메뉴 건너뛰기




Volumn 86, Issue 5, 2009, Pages 1039-1048

Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes

Author keywords

Cell cycle; T cell and B cell chronic lymphoblastic leukemia; T lymphoblasts

Indexed keywords

CYCLIN B; CYTOKINE; GELATINASE B; INTERLEUKIN 2; INTERLEUKIN 7; LIVER X RECEPTOR; PROTEIN BCL 2; RETINOBLASTOMA PROTEIN;

EID: 70350724700     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1008663     Document Type: Article
Times cited : (56)

References (58)
  • 1
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: Potential new players in atherosclerosis
    • DOI 10.1038/nm1102-1243
    • Repa, J. J., Mangelsdorf, D. J. (2002) The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8, 1243-1248. (Pubitemid 35373555)
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 2
    • 33645068185 scopus 로고    scopus 로고
    • Liver X receptors in cardiovascular and metabolic disease
    • Geyeregger, R., Zeyda, M., Stulnig, T. M. (2006) Liver X receptors in cardiovascular and metabolic disease. Cell. Mol. Life Sci. 63, 524-539.
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 524-539
    • Geyeregger, R.1    Zeyda, M.2    Stulnig, T.M.3
  • 3
    • 8444233254 scopus 로고    scopus 로고
    • Nuclear receptors in macrophage biology: At the crossroads of lipid metabolism and inflammation
    • DOI 10.1146/annurev.cellbio.20.012103.134432
    • Castrillo, A., Tontonoz, P. (2004) Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. Annu. Rev. Cell Dev. Biol. 20, 455-480. (Pubitemid 39488646)
    • (2004) Annual Review of Cell and Developmental Biology , vol.20 , pp. 455-480
    • Castrillo, A.1    Tontonoz, P.2
  • 4
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • DOI 10.1038/nm820
    • Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., Tontonoz, P. (2003) Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9, 213-219. (Pubitemid 36227724)
    • (2003) Nature Medicine , vol.9 , Issue.2 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 5
    • 0037289786 scopus 로고    scopus 로고
    • Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: Liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    • DOI 10.1046/j.1523-1747.2003.12033.x
    • Fowler, A. J., Sheu, M. Y., Schmuth, M., Kao, J., Fluhr, J. W., Rhein, L., Collins, J. L., Willson, T. M., Mangelsdorf, D. J., Elias, P. M., Feingold, K. R. (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J. Invest. Dermatol. 120, 246-255. (Pubitemid 36513075)
    • (2003) Journal of Investigative Dermatology , vol.120 , Issue.2 , pp. 246-255
    • Fowler, A.J.1    Sheu, M.Y.2    Schmuth, M.3    Kao, J.4    Fluhr, J.W.5    Rhein, L.6    Collins, J.L.7    Willson, T.M.8    Mangelsdorf, D.J.9    Elias, P.M.10    Feingold, K.R.11
  • 8
    • 34047190250 scopus 로고    scopus 로고
    • Immunomodulatory properties of increased levels of liver X receptor β in peripheral blood mononuclear cells from multiple sclerosis patients
    • DOI 10.1016/j.expneurol.2007.01.013, PII S0014488607000283
    • Giorelli, M., Livrea, P., Minervini, M. G., Trojano, M. (2007) Immunomodulatory properties of increased levels of liver X receptor β in peripheral blood mononuclear cells from multiple sclerosis patients. Exp. Neurol. 204, 759-766. (Pubitemid 46509501)
    • (2007) Experimental Neurology , vol.204 , Issue.2 , pp. 759-766
    • Giorelli, M.1    Livrea, P.2    Minervini, M.G.3    Trojano, M.4
  • 9
    • 34248399632 scopus 로고    scopus 로고
    • Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin
    • DOI 10.1182/blood-2006-08-043422
    • Geyeregger, R., Zeyda, M., Bauer, W., Kriehuber, E., Saemann, M. D., Zlabinger, G. J., Maurer, D., Stulnig, T. M. (2007) Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin. Blood 109, 4288-4295. (Pubitemid 46743395)
    • (2007) Blood , vol.109 , Issue.10 , pp. 4288-4295
    • Geyeregger, R.1    Zeyda, M.2    Bauer, W.3    Kriehuber, E.4    Saemann, M.D.5    Zlabinger, G.J.6    Maurer, D.7    Stulnig, T.M.8
  • 12
    • 33746176754 scopus 로고    scopus 로고
    • Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
    • DOI 10.1158/0008-5472.CAN-06-0632
    • Chuu, C. P., Hiipakka, R. A., Kokontis, J. M., Fukuchi, J., Chen, R. Y., Liao, S. (2006) Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Cancer Res. 66, 6482-6486. (Pubitemid 44085600)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6482-6486
    • Chuu, C.-P.1    Hiipakka, R.A.2    Kokontis, J.M.3    Fukuchi, J.4    Chen, R.-Y.5    Liao, S.6
  • 13
    • 34547475143 scopus 로고    scopus 로고
    • Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor
    • DOI 10.1210/me.2007-0187
    • Gong, H., Guo, P., Zhai, Y., Zhou, J., Uppal, H., Jarzynka, M. J., Song, W. C., Cheng, S. Y., Xie, W. (2007) Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol. Endocrinol. 21, 1781-1790. (Pubitemid 47173791)
    • (2007) Molecular Endocrinology , vol.21 , Issue.8 , pp. 1781-1790
    • Gong, H.1    Guo, P.2    Zhai, Y.3    Zhou, J.4    Uppal, H.5    Jarzynka, M.J.6    Song, W.-C.7    Cheng, S.-Y.8    Xie, W.9
  • 14
    • 0033491981 scopus 로고    scopus 로고
    • Biology of the interleukin-2 receptor
    • Nelson, B. H., Willerford, D. M. (1998) Biology of the interleukin-2 receptor. Adv. Immunol. 70, 1-81.
    • (1998) Adv. Immunol. , vol.70 , pp. 1-81
    • Nelson, B.H.1    Willerford, D.M.2
  • 15
    • 0031433335 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
    • DOI 10.1016/S1074-7613(00)80388-X
    • Brennan, P., Babbage, J. W., Burgering, B. M., Groner, B., Reif, K., Cantrell, D. A. (1997) Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7, 679-689. (Pubitemid 28156635)
    • (1997) Immunity , vol.7 , Issue.5 , pp. 679-689
    • Brennan, P.1    Babbage, J.W.2    Burgering, B.M.T.3    Groner, B.4    Reif, K.5    Cantrell, D.A.6
  • 16
    • 10444276464 scopus 로고    scopus 로고
    • Common γ chain-signaling cytokines promote proliferation of T-cell lymphoblastic leukemia
    • Barata, J. T., Keenan, T. D., Silva, A., Nadler, L. M., Boussiotis, V. A., Cardoso, A. A. (2004) Common γ chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica 89, 1459-1467. (Pubitemid 39643513)
    • (2004) Haematologica , vol.89 , Issue.12 , pp. 1459-1467
    • Barata, J.T.1    Keenan, T.D.2    Silva, A.3    Nadler, L.M.4    Boussiotis, V.A.5    Cardoso, A.A.6
  • 18
    • 0028286627 scopus 로고
    • Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling
    • DOI 10.1038/369330a0
    • Nakamura, Y., Russell, S. M., Mess, S. A., Friedmann, M., Erdos, M., Francois, C., Jacques, Y., Adelstein, S., Leonard, W. J. (1994) Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signaling. Nature 369, 330-333. (Pubitemid 24159545)
    • (1994) Nature , vol.369 , Issue.6478 , pp. 330-333
    • Nakamura, Y.1    Russell, S.M.2    Mess, S.A.3    Friedmann, M.4    Erdos, M.5    Francois, C.6    Jacques, Y.7    Adelstein, S.8    Leonard, W.J.9
  • 19
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard, W. J., O'Shea, J. J. (1998) Jaks and STATs: biological implications. Annu. Rev. Immunol. 16, 293-322.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 20
    • 0028953576 scopus 로고
    • IL-2 signaling: Recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor
    • Minami, Y., Taniguchi, T. (1995) IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor. Curr. Opin. Cell Biol. 7, 156-162.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 156-162
    • Minami, Y.1    Taniguchi, T.2
  • 21
    • 0033548678 scopus 로고    scopus 로고
    • Role of interleukin (IL)-2 receptor β-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein kinase/c-Jun N-terminal kinase) activation: IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation
    • Hunt, A. E., Lali, F. V., Lord, J. D., Nelson, B. H., Miyazaki, T., Tracey, K. J., Foxwell, B. M. (1999) Role of interleukin (IL)-2 receptor β-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein Kinase/c-Jun N-terminal kinase) activation. IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation. J. Biol. Chem. 274, 7591-7597. (Pubitemid 129505057)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.2-11 , pp. 7591-7597
    • Hunt, A.E.1    Lali, F.V.2    Lord, J.D.3    Nelson, B.H.4    Miyazaki, T.5    Tracey, K.J.6    Foxwell, B.M.J.7
  • 22
    • 0033826512 scopus 로고    scopus 로고
    • New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
    • Gu, H., Maeda, H., Moon, J. J., Lord, J. D., Yoakim, M., Nelson, B. H., Neel, B. G. (2000) New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol. Cell. Biol. 20, 7109-7120.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7109-7120
    • Gu, H.1    Maeda, H.2    Moon, J.J.3    Lord, J.D.4    Yoakim, M.5    Nelson, B.H.6    Neel, B.G.7
  • 23
    • 0029813118 scopus 로고    scopus 로고
    • Distinct tyrosine residues within the interleukin-2 receptor β chain drive signal transduction specificity, redundancy, and diversity
    • DOI 10.1074/jbc.271.35.21381
    • Gaffen, S. L., Lai, S. Y., Ha, M., Liu, X., Hennighausen, L., Greene, W. C., Goldsmith, M. A. (1996) Distinct tyrosine residues within the interleukin-2 receptor β chain drive signal transduction specificity, redundancy, and diversity. J. Biol. Chem. 271, 21381-21390. (Pubitemid 26293001)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.35 , pp. 21381-21390
    • Gaffen, S.L.1    Lai, S.Y.2    Ha, M.3    Liu, X.4    Hennighausen, L.5    Greene, W.C.6    Goldsmith, M.A.7
  • 24
    • 0033180185 scopus 로고    scopus 로고
    • Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells
    • DOI 10.1016/S1074-7613(00)80097-7
    • Moriggl, R., Sexl, V., Piekorz, R., Topham, D., Ihle, J. N. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11, 225-230. (Pubitemid 29428815)
    • (1999) Immunity , vol.11 , Issue.2 , pp. 225-230
    • Moriggl, R.1    Sexl, V.2    Piekorz, R.3    Topham, D.4    Ihle, J.N.5
  • 25
    • 0030882317 scopus 로고    scopus 로고
    • STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727
    • DOI 10.1074/jbc.272.39.24542
    • Ng, J., Cantrell, D. (1997) STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727. J. Biol. Chem. 272, 24542-24549. (Pubitemid 27418667)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.39 , pp. 24542-24549
    • Ng, J.1    Cantrell, D.2
  • 26
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. (1995) The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 27
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D- Type cyclins
    • DOI 10.1016/0092-8674(93)90136-E
    • Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J., Livingston, D. M. (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497. (Pubitemid 23143348)
    • (1993) Cell , vol.73 , Issue.3 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.-Y.5    Livingston, D.M.6
  • 28
    • 0028363519 scopus 로고
    • P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • DOI 10.1016/0092-8674(94)90573-8
    • Toyoshima, H., Hunter, T. (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78, 67-74. (Pubitemid 24228301)
    • (1994) Cell , vol.78 , Issue.1 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 29
    • 0032941221 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia: A bird of a different feather
    • Caligaris-Cappio, F., Hamblin, T. J. (1999) B-cell chronic lymphocytic leukemia: a bird of a different feather. J. Clin. Oncol. 17, 399-408. (Pubitemid 29022419)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.1 , pp. 399-408
    • Caligaris-Cappio, F.1    Hamblin, T.J.2
  • 30
    • 0024556599 scopus 로고
    • Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro
    • Collins, R. J., Verschuer, L. A., Harmon, B. V., Prentice, R. L., Pope, J. H., Kerr, J. F. (1989) Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br. J. Haematol. 71, 343-350.
    • (1989) Br. J. Haematol. , vol.71 , pp. 343-350
    • Collins, R.J.1    Verschuer, L.A.2    Harmon, B.V.3    Prentice, R.L.4    Pope, J.H.5    Kerr, J.F.6
  • 31
    • 0027379859 scopus 로고
    • Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis, P., Ganeshaguru, K., Jabbar, S. A., Hoffbrand, A. V. (1993) Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro. Br. J. Haematol. 85, 439-445. (Pubitemid 23349043)
    • (1993) British Journal of Haematology , vol.85 , Issue.3 , pp. 439-445
    • Panayiotidis, P.1    Ganeshaguru, K.2    Jabbar, S.A.B.3    Hoffbrand, A.V.4
  • 33
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis, P., Jones, D., Ganeshaguru, K., Foroni, L., Hoffbrand, A. V. (1996) Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br. J. Haematol. 92, 97-103. (Pubitemid 26018774)
    • (1996) British Journal of Haematology , vol.92 , Issue.1 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3    Foroni, L.4    Hoffbrand, A.V.5
  • 34
    • 0025837192 scopus 로고
    • Development of a bone marrow culture for maintenance and growth of normal human B cell precursors
    • Wolf, M. L., Buckley, J. A., Goldfarb, A., Law, C. L., LeBien, T. W. (1991) Development of a bone marrow culture for maintenance and growth of normal human B cell precursors. J. Immunol. 147, 3324-3330.
    • (1991) J. Immunol. , vol.147 , pp. 3324-3330
    • Wolf, M.L.1    Buckley, J.A.2    Goldfarb, A.3    Law, C.L.4    Lebien, T.W.5
  • 36
    • 0033957377 scopus 로고    scopus 로고
    • Chemosensitivity of B cell chronic lymphocytic leukemia and correlated expression of proteins regulating apoptosis, cell cycle and DNA repair
    • Klein, A., Miera, O., Bauer, O., Golfier, S., Schriever, F. (2000) Chemosensitivity of B cell chronic lymphocytic leukemia and correlated expression of proteins regulating apoptosis, cell cycle and DNA repair. Leukemia 14, 40-46. (Pubitemid 30068371)
    • (2000) Leukemia , vol.14 , Issue.1 , pp. 40-46
    • Klein, A.1    Miera, O.2    Bauer, O.3    Golfier, S.4    Schriever, F.5
  • 37
    • 0033011755 scopus 로고    scopus 로고
    • Molecular pathogenesis of chronic lymphocytic leukemia: Factors and signaling pathways regulating cell growth and survival
    • Meinhardt, G., Wendtner, C. M., Hallek, M. (1999) Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and survival. J. Mol. Med. 77, 282-293. (Pubitemid 29146579)
    • (1999) Journal of Molecular Medicine , vol.77 , Issue.2 , pp. 282-293
    • Meinhardt, G.1    Wendtner, C.-M.2    Hallek, M.3
  • 39
    • 0023620692 scopus 로고
    • Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus
    • Hori, T., Uchiyama, T., Tsudo, M., Umadome, H., Ohno, H., Fukuhara, S., Kita, K., Uchino, H. (1987) Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus. Blood 70, 1069-1072. (Pubitemid 18022384)
    • (1987) Blood , vol.70 , Issue.4 , pp. 1069-1072
    • Hori, T.1    Uchiyama, T.2    Tsudo, M.3    Umadome, H.4    Ohno, H.5    Fukuhara, S.6    Kita, K.7    Uchino, H.8
  • 41
    • 0035710746 scopus 로고    scopus 로고
    • -Δ ΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak, K. J., Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Δ Δ C(T)) Method. Methods 25, 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 42
    • 0029946514 scopus 로고    scopus 로고
    • Selective suppression of endothelial cell activation by arachidonic acid
    • DOI 10.1002/eji.1830260703
    • Stuhlmeier, K. M., Tarn, C., Csizmadia, V., Bach, F. H. (1996) Selective suppression of endothelial cell activation by arachidonic acid. Eur. J. Immunol. 26, 1417-1423. (Pubitemid 26229983)
    • (1996) European Journal of Immunology , vol.26 , Issue.7 , pp. 1417-1423
    • Stuhlmeier, K.M.1    Tarn, C.2    Csizmadia, V.3    Bach, F.H.4
  • 44
    • 0036721788 scopus 로고    scopus 로고
    • Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis
    • Quemeneur, L., Flacher, M., Gerland, L. M., Ffrench, M., Revillard, J. P., Bonnefoy-Berard, N. (2002) Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis. J. Immunol. 169, 2747-2755. (Pubitemid 34921024)
    • (2002) Journal of Immunology , vol.169 , Issue.5 , pp. 2747-2755
    • Quemeneur, L.1    Flacher, M.2    Gerland, L.-M.3    Ffrench, M.4    Revillard, J.-P.5    Bonnefoy-Berard, N.6
  • 45
    • 0037093322 scopus 로고    scopus 로고
    • Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins
    • DOI 10.1093/emboj/21.10.2485
    • Frouin, I., Montecucco, A., Biamonti, G., Hubscher, U., Spadari, S., Maga, G. (2002) Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. EMBO J. 21, 2485-2495. (Pubitemid 34546720)
    • (2002) EMBO Journal , vol.21 , Issue.10 , pp. 2485-2495
    • Frouin, I.1    Montecucco, A.2    Biamonti, G.3    Hubscher, U.4    Spadari, S.5    Maga, G.6
  • 46
    • 0032488972 scopus 로고    scopus 로고
    • G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27(Kip1) and inhibition of G1 CDKs in choroidal melanoma cells
    • DOI 10.1016/S0014-5793(98)00043-X, PII S001457939800043X
    • Casagrande, F., Bacqueville, D., Pillaire, M. J., Malecaze, F., Manenti, S., Breton-Douillon, M., Darbon, J. M. (1998) G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells. FEBS Lett. 422, 385-390. (Pubitemid 28075501)
    • (1998) FEBS Letters , vol.422 , Issue.3 , pp. 385-390
    • Casagrande, F.1    Bacqueville, D.2    Pillaire, M.-J.3    Malecaze, F.4    Manenti, S.5    Breton-Douillon, M.6    Darbon, J.-M.7
  • 47
    • 0037409458 scopus 로고    scopus 로고
    • IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells
    • DOI 10.1016/S0898-6568(03)00003-2
    • Fung, M. M., Rohwer, F., McGuire, K. L. (2003) IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells. Cell. Signal. 15, 625-636. (Pubitemid 36385168)
    • (2003) Cellular Signalling , vol.15 , Issue.6 , pp. 625-636
    • Fung, M.M.1    Rohwer, F.2    McGuire, K.L.3
  • 50
    • 0030970643 scopus 로고    scopus 로고
    • Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein
    • Yamauchi, A., Bloom, E. T. (1997) Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein. Blood 89, 4092-4099. (Pubitemid 27220956)
    • (1997) Blood , vol.89 , Issue.11 , pp. 4092-4099
    • Yamauchi, A.1    Bloom, E.T.2
  • 51
    • 0033000334 scopus 로고    scopus 로고
    • P70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin- Regulated signals for E2F regulation in T lymphocytes
    • Brennan, P., Babbage, J. W., Thomas, G., Cantrell, D. (1999) p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol. Cell. Biol. 19, 4729-4738. (Pubitemid 29289511)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.7 , pp. 4729-4738
    • Brennan, P.1    Babbage, J.W.2    Thomas, G.3    Cantrell, D.4
  • 52
    • 0028931830 scopus 로고
    • Advances in the biology and treatment of B-cell chronic lymphocytic leukemia
    • O'Brien, S., del Giglio, A., Keating, M. (1995) Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood 85, 307-318.
    • (1995) Blood , vol.85 , pp. 307-318
    • O'Brien, S.1    Del Giglio, A.2    Keating, M.3
  • 53
    • 33644536722 scopus 로고    scopus 로고
    • Mechanisms of apoptosis-induction by rottlerin: Therapeutic implications for B-CLL
    • DOI 10.1038/sj.leu.2404113, PII 2404113
    • Ringshausen, I., Oelsner, M., Weick, K., Bogner, C., Peschel, C., Decker, T. (2006) Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL. Leukemia 20, 514-520. (Pubitemid 43291752)
    • (2006) Leukemia , vol.20 , Issue.3 , pp. 514-520
    • Ringshausen, I.1    Oelsner, M.2    Weick, K.3    Bogner, C.4    Peschel, C.5    Decker, T.6
  • 54
    • 11144268038 scopus 로고    scopus 로고
    • Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells
    • DOI 10.1038/sj.leu.2403544
    • Ringshausen, I., Dechow, T., Schneller, F., Weick, K., Oelsner, M., Peschel, C., Decker, T. (2004) Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells. Leukemia 18, 1964-1970. (Pubitemid 40028422)
    • (2004) Leukemia , vol.18 , Issue.12 , pp. 1964-1970
    • Ringshausen, I.1    Dechow, T.2    Schneller, F.3    Weick, K.4    Oelsner, M.5    Peschel, C.6    Decker, T.7
  • 55
    • 0038193542 scopus 로고    scopus 로고
    • Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages
    • DOI 10.1074/jbc.M213071200
    • Castrillo, A., Joseph, S. B., Marathe, C., Mangelsdorf, D. J., Tontonoz, P. (2003) Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J. Biol. Chem. 278, 10443-10449. (Pubitemid 36800310)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.12 , pp. 10443-10449
    • Castrillo, A.1    Joseph, S.B.2    Marathe, C.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 56
    • 7244251612 scopus 로고    scopus 로고
    • BCL2 protein expression parallels its mRNA level in normal and malignant B cells
    • DOI 10.1182/blood-2004-01-0243
    • Shen, Y., Iqbal, J., Huang, J. Z., Zhou, G., Chan, W. C. (2004) BCL2 protein expression parallels its mRNA level in normal and malignant B cells. Blood 104, 2936-2939. (Pubitemid 39434983)
    • (2004) Blood , vol.104 , Issue.9 , pp. 2936-2939
    • Shen, Y.1    Iqbal, J.2    Huang, J.Z.3    Zhou, G.4    Chan, W.C.5
  • 57
    • 0030952902 scopus 로고    scopus 로고
    • Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia
    • Findley, H. W., Gu, L., Yeager, A. M., Zhou, M. (1997) Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 89, 2986-2993. (Pubitemid 27172586)
    • (1997) Blood , vol.89 , Issue.8 , pp. 2986-2993
    • Findley, H.W.1    Gu, L.2    Yeager, A.M.3    Zhou, M.4
  • 58
    • 0027239823 scopus 로고
    • Bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada, M., Delia, D., Aiello, A., Stadtmauer, E., Reed, J. C. (1993) bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 82, 1820-1828. (Pubitemid 23278773)
    • (1993) Blood , vol.82 , Issue.6 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3    Stadtmauer, E.4    Reed, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.