Liver Regeneration

Zakim and Boyer's Hepatology

Volumn , Issue , 2012, Pages 20-35

  Nevzorova, Yulia A ^a   Trautwein, Christian ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882544295     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4377-0881-3.00002-4     Document Type: Chapter

References (275)

1. Apte U, et al. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology 2006, 44(4):992-1002. (Ref.90).
2. Baena E, et al. c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci USA 2005, 102(20):7286-7291. (Ref.77).
3. Bailly-Maitre B, et al. Mice lacking bi-1 gene show accelerated liver regeneration. Cancer Res 2007, 67(4):1442-1450. (Ref.61).
4. Barriere C, et al. Mice thrive without Cdk4 and Cdk2. Mol Oncol 2007, 1(1):72-83. (Ref.121).
5. Behrens A, et al. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 2002, 21(7):1782-1790. (Ref.73).
6. Ben Moshe T, et al. Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 2007, 45(4):1014-1024. (Ref.67).
7. Berthet C, et al. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 2006, 10(5):563-573. (Ref.140).
8. Birchmeier C, et al. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003, 4(12):915-925. (Ref.80).
9. Blindenbacher A, et al. Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology 2003, 38(3):674-682. (Ref.12).
10. Boonstra J Progression through the G1-phase of the on-going cell cycle. J Cell Biochem 2003, 90(2):244-252. (Ref.113).
11. Borowiak M, et al. Met provides essential signals for liver regeneration. Proc Natl Acad Sci USA 2004, 101(29):10608-10613. (Ref.84).
12. Chaisson ML, et al. Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest 2002, 110(2):193-202. (Ref.48).
13. Conner EA, et al. Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis. Oncogene 2000, 19(44):5054-5062. (Ref.129).
14. Croquelois A, et al. Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology 2005, 41(3):487-496. (Ref.111).
15. Declercq W, Vanden Berghe T, Vandenabeele P RIP kinases at the crossroads of cell death and survival. Cell 2009, 138(2):229-232. (Ref.25).
16. Delhase M, et al. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999, 284(5412):309-313. (Ref.31).
17. Desbarats J, Newell MK Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 2000, 6(8):920-923. (Ref.58).
18. Dierssen U, et al. Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration. J Biol Chem 2008, 283(15):9886-9895. (Ref.18).
19. Eferl R, et al. Functions of c-Jun in liver and heart development. J Cell Biol 1999, 145(5):1049-1061. (Ref.72).
20. Elliott J SOCS3 in liver regeneration and hepatocarcinoma. Mol Interv 2008, 8(1):19-21. 2.
21. Fausto N Liver regeneration. J Hepatol 2000, 32(Suppl 1):19-31. (Ref.3).
22. Galluzzi L, Kepp O, Kroemer G RIP kinases initiate programmed necrosis. J Mol Cell Biol 2009, 1(1):8-10. (Ref.26).
23. Geng Y, et al. Cyclin E ablation in the mouse. Cell 2003, 114(4):431-443. (Ref.137).
24. Giacinti C, Giordano A RB and cell cycle progression. Oncogene 2006, 25(38):5220-5227. (Ref.122).
25. Guttridge DC, et al. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 1999, 19(8):5785-5799. (Ref.45).
26. Hayashi E, et al. Loss of p27(Kip1) accelerates DNA replication after partial hepatectomy in mice. J Surg Res 2003, 111(2):196-202. (Ref.151).
27. Hinz M, et al. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 1999, 19(4):2690-2698. (Ref.46).
28. Hu Y, et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999, 284(5412):316-320. (Ref.36).
29. Huh CG, et al. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004, 101(13):4477-4482. (Ref.85).
30. Hui L, et al. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008, 118(12):3943-3953. (Ref.176).
31. Hui L, et al. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008, 118(12):3943-3953. (Ref.56).
32. Ikeda H, et al. Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology 2003, 124(2):459-469. (Ref.174).
33. Ikeda H, et al. Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res 2009, 50(3):556-564. (Ref.175).
34. Ju W, et al. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol 2006, 26(2):654-667. (Ref.173).
35. Kaldis P, Aleem E Cell cycle sibling rivalry: Cdc2 vs. Cdk2. Cell Cycle 2005, 4(11):1491-1494. (Ref.114).
36. Karin M How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 1999, 18(49):6867-6874. (Ref.35).
37. Kiso S, et al. Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy. Gastroenterology 2003, 124(3):701-707. (Ref.99).
38. Kohler C, et al. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology 2004, 39(4):1056-1065. (Ref.110).
39. Kossatz U, et al. Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev 2004, 18(21):2602-2607. (Ref.156).
40. Kovalovich K, et al. Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem 2001, 276(28):26605-26613. (Ref.15).
41. Kozar K, Sicinski P Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes. Cell Cycle 2005, 4(3):388-391. (Ref.132).
42. Ledda-Columbano GM, et al. Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli. Hepatology 2002, 36(5):1098-1105. (Ref.134).
43. Leone G, et al. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell 2001, 8(1):105-113. (Ref.126).
44. Li Q, et al. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999, 284(5412):321-325. (Ref.38).
45. Li W, et al. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 2002, 277(32):28411-28417. (Ref.11).
46. Li ZW, et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999, 189(11):1839-1845. (Ref.39).
47. Luedde T, et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest 2005, 115(4):849-859. (Ref.49).
48. Luedde T, et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007, 11(2):119-132. (Ref.43).
49. Luedde T, et al. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology 2003, 37(4):833-841. (Ref.158).
50. Luedde T, Beraza N, Trautwein C Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models. J Gastroenterol Hepatol 2006, 21(Suppl 3):S43-S46. (Ref.42).
51. Macias-Silva M, et al. Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. J Biol Chem 2002, 277(32):28483-28490. (Ref.165).
52. Malato Y, et al. Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration. Hepatology 2008, 47(6):2036-2050. (Ref.50).
53. Malumbres M, et al. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004, 118(4):493-504. (Ref.118).
54. Mayhew CN, et al. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Res 2005, 65(11):4568-4577. (Ref.125).
55. Michalopoulos GK Liver regeneration. J Cell Physiol 2007, 213(2):286-300. (Ref.92).
56. Minamishima YA, Nakayama K Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res 2002, 62(4):995-999. (Ref.155).
57. Monga SP, et al. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology 2001, 33(5):1098-1109. (Ref.88).
58. Monga SP, et al. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 2002, 62(7):2064-2071. (Ref.87).
59. Moroy T, Geisen C Cyclin E. Int J Biochem Cell Biol 2004, 36(8):1424-1439. (Ref.136).
60. Nakayama K, et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000, 19(9):2069-2081. (Ref.154).
61. Natarajan A, Wagner B, Sibilia M The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci USA 2007, 104(43):17081-17086. (Ref.100).
62. Nevzorova YA, et al. Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin. Gastroenterology 2009, 137(2):691-703.
63. HM Ni, et al. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 2008, 173(4):962-972. (Ref.63).
64. Oe S, et al. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 2004, 40(5):1098-1105. (Ref.168).
65. Olayioye MA, et al. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 2000, 19(13):3159-3167. (Ref.93).
66. Ortega S, et al. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet 2003, 35(1):25-31. (Ref.119).
67. Paranjpe S, et al. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology 2007, 45(6):1471-1477. (Ref.86).
68. Porter LA, Donoghue DJ Cyclin B1 and CDK1: nuclear localization and upstream regulators. Prog Cell Cycle Res 2003, 5:335-347. (Ref.143).
69. Ren X, et al. Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. J Clin Invest 2003, 112(9):1407-1418. (Ref.9).
70. Rickheim DG, et al. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology 2002, 36(1):30-38. (Ref.133).
71. Riehle KJ, et al. Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med 2008, 205(1):91-103. (Ref.21).
72. Roberts AW, et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci USA 2001, 98(16):9324-9329. (Ref.20).
73. Romero-Gallo J, et al. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene 2005, 24(18):3028-3041. (Ref.167).
74. Rudolph D, et al. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev 2000, 14(7):854-862. (Ref.41).
75. Sabapathy K, Wagner EF JNK2: a negative regulator of cellular proliferation. Cell Cycle 2004, 3(12):1520-1523. (Ref.55).
76. Santamaria D, et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 2007, 448(7155):811-815. (Ref.120).
77. Satyanarayana A, et al. Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice. Cell Cycle 2004, 3(11):1405-1417. (Ref.112).
78. Satyanarayana A, Hilton MB, Kaldis P p21 inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol Biol Cell 2008, 19(1):65-77. (Ref.139).
79. Schlessinger J Cell signaling by receptor tyrosine kinases. Cell 2000, 103(2):211-225. (Ref.94).
80. Schwabe RF, et al. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003, 37(4):824-832. (Ref.54).
81. Shi Y, Massague J Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113(6):685-700. (Ref.159).
82. Skarpen E, et al. Altered regulation of EGF receptor signaling following a partial hepatectomy. J Cell Physiol 2005, 202(3):707-716. (Ref.97).
83. Skaug B, Jiang X, Chen ZJ The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem 2009, 78:769-796. (Ref.29).
84. Stepniak E, et al. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 2006, 20(16):2306-2314. (Ref.74).
85. Streetz KL, et al. Lack of gp130 expression in hepatocytes promotes liver injury. Gastroenterology 2003, 125(2):532-543. (Ref.14).
86. Strey CW, et al. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 2003, 198(6):913-923. (Ref.16).
87. Takeda K, et al. Role of early continuous regional arterial infusion of protease inhibitor and antibiotic in nonsurgical treatment of acute necrotizing pancreatitis. Digestion 1999, 60(Suppl 1)):9-13. (Ref.37).
88. Tan X, et al. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 2006, 131(5):1561-1572. (Ref.91).
89. Tan X, et al. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology 2005, 129(1):285-302. (Ref.89).
90. Tanaka M, et al. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity 1999, 10(4):421-429. (Ref.40).
91. Vail ME, et al. Bcl-2 expression delays hepatocyte cell cycle progression during liver regeneration. Oncogene 2002, 21(10):1548-1555. (Ref.60).
92. Vail ME, Pierce RH, Fausto N Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha. Cancer Res 2001, 61(2):594-601. (Ref.59).
93. Volkmann X, et al. Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology 2008, 47(5):1624-1633. (Ref.67).
94. Wuestefeld T, et al. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 2003, 278(13):11281-11288. (Ref.13).
95. Wullaert A, et al. Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond. Endocr Rev 2007, 28(4):365-386. (Ref.64).
96. Yam CH, Fung TK, Poon RY Cyclin A in cell cycle control and cancer. Cell Mol Life Sci 2002, 59(8):1317-1326. (Ref.142).
97. Yamamoto Y, Gaynor RB IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 2004, 29(2):72-79. (Ref.34).
98. Yarden Y, Sliwkowski MX Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001, 2(2):127-137. (Ref.95).
99. Zimmermann A Regulation of liver regeneration. Nephrol Dial Transplant 2004, 19(Suppl 4):6-10. (Ref.4).
100. Zorde-Khvalevsky E, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology 2009, 50(1):198-206. (Ref.62).
101. Michalopoulos GK, DeFrances MC Liver regeneration. Science 1997, 276(5309):60-66.
102. Columbano A, Shinozuka H Liver regeneration versus direct hyperplasia. FASEB J 1996, 10(10):1118-1128.
103. Fausto N Liver regeneration. J Hepatol 2000, 32(1 Suppl):19-31.
104. Zimmermann A Regulation of liver regeneration. Nephrol Dial Transplant 2004, 19(Suppl 4)):6-10.
105. Taga T, Kishimoto T Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997, 15:797-819.
106. Heinrich PC, et al. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 1998, 334(Pt 2):297-314.
107. Cressman DE, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996, 274(5291):1379-1383.
108. Yamada Y, et al. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 1997, 94(4):1441-1446.
109. Ren X, et al. Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. J Clin Invest 2003, 112(9):1407-1418.
110. Takeda K, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997, 94(8):3801-3804.
111. Li W, et al. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 2002, 277(32):28411-28417.
112. Blindenbacher A, et al. Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology 2003, 38(3):674-682.
113. Wuestefeld T, et al. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 2003, 278(13):11281-11288.
114. Streetz KL, et al. Lack of gp130 expression in hepatocytes promotes liver injury. Gastroenterology 2003, 125(2):532-543.
115. Kovalovich K, et al. Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem 2001, 276(28):26605-26613.
116. Strey CW, et al. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 2003, 198(6):913-923.
117. Betz UA, et al. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med 1998, 188(10):1955-1965.
118. Dierssen U, et al. Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration. J Biol Chem 2008, 283(15):9886-9895.
119. Elliott J SOCS3 in liver regeneration and hepatocarcinoma. Mol Interv 2008, 8(1):19-21. 2.
120. Roberts AW, et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci USA 2001, 98(16):9324-9329.
121. Riehle KJ, et al. Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med 2008, 205(1):91-103.
122. Fausto N, Laird AD, Webber EM Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J 1995, 9(15):1527-1536.
123. Akerman P, et al. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 1992, 263(4 Pt 1):G579-G585.
124. Yamada Y, et al. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology 1998, 28(4):959-970.
125. Declercq W, Vanden Berghe T, Vandenabeele P RIP kinases at the crossroads of cell death and survival. Cell 2009, 138(2):229-232.
126. Galluzzi L, Kepp O, Kroemer G RIP kinases initiate programmed necrosis. J Mol Cell Biol 2009, 1(1):8-10.
127. Rothwarf DM, et al. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 1998, 395(6699):297-300.
128. Yamaoka S, et al. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 1998, 93(7):1231-1240.
129. Skaug B, Jiang X, Chen ZJ The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem 2009, 78:769-796.
130. Zandi E, Chen Y, Karin M Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science 1998, 281(5381):1360-1363.
131. Delhase M, et al. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999, 284(5412):309-313.
132. Woronicz JD, et al. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 1997, 278(5339):866-869.
133. Zandi E, et al. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997, 91(2):243-252.
134. Yamamoto Y, Gaynor RB IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 2004, 29(2):72-79.
135. Karin M How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 1999, 18(49):6867-6874.
136. Hu Y, et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999, 284(5412):316-320.
137. Takeda K, et al. Role of early continuous regional arterial infusion of protease inhibitor and antibiotic in nonsurgical treatment of acute necrotizing pancreatitis. Digestion 1999, 60(Suppl 1)):9-13.
138. Li Q, et al. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999, 284(5412):321-325.
139. ZW Li, et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999, 189(11):1839-1845.
140. Tanaka M, et al. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity 1999, 10(4):421-429.
141. Rudolph D, et al. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev 2000, 14(7):854-862.
142. Luedde T, Beraza N, Trautwein C Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models. J Gastroenterol Hepatol 2006, 21(Suppl 3):S43-S46.
143. Luedde T, et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007, 11(2):119-132.
144. Cressman DE, et al. Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver. J Biol Chem 1994, 269(48):30429-30435.
145. Guttridge DC, et al. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 1999, 19(8):5785-5799.
146. Hinz M, et al. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 1999, 19(4):2690-2698.
147. Iimuro Y, et al. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998, 101(4):802-811.
148. Chaisson ML, et al. Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest 2002, 110(2):193-202.
149. Luedde T, et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest 2005, 115(4):849-859.
150. Malato Y, et al. Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration. Hepatology 2008, 47(6):2036-2050.
151. Diehl AM, et al. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol 1994, 267(4 Pt 1):G552-G561.
152. Westwick JK, et al. Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest 1995, 95(2):803-810.
153. Diehl AM, Rai RM Liver regeneration 3: regulation of signal transduction during liver regeneration. FASEB J 1996, 10(2):215-227.
154. Schwabe RF, et al. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003, 37(4):824-832.
155. Sabapathy K, Wagner EF JNK2: a negative regulator of cellular proliferation. Cell Cycle 2004, 3(12):1520-1523.
156. Hui L, et al. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008, 118(12):3943-3953.
157. Galle PR, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 1995, 182(5):1223-1230.
158. Desbarats J, Newell MK Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 2000, 6(8):920-923.
159. Vail ME, Pierce RH, Fausto N Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha. Cancer Res 2001, 61(2):594-601.
160. Vail ME, et al. Bcl-2 expression delays hepatocyte cell cycle progression during liver regeneration. Oncogene 2002, 21(10):1548-1555.
161. Bailly-Maitre B, et al. Mice lacking bi-1 gene show accelerated liver regeneration. Cancer Res 2007, 67(4):1442-1450.
162. Zorde-Khvalevsky E, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology 2009, 50(1):198-206.
163. Ni HM, et al. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 2008, 173(4):962-972.
164. Wullaert A, et al. Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond. Endocr Rev 2007, 28(4):365-386.
165. Volkmann X, et al. Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology 2008, 47(5):1624-1633.
166. Tzung SP, Fausto N, Hockenbery DM Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 1997, 150(6):1985-1995.
167. Ben Moshe T, et al. Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 2007, 45(4):1014-1024.
168. Morello D, et al. c-myc, c-fos, and c-jun regulation in the regenerating livers of normal and H-2K/c-myc transgenic mice. Mol Cell Biol 1990, 10(6):3185-3193.
169. Pistoi S, Morello D Liver regeneration 7. Prometheus' myth revisited: transgenic mice as a powerful tool to study liver regeneration. FASEB J 1996, 10(8):819-828.
170. Johnson RS, Spiegelman BM, Papaioannou V Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 1992, 71(4):577-586.
171. Hilberg F, et al. c-jun is essential for normal mouse development and hepatogenesis. Nature 1993, 365(6442):179-181.
172. Eferl R, et al. Functions of c-Jun in liver and heart development. J Cell Biol 1999, 145(5):1049-1061.
173. Behrens A, et al. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 2002, 21(7):1782-1790.
174. Stepniak E, et al. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 2006, 20(16):2306-2314.
175. Steer CJ Liver regeneration. FASEB J 1995, 9(14):1396-1400.
176. Davis AC, et al. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 1993, 7(4):671-682.
177. Baena E, et al. c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci USA 2005, 102(20):7286-7291.
178. Gohda E, et al. Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. J Clin Invest 1988, 81(2):414-419.
179. Naldini L, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 1991, 10(10):2867-2878.
180. Birchmeier C, et al. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003, 4(12):915-925.
181. Schmidt C, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995, 373(6516):699-702.
182. Patijn GA, et al. Hepatocyte growth factor induces hepatocyte proliferation in vivo and allows for efficient retroviral-mediated gene transfer in mice. Hepatology 1998, 28(3):707-716.
183. Stolz DB, et al. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat. Cancer Res 1999, 59(16):3954-3960.
184. Borowiak M, et al. Met provides essential signals for liver regeneration. Proc Natl Acad Sci USA 2004, 101(29):10608-10613.
185. Huh CG, et al. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004, 101(13):4477-4482.
186. Paranjpe S, et al. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology 2007, 45(6):1471-1477.
187. Monga SP, et al. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 2002, 62(7):2064-2071.
188. Monga SP, et al. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology 2001, 33(5):1098-1109.
189. Tan X, et al. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology 2005, 129(1):285-302.
190. Apte U, et al. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology 2006, 44(4):992-1002.
191. Tan X, et al. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 2006, 131(5):1561-1572.
192. Michalopoulos GK Liver regeneration. J Cell Physiol 2007, 213(2):286-300.
193. Olayioye MA, et al. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 2000, 19(13):3159-3167.
194. Schlessinger J Cell signaling by receptor tyrosine kinases. Cell 2000, 103(2):211-225.
195. Yarden Y, Sliwkowski MX Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001, 2(2):127-137.
196. Sibilia M, Wagner EF Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995, 269(5221):234-238.
197. Skarpen E, et al. Altered regulation of EGF receptor signaling following a partial hepatectomy. J Cell Physiol 2005, 202(3):707-716.
198. Noguchi S, Ohba Y, Oka T Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice. J Endocrinol 1991, 128(3):425-431.
199. Kiso S, et al. Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy. Gastroenterology 2003, 124(3):701-707.
200. Natarajan A, Wagner B, Sibilia M The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci USA 2007, 104(43):17081-17086.
201. Russell WE, et al. Transforming growth factor-alpha (TGF alpha) concentrations increase in regenerating rat liver: evidence for a delayed accumulation of mature TGF alpha. Endocrinology 1993, 133(4):1731-1738.
202. Russell WE, et al. Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice. Mol Carcinog 1996, 15(3):183-189.
203. Webber EM, et al. Overexpression of transforming growth factor-alpha causes liver enlargement and increased hepatocyte proliferation in transgenic mice. Am J Pathol 1994, 145(2):398-408.
204. Gassmann M, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 1995, 378(6555):390-394.
205. Lee KF, et al. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995, 378(6555):394-398.
206. Riethmacher D, et al. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 1997, 389(6652):725-730.
207. Xue Y, et al. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet 1999, 8(5):723-730.
208. Swiatek PJ, et al. Notch1 is essential for postimplantation development in mice. Genes Dev 1994, 8(6):707-719.
209. Hamada Y, et al. Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development 1999, 126(15):3415-3424.
210. Kohler C, et al. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology 2004, 39(4):1056-1065.
211. Croquelois A, et al. Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology 2005, 41(3):487-496.
212. Satyanarayana A, et al. Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice. Cell Cycle 2004, 3(11):1405-1417.
213. Boonstra J Progression through the G1-phase of the on-going cell cycle. J Cell Biochem 2003, 90(2):244-252.
214. Kaldis P, Aleem E Cell cycle sibling rivalry: Cdc2 vs. Cdk2. Cell Cycle 2005, 4(11):1491-1494.
215. Nigg EA Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 1995, 17(6):471-480.
216. Sherr CJ D-type cyclins. Trends Biochem Sci 1995, 20(5):187-190.
217. Rane SG, et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 1999, 22(1):44-52.
218. Malumbres M, et al. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004, 118(4):493-504.
219. Ortega S, et al. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet 2003, 35(1):25-31.
220. Santamaria D, et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 2007, 448(7155):811-815.
221. Barriere C, et al. Mice thrive without Cdk4 and Cdk2. Mol Oncol 2007, 1(1):72-83.
222. Giacinti C, Giordano A RB and cell cycle progression. Oncogene 2006, 25(38):5220-5227.
223. Grana X, Garriga J, Mayol X Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth. Oncogene 1998, 17(25):3365-3383.
224. Jacks T, et al. Effects of an Rb mutation in the mouse. Nature 1992, 359(6393):295-300.
225. Mayhew CN, et al. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Res 2005, 65(11):4568-4577.
226. Leone G, et al. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell 2001, 8(1):105-113.
227. Kowalik TF, et al. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 1995, 69(4):2491-2500.
228. Shan B, Lee WH Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol 1994, 14(12):8166-8173.
229. Conner EA, et al. Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis. Oncogene 2000, 19(44):5054-5062.
230. Lukas ER, et al. No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog 1999, 25(4):295-303.
231. Hinds PW, et al. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 1992, 70(6):993-1006.
232. Kozar K, Sicinski P Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes. Cell Cycle 2005, 4(3):388-391.
233. Rickheim DG, et al. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology 2002, 36(1):30-38.
234. Ledda-Columbano GM, et al. Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli. Hepatology 2002, 36(5):1098-1105.
235. Koff A, et al. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 1992, 257(5077):1689-1694.
236. Moroy T, Geisen C Cyclin E. Int J Biochem Cell Biol 2004, 36(8):1424-1439.
237. Geng Y, et al. Cyclin E ablation in the mouse. Cell 2003, 114(4):431-443.
238. Nevzorova YA, et al. Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin. Gastroenterology 2009, 137(2):691-703.
239. Satyanarayana A, Hilton MB, Kaldis P p21 inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol Biol Cell 2008, 19(1):65-77.
240. Berthet C, et al. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 2006, 10(5):563-573.
241. Pagano M, et al. Cyclin A is required at two points in the human cell cycle. EMBO J 1992, 11(3):961-971.
242. Yam CH, Fung TK, Poon RY Cyclin A in cell cycle control and cancer. Cell Mol Life Sci 2002, 59(8):1317-1326.
243. Porter LA, Donoghue DJ Cyclin B1 and CDK1: nuclear localization and upstream regulators. Prog Cell Cycle Res 2003, 5:335-347.
244. Albrecht JH, et al. Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases. Am J Physiol 1993, 265(5 Pt 1):G857-G864.
245. Trembley JH, et al. Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo. Cell Growth Differ 1996, 7(7):903-916.
246. Murphy M, et al. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat Genet 1997, 15(1):83-86.
247. Sherr CJ, Roberts JM Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995, 9(10):1149-1163.
248. Deng C, et al. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995, 82(4):675-684.
249. Albrecht JH, et al. Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver. Oncogene 1998, 16(16):2141-2150.
250. Nakayama K, et al. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996, 85(5):707-720.
251. Hayashi E, et al. Loss of p27(Kip1) accelerates DNA replication after partial hepatectomy in mice. J Surg Res 2003, 111(2):196-202.
252. Carrano AC, et al. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999, 1(4):193-199.
253. Amati B, Vlach J Kip1 meets SKP2: new links in cell-cycle control. Nat Cell Biol 1999, 1(4):E91-93.
254. Nakayama K, et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000, 19(9):2069-2081.
255. Minamishima YA, Nakayama K Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res 2002, 62(4):995-999.
256. Kossatz U, et al. Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev 2004, 18(21):2602-2607.
257. Franklin DS, et al. CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 1998, 12(18):2899-2911.
258. Luedde T, et al. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology 2003, 37(4):833-841.
259. Shi Y, Massague J Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113(6):685-700.
260. Alexandrow MG, Moses HL Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription. Cancer Res 1995, 55(17):3928-3932.
261. Nakamura T, et al. Inhibitory effect of transforming growth factor-beta on DNA synthesis of adult rat hepatocytes in primary culture. Biochem Biophys Res Commun 1985, 133(3):1042-1050.
262. Braun L, et al. Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci USA 1988, 85(5):1539-1543.
263. Russell WE, et al. Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc Natl Acad Sci USA 1988, 85(14):5126-5130.
264. Chari RS, et al. Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration. Am J Surg 1995, 169(1):126-131. discussion 131-132.
265. Macias-Silva M, et al. Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. J Biol Chem 2002, 277(32):28483-28490.
266. Nishikawa Y, Wang M, Carr BI Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. J Cell Physiol 1998, 176(3):612-623.
267. Romero-Gallo J, et al. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene 2005, 24(18):3028-3041.
268. Oe S, et al. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 2004, 40(5):1098-1105.
269. Yasuda H, et al. Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest 1993, 92(3):1491-1496.
270. Kogure K, et al. A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats. Gastroenterology 1995, 108(4):1136-1142.
271. Heyer J, et al. Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc Natl Acad Sci USA 1999, 96(22):12595-12600.
272. Datto MB, et al. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999, 19(4):2495-2504.
273. Ju W, et al. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol 2006, 26(2):654-667.
274. Ikeda H, et al. Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology 2003, 124(2):459-469.
275. Ikeda H, et al. Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res 2009, 50(3):556-564.