Myc requires distinct E2F activities to induce S phase and apoptosis

Molecular Cell

Volumn 8, Issue 1, 2001, Pages 105-113

  Leone, Gustavo ^a   Sears, Rosalie ^b   Huang, Erich ^b   Rempel, Rachel ^b   Nuckolls, Faison ^b   Park, Chi Hyun ^a   Giangrande, Paloma ^b   Wu, Lizhao ^a   Saavedra, Harold I ^a   Field, Seth J ^c   Thompson, Margaret A ^c   Yang, Haidi ^c   Fujiwara, Yuko ^c   Greenberg, Michael E ^c   Orkin, Stuart ^c   Smith, Clay ^b   Nevins, Joseph R ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MYC; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL FATE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FEMALE; FIBROBLAST; GENE ACTIVATION; GENE ACTIVITY; GENE DELETION; GENE FUNCTION; GENE INDUCTION; MALE; MOUSE; NONHUMAN; ONCOGENE MYC;

ANIMALIA;

EID: 17944375816     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00275-1     Document Type: Article

References (58)

1. Complex transcriptional regulatory mechanisms control expression of the E2F3 locus
2. ARF links the tumour suppressors RB and p53
3. The ornithine decarboxylase gene is a transcriptional target of c-Myc
4. Sequence-specific DNA-binding complex with Myc
5. Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
6. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
7. E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity
8. Distinct roles for E2F proteins in cell growth control and apoptosis
9. The regulation of E2F by pRB-family proteins
10. The MYC protein activates transcription of the alpha-prothymosin gene
11. c-Myc enhances protein synthesis and cell size during B lymphocyte development
12. A matter of life and cell death
13. Induction of apoptosis in fibroblasts by c-myc protein
14. E2F-1 functions in mice to promote apoptosis and suppress proliferation
15. Cdc25 cell-cycle phosphatase as a target of c-myc
16. Identification of c-Myc responsive genes using rat cDNA microarray
17. Mediation of c-Myc-induced apoptosis by p53
18. Identification of CDK4 as a target of c-MYC
19. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
20. E2F4 is essential for normal erythrocyte maturation and neonatal viability
21. E2f3 is critical for normal cellular proliferation
22. Drosophila myc regulates cellular growth druing development
23. c-Myc induced sensitization to apoptosis is mediated through cytochrome c release
24. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
25. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
26. E2F1-specific induction of apoptosis and p53 accumulation is modulated by mdm2
27. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
28. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
29. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
30. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins
31. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
32. New light on Myc and Myb. Part I: Myc
33. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
34. MYC oncogenes and human neoplastic disease
35. Toward an understanding of the functional complexity of the E2F and Retinoblastoma families
36. The Rb/E2F pathway and cancer
37. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
38. Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
39. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
40. Loss of E2F4 activity leads to abnormal development of multiple cellular lineages
41. Embryo-derived stem cells
42. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNa methylation and down-regulated by wild-type p53
43. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis
44. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
45. Ras enhances Myc protein stability
46. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
47. Cancer cell cycles
48. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
49. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
50. c-Myc induces the expression and activity of ornithine decarboxylase
51. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
52. Myc activates telomerase
53. p53 and E2F-1 cooperate to mediate apoptosis
54. Tumor induction and tissue atrophy in mice lacking E2F-1
55. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice
56. ARF promotes MDm2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppressor pathways
57. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
58. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization