Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor

Journal of Investigative Dermatology

Volumn 128, Issue 7, 2008, Pages 1696-1703

  Dijkstra, Dorothea ^a   Stark, Holger ^b   Chazot, Paul L ^c   Shenton, Fiona C ^c   Leurs, Rob ^d   Werfel, Thomas ^a   Gutzmer, Ralf ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c DURHAM UNIVERSITY   (United Kingdom)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; 4 METHYLHISTAMINE; BETAHISTINE; CLOBENPROPIT; CYTOKINE; DIMAPRIT; GAMMA INTERFERON; HISTAMINE; HISTAMINE AGONIST; HISTAMINE H4 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 12P40; METHIMEPIP; MONOCYTE CHEMOTACTIC PROTEIN 1;

ARTICLE; ATOPIC DERMATITIS; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; DRUG SELECTIVITY; EPIDERMIS CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATORY CELL; LEUKOCYTE; MONOCYTE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TH1 CELL; TH2 CELL;

EID: 45349092858     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701250     Document Type: Article

References (22)

1. Barnes JC, Brown JD, Clarke NP, Clapham J, Evans DJ, O'Shaughnessy CT (1993) Pharmacological activity of VUF 9153, an isothiourea histamine H3 receptor antagonist. Eur J Pharmacol 250:147-52
2. Dijkstra D, Leurs R, Chazot PL, Shenton FC, Stark H, Werfel T et al. (2007) Histamine downregulates monocyte CCL2 production via the histamine H4 receptor. J Allergy Clin Immunol 120:300-7
3. Gutzmer R, Diestel C, Mommert S, Kother B, Stark H, Wittmann M et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. J Immunol 174:5224-32
4. Huang BD, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM (2001) Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med 193:713-25
5. Jablonowski JA, Carruthers NI, Thurmond RL (2004) The histamine H4 receptor and potential therapeutic uses for H4 ligands. Mini Rev Med Chem 4:993-1000
6. Jablonowski JA, Grice CA, Chai W, Dvorak CA, Venable JD, Kwok AK et al. (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 46:3957-60
7. Kim Y, Sung SJ, Kuziel WA, Feldman S, Fu SM, Rose CE (2001) Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2). J Immunol 166:5183-92
8. Kitbunnadaj R, Hashimoto T, Poli E, Zuiderveld OP, Menozzi A, Hidaka R et al. (2005) N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J Med Chem 48:2100-7
9. Leung DY (2000) Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105:860-76
10. Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther 314:1310-21
11. Novak N, Kraft S, Haberstok J, Geiger E, Allam P, Bieber T (2002) A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC). J Invest Dermatol 119:842-9
12. Novak N, Valenta R, Bohle B, Laffer S, Haberstok J, Kraft S et al. (2004) FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes In Vitro. J Allergy Clin Immunol 113:949-57
13. Purwar R, Werfel T, Wittmann M (2006) IL-13-stimulated human keratinocytes preferentially attract CD4+CCR4+ T cells: possible role in atopic dermatitis. J Invest Dermatol 126:1043-51
14. Schuller E, Teichmann B, Haberstok J, Moderer M, Bieber T, Wollenberg A (2001) In situ expression of the costimulatory molecules CD80 and CD86 on Langerhans cells and inflammatory dendritic epidermal cells (IDEC) in atopic dermatitis. Arch Dermatol Res 293:448-54
15. Sozzani S, Locati M, Zhou D, Rieppi M, Luini W, Lamorte G et al. (1995) Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines. J Leukoc Biol 57:788-94
16. Stander S, Steinhoff M (2002) Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol 11:12-24
17. Szalai C, Kozma GT, Nagy A, Bojszko A, Krikovszky D, Szabo T et al. (2001) Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immunol 108:375-81
18. van Rijn RM, Chazot PL, Shenton FC, Sansuk K, Bakker RA, Leurs R (2006) Oligomerization of recombinant and endogenously expressed human histamine H(4) receptors. Mol Pharmacol 70:604-15
19. Wollenberg A, Haberstok J, Teichmann B, Wen SP (1998) Demonstration of the low-affinity IgE receptor Fc epsilonRII/CD23 in psoriatic epidermis: inflammatory dendritic epidermal cells (IDEC) but not Langerhans cells are the relevant CD1a-positive cell population. Arch Dermatol Res 290:517-21
20. Wollenberg A, Kraft S, Hanau D, Bieber T (1996) Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. J Invest Dermatol 106:446-53
21. Wollenberg A, Mommaas M, Oppel T, Schottdorf EM, Gunther S, Moderer M (2002) Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases. J Invest Dermatol 118:327-34
22. Wollenberg A, Sharma S, von Bubnoff D, Geiger E, Haberstok J, Bieber T (2001) Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. J Allergy Clin Immunol 107:519-25