Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation

Developmental Cell

Volumn 10, Issue 5, 2006, Pages 563-573

  Berthet, Cyril ^a   Klarmann, Kimberly D ^b   Hilton, Mary Beth ^a   Suh, Hyung Chan ^b   Keller, Jonathan R ^b   Kiyokawa, Hiroaki ^c   Kaldis, Philipp ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

CELLCYCLE; DEVBIO

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; PROTEIN P27; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYO DEATH; EMBRYO DEVELOPMENT; FIBROBLAST; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE LOCATION; GENE TARGETING; GENETIC CODE; HEART DISEASE; IN VIVO STUDY; MITOSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENESCENCE;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; E2F TRANSCRIPTION FACTORS; EMBRYO; FIBROBLASTS; GENE SILENCING; HEMATOPOIESIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ONCOGENE PROTEINS, VIRAL; PHENOTYPE; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN;

ANIMALIA; HUMAN PAPILLOMAVIRUS;

EID: 33646528191     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2006.03.004     Document Type: Article

References (38)

1. 3H thymidine incorporation assay. J. Immunol. Methods 170 (1994) 211-224
2. Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
3. Aleem E., Kiyokawa H., and Kaldis P. Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat. Cell Biol. 7 (2005) 831-836
4. Bartek J., Bartkova J., and Lukas J. The retinoblastoma protein pathway and the restriction point. Curr. Opin. Cell Biol. 8 (1996) 805-814
5. Berthet C., Aleem E., Coppola V., Tessarollo L., and Kaldis P. Cdk2 knockout mice are viable. Curr. Biol. 13 (2003) 1775-1785
6. Dalton S. Cell cycle regulation of the human cdc2 gene. EMBO J. 11 (1992) 1797-1804
7. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92 (1995) 9363-9367
8. Ezhevsky S.A., Ho A., Becker-Hapak M., Davis P.K., and Dowdy S.F. Differential regulation of retinoblastoma tumor suppressor protein by G1 cyclin-dependent kinase complexes in vivo. Mol. Cell. Biol. 21 (2001) 4773-4784
9. Fantl V., Stamp G., Andrews A., Rosewell I., and Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 9 (1995) 2364-2372
10. Geng Y., Yu Q., Sicinska E., Das M., Schneider J.E., Bhattacharya S., Rideout W.M., Bronson R.T., Gardner H., and Sicinski P. Cyclin E ablation in the mouse. Cell 114 (2003) 431-443
11. Harbour J.W., and Dean D.C. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14 (2000) 2393-2409
12. Harbour J.W., Luo R.X., Dei Santi A., Postigo A.A., and Dean D.C. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98 (1999) 859-869
13. Kingsley P.D., Malik J., Fantauzzo K.A., and Palis J. Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis. Blood 104 (2004) 19-25
14. Kip1. Cell 85 (1996) 721-732
15. Koff A., Cross F., Fisher A., Schumacher J., Leguellec K., Philippe M., and Roberts J.M. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66 (1991) 1217-1228
16. Kozar K., Ciemerych M.A., Rebel V.I., Shigematsu H., Zagozdzon A., Sicinska E., Geng Y., Yu Q., Bhattacharya S., Bronson R.T., et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118 (2004) 477-491
17. Lundberg A.S., and Weinberg R.A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18 (1998) 753-761
18. Malumbres M., and Barbacid M. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30 (2005) 630-641
19. Malumbres M., Sotillo R., Santamaria D., Galan J., Cerezo A., Ortega S., Dubus P., and Barbacid M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118 (2004) 493-504
20. Mittnacht S. Control of pRB phosphorylation. Curr. Opin. Genet. Dev. 8 (1998) 21-27
21. Morgan D.O. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13 (1997) 261-291
22. Münger K., and Howley P.M. Human papillomavirus immortalization and transformation functions. Virus Res. 89 (2002) 213-228
23. Ortega S., Prieto I., Odajima J., Martin A., Dubus P., Sotillo R., Barbero J.L., Malumbres M., and Barbacid M. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35 (2003) 25-31
24. Parisi T., Beck A.R., Rougier N., McNeil T., Lucian L., Werb Z., and Amati B. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22 (2003) 4794-4803
25. Rane S.G., Dubus P., Mettus R.V., Galbreath E.J., Boden G., Reddy E.P., and Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat. Genet. 22 (1999) 44-52
26. INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1378 (1998) F115-F177
27. Sherr C.J. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2 (2001) 731-737
28. 1-phase progression. Genes Dev. 13 (1999) 1501-1512
29. Sicinski P., Donaher J.L., Parker S.B., Li T., Fazeli A., Gardner H., Haslam S.Z., Bronson R.T., Elledge S.J., and Weinberg R.A. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82 (1995) 621-630
30. Sicinski P., Donaher J.L., Geng Y., Parker S.B., Gardner H., Park M.Y., Robker R.L., Richards J.S., McGinnis L.K., Biggers J.D., et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384 (1996) 470-474
31. Silver L. Mouse Genetics (1995), Oxford University Press, Oxford, UK
32. Tetsu O., and McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3 (2003) 233-245
33. Todaro G.J., and Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17 (1963) 299-313
34. Trimarchi J.M., and Lees J.A. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3 (2002) 11-20
35. Truett G.E., Heeger P., Mynatt R.L., Truett A.A., Walker J.A., and Warman M.L. Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques 29 (2000) 52 54
36. Kip1 activity. Mol. Cell. Biol. 19 (1999) 7011-7019
37. Weinberg R.A. The Retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
38. Zarkowska T.U.S., Harlow E., and Mittnacht S. Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by cdks. Oncogene 14 (1997) 249-254