메뉴 건너뛰기




Volumn 23, Issue 15, 2003, Pages 6176-6180

Proteinase-activated receptor-2 mediates itch: A novel pathway for pruritus in human skin

Author keywords

Atopy; Neuroimmunology; Neurophysiology; Protease activated receptors; Sensory nerve; Tryptase

Indexed keywords

ANTIHISTAMINIC AGENT; PROTEINASE ACTIVATED RECEPTOR 2; TRYPTASE;

EID: 0038720558     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-15-06176.2003     Document Type: Article
Times cited : (558)

References (40)
  • 2
    • 0035155197 scopus 로고    scopus 로고
    • Spinothalamic lamina 1 neurons selectively sensitive to histamine: A central neural pathway for itch
    • Andrew D, Craig AD (2001) Spinothalamic lamina 1 neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 4:72-77.
    • (2001) Nat Neurosci , vol.4 , pp. 72-77
    • Andrew, D.1    Craig, A.D.2
  • 3
    • 0036164574 scopus 로고    scopus 로고
    • Signalling pathways induced by protease-activated receptors and integrins in T cells
    • Bar-Shavit R, Maoz M, Yongjun Y, Groysman M, Dekel I, Katzav S (2002) Signalling pathways induced by protease-activated receptors and integrins in T cells. Immunology 105:35-46.
    • (2002) Immunology , vol.105 , pp. 35-46
    • Bar-Shavit, R.1    Maoz, M.2    Yongjun, Y.3    Groysman, M.4    Dekel, I.5    Katzav, S.6
  • 4
    • 0034360657 scopus 로고    scopus 로고
    • Mast cell-nerve interactions
    • Bauer O, Razin E (2000) Mast cell-nerve interactions. News Physiol Sci. 15:213-218.
    • (2000) News Physiol Sci , vol.15 , pp. 213-218
    • Bauer, O.1    Razin, E.2
  • 5
    • 0036207250 scopus 로고    scopus 로고
    • Proteinases and proteinase-activated receptor 2: A possible role to promote visceral hyperalgesia in rats
    • Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L (2002) Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology 122:1035-1047.
    • (2002) Gastroenterology , vol.122 , pp. 1035-1047
    • Coelho, A.M.1    Vergnolle, N.2    Guiard, B.3    Fioramonti, J.4    Bueno, L.5
  • 6
    • 0036444721 scopus 로고    scopus 로고
    • Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta
    • Compton SJ, McGuire JJ, Saifeddine M, Hollenberg MD (2002a) Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta. Can J Physiol Pharmacol 80:987-992.
    • (2002) Can J Physiol Pharmacol , vol.80 , pp. 987-992
    • Compton, S.J.1    McGuire, J.J.2    Saifeddine, M.3    Hollenberg, M.D.4
  • 7
    • 0036905071 scopus 로고    scopus 로고
    • Glycosylation of human proteinase-activated receptor-2 (hPAR2): Role in cell surface expression and signalling
    • Compton SJ, Sandhu S, Wijesuriya SJ, Hollenberg MD (2002b) Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling. Biochem J 368:495-505.
    • (2002) Biochem J , vol.368 , pp. 495-505
    • Compton, S.J.1    Sandhu, S.2    Wijesuriya, S.J.3    Hollenberg, M.D.4
  • 9
    • 0030745045 scopus 로고    scopus 로고
    • Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin
    • Damsgaard TE, Olesen AB, Sorensen FB, Thestrup-Pedersen K, Schiotz PO (1997) Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin. Arch Dermatol Res 289:256-260.
    • (1997) Arch Dermatol Res , vol.289 , pp. 256-260
    • Damsgaard, T.E.1    Olesen, A.B.2    Sorensen, F.B.3    Thestrup-Pedersen, K.4    Schiotz, P.O.5
  • 10
    • 0033866264 scopus 로고    scopus 로고
    • Localization of protease-activated receptors-1 and -2 in human mast cells: Indications for an amplified mast cell degranulation cascade
    • D'Andrea MR, Rogahn CJ, Andrade-Gordon P (2000) Localization of protease-activated receptors-1 and -2 in human mast cells: indications for an amplified mast cell degranulation cascade. Biotech Histochem 75:85-90.
    • (2000) Biotech Histochem , vol.75 , pp. 85-90
    • D'Andrea, M.R.1    Rogahn, C.J.2    Andrade-Gordon, P.3
  • 11
    • 0024366520 scopus 로고
    • Evaluation and relevance of atopic basic and minor features in patients with atopic dermatitis and in the general population
    • Diepgen TL, Fartasch M, Hornstein OP (1989) Evaluation and relevance of atopic basic and minor features in patients with atopic dermatitis and in the general population. Acta Derm Venereol Suppl (Stockh) 144:50-54.
    • (1989) Acta Derm Venereol Suppl (Stockh) , vol.144 , pp. 50-54
    • Diepgen, T.L.1    Fartasch, M.2    Hornstein, O.P.3
  • 12
  • 13
    • 0034809563 scopus 로고    scopus 로고
    • Human skin mast cells rapidly release preformed and newly generated TNF-α and IL-8 following stimulation with anti-IgE and other secretagogues
    • Gibbs BF, Wierecky J, Welker P, Henz BM, Wolff HH, Grabbe J (2001) Human skin mast cells rapidly release preformed and newly generated TNF-α and IL-8 following stimulation with anti-IgE and other secretagogues. Exp Dermatol 10:312-320.
    • (2001) Exp Dermatol , vol.10 , pp. 312-320
    • Gibbs, B.F.1    Wierecky, J.2    Welker, P.3    Henz, B.M.4    Wolff, H.H.5    Grabbe, J.6
  • 14
    • 0015801788 scopus 로고
    • Influence of antihistamines, sedatives, and aspirin on experimental itch
    • Hägermark O (1973) Influence of antihistamines, sedatives, and aspirin on experimental itch. Acta Derm Venereol 53:363-368.
    • (1973) Acta Derm Venereol , vol.53 , pp. 363-368
    • Hägermark, O.1
  • 17
    • 0037059328 scopus 로고    scopus 로고
    • The IKK-2/IκBα/NF-κB pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in IκBα-deficient mice
    • Huber MA, Denk A, Peter RU, Weber L, Kraut N, Wirth T (2002) The IKK-2/IκBα/NF-κB pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in IκBα-deficient mice. J Biol Chem 277:1268-1275.
    • (2002) J Biol Chem , vol.277 , pp. 1268-1275
    • Huber, M.A.1    Denk, A.2    Peter, R.U.3    Weber, L.4    Kraut, N.5    Wirth, T.6
  • 18
    • 0030844701 scopus 로고    scopus 로고
    • Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema
    • Jarvikallio A, Naukkarinen A, Harvima IT, Aalto ML, Horsmanheimo M (1997) Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema. Br J Dermatol 136:871-877.
    • (1997) Br J Dermatol , vol.136 , pp. 871-877
    • Jarvikallio, A.1    Naukkarinen, A.2    Harvima, I.T.3    Aalto, M.L.4    Horsmanheimo, M.5
  • 19
    • 0035943658 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory κB kinases in NCTC 2544 keratinocytes
    • Kanke T, Macfarlane SR, Seatter MJ, Davenport E, Paul A, McKenzie RC, Plevin R (2001) Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory κB kinases in NCTC 2544 keratinocytes. J Biol Chem 276:31657-31666.
    • (2001) J Biol Chem , vol.276 , pp. 31657-31666
    • Kanke, T.1    Macfarlane, S.R.2    Seatter, M.J.3    Davenport, E.4    Paul, A.5    McKenzie, R.C.6    Plevin, R.7
  • 20
    • 0035953151 scopus 로고    scopus 로고
    • Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
    • Kawabata A, Kawao N, Kuroda R, Tanaka A, Itoh H, Nishikawa H (2001) Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats. NeuroReport 12:715-719.
    • (2001) NeuroReport , vol.12 , pp. 715-719
    • Kawabata, A.1    Kawao, N.2    Kuroda, R.3    Tanaka, A.4    Itoh, H.5    Nishikawa, H.6
  • 22
    • 0032801364 scopus 로고    scopus 로고
    • An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis
    • Klein PA, Clark RA (1999) An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol 135:1522-1525.
    • (1999) Arch Dermatol , vol.135 , pp. 1522-1525
    • Klein, P.A.1    Clark, R.A.2
  • 23
    • 0035184146 scopus 로고    scopus 로고
    • Protease-activated receptors in human airways: Upregulation of PAR-2 in respiratory epithelium from patients with asthma
    • Knight DA, Lim S, Scaffidi AK, Roche N, Chung KF, Stewart GA, Thompson PJ (2001) Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol 108:797-803.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 797-803
    • Knight, D.A.1    Lim, S.2    Scaffidi, A.K.3    Roche, N.4    Chung, K.F.5    Stewart, G.A.6    Thompson, P.J.7
  • 26
    • 0034521238 scopus 로고    scopus 로고
    • Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor
    • Pastore S, Giustizieri ML, Mascia F, Giannetti A, Kaushansky K, Girolomoni G (2000) Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor. J Invest Dermatol 115:1134-1143.
    • (2000) J Invest Dermatol , vol.115 , pp. 1134-1143
    • Pastore, S.1    Giustizieri, M.L.2    Mascia, F.3    Giannetti, A.4    Kaushansky, K.5    Girolomoni, G.6
  • 27
    • 0028062869 scopus 로고
    • The use of cutaneous microdialysis to measure substance P-induced histamine release in intact human skin in vivo
    • Petersen LJ, Poulsen LK, Sondergaard J, Skov PS (1994) The use of cutaneous microdialysis to measure substance P-induced histamine release in intact human skin in vivo. J Allergy Clin Immunol 94:773-783.
    • (1994) J Allergy Clin Immunol , vol.94 , pp. 773-783
    • Petersen, L.J.1    Poulsen, L.K.2    Sondergaard, J.3    Skov, P.S.4
  • 28
    • 0014455431 scopus 로고
    • Latency and duration of pruritus elicited by trypsin in aged patients with itching eczema and psoriasis
    • Rajka G (1969) Latency and duration of pruritus elicited by trypsin in aged patients with itching eczema and psoriasis. Acta Derm Venereol 49:401-403.
    • (1969) Acta Derm Venereol , vol.49 , pp. 401-403
    • Rajka, G.1
  • 29
    • 0034088058 scopus 로고    scopus 로고
    • Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: A dermal microdialysis study
    • Rukwied R, Lischetzki G, McGlone F, Heyer G, Schmelz M (2000) Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Br J Dermatol 142:1114-1120.
    • (2000) Br J Dermatol , vol.142 , pp. 1114-1120
    • Rukwied, R.1    Lischetzki, G.2    McGlone, F.3    Heyer, G.4    Schmelz, M.5
  • 32
    • 0025217194 scopus 로고
    • Immunologic and physicochemical evidence for conformational changes occurring on conversion of human mast cell tryptase from active tetramer to inactive monomer. Production of monoclonal antibodies recognizing active tryptase
    • Schwartz LB, Bradford TR, Lee DC, Chlebowski JF (1990) Immunologic and physicochemical evidence for conformational changes occurring on conversion of human mast cell tryptase from active tetramer to inactive monomer. Production of monoclonal antibodies recognizing active tryptase. J Immunol 144:2304-2311.
    • (1990) J Immunol , vol.144 , pp. 2304-2311
    • Schwartz, L.B.1    Bradford, T.R.2    Lee, D.C.3    Chlebowski, J.F.4
  • 33
    • 0035105759 scopus 로고    scopus 로고
    • The role of Th2 cytokines in mast cell homeostasis
    • Shelburne CP, Ryan JJ (2001) The role of Th2 cytokines in mast cell homeostasis. Immunol Rev 179:82-93.
    • (2001) Immunol Rev , vol.179 , pp. 82-93
    • Shelburne, C.P.1    Ryan, J.J.2
  • 38
    • 0030893530 scopus 로고    scopus 로고
    • Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes
    • Wakita H, Furukawa F, Takigawa M (1997) Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes. Proc Assoc Am Physicians 109:190-207.
    • (1997) Proc Assoc Am Physicians , vol.109 , pp. 190-207
    • Wakita, H.1    Furukawa, F.2    Takigawa, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.