Cyclin A in cell cycle control and cancer

Cellular and Molecular Life Sciences

Volumn 59, Issue 8, 2002, Pages 1317-1326

  Yam, C H ^b   Fung, T K ^a   Poon, R Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cell cycle control; Cyclin; Cyclin dependent kinases; Proteolysis; Tumorigenesis

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE; DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ASTROCYTOMA; BREAST CANCER; CARCINOGENESIS; CELL CYCLE; DIGESTIVE SYSTEM CANCER; DNA REPLICATION; ENZYME ACTIVATION; ENZYME SUBUNIT; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; LEUKEMIA; MELANOMA; NONHUMAN; OSTEOSARCOMA; PROTEIN DEGRADATION; REVIEW; SPERMATOGENESIS; UROGENITAL TRACT CANCER;

ANIMALS; CELL CYCLE; CYCLIN A; HUMANS; NEOPLASMS;

ANIMALIA;

EID: 0036692835     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8510-y     Document Type: Review

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15. The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle
16. Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation
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18. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines
19. Cyclin Al is required for meiosis in the male mouse
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22. p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes
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32. Kip1
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41. cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication
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45. 2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process
46. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
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50. Structure and cell cycle-regulated transcription of the human cyclin A gene
51. Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression
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53. Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position
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55. Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107
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58. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
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61. A new model of cell cycle-regulated transcription: Repression of the cyclin A promoter by CDF-1 and anti-repression by E2F
62. CHF: A novel factor binding to cyclin A CHR corepressor element
63. TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins
64. The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter
65. Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 expression and normal p53 suppresses cyclin A expression
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67. Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM
68. Down-regulation of the cyclin A promoter in differentiating human embryonal carcinoma cells is mediated by depletion of ATF-1 and ATF-2 in the complex at the ATF/CRE site
69. Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein
70. TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways
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73. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase
74. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
75. Cyclin is degraded by the ubiquitin pathway
76. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts
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79. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis
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82. Mitotic regulation of the APC activator proteins CDC20 and CDH1
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85. Cyclin A-Cys41 does not undergo cell cycle-dependent degradation in Xenopus extracts
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87. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase
88. Cell cycle-regulated proteolysis of mitotic target proteins
89. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
90. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3
91. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts
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101. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
102. Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma
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114. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
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125. Overexpression of cyclin A is highly associated with early relapse and reduced survival in patients with primary breast carcinomas
126. Immunohistochemical detection of sex steroid receptors, cyclins, and cyclin-dependent kinases in the normal and neoplastic squamous epithelia of the uterine cervix
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158. A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma patients
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