NFκB prevents apoptosis and liver dysfunction during liver regeneration

Journal of Clinical Investigation

Volumn 101, Issue 4, 1998, Pages 802-811

  Íimuro, Yuji ^a   Nishiura, Teruhiro ^a   Hellerbrand, Claus ^a   Behrns, Kevin E ^a   Schoonhoven, Robert ^a   Grisham, Joe W ^a   Brenner, David A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenoviruses; Cell division; Gene transfer; Hepatectomy; I B

Indexed keywords

AMMONIA; BILIRUBIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; RNA; VIRUS VECTOR; DNA BINDING PROTEIN; HYBRID PROTEIN; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIVISION; CONTROLLED STUDY; DNA BINDING; DNA SYNTHESIS; ELECTROPHORETIC MOBILITY; GENE TRANSFER; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER DYSFUNCTION; LIVER REGENERATION; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; GENE VECTOR; GENETICS; HUMAN; LIVER; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; GENETIC VECTORS; HUMANS; I-KAPPA B PROTEINS; LIVER; LIVER REGENERATION; NF-KAPPA B; RATS; RECOMBINANT FUSION PROTEINS;

EID: 0032519007     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI483     Document Type: Article

References (53)

1. Michalopoulos, G.K., and M.C. DeFrances. 1997. Liver regeneration. Science. 276:60-66.
2. Bucher, N.L.R. 1995. Liver Regeneration and Carcinogenesis: Molecular and Cellular Mechanisms. R.L. Jirtle, editor. Academic Press, San Diego. 1-25.
3. Diehl, A.M., M. Yin, J. Fleckenstein, S.Q. Yang, H.Z. Lin, D.A. Brenner, J. Westwick, G. Bagby, and S. Nelson. 1994. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am. J. Physiol. 267: G552-G561.
4. Westwick, J.K., C. Weitzel, H.L. Leffert, and D.A. Brenner. 1995. Activation of Jun kinase is an early event in hepatic regeneration. J. Clin. Invest. 95: 803-810.
5. Westwick, J.K., J. Fleckenstein, M. Yin, H.Z. Lin, C.A. Bradham, D.A. Brenner, and A.M. Diehl. 1996. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro and in vivo. Am. J. Physiol. 271:G780-G790.
6. Tewari, M., P. Dobrzanski, K.L. Mohn, D.E. Cressman, J.-C. Hsu, R. Bravo, and R. Taub. 1992. Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex. Mol. Cell. Biol. 12:2898-2908.
7. Cressman, D.E., L.E. Greenbaum, B.A. Haber, and R. Taub. 1994. Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver. J. Biol. Chem. 269:30429-30435.
8. Fitzgerald, M.J., E.M. Webber, J.R. Donovan, and N. Fausto. 1995. Rapid DNA binding by nuclear factor κB in hepatocytes at the start of liver regeneration. Cell Growth Differ. 6:417-427.
9. Cressman, D.E., L.E. Greenbaum, R.A. DeAngelis, G. Ciliberto, E.E. Furth, V. Poli, and R. Taub. 1996. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science. 274:1379-1383.
10. Cressman, D.E., and R. Taub. 1994. Physiologic turnover of nuclear factor kappa B by nuclear proteolysis. J. Biol. Chem. 269:26594-26597.
11. Baldwin, A.S., Jr., J.C. Azizkhan, D.E. Jensen, A.A. Beg, and L.R. Coodly. 1991. Induction of NF-kappa B DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts. Mol. Cell. Biol. 11:4943-4951.
12. Verma, I.M., J.K. Stevenson, E.M. Schwarz, D.V. Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
13. Haskill, S., A.A. Beg, S.M. Tompkins, J.S. Morris, A.D. Yurochko, A. Sampson-Johannes, K. Mondal, P. Ralph, and A.S. Baldwin, Jr. 1991. Characterization of an immediate-early gene induced in adherent monocytes that encloses I kappa B-like activity. Cell. 65:1281-1289.
14. Henkel, T., T. Machleidt, I. Alkalay, M. Kronke, Y. Ben-Neirah, and P.A. Baeuerie. 1993. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature. 365:182-185.
15. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and D. Siebenlist. 1995. Control of IκBα proteolysis by site-specific, signal induced phosphorylation. Science. 267:1485-1488.
16. Didonato, J.A., F. Mercurio, and M. Karin. 1995. Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NF-κB. Mol. Cell. Biol. 15:1302-1311.
17. Finco, T.S., and A.S. Baldwin. 1995. Mechanistic aspects of NF-kappaB regulation: the emerging role of phosphorylation and proteolysis. Immunity. 3: 263-272.
18. Beg, A.A., T.S. Finco, P.V. Nantermet, and A.S. Baldwin, Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol. Cell. Biol. 13: 3301-3310.
19. Wang, C.Y., M.W. Mayo, and A.S. Baldwin. Jr. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science. 274:784-787.
20. Van Antwerp, D.J., S.J. Martin, T. Kafri, D.R. Green, and I.M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 274:787-789.
21. Beg, A.A., W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the ReIA component of NF kappa B. Nature. 376:167-170.
22. Graham, F.L., and L. Prevec. 1991. Manipulation of adenovirus vectors. In Methods in Molecular Biology: Gene Transfer and Expression Protocols. E.J. Murray, editor. The Humana Press Inc., Clifton, NJ. 109-128.
23. Bett, A.J., W. Hauddara, L. Prevec, and F.L. Graham. 1994. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA. 91:8802-8806.
24. Westwick, J.K., A.E. Bielawska, G. Dbaibo, Y.A. Hannun, and D.A. Brenner. 1993. Ceramide activates the stress-activated protein kinases. J. Biol. Chem. 270:22689-22692.
25. Beg, A.A., S.M. Ruben, R.I. Scheinman, S. Haskill, C.A. Rosen, and A.S. Baldwin, Jr. 1992. I-kappa-B interacts with the nuclear localization sequences of the subunits of NF-kappa-B: a mechanism for cytoplasmic retention. Genes Dev. 6:1899-1913.
26. Hattori, M., A. Tugores, M. Karin, and D.A. Brenner. 1990. A simplified method for the preparation of transcriptionally active liver nuclear extracts. DNA Cell Biol. 9:777-781.
27. Bradham, C.A., R.F. Stachlewitz, G.P. Gao, T. Qian, S. Jayadev, G. Jenkins, Y. Hannun, J.J. Lemasters, R.G. Thurman, and D.A. Brenner. 1997. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 25:1128-1135.
28. Higgins, G.M., and R.M. Anderson, 1993. Experimental pathology of liver: restoration of liver of the white rat following partial surgical removal. Arch. Pathol. 365:179-183.
29. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
30. Inagaki, Y., S. Truter, and F. Ramirez. 1994. Transforming growth factor-β stimulates α2 (I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J. Biol. Chem. 269:14828-14834.
31. Taub, R. 1996. Transcriptional control of liver regeneration. FASEB (Fed. Am. Soc. Exp. Biol.) J. 10:413-427.
32. Trautwein, C., T. Rakemann, M. Niehof, S. Rose-John, and M.P. Manns. 1996. Acute-phase response factor, increased binding, and target gene transcription during liver regeneration. Gastroenterology. 110:1854-1862.
33. Yamada, Y., I. Kirillova, J.J. Peschon, and N. Fausto. 1997. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA. 94:1441-1446.
34. Li, Q., M.A. Kay, M. Finegold, L.D. Stratford-Perricaudet, and S.L.C. Woo. 1993. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum. Gene Ther. 4:403-409.
35. Drazan, K.E., X.D. Shen, M.E. Csete, W.W. Zhang, J.A. Roth, R.W. Busuttil, and A. Snaked. 1994. In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection. Surgery. 116:197-203.
36. Chang, A.G.Y., and G.Y. Wu. 1994. Gene therapy: applications to the treatment of gastrointestinal and liver diseases. Gastroenterology. 106:1076-1084.
37. Kozarsky, K.F., D.R. McKinley, L.L. Austin, S.E. Raper, L.D. Stratford-Perricaudet, and J.M. Wilson. 1994. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J. Biol. Chem. 269:13695-13702.
38. Kay, M.A., C.N. Landen, S.R. Rothenberg, L.A. Taylor, F. Leland, S. Wiehle, B. Fang, D. Bellinger, M. Finegold, and A.R. Thompson. 1994. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc. Natl. Acad. Sci. USA. 91:2353-2357.
39. Lee, Y.-H., B. Sauer, P.F. Johnson, and F.J. Gonzalez. 1997. Disruption of the c/ebp alpha gene in adult mouse liver. Mol. Cell. Biol. 17:6014-6022.
40. Engelhardt, J.F., X. Ye, B. Doranz, and J.M. Wilson. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA. 91: 6196-6200.
41. Gao, O.P., Y. Yang, and Y.M. Wilson. 1996. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J. Virol. 70:8934-8943.
42. Drazan, K.E., M.E. Csete, X. Da Shen, D. Bullington, G. Cottle, R.W. Busuttil, and A. Shaked. 1995. Hepatic function is preserved following liver-directed, adenovirus-mediated gene transfer. J. Surg. Res. 59:299-304.
43. Drazan, K.J.E., L. Wu, K.M. Olthoff, O. Jurim, R.W. Busuttil, and A. Shaked. 1995. Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro. J. Surg. Res. 59:219-223.
44. Evan, G.I., L. Brown, M. Whyte, and E. Harrington. 1995. Apoptosis and the cell cycle. Curr. Opin. Cell. Biol. 7:825-834.
45. Akerman, P.A., P. Cote, S.Q. Yang, C. McClain, S. Nelson, G.J. Bagby, and A.M. Diehl. 1992. Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy. Am. J. Physiol. 263:G579-G585.
46. Beg, A.A., and D. Baltimore. 1996. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science. 274:782-784.
47. Liu, Z.G., H. Hsu, D.V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor I effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. 87:565-576.
48. Reinhard, C., B. Shamoon, V. Shyamala, and L.T. Williams. 1997. Tumor necrosis factor α-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO (Eur. Mol. Biol. Organ.) J. 16:1080-1092.
49. Rothe, M., V. Sarma, V.M. Dixit, and S.V. Goeddel. 1995. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science. 269: 1424-1427.
50. Wallach, D. 1996. Suicide by order: some open questions about the cell-killing activities of the TNF ligand and receptor families. Cytokine Growth Factor Revs. 7:211-221.
51. Hsu, H., J. Xiong, and D.V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappaB activation. Cell. 81: 495-504.
52. Gorczyc, W., J. Gong, B. Ardelt, F. Traganos, and Z. Darzynkiewicz. 1993. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53:3186-3192.
53. Li, X., F. Traganos, and Z. Darzynkiewicz. 1994. Simultaneous analysis of DNA replication and apoptosis during treatment of HL-60 cells with camptothecin and hyperthermia and mitogen stimulation of human lymphocytes. Cancer Res. 54:4289-4293.