Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

Journal of Allergy and Clinical Immunology

Volumn 119, Issue 1, 2007, Pages 176-183

  Dunford, Paul J ^a   Williams, Kacy N ^a   Desai, Pragnya J ^a   Karlsson, Lars ^a   McQueen, Daniel ^b   Thurmond, Robin L ^a  

^a JOHNSON AND JOHNSON   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Histamine; histamine H1 receptor; histamine H4 receptor; mast cells; pruritus

Indexed keywords

4 METHYLHISTAMINE; ANTIHISTAMINIC AGENT; DESLORATADINE; DIPHENHYDRAMINE; FEXOFENADINE; HISTAMINE; HISTAMINE AGONIST; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; HISTAMINE H3 RECEPTOR ANTAGONIST; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; JNJ 5207852; JNJ 7777120; LORATADINE; RANITIDINE; UNCLASSIFIED DRUG; 1 ((5 CHLORO 1H INDOL 2 YL)CARBONYL) 4 METHYLPIPERAZINE; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HEMATOPOIETIC CELL; MAST CELL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PRURITUS; SCRATCHING; TREATMENT RESPONSE; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG POTENTIATION; EDEMA; FOOT; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT;

ANIMALS; DISEASE MODELS, ANIMAL; EDEMA; FEMALE; FOOT; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; INDOLES; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PIPERAZINES; PRURITUS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H1;

EID: 33845924770     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.08.034     Document Type: Article

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