Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

Biochemistry

Volumn 45, Issue 43, 2006, Pages 12929-12941

  Singh, Vipender ^a   Shi, Wuxian ^a   Almo, Steven C ^a   Evans, Gary B ^b   Furneaux, Richard H ^b   Tyler, Peter C ^b   Painter, Gavin F ^b   Lenz, Dirk H ^b   Mee, Simon ^b   Zheng, Renjian ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; ESCHERICHIA COLI; GENETIC ENGINEERING; HYDROLYSIS; IMMUNOLOGY; X RAY ANALYSIS;

CATALYTIC SITE EFFICIENCY; IMMUCILLINS; INHIBITORY POTENTIAL; QUORUM SENSING;

ENZYME INHIBITION;

1 (9 DEAZAADENIN 9 YL) 1,4 DIDEOXY 1,4 IMINO 5 (3 METHYLPHENYLTHIO) DEXTRO RIBITOL; 1 (9 DEAZAADENIN 9 YL) 1,4 DIDEOXY 1,4 IMINO 5 (4 METHYLPHENYLTHIO) DEXTRO RIBITOL; 1 [(9 DEAZAADENIN 9 YL)METHYL] 3 HYDROXY 4 (METHYLTHIOMETHYL)PYRROLIDINE; 4 (4 CHLOROPHENYLTHIOMETHYL) 1 [(9 DEAZAADENIN 9 YL)METHYL] 3 HYDROXYPYRROLIDINE; 5 METHYLTHIORIBOSE; 5' METHYLTHIOADENOSINE ADENOSYLHOMOCYSTEINE HYDROLASE; 5' METHYLTHIOIMMUCILLIN A; ADENINE; ETHYLTHIOIMMUCILLIN A; HOMOCYSTEINE; HYDROLASE; HYDROLASE INHIBITOR; IMMUCILLIN A; PHENYLTHIOIMMUCILLIN A; RIBOSE; RIBOSYLHOMOCYSTEINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CATALYST; CRYSTAL STRUCTURE; DISSOCIATION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE DISRUPTION; GEOMETRY; HYDROLYSIS; HYDROPHOBICITY; ISOTOPE ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; QUORUM SENSING; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE; X RAY ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-GLYCOSYL HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBITOL; SEQUENCE ANALYSIS, PROTEIN; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; STREPTOCOCCUS PNEUMONIAE;

EID: 33751083094     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061184i     Document Type: Article

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