메뉴 건너뛰기




Volumn 22, Issue 9, 2013, Pages 1167-1179

Investigational drugs for pruritus

Author keywords

Chronic pruritus; Neurokinin 1 receptor; Opioid receptors; Therapy of CP

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; A 940894; A 987306; ANTIPRURITIC AGENT; APREPITANT; CAPSAICIN; CZC 13788; GASTRIN RELATED PEPTIDE RECEPTOR; HISTAMINE H1 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; IMMUBALANCE; INCB 38579; INTERLEUKIN 31; INTERLEUKIN 31 RECEPTOR; INTERLEUKIN RECEPTOR; NALFURAFINE; NALOXONE; NERVE GROWTH FACTOR; PF 2988403; PIMECROLIMUS; PROTEINASE ACTIVATED RECEPTOR 2; RECEPTOR; SEMAPHORIN 3A; TACROLIMUS; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

EID: 84882272329     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.813932     Document Type: Review
Times cited : (14)

References (169)
  • 1
    • 34247401321 scopus 로고    scopus 로고
    • Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin
    • Ständer S, Ständer H, Seeliger S, et al. Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. Br J Dermatol 2007;156(5):1020-6
    • (2007) Br J Dermatol , vol.156 , Issue.5 , pp. 1020-1026
    • Ständer, S.1    Ständer, H.2    Seeliger, S.3
  • 2
    • 84876582015 scopus 로고    scopus 로고
    • Gender differences in chronic pruritus: Women present different morbidity, more scratch lesions and higher burden
    • Ständer S, Stumpf A, Osada N, et al. Gender differences in chronic pruritus: women present different morbidity, more scratch lesions and higher burden. Br J Dermatol 2013;168(6):1273-80
    • (2013) Br J Dermatol , vol.168 , Issue.6 , pp. 1273-1280
    • Ständer, S.1    Stumpf, A.2    Osada, N.3
  • 3
    • 85028105781 scopus 로고    scopus 로고
    • Prevalence of chronic pruritus in Germany: Results of a cross-sectional study in a sample working population of 11730
    • Ständer S, Schäfer I, Phan NQ, et al. Prevalence of chronic pruritus in Germany: results of a cross-sectional study in a sample working population of 11,730. Dermatology 2010;221(3):229-35
    • (2010) Dermatology , vol.221 , Issue.3 , pp. 229-235
    • Ständer, S.1    Schäfer, I.2    Phan, N.Q.3
  • 4
    • 84925581702 scopus 로고    scopus 로고
    • Lysophosphatidic acid is a potential mediator of cholestatic pruritus
    • 1018.e1
    • Kremer AE, Martens JJWW, Kulik W, et al. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 2010;139(3):1008-18, 1018.e1
    • (2010) Gastroenterology , vol.139 , Issue.3 , pp. 1008-1018
    • Kremer, A.E.1    Martens, J.J.W.W.2    Kulik, W.3
  • 5
    • 84875848761 scopus 로고    scopus 로고
    • The TGR5 receptor mediates bile acid-induced itch and analgesia
    • Alemi F, Kwon E, Poole DP, et al. The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest 2013;123(4):1513-30
    • (2013) J Clin Invest , vol.123 , Issue.4 , pp. 1513-1530
    • Alemi, F.1    Kwon, E.2    Poole, D.P.3
  • 6
    • 8044234352 scopus 로고    scopus 로고
    • Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice
    • Matsuda H, Watanabe N, Geba GP, et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 1997;9(3):461-6
    • (1997) Int Immunol , vol.9 , Issue.3 , pp. 461-466
    • Matsuda, H.1    Watanabe, N.2    Geba, G.P.3
  • 7
    • 79251551365 scopus 로고    scopus 로고
    • Evaluation of itch by using NC/NgaTnd mice: A model of human atopic dermatitis
    • Tanaka A, Matsuda H. Evaluation of itch by using NC/NgaTnd mice: a model of human atopic dermatitis. J Biomed Biotechnol 2011;2011:790436
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 790436
    • Tanaka, A.1    Matsuda, H.2
  • 8
    • 84861466366 scopus 로고    scopus 로고
    • Recent findings in mouse models for human atopic dermatitis
    • Tanaka A, Amagai Y, Oida K, Matsuda H. Recent findings in mouse models for human atopic dermatitis. Exp Anim 2012;61(2):77-84
    • (2012) Exp Anim , vol.61 , Issue.2 , pp. 77-84
    • Tanaka, A.1    Amagai, Y.2    Oida, K.3    Matsuda, H.4
  • 9
    • 0032510842 scopus 로고    scopus 로고
    • Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice
    • Sugimoto Y, Umakoshi K, Nojiri N, Kamei C. Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. Eur J Pharmacol 1998;351(1):1-5
    • (1998) Eur J Pharmacol , vol.351 , Issue.1 , pp. 1-5
    • Sugimoto, Y.1    Umakoshi, K.2    Nojiri, N.3    Kamei, C.4
  • 10
    • 77649216982 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: A multi-centre double-blind randomized placebo-controlled study
    • Zuberbier T, Oanta A, Bogacka E, et al. Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study. Allergy 2010;65(4):516-28
    • (2010) Allergy , vol.65 , Issue.4 , pp. 516-528
    • Zuberbier, T.1    Oanta, A.2    Bogacka, E.3
  • 11
    • 0141543889 scopus 로고    scopus 로고
    • Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice
    • Hossen MA, Sugimoto Y, Kayasuga R, Kamei C. Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice. Br J Dermatol 2003;149(1):17-22
    • (2003) Br J Dermatol , vol.149 , Issue.1 , pp. 17-22
    • Hossen, M.A.1    Sugimoto, Y.2    Kayasuga, R.3    Kamei, C.4
  • 12
    • 1642295821 scopus 로고    scopus 로고
    • Pruritus-associated response mediated by cutaneous histamine H3 receptors
    • Sugimoto Y, Iba Y, Nakamura Y, et al. Pruritus-associated response mediated by cutaneous histamine H3 receptors. Clin Exp Allergy 2004;34(3):456-9
    • (2004) Clin Exp Allergy , vol.34 , Issue.3 , pp. 456-459
    • Sugimoto, Y.1    Iba, Y.2    Nakamura, Y.3
  • 13
    • 2942530381 scopus 로고    scopus 로고
    • Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb/c mice
    • Bell JK, McQueen DS, Rees JL. Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb/c mice. Br J Pharmacol 2004;142(2):374-80
    • (2004) Br J Pharmacol , vol.142 , Issue.2 , pp. 374-380
    • Bell, J.K.1    McQueen, D.S.2    Rees, J.L.3
  • 14
    • 33845924770 scopus 로고    scopus 로고
    • Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
    • Dunford PJ, Williams KN, Desai PJ, et al. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J Allergy Clin Immunol 2007;119(1):176-83
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.1 , pp. 176-183
    • Dunford, P.J.1    Williams, K.N.2    Desai, P.J.3
  • 15
    • 77949541373 scopus 로고    scopus 로고
    • The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation
    • Cowden JM, Zhang M, Dunford PJ, Thurmond RL. The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. J Investig Dermatol 2009;130(4):1023-33
    • (2009) J Investig Dermatol , vol.130 , Issue.4 , pp. 1023-1033
    • Cowden, J.M.1    Zhang, M.2    Dunford, P.J.3    Thurmond, R.L.4
  • 16
    • 57749180233 scopus 로고    scopus 로고
    • Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation
    • Rossbach K, Wendorff S, Sander K, et al. Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation. Exp Dermatol 2009;18(1):57-63
    • (2009) Exp Dermatol , vol.18 , Issue.1 , pp. 57-63
    • Rossbach, K.1    Wendorff, S.2    Sander, K.3
  • 17
    • 51349097261 scopus 로고    scopus 로고
    • Histamine H4 receptors modulate dendritic cell migration through skin-immunomodulatory role of histamine
    • Bäumer W, Wendorff S, Gutzmer R, et al. Histamine H4 receptors modulate dendritic cell migration through skin-immunomodulatory role of histamine. Allergy 2008;63(10):1387-94
    • (2008) Allergy , vol.63 , Issue.10 , pp. 1387-1394
    • Bäumer, W.1    Wendorff, S.2    Gutzmer, R.3
  • 18
    • 61549091886 scopus 로고    scopus 로고
    • The histamine H4 receptor is functionally expressed on T(H)2 cells
    • Gutzmer R, Mommert S, Gschwandtner M, et al. The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol 2009;123(3):619-25
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.3 , pp. 619-625
    • Gutzmer, R.1    Mommert, S.2    Gschwandtner, M.3
  • 19
    • 34547092690 scopus 로고    scopus 로고
    • Histamine downregulates monocyte CCL2 production through the histamine H4 receptor
    • Dijkstra D, Leurs R, Chazot P, et al. Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J Allergy Clin Immunol 2007;120(2):300-7
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.2 , pp. 300-307
    • Dijkstra, D.1    Leurs, R.2    Chazot, P.3
  • 20
    • 45349092858 scopus 로고    scopus 로고
    • Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor
    • Dijkstra D, Stark H, Chazot PL, et al. Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor. J Invest Dermatol 2008;128(7):1696-703
    • (2008) J Invest Dermatol , vol.128 , Issue.7 , pp. 1696-1703
    • Dijkstra, D.1    Stark, H.2    Chazot, P.L.3
  • 21
    • 77953102212 scopus 로고    scopus 로고
    • Murine and human Langerhans cells express a functional histamine H4 receptor: Modulation of cell migration and function
    • Gschwandtner M, Rossbach K, Dijkstra D, et al. Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function. Allergy 2010;65(7):840-9
    • (2010) Allergy , vol.65 , Issue.7 , pp. 840-849
    • Gschwandtner, M.1    Rossbach, K.2    Dijkstra, D.3
  • 22
    • 80053374621 scopus 로고    scopus 로고
    • The histamine H4 receptor is highly expressed on plasmacytoid dendritic cells in psoriasis and histamine regulates their cytokine production and migration
    • Gschwandtner M, Mommert S, Kother B, et al. The histamine H4 receptor is highly expressed on plasmacytoid dendritic cells in psoriasis and histamine regulates their cytokine production and migration. J Invest Dermatol 2011;131(8):1668-76
    • (2011) J Invest Dermatol , vol.131 , Issue.8 , pp. 1668-1676
    • Gschwandtner, M.1    Mommert, S.2    Kother, B.3
  • 23
    • 83455258015 scopus 로고    scopus 로고
    • Human memory Th17 cells express a functional histamine H4 receptor
    • Mommert S, Gschwandtner M, Koether B, et al. Human memory Th17 cells express a functional histamine H4 receptor. Am J Pathol 2012;180(1):177-85
    • (2012) Am J Pathol , vol.180 , Issue.1 , pp. 177-185
    • Mommert, S.1    Gschwandtner, M.2    Koether, B.3
  • 24
    • 84883723002 scopus 로고    scopus 로고
    • Azines as histamine H4 receptor antagonists
    • Schol Ed
    • Lazewska D, Kiec-Kononowicz K. Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed) 2012;4:967-87
    • (2012) Front Biosci , vol.4 , pp. 967-987
    • Lazewska, D.1    Kiec-Kononowicz, K.2
  • 25
    • 84855440025 scopus 로고    scopus 로고
    • INCB38579, a novel and potent histamine H(4) receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions
    • Shin N, Covington M, Bian D, et al. INCB38579, a novel and potent histamine H(4) receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions. Eur J Pharmacol 2012;675(1-3):47-56
    • (2012) Eur J Pharmacol , vol.675 , Issue.1-3 , pp. 47-56
    • Shin, N.1    Covington, M.2    Bian, D.3
  • 26
    • 12144288036 scopus 로고    scopus 로고
    • A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties
    • Thurmond RL, Desai PJ, Dunford PJ, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther 2004;309(1):404-13
    • (2004) J Pharmacol Exp Ther , vol.309 , Issue.1 , pp. 404-413
    • Thurmond, R.L.1    Desai, P.J.2    Dunford, P.J.3
  • 27
    • 84858736646 scopus 로고    scopus 로고
    • Histamine H4 receptor ligands and their potential therapeutic applications: An update
    • Kiss R, Keseru GM. Histamine H4 receptor ligands and their potential therapeutic applications: an update. Expert Opin Ther Pat 2012;22(3):205-21
    • (2012) Expert Opin Ther Pat , vol.22 , Issue.3 , pp. 205-221
    • Kiss, R.1    Keseru, G.M.2
  • 28
    • 84863845497 scopus 로고    scopus 로고
    • The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice
    • Ohsawa Y, Hirasawa N. The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice. Allergy 2012;67(8):1014-22
    • (2012) Allergy , vol.67 , Issue.8 , pp. 1014-1022
    • Ohsawa, Y.1    Hirasawa, N.2
  • 29
    • 78449273231 scopus 로고    scopus 로고
    • Chronic pruritus: A paraneoplastic sign
    • Yosipovitch G. Chronic pruritus: a paraneoplastic sign. Dermatol Ther 2010;23(6):590-6
    • (2010) Dermatol Ther , vol.23 , Issue.6 , pp. 590-596
    • Yosipovitch, G.1
  • 30
    • 3242798310 scopus 로고    scopus 로고
    • Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
    • Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 2004;5(7):752-60
    • (2004) Nat Immunol , vol.5 , Issue.7 , pp. 752-760
    • Dillon, S.R.1    Sprecher, C.2    Hammond, A.3
  • 31
    • 12344255693 scopus 로고    scopus 로고
    • Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling
    • Diveu C, Lak-Hal AL, Froger J, et al. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur Cytokine Netw 2004;15(4):291-302
    • (2004) Eur Cytokine Netw , vol.15 , Issue.4 , pp. 291-302
    • Diveu, C.1    Lak-Hal, A.L.2    Froger, J.3
  • 32
    • 20444363845 scopus 로고    scopus 로고
    • Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis
    • Takaoka A, Arai I, Sugimoto M, et al. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. Eur J Pharmacol 2005;516(2):180-1
    • (2005) Eur J Pharmacol , vol.516 , Issue.2 , pp. 180-181
    • Takaoka, A.1    Arai, I.2    Sugimoto, M.3
  • 33
    • 32044437848 scopus 로고    scopus 로고
    • IL-31: A new link between T cells and pruritus in atopic skin inflammation
    • Sonkoly E, Muller A, Lauerma AI, et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006;117(2):411-17
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.2 , pp. 411-417
    • Sonkoly, E.1    Muller, A.2    Lauerma, A.I.3
  • 34
    • 84872700908 scopus 로고    scopus 로고
    • Interleukin-31: Its role in canine pruritus and naturally occurring canine atopic dermatitis
    • e11-2
    • Gonzales AJ, Humphrey WR, Messamore JE, et al. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Vet Dermatol 2013;24(1):48-53.e11-2
    • (2013) Vet Dermatol , vol.24 , Issue.1 , pp. 48-53
    • Gonzales, A.J.1    Humphrey, W.R.2    Messamore, J.E.3
  • 35
    • 33749334907 scopus 로고    scopus 로고
    • Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis
    • Neis MM, Peters B, Dreuw A, et al. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol 2006;118(4):930-7
    • (2006) J Allergy Clin Immunol , vol.118 , Issue.4 , pp. 930-937
    • Neis, M.M.1    Peters, B.2    Dreuw, A.3
  • 36
    • 33645934213 scopus 로고    scopus 로고
    • Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis
    • Takaoka A, Arai I, Sugimoto M, et al. Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis. Exp Dermatol 2006;15(3):161-7
    • (2006) Exp Dermatol , vol.15 , Issue.3 , pp. 161-167
    • Takaoka, A.1    Arai, I.2    Sugimoto, M.3
  • 37
    • 79751508913 scopus 로고    scopus 로고
    • Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: Elevated levels correlate with severity scoring
    • Ezzat MHM, Hasan ZE, Shaheen KYA. Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring. J Eur Acad Dermatol Venereol 2011;25(3):334-9
    • (2011) J Eur Acad Dermatol Venereol , vol.25 , Issue.3 , pp. 334-339
    • Ezzat, M.H.M.1    Hasan, Z.E.2    Shaheen, K.Y.A.3
  • 38
    • 84859833131 scopus 로고    scopus 로고
    • IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis
    • Raap U, Weissmantel S, Gehring M, et al. IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis. Pediatr Allergy Immunol 2012;23(3):285-8
    • (2012) Pediatr Allergy Immunol , vol.23 , Issue.3 , pp. 285-288
    • Raap, U.1    Weissmantel, S.2    Gehring, M.3
  • 39
    • 57649243697 scopus 로고    scopus 로고
    • Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: A model of atopic dermatitis
    • Grimstad O, Sawanobori Y, Vestergaard C, et al. Anti-interleukin-31- antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis. Exp Dermatol 2009;18(1):35-43
    • (2009) Exp Dermatol , vol.18 , Issue.1 , pp. 35-43
    • Grimstad, O.1    Sawanobori, Y.2    Vestergaard, C.3
  • 41
    • 84865590838 scopus 로고    scopus 로고
    • Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: A literature review
    • Phan NQ, Lotts T, Antal A, et al. Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. Acta Derm Venerol 2012;92(5):555-60
    • (2012) Acta Derm Venerol , vol.92 , Issue.5 , pp. 555-560
    • Phan, N.Q.1    Lotts, T.2    Antal, A.3
  • 42
    • 55549087935 scopus 로고    scopus 로고
    • Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice
    • Kuraishi Y, Yageta Y, Konno M, et al. Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice. Biol Pharm Bull 2008;31(11):2143-5
    • (2008) Biol Pharm Bull , vol.31 , Issue.11 , pp. 2143-2145
    • Kuraishi, Y.1    Yageta, Y.2    Konno, M.3
  • 43
    • 68349137947 scopus 로고    scopus 로고
    • Nalfurafine prevents 5'-guanidinonaltrindole-and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice
    • Inan S, Dun NJ, Cowan A. Nalfurafine prevents 5'-guanidinonaltrindole-and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice. Neuroscience 2009;163(1):23-33
    • (2009) Neuroscience , vol.163 , Issue.1 , pp. 23-33
    • Inan, S.1    Dun, N.J.2    Cowan, A.3
  • 44
    • 80054709876 scopus 로고    scopus 로고
    • Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
    • Liu X, Liu Z, Sun Y, et al. Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Cell 2011;147(2):447-58
    • (2011) Cell , vol.147 , Issue.2 , pp. 447-458
    • Liu, X.1    Liu, Z.2    Sun, Y.3
  • 45
    • 0037256736 scopus 로고    scopus 로고
    • Itch: Scratching more than the surface
    • Twycross R, Greaves MW, Handwerker H, et al. Itch: scratching more than the surface. QJM 2003;96(1):7-26
    • (2003) QJM , vol.96 , Issue.1 , pp. 7-26
    • Twycross, R.1    Greaves, M.W.2    Handwerker, H.3
  • 46
    • 33747161622 scopus 로고    scopus 로고
    • Treating itch in psoriasis
    • Dawn A, Yosipovitch G. Treating itch in psoriasis. Dermatol Nurs 2006;18(3):227-33
    • (2006) Dermatol Nurs , vol.18 , Issue.3 , pp. 227-233
    • Dawn, A.1    Yosipovitch, G.2
  • 47
    • 3042593116 scopus 로고    scopus 로고
    • The role of central mu opioid receptors in opioid-induced itch in primates
    • Ko MCH, Song MS, Edwards T, et al. The role of central mu opioid receptors in opioid-induced itch in primates. J Pharmacol Exp Ther 2004;310(1):169-76
    • (2004) J Pharmacol Exp Ther , vol.310 , Issue.1 , pp. 169-176
    • Ko, M.C.H.1    Song, M.S.2    Edwards, T.3
  • 48
    • 0032033683 scopus 로고    scopus 로고
    • Mu-Opposing actions of the kappa-opioid receptor
    • Pan ZZ. mu-Opposing actions of the kappa-opioid receptor. Trends Pharmacol Sci 1998;19(3):94-8
    • (1998) Trends Pharmacol Sci , vol.19 , Issue.3 , pp. 94-98
    • Pan, Z.Z.1
  • 49
    • 78049487522 scopus 로고    scopus 로고
    • Differential itch-and pain-related behavioral responses and ?-opoid modulation in mice
    • Carstens E, Akiyama T, Carstens MI. Differential itch-and pain-related behavioral responses and ?-opoid modulation in mice. Acta Derm Venerol 2010;90(6):575-81
    • (2010) Acta Derm Venerol , vol.90 , Issue.6 , pp. 575-581
    • Carstens, E.1    Akiyama, T.2    Carstens, M.I.3
  • 50
    • 1642408015 scopus 로고    scopus 로고
    • Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system
    • Umeuchi H, Togashi Y, Honda T, et al. Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system. Eur J Pharmacol 2003;477(1):29-35
    • (2003) Eur J Pharmacol , vol.477 , Issue.1 , pp. 29-35
    • Umeuchi, H.1    Togashi, Y.2    Honda, T.3
  • 51
    • 0035917683 scopus 로고    scopus 로고
    • Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice
    • Kamei J, Nagase H. Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice. Eur J Pharmacol 2001;418(1-2):141-5
    • (2001) Eur J Pharmacol , vol.418 , Issue.1-2 , pp. 141-145
    • Kamei, J.1    Nagase, H.2
  • 52
    • 0037169176 scopus 로고    scopus 로고
    • Antipruritic activity of the kappa-opioid receptor agonist, TRK-820
    • Togashi Y, Umeuchi H, Okano K, et al. Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. Eur J Pharmacol 2002;435(2-3):259-64
    • (2002) Eur J Pharmacol , vol.435 , Issue.2-3 , pp. 259-264
    • Togashi, Y.1    Umeuchi, H.2    Okano, K.3
  • 53
    • 5344243136 scopus 로고    scopus 로고
    • Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys
    • Wakasa Y, Fujiwara A, Umeuchi H, et al. Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys. Life Sci 2004;75(24):2947-57
    • (2004) Life Sci , vol.75 , Issue.24 , pp. 2947-2957
    • Wakasa, Y.1    Fujiwara, A.2    Umeuchi, H.3
  • 54
    • 23644458759 scopus 로고    scopus 로고
    • Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride
    • Umeuchi H, Kawashima Y, Aoki CA, et al. Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride. Eur J Pharmacol 2005;518(2-3):133-9
    • (2005) Eur J Pharmacol , vol.518 , Issue.2-3 , pp. 133-139
    • Umeuchi, H.1    Kawashima, Y.2    Aoki, C.A.3
  • 55
    • 19944426642 scopus 로고    scopus 로고
    • Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo
    • Wang Y, Tang K, Inan S, et al. Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo. J Pharmacol Exp Ther 2005;312(1):220-30
    • (2005) J Pharmacol Exp Ther , vol.312 , Issue.1 , pp. 220-230
    • Wang, Y.1    Tang, K.2    Inan, S.3
  • 56
    • 33751074425 scopus 로고    scopus 로고
    • Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats
    • Inan S, Cowan A. Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 2006;85(1):39-43
    • (2006) Pharmacol Biochem Behav , vol.85 , Issue.1 , pp. 39-43
    • Inan, S.1    Cowan, A.2
  • 57
    • 44449136187 scopus 로고    scopus 로고
    • Effect of TRK-820, a selective kappa opioid receptor agonist, on scratching behavior in an animal model of atopic dermatitis
    • Nakao K, Ikeda K, Kurokawa T, et al. Effect of TRK-820, a selective kappa opioid receptor agonist, on scratching behavior in an animal model of atopic dermatitis. Nihon Shinkei Seishin Yakurigaku Zasshi 2008;28(2):75-83
    • (2008) Nihon Shinkei Seishin Yakurigaku Zasshi , vol.28 , Issue.2 , pp. 75-83
    • Nakao, K.1    Ikeda, K.2    Kurokawa, T.3
  • 58
    • 32644464871 scopus 로고    scopus 로고
    • Butorphanol for treatment of intractable pruritus
    • Dawn AG, Yosipovitch G. Butorphanol for treatment of intractable pruritus. J Am Acad Dermatol 2006;54(3):527-31
    • (2006) J Am Acad Dermatol , vol.54 , Issue.3 , pp. 527-531
    • Dawn, A.G.1    Yosipovitch, G.2
  • 59
    • 34548210952 scopus 로고    scopus 로고
    • Effects of butorphanol on morphine-induced itch and analgesia in primates
    • Lee H, Naughton NN, Woods JH, Ko M. Effects of butorphanol on morphine-induced itch and analgesia in primates. Anesthesiology 2007;107(3):478-85
    • (2007) Anesthesiology , vol.107 , Issue.3 , pp. 478-485
    • Lee, H.1    Naughton, N.N.2    Woods, J.H.3    Ko, M.4
  • 60
    • 77956719480 scopus 로고    scopus 로고
    • Antipruritic treatment with systemic mu-opioid receptor antagonists: A review
    • Phan NQ, Bernhard JD, Luger TA, Ständer S. Antipruritic treatment with systemic mu-opioid receptor antagonists: a review. J Am Acad Dermatol 2010;63(4):680-8
    • (2010) J Am Acad Dermatol , vol.63 , Issue.4 , pp. 680-688
    • Phan, N.Q.1    Bernhard, J.D.2    Luger, T.A.3    Ständer, S.4
  • 61
    • 33645952393 scopus 로고    scopus 로고
    • Kappa-opioid system in uremic pruritus: Multicenter, randomized, double-blind, placebo-controlled clinical studies
    • Wikstrom B, Gellert R, Ladefoged SD, et al. Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 2005;16(12):3742-7
    • (2005) J Am Soc Nephrol , vol.16 , Issue.12 , pp. 3742-3747
    • Wikstrom, B.1    Gellert, R.2    Ladefoged, S.D.3
  • 62
    • 77950267997 scopus 로고    scopus 로고
    • Effect of a novel kappa-receptor agonist nalfurafine hydrochloride on severe itch in 337 haemodialysis patients: A Phase III randomized double-blind placebo-controlled study
    • Kumagai H, Ebata T, Takamori K, et al. Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant 2010;25(4):1251-7
    • (2010) Nephrol Dial Transplant , vol.25 , Issue.4 , pp. 1251-1257
    • Kumagai, H.1    Ebata, T.2    Takamori, K.3
  • 63
    • 84863084178 scopus 로고    scopus 로고
    • Nalfurafine hydrochloride for the treatment of pruritus
    • Inui S. Nalfurafine hydrochloride for the treatment of pruritus. Expert Opin Pharmacother 2012;13(10):1507-13
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.10 , pp. 1507-1513
    • Inui, S.1
  • 64
    • 34547726181 scopus 로고    scopus 로고
    • A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
    • Sun Y, Chen Z. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007;448(7154):700-3
    • (2007) Nature , vol.448 , Issue.7154 , pp. 700-703
    • Sun, Y.1    Chen, Z.2
  • 65
    • 70349317480 scopus 로고    scopus 로고
    • Cellular basis of itch sensation
    • Sun Y, Zhao Z, Meng X, et al. Cellular basis of itch sensation. Science 2009;325(5947):1531-4
    • (2009) Science , vol.325 , Issue.5947 , pp. 1531-1534
    • Sun, Y.1    Zhao, Z.2    Meng, X.3
  • 66
    • 84865761686 scopus 로고    scopus 로고
    • Design synthesis and anti-itch activity evaluation of aromatic amino acid derivatives as gastrin-releasing peptide receptor antagonists
    • Yao R, Li T, Xu J, et al. Design, synthesis and anti-itch activity evaluation of aromatic amino acid derivatives as gastrin-releasing peptide receptor antagonists. Med Chem 2012;8(5):865-73
    • (2012) Med Chem , vol.8 , Issue.5 , pp. 865-873
    • Yao, R.1    Li, T.2    Xu, J.3
  • 67
    • 84861794417 scopus 로고    scopus 로고
    • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    • Liu T, Berta T, Xu Z, et al. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest 2012;122(6):2195-207
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 2195-2207
    • Liu, T.1    Berta, T.2    Xu, Z.3
  • 68
    • 80054060012 scopus 로고    scopus 로고
    • Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice
    • Andoh T, Kuwazono T, Lee J, Kuraishi Y. Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice. Peptides 2011;32(10):2098-103
    • (2011) Peptides , vol.32 , Issue.10 , pp. 2098-2103
    • Andoh, T.1    Kuwazono, T.2    Lee, J.3    Kuraishi, Y.4
  • 69
    • 0034088058 scopus 로고    scopus 로고
    • Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: A dermal microdialysis study
    • Rukwied R, Lischetzki G, McGlone F, et al. Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Br J Dermatol 2000;142(6):1114-20
    • (2000) Br J Dermatol , vol.142 , Issue.6 , pp. 1114-1120
    • Rukwied, R.1    Lischetzki, G.2    McGlone, F.3
  • 70
    • 26644466298 scopus 로고    scopus 로고
    • Expression of nerve growth factor in itchy skins of atopic NC/NgaTnd mice
    • Tanaka A, Matsuda H. Expression of nerve growth factor in itchy skins of atopic NC/NgaTnd mice. J Vet Med Sci 2005;67(9):915-19
    • (2005) J Vet Med Sci , vol.67 , Issue.9 , pp. 915-919
    • Tanaka, A.1    Matsuda, H.2
  • 71
    • 14844333552 scopus 로고    scopus 로고
    • Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1
    • Groneberg DA, Serowka F, Peckenschneider N, et al. Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1. J Neuroimmunol 2005;161(1-2):87-92
    • (2005) J Neuroimmunol , vol.161 , Issue.1-2 , pp. 87-92
    • Groneberg, D.A.1    Serowka, F.2    Peckenschneider, N.3
  • 72
    • 23444455301 scopus 로고
    • Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system
    • Albers KM, Wright DE, Davis BM. Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci 1994;14(3 Pt 2):1422-32
    • (1994) J Neurosci , vol.14 , Issue.3 PART 2 , pp. 1422-1432
    • Albers, K.M.1    Wright, D.E.2    Davis, B.M.3
  • 73
    • 33846192390 scopus 로고    scopus 로고
    • Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model
    • Takano N, Sakurai T, Ohashi Y, Kurachi M. Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model. Br J Dermatol 2007;156(2):241-6
    • (2007) Br J Dermatol , vol.156 , Issue.2 , pp. 241-246
    • Takano, N.1    Sakurai, T.2    Ohashi, Y.3    Kurachi, M.4
  • 74
    • 84858149476 scopus 로고    scopus 로고
    • Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis
    • Negi O, Tominaga M, Tengara S, et al. Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci 2012;66(1):37-43
    • (2012) J Dermatol Sci , vol.66 , Issue.1 , pp. 37-43
    • Negi, O.1    Tominaga, M.2    Tengara, S.3
  • 75
    • 84863866496 scopus 로고    scopus 로고
    • Supplementation of the fermented soy product ImmuBalance effectively reduces itching behavior of atopic NC/Tnd mice
    • Matsuda A, Tanaka A, Pan W, et al. Supplementation of the fermented soy product ImmuBalance effectively reduces itching behavior of atopic NC/Tnd mice. J Dermatol Sci 2012;67(2):130-9
    • (2012) J Dermatol Sci , vol.67 , Issue.2 , pp. 130-139
    • Matsuda, A.1    Tanaka, A.2    Pan, W.3
  • 76
    • 77957654538 scopus 로고    scopus 로고
    • A role of Staphyococcus aureus interleukin-18 nerve growth factor and semaphorin 3A an axon guidance molecule in pathogenesis and treatment of atopic dermatitis
    • Ikezawa Z, Komori J, Ikezawa Y, et al. A role of Staphyococcus aureus, interleukin-18, nerve growth factor and semaphorin 3A, an axon guidance molecule, in pathogenesis and treatment of atopic dermatitis. Allergy Asthma Immunol Res 2010;2(4):235-46
    • (2010) Allergy Asthma Immunol Res , vol.2 , Issue.4 , pp. 235-246
    • Ikezawa, Z.1    Komori, J.2    Ikezawa, Y.3
  • 77
    • 79960625424 scopus 로고    scopus 로고
    • Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch
    • Taneda K, Tominaga M, Negi O, et al. Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch. Br J Dermatol 2011;165(2):277-84
    • (2011) Br J Dermatol , vol.165 , Issue.2 , pp. 277-284
    • Taneda, K.1    Tominaga, M.2    Negi, O.3
  • 78
    • 84868343798 scopus 로고    scopus 로고
    • Decreased expression of semaphorin-3A a neurite-collapsing factor is associated with itch in psoriatic skin
    • Kou K, Nakamura F, Aihara M, et al. Decreased expression of semaphorin-3A, a neurite-collapsing factor, is associated with itch in psoriatic skin. Acta Derm Venereol 2012;92(5):521-8
    • (2012) Acta Derm Venereol , vol.92 , Issue.5 , pp. 521-528
    • Kou, K.1    Nakamura, F.2    Aihara, M.3
  • 79
    • 0023193410 scopus 로고
    • Occurrence and distribution of neuropeptides in the human skin An immunocytochemical and immunochemical study on normal skin and blister fluid from inflamed skin
    • Wallengren J, Ekman R, Sundler F. Occurrence and distribution of neuropeptides in the human skin. An immunocytochemical and immunochemical study on normal skin and blister fluid from inflamed skin. Acta Derm Venereol 1987;67(3):185-92
    • (1987) Acta Derm Venereol , vol.67 , Issue.3 , pp. 185-192
    • Wallengren, J.1    Ekman, R.2    Sundler, F.3
  • 80
    • 0025375985 scopus 로고
    • Neuropeptides in skin from patients with atopic dermatitis: An immunohistochemical study
    • Pincelli C, Fantini F, Massimi P, et al. Neuropeptides in skin from patients with atopic dermatitis: an immunohistochemical study. Br J Dermatol 1990;122(6):745-50
    • (1990) Br J Dermatol , vol.122 , Issue.6 , pp. 745-750
    • Pincelli, C.1    Fantini, F.2    Massimi, P.3
  • 81
    • 0030777781 scopus 로고    scopus 로고
    • Intraepidermal nerve fiber expression of calcitonin gene-related peptide, vasoactive intestinal peptide and substance P in psoriasis
    • Chan J, Smoller BR, Raychauduri SP, et al. Intraepidermal nerve fiber expression of calcitonin gene-related peptide, vasoactive intestinal peptide and substance P in psoriasis. Arch Dermatol Res 1997;289(11):611-16
    • (1997) Arch Dermatol Res , vol.289 , Issue.11 , pp. 611-616
    • Chan, J.1    Smoller, B.R.2    Raychauduri, S.P.3
  • 82
    • 0032161858 scopus 로고    scopus 로고
    • Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice
    • Andoh T, Nagasawa T, Satoh M, Kuraishi Y. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J Pharmacol Exp Ther 1998;286(3):1140-5
    • (1998) J Pharmacol Exp Ther , vol.286 , Issue.3 , pp. 1140-1145
    • Andoh, T.1    Nagasawa, T.2    Satoh, M.3    Kuraishi, Y.4
  • 83
    • 0033973163 scopus 로고    scopus 로고
    • New feelings about the role of sensory nerves in inflammation
    • Brain SD. New feelings about the role of sensory nerves in inflammation. Nat Med 2000;6(2):134-5
    • (2000) Nat Med , vol.6 , Issue.2 , pp. 134-135
    • Brain, S.D.1
  • 84
    • 0033971235 scopus 로고    scopus 로고
    • Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
    • Steinhoff M, Vergnolle N, Young SH, et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000;6(2):151-8
    • (2000) Nat Med , vol.6 , Issue.2 , pp. 151-158
    • Steinhoff, M.1    Vergnolle, N.2    Young, S.H.3
  • 85
    • 0028926504 scopus 로고
    • Scratching behavior induced by pruritogenic but not algesiogenic agents in mice
    • Kuraishi Y, Nagasawa T, Hayashi K, Satoh M. Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol 1995;275(3):229-33
    • (1995) Eur J Pharmacol , vol.275 , Issue.3 , pp. 229-233
    • Kuraishi, Y.1    Nagasawa, T.2    Hayashi, K.3    Satoh, M.4
  • 87
    • 0035678082 scopus 로고    scopus 로고
    • Involvement of leukotriene B (4) in substance P-induced itch-associated response in mice
    • Andoh T, Katsube N, Maruyama M, Kuraishi Y. Involvement of leukotriene B (4) in substance P-induced itch-associated response in mice. J Invest Dermatol 2001;117(6):1621-6
    • (2001) J Invest Dermatol , vol.117 , Issue.6 , pp. 1621-1626
    • Andoh, T.1    Katsube, N.2    Maruyama, M.3    Kuraishi, Y.4
  • 88
    • 0029036654 scopus 로고
    • The effect of azelastin hydrochloride on pruritus and leukotriene B4 in hemodialysis patients
    • Kanai H, Nagashima A, Hirakata E, et al. The effect of azelastin hydrochloride on pruritus and leukotriene B4 in hemodialysis patients. Life Sci 1995;57(3):207-13
    • (1995) Life Sci , vol.57 , Issue.3 , pp. 207-213
    • Kanai, H.1    Nagashima, A.2    Hirakata, E.3
  • 89
    • 0037006368 scopus 로고    scopus 로고
    • Inhibitory effects of azelastine on substance P-induced itch-associated response in mice
    • Andoh T, Kuraishi Y. Inhibitory effects of azelastine on substance P-induced itch-associated response in mice. Eur J Pharmacol 2002;436(3):235-9
    • (2002) Eur J Pharmacol , vol.436 , Issue.3 , pp. 235-239
    • Andoh, T.1    Kuraishi, Y.2
  • 90
    • 0029816638 scopus 로고    scopus 로고
    • Neurogenic amplification of immune complex inflammation
    • Bozic CR, Lu B, Hopken UE, et al. Neurogenic amplification of immune complex inflammation. Science 1996;273(5282):1722-5
    • (1996) Science , vol.273 , Issue.5282 , pp. 1722-1725
    • Bozic, C.R.1    Lu, B.2    Hopken, U.E.3
  • 91
    • 33751220216 scopus 로고    scopus 로고
    • How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom
    • Costa SKP, Starr A, Hyslop S, et al. How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom. Vascul Pharmacol 2006;45(4):209-14
    • (2006) Vascul Pharmacol , vol.45 , Issue.4 , pp. 209-214
    • Costa, S.K.P.1    Starr, A.2    Hyslop, S.3
  • 92
    • 0345701545 scopus 로고    scopus 로고
    • Deletion of the preprotachykinin A gene in mice does not reduce scratching behavior elicited by intradermal serotonin
    • Cuellar JM, Jinks SL, Simons CT, Carstens E. Deletion of the preprotachykinin A gene in mice does not reduce scratching behavior elicited by intradermal serotonin. Neurosci Lett 2003;339(1):72-6
    • (2003) Neurosci Lett , vol.339 , Issue.1 , pp. 72-76
    • Cuellar, J.M.1    Jinks, S.L.2    Simons, C.T.3    Carstens, E.4
  • 93
    • 78651393548 scopus 로고    scopus 로고
    • Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model
    • Lee JH, Cho SH. Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: an atopic dermatitis model. J Ethnopharmacol 2011;133(2):810-17
    • (2011) J Ethnopharmacol , vol.133 , Issue.2 , pp. 810-817
    • Lee, J.H.1    Cho, S.H.2
  • 94
    • 33747193244 scopus 로고    scopus 로고
    • Tachykinin receptors antagonists: From research to clinic
    • Quartara L, Altamura M. Tachykinin receptors antagonists: from research to clinic. Curr Drug Targets 2006;7(8):975-92
    • (2006) Curr Drug Targets , vol.7 , Issue.8 , pp. 975-992
    • Quartara, L.1    Altamura, M.2
  • 95
    • 34447092362 scopus 로고    scopus 로고
    • Neuropeptides and their receptors in psoriatic skin in relation to pruritus
    • Chang S, Han S, Jung H, Choi J. Neuropeptides and their receptors in psoriatic skin in relation to pruritus. Br J Dermatol 2007;156(6):1272-7
    • (2007) Br J Dermatol , vol.156 , Issue.6 , pp. 1272-1277
    • Chang, S.1    Han, S.2    Jung, H.3    Choi, J.4
  • 96
    • 77956193969 scopus 로고    scopus 로고
    • Targeting the neurokinin receptor 1 with aprepitant: A novel antipruritic strategy
    • Ständer S, Siepmann D, Herrgott I, et al. Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy. PLoS One 2010;5(6):e10968
    • (2010) PLoS One , vol.5 , Issue.6
    • Ständer, S.1    Siepmann, D.2    Herrgott, I.3
  • 97
    • 84873326725 scopus 로고    scopus 로고
    • Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors
    • Akiyama T, Tominaga M, Davoodi A, et al. Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors. J Neurophysiol 2013;109(3):742-8
    • (2013) J Neurophysiol , vol.109 , Issue.3 , pp. 742-748
    • Akiyama, T.1    Tominaga, M.2    Davoodi, A.3
  • 98
    • 84869021312 scopus 로고    scopus 로고
    • Transient receptor potential channels and pruritus
    • Szallasi A, B?́ró T, editors Springer Human Press; New York, Heidelberg
    • Benecke H, Wäring J, Lotts T, Ständer S. Transient receptor potential channels and pruritus. In: Szallasi A, B?́ró T, editors. TRP channels in drug discovery: volume II. Springer, Human Press; New York, Heidelberg: 2012. p. 255-78
    • (2012) TRP Channels in Drug Discovery , vol.2 , pp. 255-278
    • Benecke, H.1    Wäring, J.2    Lotts, T.3    Ständer, S.4
  • 99
    • 67650494652 scopus 로고    scopus 로고
    • TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms
    • Imamachi N, Park GH, Lee H, et al. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci USA 2009;106(27):11330-5
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.27 , pp. 11330-11335
    • Imamachi, N.1    Park, G.H.2    Lee, H.3
  • 100
    • 0036485026 scopus 로고    scopus 로고
    • Pathophysiology of pruritus in atopic dermatitis: An overview
    • Ständer S, Steinhoff M. Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol 2002;11(1):12-24
    • (2002) Exp Dermatol , vol.11 , Issue.1 , pp. 12-24
    • Ständer, S.1    Steinhoff, M.2
  • 101
    • 34547609914 scopus 로고    scopus 로고
    • TRP channels as novel players in the pathogenesis and therapy of itch
    • B?́ró T, Toth BI, Marincsak R, et al. TRP channels as novel players in the pathogenesis and therapy of itch. Biochim Biophys Acta 2007;1772(8):1004-21
    • (2007) Biochim Biophys Acta , vol.1772 , Issue.8 , pp. 1004-1021
    • B́ró, T.1    Toth, B.I.2    Marincsak, R.3
  • 102
    • 33847400543 scopus 로고    scopus 로고
    • TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    • Shim W, Tak M, Lee M, et al. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci 2007;27(9):2331-7
    • (2007) J Neurosci , vol.27 , Issue.9 , pp. 2331-2337
    • Shim, W.1    Tak, M.2    Lee, M.3
  • 103
    • 79952763777 scopus 로고    scopus 로고
    • Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons
    • Kim S, Park GH, Kim D, et al. Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. Proc Natl Acad Sci USA 2011;108(8):3371-6
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.8 , pp. 3371-3376
    • Kim, S.1    Park, G.H.2    Kim, D.3
  • 104
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389(6653):816-24
    • (1997) Nature , vol.389 , Issue.6653 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3
  • 105
    • 0034646740 scopus 로고    scopus 로고
    • Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    • Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288(5464):306-13
    • (2000) Science , vol.288 , Issue.5464 , pp. 306-313
    • Caterina, M.J.1    Leffler, A.2    Malmberg, A.B.3
  • 106
    • 0344884588 scopus 로고    scopus 로고
    • Characterization of functional vanilloid receptors expressed by mast cells
    • B?́ró T, Maurer M, Modarres S, et al. Characterization of functional vanilloid receptors expressed by mast cells. Blood 1998;91(4):1332-40
    • (1998) Blood , vol.91 , Issue.4 , pp. 1332-1340
    • B́ró, T.1    Maurer, M.2    Modarres, S.3
  • 107
    • 0034801364 scopus 로고    scopus 로고
    • Immunoreactivity of VR1 on epidermal keratinocyte of human skin
    • Denda M, Fuziwara S, Inoue K, et al. Immunoreactivity of VR1 on epidermal keratinocyte of human skin. Biochem Biophys Res Commun 2001;285(5):1250-2
    • (2001) Biochem Biophys Res Commun , vol.285 , Issue.5 , pp. 1250-1252
    • Denda, M.1    Fuziwara, S.2    Inoue, K.3
  • 108
    • 0036085872 scopus 로고    scopus 로고
    • Functional vanilloid receptors in cultured normal human epidermal keratinocytes
    • Inoue K, Koizumi S, Fuziwara S, et al. Functional vanilloid receptors in cultured normal human epidermal keratinocytes. Biochem Biophys Res Commun 2002;291(1):124-9
    • (2002) Biochem Biophys Res Commun , vol.291 , Issue.1 , pp. 124-129
    • Inoue, K.1    Koizumi, S.2    Fuziwara, S.3
  • 109
    • 12144287525 scopus 로고    scopus 로고
    • Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    • Ständer S, Moormann C, Schumacher M, et al. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol 2004;13(3):129-39
    • (2004) Exp Dermatol , vol.13 , Issue.3 , pp. 129-139
    • Ständer, S.1    Moormann, C.2    Schumacher, M.3
  • 110
    • 17044421275 scopus 로고    scopus 로고
    • Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells
    • Basu S, Srivastava P. Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Proc Natl Acad Sci USA 2005;102(14):5120-5
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.14 , pp. 5120-5125
    • Basu, S.1    Srivastava, P.2
  • 111
    • 20244381982 scopus 로고    scopus 로고
    • A hot new twist to hair biology: Involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control
    • Bodó E, B?́ró T, Telek A, et al. A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am J Pathol 2005;166(4):985-98
    • (2005) Am J Pathol , vol.166 , Issue.4 , pp. 985-998
    • Bodó, E.1    B́ró, T.2    Telek, A.3
  • 112
    • 84877939975 scopus 로고    scopus 로고
    • The cells and circuitry for itch responses in mice
    • Mishra SK, Hoon MA. The cells and circuitry for itch responses in mice. Science 2013;340(6135):968-71
    • (2013) Science , vol.340 , Issue.6135 , pp. 968-971
    • Mishra, S.K.1    Hoon, M.A.2
  • 113
    • 0032169804 scopus 로고    scopus 로고
    • The cloned capsaicin receptor integrates multiple pain-producing stimuli
    • Tominaga M, Caterina MJ, Malmberg AB, et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998;21(3):531-43
    • (1998) Neuron , vol.21 , Issue.3 , pp. 531-543
    • Tominaga, M.1    Caterina, M.J.2    Malmberg, A.B.3
  • 114
    • 0024382437 scopus 로고
    • Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
    • Szallasi A, Blumberg PM. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience 1989;30(2):515-20
    • (1989) Neuroscience , vol.30 , Issue.2 , pp. 515-520
    • Szallasi, A.1    Blumberg, P.M.2
  • 115
    • 33646443548 scopus 로고    scopus 로고
    • Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus
    • Steinhoff M, Bienenstock J, Schmelz M, et al. Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. J Invest Dermatol 2006;126(8):1705-18
    • (2006) J Invest Dermatol , vol.126 , Issue.8 , pp. 1705-1718
    • Steinhoff, M.1    Bienenstock, J.2    Schmelz, M.3
  • 116
    • 0028833359 scopus 로고
    • Successful treatment of notalgia paresthetica with topical capsaicin: Vehicle-controlled, double-blind, crossover study
    • Wallengren J, Klinker M. Successful treatment of notalgia paresthetica with topical capsaicin: vehicle-controlled, double-blind, crossover study. J Am Acad Dermatol 1995;32(2 Pt 1):287-9
    • (1995) J Am Acad Dermatol , vol.32 , Issue.2 PART 1 , pp. 287-289
    • Wallengren, J.1    Klinker, M.2
  • 117
    • 0035106681 scopus 로고    scopus 로고
    • Treatment of prurigo nodularis with topical capsaicin
    • Ständer S, Luger T, Metze D. Treatment of prurigo nodularis with topical capsaicin. J Am Acad Dermatol 2001;44(3):471-8
    • (2001) J Am Acad Dermatol , vol.44 , Issue.3 , pp. 471-478
    • Ständer, S.1    Luger, T.2    Metze, D.3
  • 118
    • 0017818831 scopus 로고
    • Capsaicin-induced depletion of substance P from primary sensory neurones
    • Jessell TM, Iversen LL, Cuello AC. Capsaicin-induced depletion of substance P from primary sensory neurones. Brain Res 1978;152(1):183-8
    • (1978) Brain Res , vol.152 , Issue.1 , pp. 183-188
    • Jessell, T.M.1    Iversen, L.L.2    Cuello, A.C.3
  • 119
    • 33747839772 scopus 로고    scopus 로고
    • Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes
    • Dallos A, Kiss M, Polyanka H, et al. Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides 2006;40(4):251-63
    • (2006) Neuropeptides , vol.40 , Issue.4 , pp. 251-263
    • Dallos, A.1    Kiss, M.2    Polyanka, H.3
  • 121
    • 84875995695 scopus 로고    scopus 로고
    • Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease
    • Belghiti M, Estevez-Herrera J, Gimenez-Garzo C, et al. Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease. J Biol Chem 2013;288(14):9675-85
    • J Biol Chem 2013 , vol.288 , Issue.14 , pp. 9675-9685
    • Belghiti, M.1    Estevez-Herrera, J.2    Gimenez-Garzo, C.3
  • 122
    • 33748323235 scopus 로고    scopus 로고
    • Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone
    • Inagaki N, Shiraishi N, Igeta K, et al. Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone. Eur J Pharmacol 2006;546(1-3):189-96
    • (2006) Eur J Pharmacol , vol.546 , Issue.1-3 , pp. 189-196
    • Inagaki, N.1    Shiraishi, N.2    Igeta, K.3
  • 123
    • 0026567782 scopus 로고
    • Topical capsaicin for treatment of hemodialysis-related pruritus
    • Breneman DL, Cardone JS, Blumsack RF, et al. Topical capsaicin for treatment of hemodialysis-related pruritus. J Am Acad Dermatol 1992;26(1):91-4
    • (1992) J Am Acad Dermatol , vol.26 , Issue.1 , pp. 91-94
    • Breneman, D.L.1    Cardone, J.S.2    Blumsack, R.F.3
  • 124
    • 0027184020 scopus 로고
    • A double-blind evaluation of topical capsaicin in pruritic psoriasis
    • Ellis CN, Berberian B, Sulica VI, et al. A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol 1993;29(3):438-42
    • (1993) J Am Acad Dermatol , vol.29 , Issue.3 , pp. 438-442
    • Ellis, C.N.1    Berberian, B.2    Sulica, V.I.3
  • 125
    • 0027302396 scopus 로고
    • The sensory response to capsaicin during repeated topical exposures: Differential effects on sensations of itching and pungency
    • Green BG, Shaffer GS. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 1993;53(3):323-34
    • (1993) Pain , vol.53 , Issue.3 , pp. 323-334
    • Green, B.G.1    Shaffer, G.S.2
  • 126
    • 0032954612 scopus 로고    scopus 로고
    • Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation
    • Nolano M, Simone DA, Wendelschafer-Crabb G, et al. Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain 1999;81(1-2):135-45
    • (1999) Pain , vol.81 , Issue.1-2 , pp. 135-145
    • Nolano, M.1    Simone, D.A.2    Wendelschafer-Crabb, G.3
  • 127
    • 79952447482 scopus 로고    scopus 로고
    • Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1
    • Liang J, Ji Q, Ji W. Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1. Neurosci Lett 2011;492(3):175-8
    • (2011) Neurosci Lett , vol.492 , Issue.3 , pp. 175-178
    • Liang, J.1    Ji, Q.2    Ji, W.3
  • 128
    • 33751415591 scopus 로고    scopus 로고
    • 12(S-HPETE induces itch-associated scratchings in mice
    • Kim D, Kim H, Sung K, et al. 12(S)-HPETE induces itch-associated scratchings in mice. Eur J Pharmacol 2007;554(1):30-3
    • (2007) Eur J Pharmacol , vol.554 , Issue.1 , pp. 30-33
    • Kim, D.1    Kim, H.2    Sung, K.3
  • 129
    • 37549070754 scopus 로고    scopus 로고
    • Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETEinduced scratching in mice
    • Kim D, Kim H, Kim H, et al. Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETEinduced scratching in mice. Eur J Pharmacol 2008;579(1-3):390-4
    • (2008) Eur J Pharmacol , vol.579 , Issue.1-3 , pp. 390-394
    • Kim, D.1    Kim, H.2    Kim, H.3
  • 130
    • 42949125051 scopus 로고    scopus 로고
    • Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1
    • Kim AY, Tang Z, Liu Q, et al. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell 2008;133(3):475-85
    • (2008) Cell , vol.133 , Issue.3 , pp. 475-485
    • Kim, A.Y.1    Tang, Z.2    Liu, Q.3
  • 131
    • 79957823351 scopus 로고    scopus 로고
    • Pirt a TRPV1 modulator is required for histamine-dependent and-independent itch
    • Patel KN, Liu Q, Meeker S, et al. Pirt, a TRPV1 modulator, is required for histamine-dependent and-independent itch. PLoS One 2011;6(5):e20559
    • (2011) PLoS One , vol.6 , Issue.5
    • Patel, K.N.1    Liu, Q.2    Meeker, S.3
  • 132
    • 84858935601 scopus 로고    scopus 로고
    • Treatment of pruritic skin diseases with topical capsaicin
    • Yosipovitch G, Greaves MW, Fleischer AB, McGlone F, editors Marcel Dekker New York, Basel
    • Ständer S, Metze D. Treatment of pruritic skin diseases with topical capsaicin. In: Yosipovitch G, Greaves MW, Fleischer AB, McGlone F, editors. Itch: basic mechanisms and therapy. Marcel Dekker; New York, Basel: 2004. p. 287-304
    • (2004) Itch: Basic Mechanisms and Therapy , pp. 287-304
    • Ständer, S.1    Metze, D.2
  • 133
    • 77954924312 scopus 로고    scopus 로고
    • Systematic review of topical capsaicin in the treatment of pruritus
    • Gooding SMD, Canter PH, Coelho HF, et al. Systematic review of topical capsaicin in the treatment of pruritus. Int J Dermatol 2010;49(8):858-65
    • (2010) Int J Dermatol , vol.49 , Issue.8 , pp. 858-865
    • Gooding, S.M.D.1    Canter, P.H.2    Coelho, H.F.3
  • 134
    • 79958822176 scopus 로고    scopus 로고
    • Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models
    • Yun J, Seo JA, Jang W, et al. Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models. J Invest Dermatol 2011;131(7):1576-9
    • (2011) J Invest Dermatol , vol.131 , Issue.7 , pp. 1576-1579
    • Yun, J.1    Seo, J.A.2    Jang, W.3
  • 135
    • 79952706906 scopus 로고    scopus 로고
    • TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery
    • Yun J, Seo JA, Jeong YS, et al. TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J Dermatol Sci 2011;62(1):8-15
    • (2011) J Dermatol Sci , vol.62 , Issue.1 , pp. 8-15
    • Yun, J.1    Seo, J.A.2    Jeong, Y.S.3
  • 136
    • 84862869336 scopus 로고    scopus 로고
    • Development of PAC-14028 a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases
    • Lim K, Park Y. Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res 2012;35(3):393-6
    • (2012) Arch Pharm Res , vol.35 , Issue.3 , pp. 393-396
    • Lim, K.1    Park, Y.2
  • 137
    • 84857746372 scopus 로고    scopus 로고
    • Anti pruritic effects of topical crotamiton capsaicin and a corticosteroid on pruritogen-induced scratching behavior
    • Sekine R, Satoh T, Takaoka A, et al. Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp Dermatol 2012;21(3):201-4
    • (2012) Exp Dermatol , vol.21 , Issue.3 , pp. 201-204
    • Sekine, R.1    Satoh, T.2    Takaoka, A.3
  • 138
    • 38749149923 scopus 로고    scopus 로고
    • Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation
    • Akopian AN, Ruparel NB, Patwardhan A, Hargreaves KM. Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. J Neurosci 2008;28(5):1064-75
    • (2008) J Neurosci , vol.28 , Issue.5 , pp. 1064-1075
    • Akopian, A.N.1    Ruparel, N.B.2    Patwardhan, A.3    Hargreaves, K.M.4
  • 139
    • 79955382061 scopus 로고    scopus 로고
    • Scratching the surface: A role of pain-sensing TRPA1 in itch
    • Xiao B, Patapoutian A. Scratching the surface: a role of pain-sensing TRPA1 in itch. Nat Neurosci 2011;14(5):540-2
    • (2011) Nat Neurosci , vol.14 , Issue.5 , pp. 540-542
    • Xiao, B.1    Patapoutian, A.2
  • 140
    • 1842475312 scopus 로고    scopus 로고
    • Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    • Bandell M, Story GM, Hwang SW, et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004;41(6):849-57
    • (2004) Neuron , vol.41 , Issue.6 , pp. 849-857
    • Bandell, M.1    Story, G.M.2    Hwang, S.W.3
  • 141
    • 1642430679 scopus 로고    scopus 로고
    • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    • Jordt S, Bautista DM, Chuang H, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004;427(6971):260-5
    • (2004) Nature , vol.427 , Issue.6971 , pp. 260-265
    • Jordt, S.1    Bautista, D.M.2    Chuang, H.3
  • 142
    • 24744446008 scopus 로고    scopus 로고
    • Pungent products from garlic activate the sensory ion channel TRPA1
    • Bautista DM, Movahed P, Hinman A, et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA 2005;102(34):12248-52
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.34 , pp. 12248-12252
    • Bautista, D.M.1    Movahed, P.2    Hinman, A.3
  • 143
    • 33646045075 scopus 로고    scopus 로고
    • TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    • Bautista DM, Jordt S, Nikai T, et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 2006;124(6):1269-82
    • (2006) Cell , vol.124 , Issue.6 , pp. 1269-1282
    • Bautista, D.M.1    Jordt, S.2    Nikai, T.3
  • 144
    • 33746716158 scopus 로고    scopus 로고
    • More than cool: Promiscuous relationships of menthol and other sensory compounds
    • Macpherson LJ, Hwang SW, Miyamoto T, et al. More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 2006;32(4):335-43
    • (2006) Mol Cell Neurosci , vol.32 , Issue.4 , pp. 335-343
    • MacPherson, L.J.1    Hwang, S.W.2    Miyamoto, T.3
  • 145
    • 0345616438 scopus 로고    scopus 로고
    • ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    • Story GM, Peier AM, Reeve AJ, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003;112(6):819-29
    • (2003) Cell , vol.112 , Issue.6 , pp. 819-829
    • Story, G.M.1    Peier, A.M.2    Reeve, A.J.3
  • 146
    • 34447121851 scopus 로고    scopus 로고
    • Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
    • Dai Y, Wang S, Tominaga M, et al. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest 2007;117(7):1979-87
    • (2007) J Clin Invest , vol.117 , Issue.7 , pp. 1979-1987
    • Dai, Y.1    Wang, S.2    Tominaga, M.3
  • 147
    • 56649119156 scopus 로고    scopus 로고
    • Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and-independent pathways in mice
    • Tsujii K, Andoh T, Lee J, Kuraishi Y. Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and-independent pathways in mice. J Pharmacol Sci 2008;108(3):385-8
    • (2008) J Pharmacol Sci , vol.108 , Issue.3 , pp. 385-388
    • Tsujii, K.1    Andoh, T.2    Lee, J.3    Kuraishi, Y.4
  • 148
    • 84860833829 scopus 로고    scopus 로고
    • Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice
    • Liu T, Ji R. Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Neurosci Bull 2012;28(2):145-54
    • (2012) Neurosci Bull , vol.28 , Issue.2 , pp. 145-154
    • Liu, T.1    Ji, R.2
  • 149
    • 79955385137 scopus 로고    scopus 로고
    • TRPA1 is required for histamine-independent Mas-related G protein-coupled receptormediated itch
    • Wilson SR, Gerhold KA, Bifolck-Fisher A, et al. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptormediated itch. Nat Neurosci 2011;14(5):595-602
    • (2011) Nat Neurosci , vol.14 , Issue.5 , pp. 595-602
    • Wilson, S.R.1    Gerhold, K.A.2    Bifolck-Fisher, A.3
  • 150
    • 46249121027 scopus 로고    scopus 로고
    • Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice
    • Costa R, Marotta DM, Manjavachi MN, et al. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol 2008;154(5):1094-103
    • (2008) Br J Pharmacol , vol.154 , Issue.5 , pp. 1094-1103
    • Costa, R.1    Marotta, D.M.2    Manjavachi, M.N.3
  • 151
    • 0038720558 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 mediates itch: A novel pathway for pruritus in human skin
    • Steinhoff M, Neisius U, Ikoma A, et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 2003;23(15):6176-80
    • (2003) J Neurosci , vol.23 , Issue.15 , pp. 6176-6180
    • Steinhoff, M.1    Neisius, U.2    Ikoma, A.3
  • 152
    • 30444454009 scopus 로고    scopus 로고
    • Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
    • Shimada SG, Shimada KA, Collins JG. Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2. Eur J Pharmacol 2006;530(3):281-3
    • (2006) Eur J Pharmacol , vol.530 , Issue.3 , pp. 281-283
    • Shimada, S.G.1    Shimada, K.A.2    Collins, J.G.3
  • 153
    • 79960365417 scopus 로고    scopus 로고
    • The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia
    • ra45
    • Liu Q, Weng H, Patel KN, et al. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal 2011;4(181):ra45
    • (2011) Sci Signal , vol.4 , pp. 181
    • Liu, Q.1    Weng, H.2    Patel, K.N.3
  • 154
    • 50549099078 scopus 로고    scopus 로고
    • Histamine-induced itch and its relationship with pain
    • Shim W, Oh U. Histamine-induced itch and its relationship with pain. Mol Pain 2008;4:29
    • (2008) Mol Pain , vol.4 , pp. 29
    • Shim, W.1    Oh, U.2
  • 155
    • 84868338495 scopus 로고    scopus 로고
    • Topical TRPM8 agonist (icilin) relieved vulva pruritus originating from lichen sclerosus et atrophicus
    • Han JH, Choi H, Kim SJ. Topical TRPM8 agonist (icilin) relieved vulva pruritus originating from lichen sclerosus et atrophicus. Acta Derm Venereol 2012;92(5):561-2
    • (2012) Acta Derm Venereol , vol.92 , Issue.5 , pp. 561-562
    • Han, J.H.1    Choi, H.2    Kim, S.J.3
  • 156
    • 20144386128 scopus 로고    scopus 로고
    • How best to fight that nasty itch-from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches
    • B?́ró T, Ko MC, Bromm B, et al. How best to fight that nasty itch-from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches. Exp Dermatol 2005;14(3):225-40
    • (2005) Exp Dermatol , vol.14 , Issue.3 , pp. 225-240
    • B́ró, T.1    Ko, M.C.2    Bromm, B.3
  • 157
    • 84859886840 scopus 로고    scopus 로고
    • Modulation of thermoreceptor TRPM8 by cooling compounds
    • Bharate SS, Bharate SB. Modulation of thermoreceptor TRPM8 by cooling compounds. ACS Chem Neurosci 2012;3(4):248-67
    • (2012) ACS Chem Neurosci , vol.3 , Issue.4 , pp. 248-267
    • Bharate, S.S.1    Bharate, S.B.2
  • 158
    • 0037034931 scopus 로고    scopus 로고
    • Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    • McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002;416(6876):52-8
    • (2002) Nature , vol.416 , Issue.6876 , pp. 52-58
    • McKemy, D.D.1    Neuhausser, W.M.2    Julius, D.3
  • 159
    • 18344386202 scopus 로고    scopus 로고
    • A TRP channel that senses cold stimuli and menthol
    • Peier AM, Moqrich A, Hergarden AC, et al. A TRP channel that senses cold stimuli and menthol. Cell 2002;108(5):705-15
    • (2002) Cell , vol.108 , Issue.5 , pp. 705-715
    • Peier, A.M.1    Moqrich, A.2    Hergarden, A.C.3
  • 160
    • 77958161045 scopus 로고    scopus 로고
    • TRPM8 mediates cold and menthol allergies associated with mast cell activation
    • Cho Y, Jang Y, Yang YD, et al. TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium 2010;48(4):202-8
    • (2010) Cell Calcium , vol.48 , Issue.4 , pp. 202-208
    • Cho, Y.1    Jang, Y.2    Yang, Y.D.3
  • 161
    • 80053946332 scopus 로고    scopus 로고
    • Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria
    • Medic N, Desai A, Komarow H, et al. Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria. Cell Calcium 2011;50(5):473-80
    • (2011) Cell Calcium , vol.50 , Issue.5 , pp. 473-480
    • Medic, N.1    Desai, A.2    Komarow, H.3
  • 164
    • 77954832203 scopus 로고    scopus 로고
    • Aprepitant for erlotinib-induced pruritus
    • Vincenzi B, Tonini G, Santini D. Aprepitant for erlotinib-induced pruritus. N Engl J Med 2010;363(4):397-8
    • (2010) N Engl J Med , vol.363 , Issue.4 , pp. 397-398
    • Vincenzi, B.1    Tonini, G.2    Santini, D.3
  • 165
    • 84866904056 scopus 로고    scopus 로고
    • Aprepitant for management of severe pruritus related to biological cancer treatments: A pilot study
    • Santini D, Vincenzi B, Guida FM, et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. Lancet Oncol 2012;13(10):1020-4
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1020-1024
    • Santini, D.1    Vincenzi, B.2    Guida, F.M.3
  • 166
    • 70349626195 scopus 로고    scopus 로고
    • Aprepitant as an antipruritic agent?
    • Duval A, Dubertret L. Aprepitant as an antipruritic agent? N Engl J Med 2009;361(14):1415-16
    • (2009) N Engl J Med , vol.361 , Issue.14 , pp. 1415-1416
    • Duval, A.1    Dubertret, L.2
  • 167
    • 79952407608 scopus 로고    scopus 로고
    • Oral aprepitant in the therapy of refractory pruritus in erythrodermic cutaneous T-cell lymphoma
    • Booken N, Heck M, Nicolay JP, et al. Oral aprepitant in the therapy of refractory pruritus in erythrodermic cutaneous T-cell lymphoma. Br J Dermatol 2011;164(3):665-7
    • (2011) Br J Dermatol , vol.164 , Issue.3 , pp. 665-667
    • Booken, N.1    Heck, M.2    Nicolay, J.P.3
  • 168
    • 83655192773 scopus 로고    scopus 로고
    • Aprepitant: Evidence of its effectiveness in patients with refractory pruritus continues
    • Torres T, Fernandes I, Selores M, et al. Aprepitant: evidence of its effectiveness in patients with refractory pruritus continues. J Am Acad Dermatol 2012;66(1):e14-15
    • (2012) J Am Acad Dermatol , vol.66 , Issue.1
    • Torres, T.1    Fernandes, I.2    Selores, M.3
  • 169
    • 77956459887 scopus 로고    scopus 로고
    • Aprepitant against pruritus in patients with solid tumours
    • Vincenzi B, Fratto ME, Santini D, Tonini G. Aprepitant against pruritus in patients with solid tumours. Support Care Cancer 2010;18(9):1229-30
    • (2010) Support Care Cancer , vol.18 , Issue.9 , pp. 1229-1230
    • Vincenzi, B.1    Fratto, M.E.2    Santini, D.3    Tonini, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.