Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases

Archives of Pharmacal Research

Volumn 35, Issue 3, 2012, Pages 393-396

  Lim, Kyung Min ^a   Park, Young Ho ^a  

^a AmorePacific Corporation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CALCINEURIN INHIBITOR; CORTICOSTEROID; DERMATOLOGICAL AGENT; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; N[1 (3,5 DIFLUORO 4 METHANESULFONYLAMINO PHENYL)ETHYL] 3 (2 PROPYL 6 TRIFLUOROMETHYL PYRIDINE 3 YL)ACRYLAMIDE; PAC 14028; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; CORTICOSTEROID THERAPY; DERMATITIS; DRUG EFFICACY; DRUG FEVER; DRUG SAFETY; DRUG SYNTHESIS; DRUG TREATMENT FAILURE; ENTERITIS; HUMAN; HYPERALGESIA; INFLAMMATION; NEUROPATHIC PAIN; NONHUMAN; PAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; VISCERAL PAIN;

ACRYLAMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIPRURITICS; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; DRUGS, INVESTIGATIONAL; HUMANS; PRURITUS; PYRIDINES; TRPV CATION CHANNELS;

EID: 84862869336     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0321-6     Document Type: Article

References (16)

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