-
1
-
-
0034604660
-
Femtochemistry: atomic-scale dynamics of the chemical bond using ultrafast lasers (Nobel Lecture)
-
Zewail A. H. (2000) Femtochemistry: atomic-scale dynamics of the chemical bond using ultrafast lasers (Nobel Lecture). Angew Chem. Int. Ed. Engl., 39, 2586-2631.
-
(2000)
Angew Chem. Int. Ed. Engl.
, vol.39
, pp. 2586-2631
-
-
Zewail, A.H.1
-
2
-
-
0020435222
-
The use of isotope effects to determine transition-state structure for enzymic reactions
-
Cleland, W.W. (1982) The use of isotope effects to determine transition-state structure for enzymic reactions. Methods Enzymol., 87, 625-641.
-
(1982)
Methods Enzymol.
, vol.87
, pp. 625-641
-
-
Cleland, W.W.1
-
3
-
-
0000529274
-
Isotopic mapping of transition-state structural features associated with enzymatic catalysis of methyl transfer
-
Rodgers, J., Femec, D.A. and Schowen, R.L. (1982) Isotopic mapping of transition-state structural features associated with enzymatic catalysis of methyl transfer. J. Am. Chem. Soc., 104, 3263-3268.
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 3263-3268
-
-
Rodgers, J.1
Femec, D.A.2
Schowen, R.L.3
-
4
-
-
0031688282
-
Enzymatic transition states and transition state analogue design
-
Schramm, V.L. (1998) Enzymatic transition states and transition state analogue design. Ann. Rev. Biochem., 67, 693-720.
-
(1998)
Ann. Rev. Biochem.
, vol.67
, pp. 693-720
-
-
Schramm, V.L.1
-
5
-
-
33748584863
-
Mechanisms and free energies of enzymatic reactions
-
Gao, J., Ma, S., Major, D. T., Nam, K., Pu, J. and Truhlar, D. G. (2006) Mechanisms and free energies of enzymatic reactions. Chem. Rev., 106, 3188-3209.
-
(2006)
Chem. Rev.
, vol.106
, pp. 3188-3209
-
-
Gao, J.1
Ma, S.2
Major, D.T.3
Nam, K.4
Pu, J.5
Truhlar, D.G.6
-
6
-
-
33748613208
-
Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions
-
Pu, J., Gao, J. and Truhlar, D. G. (2006) Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions. Chem. Rev., 106, 3140-3169.
-
(2006)
Chem. Rev.
, vol.106
, pp. 3140-3169
-
-
Pu, J.1
Gao, J.2
Truhlar, D.G.3
-
7
-
-
33748614305
-
Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis
-
Antoniou, D., Basner, J., Nunez, S. and Schwartz, S. D. (2006) Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis. Chem. Rev., 106, 3170-3187.
-
(2006)
Chem. Rev.
, vol.106
, pp. 3170-3187
-
-
Antoniou, D.1
Basner, J.2
Nunez, S.3
Schwartz, S.D.4
-
8
-
-
84912208190
-
Chemical achievement and hope for the future
-
Pauling, L. (1948) Chemical achievement and hope for the future. Amer. Sci., 36, 50-58.
-
(1948)
Amer. Sci.
, vol.36
, pp. 50-58
-
-
Pauling, L.1
-
10
-
-
0016624901
-
Binding energy, specificity, and enzymatic catalysis: the Circe effect
-
Jencks, W.P. (1975) Binding energy, specificity, and enzymatic catalysis: the Circe effect. Adv. Enzymol., 43, 219-410.
-
(1975)
Adv. Enzymol.
, vol.43
, pp. 219-410
-
-
Jencks, W.P.1
-
11
-
-
0014681301
-
Transition state analogues for enzyme catalysis
-
Wolfenden, R. (1969) Transition state analogues for enzyme catalysis. Nature, 223, 704-705.
-
(1969)
Nature
, vol.223
, pp. 704-705
-
-
Wolfenden, R.1
-
12
-
-
0015924871
-
Enzymatic catalysis and transition-state theory
-
Leinhard, G. E. (1973) Enzymatic catalysis and transition-state theory. Science, 180, 149-154.
-
(1973)
Science
, vol.180
, pp. 149-154
-
-
Leinhard, G.E.1
-
14
-
-
0034640453
-
Hydrogen bonds and proton transfer in general-catalytic transition-state stabilization in enzyme catalysis
-
Schowen, K. B., Limbach, H. H., Denisov, G. S. and Schowen, R. L. (2000) Hydrogen bonds and proton transfer in general-catalytic transition-state stabilization in enzyme catalysis. Biochem. Biophys. Acta, 1458, 43-62.
-
(2000)
Biochem. Biophys. Acta
, vol.1458
, pp. 43-62
-
-
Schowen, K.B.1
Limbach, H.H.2
Denisov, G.S.3
Schowen, R.L.4
-
15
-
-
0031688282
-
Enzymatic transition states and transition state analogue design
-
Schramm, V.L. (1998) Enzymatic transition states and transition state analogue design. Ann. Rev. Biochem., 67, 693-720.
-
(1998)
Ann. Rev. Biochem.
, vol.67
, pp. 693-720
-
-
Schramm, V.L.1
-
16
-
-
0032860328
-
Enzymatic transition-state analysis and transition-state analogs
-
Schramm, V.L. (1999) Enzymatic transition-state analysis and transition-state analogs. Methods Enzymol., 308, 301-355.
-
(1999)
Methods Enzymol.
, vol.308
, pp. 301-355
-
-
Schramm, V.L.1
-
17
-
-
9744244983
-
Enzymatic transition states: thermodynamics, dynamics and analogue design
-
Schramm, V. L. (2005) Enzymatic transition states: thermodynamics, dynamics and analogue design. Arch. Biochem. Biophys., 433, 13-26.
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, pp. 13-26
-
-
Schramm, V.L.1
-
18
-
-
0026341458
-
Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata
-
Horenstein, B.A., Parkin, D.W., Estupinan, B. and Schramm, V.L. (1991) Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata. Biochemistry, 30, 10788-10795.
-
(1991)
Biochemistry
, vol.30
, pp. 10788-10795
-
-
Horenstein, B.A.1
Parkin, D.W.2
Estupinan, B.3
Schramm, V.L.4
-
19
-
-
0041472499
-
Enzymatic transition state poise and transition state analogues
-
Schramm, V. L. (2003) Enzymatic transition state poise and transition state analogues. Acc. Chem. Res., 36, 588-596.
-
(2003)
Acc. Chem. Res.
, vol.36
, pp. 588-596
-
-
Schramm, V.L.1
-
20
-
-
0027729453
-
Purine nucleoside phosphorylase. Catalytic mechanism and transition state analysis of the arsenolysis reaction
-
Kline, P.C. and Schramm, V.L. (1993) Purine nucleoside phosphorylase. Catalytic mechanism and transition state analysis of the arsenolysis reaction. Biochemistry, 32, 13212-13219.
-
(1993)
Biochemistry
, vol.32
, pp. 13212-13219
-
-
Kline, P.C.1
Schramm, V.L.2
-
21
-
-
1042299983
-
Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases
-
Lewandowicz, A. and Schramm, V. L. (2004) Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases. Biochemistry, 43, 1458-1468.
-
(2004)
Biochemistry
, vol.43
, pp. 1458-1468
-
-
Lewandowicz, A.1
Schramm, V.L.2
-
22
-
-
33750979005
-
Transition state structure of human 5'-methylthioadenosine phosphorylase
-
Singh, V. and Schramm, V. L. (2006) Transition state structure of human 5'-methylthioadenosine phosphorylase. J. Am. Chem. Soc., 128, 14691-14696.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 14691-14696
-
-
Singh, V.1
Schramm, V.L.2
-
23
-
-
23944446462
-
Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues
-
Singh, V., Lee, J. E., Nunez, S., Howell, P. L. and Schramm, V. L. (2005) Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Biochemistry, 44, 11647-11659.
-
(2005)
Biochemistry
, vol.44
, pp. 11647-11659
-
-
Singh, V.1
Lee, J.E.2
Nunez, S.3
Howell, P.L.4
Schramm, V.L.5
-
24
-
-
33947201538
-
Transition state structure of. pneumoniae 5'-methylthioadenosine phosphorylase
-
Singh, V. and Schramm, V. L. (2007) Transition state structure of. pneumoniae 5'-methylthioadenosine phosphorylase. J. Am. Chem. Soc., 129, 2783-2795.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 2783-2795
-
-
Singh, V.1
Schramm, V.L.2
-
25
-
-
0034088859
-
Ricin A-chain: kinetic isotope effects and transition state structures with stem-loop RNA
-
Chen, X.-Y., Berti, P. J. and Schramm, V. L. (2000) Ricin A-chain: kinetic isotope effects and transition state structures with stem-loop RNA. J. Am. Chem. Soc., 122, 1609-1617.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 1609-1617
-
-
Chen, X.-Y.1
Berti, P.J.2
Schramm, V.L.3
-
26
-
-
0034686760
-
Transition state structure for depurination of DNA by ricin A-chain
-
Chen, X.-Y., Berti, P.J. and Schramm, V. L. (2000) Transition state structure for depurination of DNA by ricin A-chain. J. Am. Chem. Soc., 122, 6527-6534.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 6527-6534
-
-
Chen, X.-Y.1
Berti, P.J.2
Schramm, V.L.3
-
27
-
-
0025074677
-
Models for nucleoside glycosylase enzymes. Evidence that the hydrolysis of α-D-Ribofuranosides requires a "backside" preassociated nucleophile
-
Cherian, X. M., Van Arman, S. A. and Czarnik, A. W. (1990) Models for nucleoside glycosylase enzymes. Evidence that the hydrolysis of α-D-Ribofuranosides requires a "backside" preassociated nucleophile. J. Am. Chem. Soc., 112, 4490-4498.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 4490-4498
-
-
Cherian, X.M.1
Van Arman, S.A.2
Czarnik, A.W.3
-
28
-
-
0029983879
-
Mechanistic diagnoses for N-ribohydrolases and purine nucleoside phosphorylase
-
Mazzella, L. J., Parkin, D. W., Tyler, P. C., Furneaux, R. H. and Schramm, V. L. (1996) Mechanistic diagnoses for N-ribohydrolases and purine nucleoside phosphorylase. J. Am. Chem. Soc., 118, 2111-2112.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2111-2112
-
-
Mazzella, L.J.1
Parkin, D.W.2
Tyler, P.C.3
Furneaux, R.H.4
Schramm, V.L.5
-
29
-
-
0030956627
-
Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases
-
Parkin, D. W., Limberg, G., Tyler, P. C. Furneaux, R. H., Chen, X.-Y. and Schramm, V.L. (1997) Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases. Biochemistry, 36, 3528-3534.
-
(1997)
Biochemistry
, vol.36
, pp. 3528-3534
-
-
Parkin, D.W.1
Limberg, G.2
Tyler, P.C.3
Furneaux, R.H.4
Chen, X.-Y.5
Schramm, V.L.6
-
30
-
-
0038290447
-
Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases
-
Sauve, A. A., Cahill, S. M., Zech, S. G., Basso, L.A., Lewandowicz, A., Santos, D. S., Grubmeyer, C., Evans, G. B., Furneaux, R. H., Tyler, P. C., McDermott, A., Girvin, M. E. and Schramm, V. L. (2003) Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. Biochemistry, 42, 5694-5705.
-
(2003)
Biochemistry
, vol.42
, pp. 5694-5705
-
-
Sauve, A.A.1
Cahill, S.M.2
Zech, S.G.3
Basso, L.A.4
Lewandowicz, A.5
Santos, D.S.6
Grubmeyer, C.7
Evans, G.B.8
Furneaux, R.H.9
Tyler, P.C.10
McDermott, A.11
Girvin, M.E.12
Schramm, V.L.13
-
31
-
-
0029808060
-
Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism
-
Parkin D. W. (1996) Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism. J. Biol. Chem., 271, 21713-21719.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21713-21719
-
-
Parkin, D.W.1
-
33
-
-
0028021726
-
Guanosine-inosine preferring nucleoside N-glycohydrolase from Crithidia fasciculata
-
Estupiñán, B. and Schramm, V.L. (1994) Guanosine-inosine preferring nucleoside N-glycohydrolase from Crithidia fasciculata. J. Biol. Chem., 269, 23068-23073.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23068-23073
-
-
Estupiñán, B.1
Schramm, V.L.2
-
34
-
-
0025833737
-
Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism
-
Horenstein, B.A., Abdulah, D.R., Estupiñán, B. and Schramm, V.L. (1991) Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism. J. Biol. Chem., 266, 20658-20665.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 20658-20665
-
-
Horenstein, B.A.1
Abdulah, D.R.2
Estupiñán, B.3
Schramm, V.L.4
-
35
-
-
84919573117
-
Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity
-
Giblett, E. R., Ammann, A. J., Wara, D. W., Sandman, R. and Diamond, L. K. (1975) Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet, 1, 1010-1013.
-
(1975)
Lancet
, vol.1
, pp. 1010-1013
-
-
Giblett, E.R.1
Ammann, A.J.2
Wara, D.W.3
Sandman, R.4
Diamond, L.K.5
-
36
-
-
0027458426
-
Structure-based design of inhibitors of purine nucleoside phosphoryla. 1. 9-(Arylmethyl) derivatives of 9-deaza-aguanine
-
Montgomery, J.A., Niwas, S., Rose, J.D., Secrist III, J.A., Babu, Y.S., Bugg, C.E., Erion, M.D., Guida, W.C. and Ealick, S.E. (1993) Structure-based design of inhibitors of purine nucleoside phosphoryla. 1. 9-(Arylmethyl) derivatives of 9-deaza-aguanine. J. Med. Chem., 36, 55-69.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 55-69
-
-
Montgomery, J.A.1
Niwas, S.2
Rose, J.D.3
Secrist III, J.A.4
Babu, Y.S.5
Bugg, C.E.6
Erion, M.D.7
Guida, W.C.8
Ealick, S.E.9
-
37
-
-
0031929844
-
Inhibitors of the enzyme purine nucleoside phosphorylase
-
Morris, P.E. Jr, and Montgomery, J.A. (1998) Inhibitors of the enzyme purine nucleoside phosphorylase. Exp. Opin. Ther. Patents, 8, 283-299.
-
(1998)
Exp. Opin. Ther. Patents
, vol.8
, pp. 283-299
-
-
Jr, M.P.E.1
Montgomery, J.A.2
-
38
-
-
0022978888
-
Design of purine nucleoside phosphorylase inhibitors
-
Stoeckler, J.D., Ealick, S.E., Bugg, C.E. and Parks, R.E., Jr. (1986) Design of purine nucleoside phosphorylase inhibitors. Fed. Proc., Fed. Am. Soc. Exp. Biol., 45, 2773-2778.
-
(1986)
Fed. Proc., Fed. Am. Soc. Exp. Biol.
, vol.45
, pp. 2773-2778
-
-
Stoeckler, J.D.1
Ealick, S.E.2
Bugg, C.E.3
Parks Jr., R.E.4
-
39
-
-
0026349524
-
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors
-
Ealick, S.E., Babu, Y.S., Bugg, C.E., Erion, M.D., Guida, W.C., Montgomery, J.A. and Secrist III, J.A. (1991) Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors. Proc. Natl. Acad. Sci. USA, 88, 11540-11544.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 11540-11544
-
-
Ealick, S.E.1
Babu, Y.S.2
Bugg, C.E.3
Erion, M.D.4
Guida, W.C.5
Montgomery, J.A.6
Secrist III, J.A.7
-
40
-
-
0017189732
-
Characterization of a cell culture model for the study of adenosine deaminase-and purine nucleoside phosphorylase-deficient immunologic disease
-
Ullman, B., Cohen, A. and Martin, D. W. (1976) Characterization of a cell culture model for the study of adenosine deaminase-and purine nucleoside phosphorylase-deficient immunologic disease. Cell, 9, 205-211.
-
(1976)
Cell
, vol.9
, pp. 205-211
-
-
Ullman, B.1
Cohen, A.2
Martin, D.W.3
-
41
-
-
0018244507
-
Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents
-
Carson, D.A. and Kaye, J. (1978) Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents. Ciba Found. Symp. 1978, 115-133.
-
(1978)
Ciba Found. Symp.
, vol.1978
, pp. 115-133
-
-
Carson, D.A.1
Kaye, J.2
-
42
-
-
0343517471
-
Inhibitors of the enzyme purine nucleoside phosphorylase as potential therapy for psoriasis
-
Morris, P.E. Jr. and Omura, G. A. (2000) Inhibitors of the enzyme purine nucleoside phosphorylase as potential therapy for psoriasis. Curr. Pharm. Des., 6, 943-959.
-
(2000)
Curr. Pharm. Des.
, vol.6
, pp. 943-959
-
-
Morris Jr., P.E.1
Omura, G.A.2
-
43
-
-
17844394417
-
A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma
-
Duvic, M., Olsen, E. A., Omura, G. A., Maize, J. C., Vonderheid, E. C., Elmets, C. A., Shupack, J. L., Demierre, M. F., Kuzel, T. M. and Sanders, D. Y. (2001) A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma. J. Am. Acad. Dermatol., 44, 940-947.
-
(2001)
J. Am. Acad. Dermatol.
, vol.44
, pp. 940-947
-
-
Duvic, M.1
Olsen, E.A.2
Omura, G.A.3
Maize, J.C.4
Vonderheid, E.C.5
Elmets, C.A.6
Shupack, J.L.7
Demierre, M.F.8
Kuzel, T.M.9
Sanders, D.Y.10
-
44
-
-
0018138030
-
A new form of nucleoside phosphorylase deficiency in two brothers with defective T-cell function
-
Biggar, W. D., Giblett, E. R., Ozere, R. L. and Grover, B. D. (1978) A new form of nucleoside phosphorylase deficiency in two brothers with defective T-cell function. J. Pediatr., 92, 354-357.
-
(1978)
J. Pediatr.
, vol.92
, pp. 354-357
-
-
Biggar, W.D.1
Giblett, E.R.2
Ozere, R.L.3
Grover, B.D.4
-
45
-
-
0027377078
-
The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine
-
Mohamedali, K.A., Guicherit, O.M., Kellems, R.E. and Rudolph, F.B. (1993) The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine. J. Biol. Chem., 268, 23728-23733.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 23728-23733
-
-
Mohamedali, K.A.1
Guicherit, O.M.2
Kellems, R.E.3
Rudolph, F.B.4
-
46
-
-
0015103752
-
Malaria parasites (Plasmodium lophurae) developing extracellularly in vitro: incorporation of labeled precursors
-
Trager, W. (1971) Malaria parasites (Plasmodium lophurae) developing extracellularly in vitro: incorporation of labeled precursors. J. Protozool., 18, 392-399.
-
(1971)
J. Protozool.
, vol.18
, pp. 392-399
-
-
Trager, W.1
-
47
-
-
0037015614
-
The genome sequence of the human malaria parasite Plasmodium falciparum
-
Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S. et al. (2002) The genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419, 498-511.
-
(2002)
Nature
, vol.419
, pp. 498-511
-
-
Gardner, M.J.1
Hall, N.2
Fung, E.3
White, O.4
Berriman, M.5
Hyman, R.W.6
Carlton, J.M.7
Pain, A.8
Nelson, K.E.9
Bowman, S.10
-
48
-
-
0036479245
-
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase
-
Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L. and Kim, K. (2002) Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase. J. Biol. Chem., 277, 3226-3231.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3226-3231
-
-
Kicska, G.A.1
Tyler, P.C.2
Evans, G.B.3
Furneaux, R.H.4
Schramm, V.L.5
Kim, K.6
-
49
-
-
2442431653
-
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function
-
Shi, W., Ting, L. M., Kicska, G. A., Lewandowicz, A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Kim, K., Almo, S. C. and Schramm, V. L. (2004) Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J. Biol. Chem., 279, 18103-18106.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18103-18106
-
-
Shi, W.1
Ting, L.M.2
Kicska, G.A.3
Lewandowicz, A.4
Tyler, P.C.5
Evans, G.B.6
Furneaux, R.H.7
Kim, K.8
Almo, S.C.9
Schramm, V.L.10
-
50
-
-
24044440419
-
Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases
-
Lewandowicz, A., Ringia, E. A., Ting, L. M., Kim, K., Tyler, P. C., Evans, G. B., Zubkova, O. V., Mee, S., Painter, G. F., Lenz, D. H., Furneaux, R. H. and Schramm, V. L. (2005) Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases. J. Biol. Chem., 280, 30320-30328.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 30320-30328
-
-
Lewandowicz, A.1
Ringia, E.A.2
Ting, L.M.3
Kim, K.4
Tyler, P.C.5
Evans, G.B.6
Zubkova, O.V.7
Mee, S.8
Painter, G.F.9
Lenz, D.H.10
Furneaux, R.H.11
Schramm, V.L.12
-
51
-
-
0032537481
-
One-third-the-sites transition state inhibitors for purine nucleoside phosphorylase
-
Miles, R. W., Tyler, P. C., Furneaux, R. H., Bagdassarian, C. K. and Schramm, V. L. (1998) One-third-the-sites transition state inhibitors for purine nucleoside phosphorylase. Biochemistry, 37, 8615-8621.
-
(1998)
Biochemistry
, vol.37
, pp. 8615-8621
-
-
Miles, R.W.1
Tyler, P.C.2
Furneaux, R.H.3
Bagdassarian, C.K.4
Schramm, V.L.5
-
52
-
-
2242437134
-
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase
-
Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Shi, W., Fedorov, A., Lewandowicz, A., Cahill, S. M., Almo, S. C. and Schramm, V. L. (2002) Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase. Biochemistry, 41, 14489-14498.
-
(2002)
Biochemistry
, vol.41
, pp. 14489-14498
-
-
Kicska, G.A.1
Tyler, P.C.2
Evans, G.B.3
Furneaux, R.H.4
Shi, W.5
Fedorov, A.6
Lewandowicz, A.7
Cahill, S.M.8
Almo, S.C.9
Schramm, V.L.10
-
53
-
-
0042357238
-
Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase
-
Lewandowicz, A., Tyler, P. C., Evans, G. B., Furneaux, R. H. and Schramm, V. L. (2003) Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. J. Biol. Chem., 278, 31465-31468.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31465-31468
-
-
Lewandowicz, A.1
Tyler, P.C.2
Evans, G.B.3
Furneaux, R.H.4
Schramm, V.L.5
-
54
-
-
0037390138
-
Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates
-
Kilpatrick, J. M., Morris, P. E., Serota, D.G., Jr., Phillips, D., Moore, D. R., Bennett, J. C. and Babu, Y. S. (2003) Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates. Int. Immunopharmacol., 3, 541-548.
-
(2003)
Int. Immunopharmacol.
, vol.3
, Issue.541-548
-
-
Kilpatrick, J.M.1
Morris, P.E.2
Serota Jr., D.G.3
Phillips, D.4
Moore, D.R.5
Bennett, J.C.6
Babu, Y.S.7
-
55
-
-
84889370492
-
-
29 April
-
http://www.biocryst.com/bcx_1777.htm (29 April 2007)
-
(2007)
-
-
-
56
-
-
84889324970
-
-
29 April
-
http://www.biocryst.com/bcx_4208.htm (29 April 2007)
-
(2007)
-
-
-
57
-
-
33745131759
-
The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum
-
El Bissati, K., Zufferey, R., Witola, W. H., Carter, N. S., Ullman, B. and Ben Mamoun, C. (2006) The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum. Proc. Natl. Acad. Sci. U. S. A., 103, 9286-9291.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 9286-9291
-
-
El Bissati, K.1
Zufferey, R.2
Witola, W.H.3
Carter, N.S.4
Ullman, B.5
Ben Mamoun, C.6
-
58
-
-
0346096864
-
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
-
Singh, V., Shi, W., Evans, G. B., Tyler, P. C., Furneaux, R. H., Almo, S. C. and Schramm, V. L. (2004) Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry, 43, 9-18.
-
(2004)
Biochemistry
, vol.43
, pp. 9-18
-
-
Singh, V.1
Shi, W.2
Evans, G.B.3
Tyler, P.C.4
Furneaux, R.H.5
Almo, S.C.6
Schramm, V.L.7
-
59
-
-
20244369305
-
Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli
-
Singh, V., Evans, G. B., Lenz, D. H., Mason, J. M., Clinch, K., Mee, S., Painter, G. F., Tyler, P. C., Furneaux, R. H., Lee, J. E., Howell, P. L. and Schramm, V. L. (2005) Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. J. Biol. Chem., 280, 18265-18273.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18265-18273
-
-
Singh, V.1
Evans, G.B.2
Lenz, D.H.3
Mason, J.M.4
Clinch, K.5
Mee, S.6
Painter, G.F.7
Tyler, P.C.8
Furneaux, R.H.9
Lee, J.E.10
Howell, P.L.11
Schramm, V.L.12
-
60
-
-
28644445326
-
Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria
-
Persson, T., Givskov, M. and Nielsen, J. (2005) Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria. Curr. Med. Chem., 12, 3103-3115.
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 3103-3115
-
-
Persson, T.1
Givskov, M.2
Nielsen, J.3
-
61
-
-
30144433680
-
Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues
-
Casero, R. A., Jr., Frydman, B., Stewart, T.M. and Woster, P.M. (2005) Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proc. West. Pharmacol. Soc., 48, 24-30.
-
(2005)
Proc. West. Pharmacol. Soc.
, vol.48
, pp. 24-30
-
-
Casero Jr., R.A.1
Frydman, B.2
Stewart, T.M.3
Woster, P.M.4
-
62
-
-
0141989893
-
Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae
-
Zhu, J. and Mekalanos, J. J. (2003) Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. Dev. Cell., 5, 647-656.
-
(2003)
Dev. Cell.
, vol.5
, pp. 647-656
-
-
Zhu, J.1
Mekalanos, J.J.2
-
63
-
-
2142649224
-
LuxS is required for persistent pneumococcal carriage and expression of virulence and biosynthesis genes
-
Joyce, E. A., Kawale, A., Censini, S., Kim, C. C., Covacci, A. and Falkow, S. (2004) LuxS is required for persistent pneumococcal carriage and expression of virulence and biosynthesis genes. Infect. Immun., 72, 2964-2975.
-
(2004)
Infect. Immun.
, vol.72
, pp. 2964-2975
-
-
Joyce, E.A.1
Kawale, A.2
Censini, S.3
Kim, C.C.4
Covacci, A.5
Falkow, S.6
-
64
-
-
0036128835
-
Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection
-
Winzer, K., Sun, Y., Green, A., Delory, M., Blackley, D., Hardie, K. R., Baldwin, T. J. and Tang, C. M. (2002) Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection. Infect. Immun., 70, 2245-2248.
-
(2002)
Infect. Immun.
, vol.70
, pp. 2245-2248
-
-
Winzer, K.1
Sun, Y.2
Green, A.3
Delory, M.4
Blackley, D.5
Hardie, K.R.6
Baldwin, T.J.7
Tang, C.M.8
-
65
-
-
33750584041
-
Contribution of quorum-sensing systems to virulence of Pseudomonas aeruginosa in an experimental pyelonephritis model
-
Mittal, R., Sharma, S., Chhibber, S. and Harjai, K. (2006) Contribution of quorum-sensing systems to virulence of Pseudomonas aeruginosa in an experimental pyelonephritis model. J. Microbiol. Immunol. Infect., 39, 302-309.
-
(2006)
J. Microbiol. Immunol. Infect.
, vol.39
, pp. 302-309
-
-
Mittal, R.1
Sharma, S.2
Chhibber, S.3
Harjai, K.4
-
66
-
-
0028098025
-
Ricin: structure, mode of action, and some current applications
-
Lord, J.M., Roberts, L. M. and Robertus, J. D. (1994) Ricin: structure, mode of action, and some current applications. FASEB J., 8, 201-208.
-
(1994)
FASEB J.
, vol.8
, pp. 201-208
-
-
Lord, J.M.1
Roberts, L.M.2
Robertus, J.D.3
-
67
-
-
0019158721
-
Georgi Markov-death in a pellet
-
Crompton, R. and Gall, D. (1980) Georgi Markov-death in a pellet. Med. Leg. J., 48, 51-62.
-
(1980)
Med. Leg. J.
, vol.48
, pp. 51-62
-
-
Crompton, R.1
Gall, D.2
-
69
-
-
0035214047
-
Toxin-labeled monoclonal antibodies
-
Kreitman, R. J. (2001) Toxin-labeled monoclonal antibodies. Curr. Pharm. Biotechnol., 2, 313-325.
-
(2001)
Curr. Pharm. Biotechnol.
, vol.2
, pp. 313-325
-
-
Kreitman, R.J.1
-
70
-
-
0013379930
-
Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma
-
Schnell, R., Borchmann, P., Staak, J. O., Schindler, J., Ghetie, V., Vitetta, E. S. and Engert, A. (2003) Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma. Ann. Oncol., 14, 729-736.
-
(2003)
Ann. Oncol.
, vol.14
, pp. 729-736
-
-
Schnell, R.1
Borchmann, P.2
Staak, J.O.3
Schindler, J.4
Ghetie, V.5
Vitetta, E.S.6
Engert, A.7
-
71
-
-
0035849504
-
Ricin A-chain inhibitors resembling the oxacarbenium ion transition state
-
Tanaka, K. S. E, Chen, X.-Y, Ichikawa, Y., Tyler, P. C., Furneaux, R. H. and Schramm, V.L. (2001) Ricin A-chain inhibitors resembling the oxacarbenium ion transition state. Biochemistry, 40, 6845-6851.
-
(2001)
Biochemistry
, vol.40
, pp. 6845-6851
-
-
Tanaka, K.S.E.1
Chen, X.-Y.2
Ichikawa, Y.3
Tyler, P.C.4
Furneaux, R.H.5
Schramm, V.L.6
-
72
-
-
0032544216
-
Ricin A-chain: kinetics, mechanism and RNA-stem-loop inhibitors
-
Chen, X.-Y., Link, T. M. and Schramm, V. L. (1998) Ricin A-chain: kinetics, mechanism and RNA-stem-loop inhibitors. Biochemistry, 37, 11605-11613.
-
(1998)
Biochemistry
, vol.37
, pp. 11605-11613
-
-
Chen, X.-Y.1
Link, T.M.2
Schramm, V.L.3
-
73
-
-
2142662114
-
Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state
-
Roday, S., Amukele, T., Evans, G. B., Tyler, P. C., Furneaux, R. H. and Schramm, V. L. (2004) Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state. Biochemistry, 43, 4923-4933.
-
(2004)
Biochemistry
, vol.43
, pp. 4923-4933
-
-
Roday, S.1
Amukele, T.2
Evans, G.B.3
Tyler, P.C.4
Furneaux, R.H.5
Schramm, V.L.6
-
74
-
-
0001480264
-
Polyhydroxylated pyrrolidines from sugar lactones: Synthesis of 1,4-dideoxy-1,4-imino-d-glucitol from d-galactonolactone and synthesis of 1,4-dideoxy-1,4-imino-d-allitol, 1,4-dideoxy-1,4-imino-d-ribitol and (2S,3R,4S)-3,4-dihydroxyproline from d-gulonolactone
-
Fleet, G. W. J. and Son, J. C. (1988) Polyhydroxylated pyrrolidines from sugar lactones: Synthesis of 1,4-dideoxy-1,4-imino-d-glucitol from d-galactonolactone and synthesis of 1,4-dideoxy-1,4-imino-d-allitol, 1,4-dideoxy-1,4-imino-d-ribitol and (2S,3R,4S)-3,4-dihydroxyproline from d-gulonolactone. Tetrahedron, 44, 2637-2647.
-
(1988)
Tetrahedron
, vol.44
, pp. 2637-2647
-
-
Fleet, G.W.J.1
Son, J.C.2
-
75
-
-
0027524581
-
A new class of C-nucleoside analogues. 1-(S)-1,4-dideoxy-1,4-imino-d-ribitols, transition state analogue inhibitors of nucleoside hydrolase
-
Horenstein, B. A., Zabinski, R. F. and Schramm, V.L. (1993) A new class of C-nucleoside analogues. 1-(S)-1,4-dideoxy-1,4-imino-d-ribitols, transition state analogue inhibitors of nucleoside hydrolase. Tetrahedron Lett., 34, 7213-7216.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 7213-7216
-
-
Horenstein, B.A.1
Zabinski, R.F.2
Schramm, V.L.3
-
76
-
-
0033490888
-
Transition state analogue inhibitors of protozoa nucleoside hydrolases
-
Furneaux, R. H., Schramm, V. L. and Tyler, P. C. (1999) Transition state analogue inhibitors of protozoa nucleoside hydrolases. Bioorg. Med. Chem., 11, 2599-2606.
-
(1999)
Bioorg. Med. Chem.
, vol.11
, pp. 2599-2606
-
-
Furneaux, R.H.1
Schramm, V.L.2
Tyler, P.C.3
-
77
-
-
0035943311
-
Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins
-
Evans, G. B., Furneaux, R. H., Hutchison, T. L., Kezar, H. S., Morris, P.E., Jr., Schramm, V. L. and Tyler, P. C. (2001) Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins. J. Org. Chem., 66, 5723-5730.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 5723-5730
-
-
Evans, G.B.1
Furneaux, R.H.2
Hutchison, T.L.3
Kezar, H.S.4
Morris Jr., P.E.5
Schramm, V.L.6
Tyler, P.C.7
-
78
-
-
0033615686
-
Improved syntheses of 3H,5H-pyrrolo[3,2-d]pyrimidines
-
Furneaux, R. H. and Tyler, P. C. (1999) Improved syntheses of 3H,5H-pyrrolo[3,2-d]pyrimidines. J. Org. Chem., 64, 8411-8412.
-
(1999)
J. Org. Chem.
, vol.64
, pp. 8411-8412
-
-
Furneaux, R.H.1
Tyler, P.C.2
-
79
-
-
0142106430
-
Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction
-
Evans, G. B., Furneaux, R. H., Tyler, P. C. and Schramm, V. L. (2003) Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. Org. Lett., 5, 3639-3640.
-
(2003)
Org. Lett.
, vol.5
, pp. 3639-3640
-
-
Evans, G.B.1
Furneaux, R.H.2
Tyler, P.C.3
Schramm, V.L.4
-
80
-
-
0242691662
-
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase
-
Evans, G. B., Furneaux, R. H., Lewandowicz, A., Schramm, V. L. and Tyler, P. C. (2003) Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. J. Med. Chem., 46, 5271-5276.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5271-5276
-
-
Evans, G.B.1
Furneaux, R.H.2
Lewandowicz, A.3
Schramm, V.L.4
Tyler, P.C.5
-
81
-
-
2542531592
-
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase
-
Evans, G. B., Furneaux, R. H., Schramm, V. L., Singh, V. and Tyler, P. C. (2004) Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. J. Med. Chem., 47, 3275-3281.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 3275-3281
-
-
Evans, G.B.1
Furneaux, R.H.2
Schramm, V.L.3
Singh, V.4
Tyler, P.C.5
-
82
-
-
22244445554
-
Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase
-
Evans, G. B., Furneaux, R. H., Lenz, D. H., Painter, G. F., Schramm, V. L., Singh, V. and Tyler, P. C. (2005) Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J. Med. Chem., 48, 4679-4689.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4679-4689
-
-
Evans, G.B.1
Furneaux, R.H.2
Lenz, D.H.3
Painter, G.F.4
Schramm, V.L.5
Singh, V.6
Tyler, P.C.7
-
83
-
-
6344287399
-
The synthesis of N-ribosyl transferase inhibitors based on a transition state blueprint
-
Evans, G. B. (2004) The synthesis of N-ribosyl transferase inhibitors based on a transition state blueprint. Aust. J. Chem., 57, 837-854.
-
(2004)
Aust. J. Chem.
, vol.57
, pp. 837-854
-
-
Evans, G.B.1
-
84
-
-
33751083094
-
Structure and inhibition of a quorum sensing target from Streptococcus Pneumoniae
-
Singh, V., Shi, W., Almo, S. C., Evans, G. B., Furneaux, R. H., Tyler, P. C., Painter, G. F., Lenz, D. H., Mee, S., Zheng, R. and Schramm, V. L. (2006) Structure and inhibition of a quorum sensing target from Streptococcus Pneumoniae. Biochemistry, 45, 12929-12941.
-
(2006)
Biochemistry
, vol.45
, pp. 12929-12941
-
-
Singh, V.1
Shi, W.2
Almo, S.C.3
Evans, G.B.4
Furneaux, R.H.5
Tyler, P.C.6
Painter, G.F.7
Lenz, D.H.8
Mee, S.9
Zheng, R.10
Schramm, V.L.11
-
85
-
-
34247857453
-
Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design
-
Sturm, M. B., Roday, S. and Schramm, V. L. (2007) Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design. J. Am. Chem. Soc., 129, 5544-5550.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 5544-5550
-
-
Sturm, M.B.1
Roday, S.2
Schramm, V.L.3
|