Teunissen, C.D. Dijkstra, C.H. Polman, E.L. Hoogervorst, K. von Bergmann, and D. Lütjohann Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients Neurosci. Lett. 347 2003 159 162 (Pubitemid 37271941)
88. C.E. Teunissen, S. Floris, K.E. Sonke, C.D. Dijkstra, H.E. DeVries, and D. Lütjohann 24S-hydroxycholesterol in relation to disease manifestation of acute experimental autoimmune encephalomyelitis Neurosci. Res. 85 2007 1499 1505 (Pubitemid 46724393)
89. L. Truyen, J.H.T.M. van Waesberghe, M.A.A. van Walderveen, B.W. vanOosten, C.H. Polman, O.R. Hommes, H.J.A. Ader, and F. Barkhof Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis Neurology 47 1996 1469 1476 (Pubitemid 26422538)
90. M.K. Tsaousidou, K. Ouahchi, T.T. Warner, Y. Yang, M.A. Simpson, N.G. Laing, P.A. Wilkinson, R.E. Madrid, H. Patel, F. Hentati, M.A. Patton, A. Hentati, P.J. Lamont, T. Siddique, and A.H. Crosby Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration Am. J. Hum. Genet. 82 2008 510 515
91. M. Valenza, J.B. Carroll, V. Leoni, L.N. Bertram, I. Bjorkhem, R.R. Singaraja, S. Di Donato, D. Lutjohann, M.R. Hayden, and E. Cattaneo Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation Hum. Mol. Genet. 16 2007 2187 2198 (Pubitemid 47354901)
92. M. Valenza, V. Leoni, J.M. Karasinska, L. Petricca, J. Fan, J. Carroll, M.A. Pouladi, E. Fossale, H.P. Nguyen, O. Riess, M. MacDonald, C. Wellington, S. DiDonato, M. Hayden, and E. Cattaneo Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes J. Neurosci. 30 2010 10844 10850
93. M. Valenza, V. Leoni, A. Tarditi, C. Mariotti, I. Björkhem, S. Di Donato, and E. Cattaneo Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease Neurobiol. Dis. 28 2007 133 142 (Pubitemid 47429978)
94. M. Valenza, D. Rigamonti, D. Goffredo, C. Zuccato, S. Fenu, L. Jamot, A. Strand, A. Tarditi, B. Woodman, M. Racchi, C. Mariotti, S. Di Donato, A. Corsini, G. Bates, R. Pruss, J.M. Olson, S. Sipione, M. Tartari, and E. Cattaneo Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease J. Neurosci. 25 2005 9932 9939 (Pubitemid 41528031)
95. T.N. van den Kommer, M.G. Dik, H.C. Comijs, K. Fassbender, D. Lütjohann, and C. Jonker Total cholesterol and oxysterols: early markers for cognitive decline in elderly? Neurobiol. Aging 30 2009 534 545
96. J.H. van Waesberghe, M.A. van Walderveen, J.A. Castelijns, P. Scheltens, A. Lycklama, G.J. Nijeholt, C.H. Polman, and F. Barkhof Patterns of lesion development in multiple sclerosis, longitudinal observations with T1-weighted spin-echo and magnetization transfer MR Am. J. Neuroradiol. 19 1998 675 683 (Pubitemid 30422711)
97. M.A.A. van Walderveen, W. Kamphorst, P. Scheltens, J. van Waesberghe, R. Ravid, J. Valk, C.H. Polman, and F. Barkhof Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis Neurology 50 1998 1282 1288 (Pubitemid 28240340)
98. C. Vedhachalam, V. Narayanaswami, N. Neto, T.M. Forte, M.C. Phillips, S. Lund-Katz, and J.K. Bielicki The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins Biochemistry 46 2007 2583 2593 (Pubitemid 46417902)
99. G.L. Vega, M. Weiner, H. Kölsch, K. von Bergmann, R. Heun, D. Lutjohan, A. Nguyen, and C. Moore The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins Curr. Alzheimer Res. 1 2004 71 77
100. P. Vemuri, H.J. Wiste, S.D. Weigand, L.M. Shaw, J.Q. Trojanowski, M.W. Weiner, D.S. Knopman, R.C. Petersen, and C.R. Jack Alzheimer's disease neuroimaging initiative. MRI and CSF biomarkers in normal, MCI, and AD subjects, diagnostic discrimination and cognitive correlations Neurology 73 2009 287 293
101. J.P. Vonsattel, R.H. Myers, T.J. Stevens, R.J. Ferrante, E.D. Bird, and E.P. Richardson Jr. Neuropathological classification of Huntington's disease J. Neuropathol. Exp. Neurol. 44 1985 559 577 (Pubitemid 16196286)
102. F.O. Walker Huntingtons disease Lancet 369 2007 218 228
103. N. Wang, L. Yvan-Charvet, D. Lütjohann, M. Mulder, T. Vabmierlo, T.W. Kim, and A.R. Tall ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain FASEB J. 22 2008 1073 1082 (Pubitemid 351519962)
104. J.Z. Willey, and M.S. Elkind 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases Arch. Neurol. 67 2010 1062 1067
105. B. Wolozin, W. Kellman, P. Ruosseau, G.G. Celesia, and G. Siegel Decreased prevalence of Alzheimer's disease associated with HMG CoA reductase inhibitors Arch. Neurol. 57 2000 1439 1443
106. C. Xie, E.G. Lund, S.D. Turley, D.W. Russell, and J.M. Dietschy Quantification of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration J. Lipid Res. 44 2003 1780 1789 (Pubitemid 37185890)
107. J.L. Yau, S. Rasmuson, R. Andrew, M. Graham, J. Noble, T. Olson, E. Fuchs, R. Lathe, and J.R. Seckl Dehydroepiandrosterone 7-hydroxylase CYP7B1: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease Neuroscience 121 2003 307 314 (Pubitemid 37176919)
108. J. Zhang, and G. Hutton Role of magnetic resonance imaging and immunotherapy in treating multiple sclerosis Annu. Rev. Med. 56 2005 273 302 (Pubitemid 40299784)