Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys

Life Sciences

Volumn 75, Issue 24, 2004, Pages 2947-2957

  Wakasa, Yoshio ^a   Fujiwara, Atsushi ^a   Umeuchi, Hideo ^b   Endoh, Takashi ^b   Okano, Kiyoshi ^b   Tanaka, Toshiaki ^b   Nagase, Hiroshi ^b  

^a N   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

Author keywords

Morphine; Rhesus monkeys; Scratching; TRK 820; U 50488H

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; KAPPA OPIATE RECEPTOR AGONIST; MORPHINE; MU OPIATE RECEPTOR AGONIST; NALFURAFINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; NONHUMAN; PRURITUS; RHESUS MONKEY; SCRATCHING; SKIN DISEASE;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MACACA MULATTA; MORPHINANS; MORPHINE; MOTOR ACTIVITY; OBSERVATION; PRURITUS; RECEPTORS, OPIOID, KAPPA; SPIRO COMPOUNDS; STATISTICS, NONPARAMETRIC;

MACACA MULATTA;

EID: 5344243136     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.05.033     Document Type: Article

References (29)

1. N. Aronin, and D.T. Krieger Plasma immunoreactive β-endorphin is elevated in uraemia Clinical Endocrinology 18 1983 459 464
2. K.E. Barke, and L.B. Hough Opiates, mast cells and histamine release Life Sciences 53 1993 1391 1399
3. N.V. Bergasa, T.L. Talbot, D.W. Alling, J.M. Schmitt, E.C. Walker, B.L. Baker, J.C. Korenman, Y. Park, J.H. Hoofnagle, and E.A. Jones A controlled trial of naloxone infusions for the pruritus of chronic cholestasis Gastroenterology 102 1992 544 549
4. N.V. Bergasa, J.M. Schmitt, T.L. Talbot, D.W. Alling, M.G. Swain, M.L. Turner, J.B. Jenkins, and E.A. Jones Open-label trial of oral nalmefene therapy for the pruritus of cholestasis Hepatology 27 1998 679 684
5. L.A. Chahl, and J.S. Chahl Plasma extravasation induced by dynorphin-(1-13) in rat skin European Journal of Pharmacology 124 1986 343 347
6. T. Endoh, H. Matsuura, A. Tajima, N. Izumimoto, C. Tajima, T. Suzuki, A. Saitoh, T. Suzuki, M. Narita, L. Tseng, and H. Nagase Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist Life Sciences 65 16 1999 1685 1694
7. T. Endoh, A. Tajima, T. Suzuki, J. Kamei, T. Suzuki, M. Narita, L. Tseng, and H. Nagase Characterization of the antinociceptive effects of TRK-820 in the rat European Journal of Pharmacology 387 2000 133 140
8. T. Endoh, A. Tajima, N. Izumimoto, T. Suzuki, A. Saitoh, T. Suzuki, M. Narita, J. Kamei, L.F. Tseng, H. Mizoguchi, and H. Nagase TRK-820, a selective κ-opioid agonist, produces potent antinociception in cynomolgus monkeys Japanese Journal of Pharmacology 85 2001 282 290
9. J.D. Friedman, and F.A. Dello Buono Opioid antagonists in the treatment of opioid-induced constipation and pruritus The Annals of Pharmacotherapy 35 2001 85 91
10. M. Funada, T. Suzuki, M. Narita, M. Misawa, and H. Nagase Blockade of morphine reward through the activation of κ-opioid receptors in mice Neuropharmacology 32 12 1993 1315 1323
11. S. Georgala, K.H. Schulpis, E.D. Papaconstantinou, and J. Stratigos Raised β-endorphin serum levels in children with atopic dermatitis and pruritus Journal of Dermatological Science 8 1994 125 128
12. J. Itoh, M. Ukai, and T. Kameyama Dynorphin A-(1-13) potently improves the impairment of spontaneous alternation performance induced by the μ-selective opioid receptor agonist DAMGO in mice Journal of Pharmacology and Experimental Therapeutics 269 1 1994 15 21
13. M.C.H. Ko, and N.N. Naughton An experimental itch model in monkeys: Characterization of intrathecal morphine-induced scratching and antinociception Anesthesiology 92 2000 795 805
14. M.C.H. Ko, H. Lee, M.S. Song, K. Sobczyk-Kojiro, H.I. Mosberg, S. Kishioka, J.H. Woods, and N.N. Naughton Activation of kappa opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys Journal of Pharmacology and Experimental Therapeutics 305 1 2003 173 179
15. E.W. Monroe Efficacy and safety of nalmefene in patients with severe pruritus caused by chronic urticaria and atopic dermatitis Journal of the American Academy of Dermatology 21 1 1989 135 136
16. H. Nagase, J. Hayakawa, K. Kawamura, K. Kawai, Y. Takezawa, H. Matsuura, C. Tajima, and T. Endo Discovery of a structurally novel opioid κ-agonist derived from 4,5-epoxymorphinan Chemical and Pharmaceutical Bulletin 46 2 1998 366 369
17. Z.Z. Pan μ-Opposing actions of the κ-opioid receptor Trends in Pharmacological Science 19 1998 94 98
18. G. Peer, S. Kivity, O. Agami, E. Fireman, D. Silverberg, M. Blum, and A. Iaina Randomised crossover trial of naltrexone in uraemic pruritus The Lancet 348 1996 1552 1554
19. T. Seki, S. Awamura, C. Kimura, S. Ide, K. Sakano, M. Minami, H. Nagase, and M. Satoh Pharmacological properties of TRK-820 on cloned μ-, δ- and κ-opioid receptors and nociceptin receptor European Journal of Pharmacology 376 1999 159 167
20. A. Sydbom, and L. Terenius The histamine-releasing effect of dynorphin and other peptides possessing Arg-Pro sequences Agents Actions 16 3-4 1985 269 272
21. D.A. Thomas, G.M. Williams, K. Iwata, D.R. Kenshalo Jr., and R. Dubner Effects of central administration of opioids on facial scratching in monkeys Brain Research 585 1992 315 317
22. D.A. Thomas, G.M. Williams, K. Iwata, D.R. Kenshalo Jr., and R. Dubner Multiple effects of morphine on facial scratching in monkeys Anesthesia and Analgesia 77 1993 933 935
23. D.A. Thomas, G.M. Williams, K. Iwata, D.R. Kenshalo Jr., and R. Dubner The medullary dorsal horn. A site of action of morphine in producing facial scratching in monkeys Anesthesiology 79 1993 548 554
24. J.R. Thornton, and M.S. Losowsky Opioid peptides and primary biliary cirrhosis British Medical Journal 297 1988 1501 1504
25. J.R. Thornton, and M.S. Losowsky Plasma β endorphin in cirrhosis and renal failure Gut 32 1991 306 308
26. Y. Togashi, H. Umeuchi, K. Okano, N. Ando, Y. Yoshizawa, T. Honda, K. Kawamura, T. Endoh, J. Utsumi, J. Kamei, T. Tanaka, and H. Nagase Antipruritic activity of the κ-opioid receptor agonist, TRK-820 European Journal of Pharmacology 435 2002 259 264
27. M. Tsuji, H. Takeda, T. Matsumiya, H. Nagase, M. Narita, and T. Suzuki The novel κ-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice Life Sciences 68 2001 1717 1725
28. Y. Wakasa, and T. Yanagita A study on mechanism of skin scratching induced by intravenous morphine in cynomolgus monkeys L.S. Harris Problems of Drug Dependence, 1999: Proceedings of the 61st Annual Scientific Meeting, Acapulco, Mexico, June 12-17, 1999 Research Monograph Series vol. 180 2000 National Institute on Drug Abuse 246
29. D.E. Withington, J.A. Patrick, and F. Reynolds Histamine release by morphine and diamorphine in man Anaesthesia 48 1993 26 29