A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

Nature

Volumn 448, Issue 7154, 2007, Pages 700-703

  Sun, Yan Gang ^a   Chen, Zhou Feng ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN RELEASING PEPTIDE; GASTRIN RELEASING PEPTIDE RECEPTOR;

DISEASE; GENE EXPRESSION; HORMONE; MODEL; MUTATION; NERVOUS SYSTEM; PEPTIDE; PHYSIOLOGICAL RESPONSE; RODENT; SKIN DISORDER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; EVOKED RESPONSE; INFLAMMATION; MECHANICAL STIMULATION; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PRURITUS; SCRATCHING; SENSATION; SPINAL CORD; SPINAL GANGLION; STIMULUS RESPONSE; THERMAL STIMULATION; WILD TYPE;

MUS;

EID: 34547726181     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06029     Document Type: Article

References (30)

1. Paus, R., Schmelz, M., Biro, T. & Steinhoff, M. Frontiers in pruritus research: scratching the brain for more effective itch therapy. J. Clin. Invest. 116, 1174-1186 (2006).
2. Ikoma, A., Steinhoff, M., Stander, S., Yosipovitch, G. & Schmelz, M. The neurobiology of itch. Nature Rev. Neurosci. 7, 535-547 (2006).
3. Greaves, M. W. Itch in systemic disease: therapeutic options. Dermatol. Ther. 18, 323-327 (2005).
4. Roesler, R., Henriques, J. A. & Schwartsmann, G. Gastrin-releasing peptide receptor as a molecular target for psychiatric and neurological disorders. CNS Neurol. Disord. Drug Targets 5, 197-204 (2006).
5. Battey, J. & Wada, E. Two distinct receptor subtypes for mammalian bombesin-like peptides. Trends Neurosci. 14, 524-528 (1991).
6. Cowan, A., Khunawat, P., Zhu, X. Z. & Gmerek, D. E. Effects of bombesin on behavior. Life Sci. 37, 135-145 (1985).
7. Gmerek, D. E. & Cowan, A. Studies on bombesin-induced grooming in rats. Peptides 4, 907-913 (1983).
8. Gmerek, D. E. & Cowan, A. Bombesin - a central mediator of pruritus? Br. J. Dermatol. 109, 239 (1983).
9. O'Donohue, T. L. et al. A role for bombesin in sensory processing in the spinal cord. J. Neurosci. 4, 2956-2962 (1984).
10. Moody, T. W. & Merali, Z. Bombesin-like peptides and associated receptors within the brain: distribution and behavioral implications. Peptides 25, 511-520 (2004).
11. Schmelz, M., Schmidt, R., Bickel, A., Handwerker, H. O. & Torebjork, H. E. Specific C-receptors for itch in human skin. J. Neurosci. 17, 8003-8008 (1997).
12. Andrew, D. & Craig, A. D. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nature Neurosci. 4, 72-77 (2001).
13. Kuraishi, Y., Nagasawa, T., Hayashi, K. & Satoh, M. Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur. J. Pharmacol. 275, 229-233 (1995).
14. Nystedt, S., Emilsson, K., Wahlestedt, C. & Sundelin, J. Molecular cloning of a potential proteinase activated receptor. Proc. Natl Acad. Sci. USA 91, 9208-9212 (1994).
15. Steinhoff, M. et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Med. 6, 151-158 (2000).
16. Steinhoff, M. et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J. Neurosci. 23, 6176-6180 (2003).
17. Shimada, S. G., Shimada, K. A. & Collins, J. G. Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2. Eur. J. Pharmacol. 530, 281-283 (2006).
18. Inan, S. & Cowan, A. Kappa opioid agonists suppress chloroquine-induced scratching in mice. Eur. J. Pharmacol. 502, 233-237 (2004).
19. Green, A. D., Young, K. K., Lehto, S. G., Smith, S. B. & Mogil, J. S. Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. Pain 124, 50-58 (2006).
20. Ladenheim, E. E., Taylor, J. E., Coy, D. H., Moore, K. A. & Moran, T. H. Hindbrain GRP receptor blockade antagonizes feeding suppression by peripherally administered GRP. Am. J. Physiol. 271, R180-R184 (1996).
21. Wang, L. H. et al. des-Met carboxyl-terminally modified analogues of bombesin function as potent bombesin receptor antagonists, partial agonists, or agonists. J. Biol. Chem. 265, 15695-15703 (1990).
22. Stander, S. & Schmelz, M. Chronic itch and pain - similarities and differences. Eur. J. Pain 10, 473-478 (2006).
23. McMahon, S. B. & Koltzenburg, M. Itching for an explanation. Trends Neurosci. 15, 497-501 (1992).
24. Shumyatsky, G. P. et al. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111, 905-918 (2002).
25. Kroog, G. S., Jensen, R. T. & Battey, J. F. Mammalian bombesin receptors. Med. Res. Rev. 15, 389-417 (1995).
26. Sowunmi, A., Walker, O. & Salako, L. A. Pruritus and antimalarial drugs in Africans. Lancet 2, 213 (1989).
27. Hampton, L. L. et al. Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice. Proc. Natl Acad. Sci. USA 95, 3188-3192 (1998).
28. Chen, Z. F. et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 31, 59-73 (2001).
29. Wozniak, D. F. et al. Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol. Dis. 17, 403-414 (2004).
30. Hylden, J. L. & Wilcox, G. L. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 67, 313-316 (1980).