c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

Hepatology

Volumn 37, Issue 4, 2003, Pages 824-832

  Schwabe, Robert F ^a   Bradham, Cynthia A ^a   Uehara, Tetsuya ^a   Hatano, Etsuro ^a   Bennett, Brydon L ^c   Schoonhoven, Robert ^b   Brenner, David A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLINE; DNA; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; LIVER REGENERATION; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0037382797     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50135     Document Type: Article

References (47)

1. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276:60-66.
2. Fausto N. Liver regeneration. J Hepatol 2000;32:19-31.
3. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, et al. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol 1994;267:G552-G561.
4. Westwick JK, Weitzel C, Leffert HL, Brenner DA. Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest 1995;95:803-810.
5. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001;20:2390-2400.
6. Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, et al. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 1999;13:607-619.
7. Behrens A, Sibilia M, Wagner EF. Amino-terminal phosphorylarion of c-Jun regulares stress-induced apoptosis and cellular proliferation. Nar Gener 1999;21:326-329.
8. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, et al. Requiremenr of JNK for stress-induced activation of rhe cytochrome c-mediared dearh pathway. Science 2000;288:870-874.
9. Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pesrell RG. Transforming p21ras muranrs and c-Ets-2 acrivate the cyclin D1 promorer through disringuishable regions. J Biol Chem 1995;270:23589-23597.
10. Nelsen CJ, Rickheim DG, Timchenko NA, Stanley MW, Albrecht JH. Transienr expression of cyclin D1 is sufficient ro promote hepatocyte replicarion and liver growrh in vivo. Cancer Res 2001;61:8564-8568.
11. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Iniriation of liver growth by rumor necrosis facror: deficient liver regenerarion in mice lacking type I rumor necrosis factor receptor. Proc Natl Acad Sci U S A 1997;94:1441-1446.
12. Taub R. Liver regeneration 4: rranscriptional control of liver regeneration. FASEB J 1996;10:413-427.
13. Bennetr BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisren JC, et al. SP600125, an anrhrapyrazolone inhibiror of Jun N-terminal kinase. Proc Natl Acad Sci U S A 2001;98:13681-13686.
14. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration [published erratum appears in J Clin Invest 1998;101:1541]. J Clin Invest 1998;101:802-811.
15. Herman B, Nieminen AL, Gores GJ, Lemasters JJ. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB J 1988;2:146-151.
16. Schwabe RF, Bennetr BL, Manning AM, Brenner DA. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. HEPATOLOGY 2001; 33:81-90.
17. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, et al. Reperfusion after liver rransplanration in rats differentially activates the mitogen-activared protein kinases. HEPATOLOGY 1997; 25:1128-1135.
18. Srefanovic B, Schnabl B, Brenner DA. Inhibition of collagen alpha 1(I) expression by the 5′ stem-loop as a molecular decoy. J Biol Chem 2002; 277:18229-18237.
19. Schwabe RF, Schnabl B, Kweon YO, Brenner DA. CD40 activares NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secrerion on activated human hepatic stellare cells. J Immunol 2001;166:6812-6819.
20. Han Z, Boyle DL, Chang L, Bennetr B, Karin M, Yang L, Manning AM, er al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001;108:73-81.
21. Loyet P, Ilyin G, Cariou S, Glaise D, Corlu A, Guguen-Guillouzo C. Progression through G1 and S phases of adult tat hepatocytes. Ptog Cell Cycle Res 1996;2:37-47.
22. Behrens A, Sibilia M, David JP, Mohle-Steinlein U, Tronche F, Schutz G, Wagner EF. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 2002;21:1782-1790.
23. Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, et al. Impaired liver regeneration in inducible nittic oxide synthase deficient mice. Proc Natl Acad Sci U S A 1998;95:13829-13834.
24. Kirillova I, Chaisson M, Fausto N. Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation. Cell Growth Differ 1999;10:819-828.
25. Cressman DE, Greenbaum LE, DeAngelis RA, Cilibetto G, Futth EE, Poli V, Taub R. Livet failute and defective hepatocyte regenetation in interleukin-6-deficient mice. Science 1996;274:1379-1383.
26. Chaisson ML, Brooling JT, Ladiges W, Tsai S, Fausto N. Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest 2002;110:193-202.
27. Auer KL, Contessa J, Btenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, et al. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists srimulate DNA synthesis in ptimary cultures of rat hepatocytes. Mol Biol Cell 1998;9:561-573.
28. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B, Brennet DA. TAK1/JNK and p38 have opposite effects on tat hepatic stellate cells. HEPATOLOGY 2001;34:953-963.
29. Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 prorein kinases are required for regional specific apoptosis during early brain development. Neuron 1999;22:667-676.
30. Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and alrered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 1999;89:115-124.
31. Liu YC, Chang HW, Lai YC, Ding ST, Ho JL. Serum responsiveness of the rat PCNA promoter involves the proximal ATF and AP-1 sites. FEBS Lett 1998;441:200-204.
32. Wisdom R, Johnson RS, Moore C. c-Jun regulates cell cycle progression and apoprosis by distincr mechanisms. EMBO J 1999;18:188-197.
33. Rickheim DG, Nelsen CJ, Fassett JT, Timchenko NA, Hansen LK, Albrecht JH. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. HEPATOLOGY 2002;36:30-38.
34. Albrecht JH, Hoffman JS, Kren BT, Steer CJ. Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases. Am J Physiol 1993;265:G857-G864.
35. Awad MM, Gruppuso PA. Cell cycle control during liver development in the rat: evidence indicating a role for cyclin D1 posttranscriptional regulation [in process citation]. Cell Growth Differ 2000;11:325-334.
36. Hong F, Nguyen VA, Shen X, Kunos G, Gao B. Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling duting liver regeneration. Biochem Biophys Res Commun 2000;279:974-979.
37. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-252.
38. Hilberg F, Aguzzi A, Howells N, Wagner EF. c-jun is essential for normal mouse development and hepatogenesis. Natute 1993;365:179-181.
39. Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev 1993;7:1309-1317.
40. Ganiatsas S, Kwee L, Fujiwara Y, Petkins A, Ikeda T, Labow MA, Zon LI. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A 1998;95:6881-6886.
41. Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, Furlonger K, et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 1999;126: 505-516.
42. Eferl R, Sibilia M, Hilbetg F, Fuchsbichlet A, Kufferath I, Guertl B, Zenz R, et al. Functions of c-Jun in liver and heart development. J Cell Biol 1999;145:1049-1061.
43. Schwabe RF, Bennett BL, Purbeck C, Brenner DA. JNK enhances TNFα-induced apoptosis in hepatocytes in a ttansctiptionally independent manner. HEPATOLOGY 2002;36:299A.
44. Uehata T, Bennett BL, Sakata ST, Satoh Y, Brenner DA. JNK inhibitors protect from hepatic ischemia/reperfusion. HEPATOLOGY 2001;34:348A.
45. Bradham CA, Hatano E, Brenner DA. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Am J Physiol 2001;281:G1279-G1289.
46. Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF. JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet 2002; 30:158-166.
47. Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 1996;87:929-939.