Oxysterols: Friends, foes, or just fellow passengers?

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 5, 2002, Pages 734-742

  Björkhem, Ingemar ^a   Diczfalusy, Ulf ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Atherosclerosis; Cholesterol homeostasis; CYP27A1; CYP46; CYP7A1

Indexed keywords

26 HYDROXYCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; CELL NUCLEUS RECEPTOR; CHOLESTEROL; LIPID BINDING PROTEIN; LIVER X RECEPTOR ALPHA; OXYSTEROL; UNCLASSIFIED DRUG;

APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; GALLSTONE FORMATION; HUMAN; IMMUNE DEFICIENCY; INFLAMMATION; MEDIAL LEMNISCUS; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEROL ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTENONES; CHOLESTEROL; HUMANS; HYDROXYCHOLESTEROLS; OXIDATIVE STRESS; OXYGEN; STEROID HYDROXYLASES;

EID: 0036096897     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000013312.32196.49     Document Type: Review

References (88)

1. Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells
2. Oxysterols and atherosclerosis
3. Biological effects of oxysterols: Current status
4. Oxysterols: Modulators of cholesterol metabolism and other processes
5. Good cholesterol, bad cholesterol: Role of oxysterols in biliary tract diseases
6. Biological activity of some oxygenated sterols
7. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
8. An oxysterol signalling pathway mediated by the nuclear receptor LXRα
9. Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry
10. Absorption of cholesterol oxidation products from ordinary foodstuff in humans
11. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
12. 2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat: Evidence for in vivo formation of 7-oxo-, 7β-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol
13. Simultaneous quantification of several cholesterol autoxidation and monohydroxylation products by isotope-dilution mass spectrometry
14. Transport of side-chain oxidized oxysterols in the human circulation
15. Antiepileptic drugs increase plasma levels of 4β-hydroxycholesterol in humans: Evidence for involvement of cytochrome P450 3A4
16. Regulation of bile acid biosynthesis
17. Nuclear orphan receptors control cholesterol catabolism
18. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
19. Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα)
20. On the possible use of the serum level of 7α-hydroxycholesterol as a marker for increased activity of the cholesterol 7α-hydroxylase
21. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans
22. 27-Hydroxycholesterol: Production rates in normal human subjects
23. Mechanism of degradation of the steroid side chain in the formation of bile acids
24. Suppression of sterol 27-hydroxylase nRNA and transcriptional activity by bile acids in cultured rat hepatocytes
25. Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids
26. Down-regulation of the rat hepatic sterol 27-hydroxylase gene by bile acids in transfected primary hepatocytes: Possible role of hepatic nuclear factor 1α
27. There is little or no coordinate regulation of sterol 27-hydroxylase and cholesterol 7α-hydroxylase in man
28. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
29. Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
30. Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: Cerebral origin of most circulating 24S-hydroxycholesterol in rats but not in mice
31. Cholesterol homeostasis in human brain: Evidence for an agedependent flux of 24S-hydroxycholesterol from the brain into the circulation
32. Importance of a novel oxidative mechanism for elimination of brain cholesterol
33. From brain to bile: Evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
34. In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge
35. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
36. 4-3-ketone derivatives by HPLC and response to physiological perturbations
37. Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by ketoconazole
38. 24(S),25-Epoxycholesterol: Evidence consistent with a role in the regulation of hepatic cholesterogenesis
39. Signaling molecules derived from the cholesterol biosynthetic pathway: Mechanisms of action and possible roles in human disease
40. Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells
41. Control of low density lipoprotein receptor gene promoter activity: Ketokonazole inhibits serum lipoprotein but not oxysterol suppression of gene transcription
42. Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts
43. Biosynthesis of cholesterol, lanosterol, and delta 7-cholestenol, but not cholestanol, in cultured fibroblasts from normal individuals and patients with cerebrotendinous xanthomatosis
44. Oxysterol regulators of 3-hydroxy-3-methylglutaryl-CoA reductase in liver
45. Evidence that 24- and 27-hydroxylation are not involved in the cholesterol-induced down-regulation of hydroxymethylglutaryl-CoA reductase in mouse liver
46. Down-regulation of hepatic HMG-CoA reductase in mice by dietary cholesterol: Importance of the delta5 double bond and evidence that oxidation at C-3, C-5, or C-7 is not involved
47. Inhibition of hepatic cholesterol synthesis in mice by sterols with shortened and stereochemically varied side chains
48. Binding of 25-hydroxycholesterol and cholesterol to different cytoplasmatic proteins
49. Cytosolic proteins that bind oxygenated sterols
50. Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding
51. Family of human oxysterol binding protein (OSBP) homologues: A novel member implicated in brain sterol metabolism
52. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport
53. Overlapping functions of the yeast oxysterol-binding protein homologues
54. Nuclear receptors and lipid physiology: Opening the X-files
55. The RXR heterodimers and orphan receptors
56. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
57. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice
58. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
59. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages
60. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα
61. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
62. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
63. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
64. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
65. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
66. Oxysterol biosynthetic enzymes
67. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
68. Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia
69. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol
70. Disruption of the oxysterol 7α-hydroxylase gene in mice
71. Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7α-hydroxylase gene causes severe neonatal liver disease
72. Lipoprotein oxidation and progression of carotid atherosclerosis
73. Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2′-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men
74. Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: Effects of vitamin E treatment
75. Cholesterol oxides in Indian ghee: Possible cause of unexplained high risk of atherosclerosis in Indian immigrant populations
76. 7β-hydroperoxycholest-5-en-3β-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein
77. 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque
78. Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture
79. Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions
80. Atherosclerosis and sterol 27-hydroxylase: Evidence for a role of this enzyme in elimination of cholesterol from human macrophages
81. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism
82. The plasma level of 7α-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7α-hydroxylase in man
83. Estimation of 26-hydroxycholesterol in serum by high-performance liquid chromatography and its measurement in patients with atherosclerosis
84. Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: Abnormal levels of 24S- and 27-hydroxycholesterol
85. Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
86. Toxicity of oxysterols to human monocyte-macrophages