IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis

Pediatric Allergy and Immunology

Volumn 23, Issue 3, 2012, Pages 285-288

  Raap, Ulrike ^a   Weißmantel, Sigo ^b,c   Gehring, Manuela ^a   Eisenberg, Anna M ^b   Kapp, Alexander ^a   Fölster Holst, Regina ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Atopic dermatitis; Children; ECP; IL 13; IL 31; IL 4; Pruritus

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 31; INTERLEUKIN 4;

ARTICLE; ATOPIC DERMATITIS; CHILD; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INSOMNIA; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PRURITUS; SCORAD SCORE; SCORING SYSTEM; TH2 CELL;

CHILD, PRESCHOOL; CYTOKINES; DERMATITIS, ATOPIC; FEMALE; HUMANS; INFANT; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKINS; MALE; SEVERITY OF ILLNESS INDEX; SLEEP INITIATION AND MAINTENANCE DISORDERS; TH2 CELLS;

EID: 84859833131     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2011.01241.x     Document Type: Article

References (14)

1. Boguniewicz M, Leung DY. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol 2010: 125: 4-13.
2. Stander S, Steinhoff M. Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol 2002: 11: 12-24.
3. Raap U, Wichmann K, Bruder M, et al. Correlation of IL-31 serum levels with severity of atopic dermatitis. J Allergy Clin Immunol 2008: 122: 421-3.
4. Sonkoly E, Muller A, Lauerma AI, et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006: 117: 411-7.
5. Neis MM, Peters B, Dreuw A, et al. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol 2006: 118: 930-7.
6. Bilsborough J, Leung DY, Maurer M, et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol 2006: 117: 418-25.
7. Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 2004: 5: 752-60.
8. Takaoka A, Arai I, Sugimoto M, Yamaguchi A, Tanaka M, Nakaike S. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. Eur J Pharmacol 2005: 516: 180-1.
9. Takaoka A, Arai I, Sugimoto M, et al. Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis. Exp Dermatol 2006: 15: 161-7.
10. Grimstad O, Sawanobori Y, Vestergaard C, et al. Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis. Exp Dermatol 2009: 18: 35-43.
11. Raap U, Wieczorek D, Gehring M, et al. Increased levels of serum IL-31 in chronic spontaneous urticaria. Exp Dermatol 2010: 19: 464-6.
12. Folster-Holst R, Henseler T, Wehde R, et al. Soluble CD30 plasma concentrations correlate with disease activity in patients with atopic dermatitis. Acta Derm Venereol 2002: 82: 245-8.
13. Ezzat MHM, Hasan ZE, Shaheen KYA. Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring. J Eur Acad Dermatol Venereol 2011: 25: 334-9.
14. Gutzmer R, Mommert S, Gschwandtner M, Zwingmann K, Stark H, Werfel T. The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol 2009: 123: 619-25.