Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice

British Journal of Pharmacology

Volumn 154, Issue 5, 2008, Pages 1094-1103

  Costa, R ^a   Marotta, D M ^a   Manjavachi, M N ^a   Fernandes, E S ^a,c   Lima Garcia, J F ^a   Paszcuk, A F ^a   Quintao N L M ^a   Juliano, L ^b   Brain, S D ^c   Calixto, J B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Mast cells; Neuropeptides; PAR 2; Scratching behaviour; TRPV1; Trypsin

Indexed keywords

3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CALCITONIN GENE RELATED PEPTIDE[8-37]; CAPSAICIN; CELECOXIB; COMPOUND 48-80; CROMOGLYCATE DISODIUM; CYPROHEPTADINE; GABEXATE MESILATE; MEPYRAMINE; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; OSANETANT; PHENYLALANYLSERYLLEUCYLLEUCYLARGINYLTYROSINE; PROTEINASE ACTIVATED RECEPTOR 2; RECEPTOR BLOCKING AGENT; SAREDUTANT; SSR 240612; TRYPSIN; VANILLOID RECEPTOR 1;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; GENE DELETION; MALE; MAST CELL; MOUSE; NECK; NEUROGENIC INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PRURITUS; RECEPTOR DOWN REGULATION; SCRATCHING;

ANILIDES; ANIMALS; ANTIPRURITICS; BEHAVIOR, ANIMAL; CALCITONIN GENE-RELATED PEPTIDE; CELL DEGRANULATION; CINNAMATES; CROMOLYN SODIUM; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DIOXOLES; DISEASE MODELS, ANIMAL; INJECTIONS, INTRADERMAL; MALE; MAST CELLS; MICE; MICE, KNOCKOUT; NERVE FIBERS, UNMYELINATED; NEUROGENIC INFLAMMATION; OLIGOPEPTIDES; P-METHOXY-N-METHYLPHENETHYLAMINE; PEPTIDE FRAGMENTS; PLANT PROTEINS; PRURITUS; PYRAZOLES; QUINOLINES; RECEPTOR, PAR-2; RECEPTORS, BRADYKININ; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SULFONAMIDES; TRPV CATION CHANNELS; TRYPSIN;

EID: 46249121027     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.172     Document Type: Article

References (47)

1. Al-Ani B, Saifeddine M, Wijesuriya SJ, Hollenberg MD (2002). Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. J Pharmacol Exp Ther 300: 702-708.
2. Alexander SPH, Mathie A, Peters JA (2007). Guide to receptors and channels (GRAC), 2nd edition (2007 revision). Br J Pharmacol 150 (Suppl 1): S1-S168.
3. Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F et al. (2006). Protease-activated receptor 2 sensitizes TRPV1 by protein kinase C epsilon- and A-dependent mechanisms in rats and mice. J Physiol 575: 555-571.
4. Babiarz-Magee L, Chen N, Seiberg M, Lin CB (2004). The expression and activation of protease-activated receptor-2 correlate with skin color. Pigment Cell Res 17: 241-251.
5. 1 receptors in scratching induced by histamine receptor agonists in Balb c mice. Br J Pharmacol 142: 374-380.
6. Bunnett NW (2006). Protease-activated receptors: how proteases signal to cells to cause inflammation and pain. Semin Thromb Hemost 32: 39-48.
7. Calixto MC, Triches KM, Calixto JB (2003). Analysis of the inflammatory response in the rat paw caused by the venom of Apis mellifera bee. Inflamm Res 52: 132-139.
8. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR et al. (2000). Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306-313.
9. Chen CL, Wang SD, Zeng ZY, Lin KJ, Kao ST, Tani T et al. (2006). Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J Allergy Clin Immunol 118: 105-112.
10. Corvera CU, Dery O, Mcconalogue K, Bohm SK, Khitin LM, Caughey GH et al. (1997). Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 100: 1383-1393.
11. Costa R, Fernandes ES, Menezes-De-Lima-Jr O, Campos MM, Calixto JB (2006). Effect of novel selective non-peptide kinin B(1) receptor antagonists on mouse pleurisy induced by carrageenan. Peptides 27: 2967-2975.
12. Cottrell GS, Amadesi S, Grady EF, Bunnett NW (2004). Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. J Biol Chem 279: 13532-13539.
13. Cottrell GS, Amadesi S, Schmidlin F, Bunnett N (2003). Protease-activated receptor 2: activation, signalling and function. Biochem Soc Trans 31: 1191-1197.
14. 4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J Allergy Clin Immunol 119: 176-183.
15. Ferreira J, Da Silva GL, Calixto JB (2004). Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice. Br J Pharmacol 141: 787-794.
16. Hayashi I, Majima M (1999). Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. Br J Pharmacol 126: 197-204.
17. Holzer P (1998). Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol 30: 5-11.
18. Hosogi M, Schmelz M, Miyachi Y, Ikoma A (2006). Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch. Pain 126: 16-23.
19. Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M (2006). The neurobiology of itch. Nat Rev Neurosci 7: 535-547.
20. Imamura T, Potempa J, Travis J (2004). Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases. Biol Chem 385: 989-996.
21. Kanda N, Koike S, Watanabe S (2005). Prostaglandin E2 enhances neurotrophin-4 production via Ep3 receptor in human keratinocytes. J Pharmacol Exp Ther 315: 796-804.
22. Koetzner L, Gregory JA, Yaksh TL (2004). Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. J Pharmacol Exp Ther 311: 356-363.
23. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R (2001). Proteinase-activated receptors. Pharmacol Rev 53: 245-282.
24. Meyer-Hoffert U, Rogalski C, Seifert S, Schmeling G, Wingertszahn J, Proksch E et al. (2004). Trypsin induces epidermal proliferation and inflammation in murine skin. Exp Dermatol 13: 234-241.
25. Newbold P, Brain SD (1993). The modulation of inflammatory oedema by calcitonin gene-related peptide. Br J Pharmacol 108: 705-710.
26. Obreja O, Rukwied R, Steinhoff M, Schmelz M (2006). Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo. Exp Dermatol 15: 58-65.
27. Paszcuk AF, Quintão NLM, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P et al. (2008). Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw. Eur J Pharmacol 581: 204-215.
28. Paus R, Schmelz M, Biro T, Steinhoff M (2006). Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest 116: 1174-1186.
29. Ramachandran R, Hollenberg MD (2008). Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol 153 (Suppl 1): S263-S282.
30. Salt TE, Hill RG (1983). Neurotransmitter candidates of somatosensory primary afferent fibres. Neuroscience 10: 1083-1103.
31. Schmidlin F, Bunnett NW (2001). Protease-activated receptors: how proteases signal to cells. Curr Opin Pharmacol 1: 575-582.
32. Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M et al. (2003). Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J 17: 1871-1885.
33. 2. Eur J Pharmacol 530: 281-283.
34. Steinhoff M, Bienenstock J, Schmelz M, Maurer M, Wei E, Biro T (2006). Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. J Invest Dermatol 126: 1705-1718.
35. Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N et al. (2005). Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26: 1-43.
36. Steinhoff M, Corvera CU, Thoma MS, Kong W, Mcalpine BE, Caughey GH et al. (1999). Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol 8: 282-294.
37. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS et al. (2003). Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23: 6176-6180.
38. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS et al. (2000). Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 6: 151-158.
39. Sun YG, Chen ZF (2007). A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448: 700-703.
40. Thomsen JS, Sonne M, Benfeldt E, Jensen SB, Serup J, Menne T (2002). Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch. Br J Dermatol 146: 792-800.
41. 4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discov 7: 41-53.
42. Ui H, Andoh T, Lee JB, Nojima H, Kuraishi Y (2006). Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. Eur J Pharmacol 530: 172-178.
43. Vergnolle N, Ferazzini M, D'andrea MR, Buddenkotte J, Steinhoff M (2003). Proteinase-activated receptors: novel signals for peripheral nerves. Trends Neurosci 26: 496-500.
44. Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD (2001). Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 22: 146-152.
45. Wakita H, Furukawa F, Takigawa M (1997). Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes. Proc Assoc Am Physicians 109: 190-207.
46. Wisner JR, Renner IG, Grendel JH, Niederau C, Ferrell LD (1987). Gabexate mesilate (foy) protects against ceruletide-induced acute pancreatitis in the rat. Pancreas 2: 181-186.
47. Zegarska B, Lelinska A, Tyrakowski T (2006). Clinical and experimental aspects of cutaneous neurogenic inflammation. Pharmacol Rep 58: 13-21.