The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation

Journal of Investigative Dermatology

Volumn 130, Issue 4, 2010, Pages 1023-1033

  Cowden, Jeffery M ^a   Zhang, Mai ^a   Dunford, Paul J ^a   Thurmond, Robin L ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; [5 FLUORO 4 METHYL 2 [5 METHYL 2 [4 (1 METHYLPIPERIDIN 4 YL)BUTOXY]PYRIDIN 4 YL] 1H BENZOIMIDAZOLE; DEXAMETHASONE; FEXOFENADINE; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; JNJ 28307474; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1 ((5 CHLORO 1H INDOL 2 YL)CARBONYL) 4 METHYLPIPERAZINE; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; ANTIHISTAMINIC AGENT; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL MIGRATION; CHEMOTAXIS; CLINICAL FEATURE; CONTACT DERMATITIS; CONTROLLED STUDY; DENDRITIC CELL; DRUG INHIBITION; EAR EDEMA; EDEMA; EX VIVO STUDY; FEMALE; HISTOPATHOLOGY; IMMUNOSTIMULATION; IN VIVO STUDY; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; SKIN INFLAMMATION; SKIN PRURITUS; TH2 CELL; ANIMAL; ATOPIC DERMATITIS; BAGG ALBINO MOUSE; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; EOSINOPHIL; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PRURITUS;

ANIMALS; CHEMOTAXIS; DENDRITIC CELLS; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; EDEMA; EOSINOPHILS; FLUORESCEIN-5-ISOTHIOCYANATE; HISTAMINE ANTAGONISTS; INDOLES; INTERLEUKIN-17; INTERLEUKIN-4; INTERLEUKIN-5; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; PIPERAZINES; PRURITUS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; TH2 CELLS;

EID: 77949541373     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.358     Document Type: Article

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