Synthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase

Journal of Medicinal Chemistry

Volumn 46, Issue 24, 2003, Pages 5271-5276

  Evans, Gary B ^a   Furneaux, Richard H ^a   Lewandowicz, Andrzej ^b   Schramm, Vern L ^b   Tyler, Peter C ^a  

^a CALLAGHAN INNOVATION   (New Zealand)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(8 AZA 9 DEAZAHYPOXANTHIN 9 YL)METHYL] 3 HYDROXY 4 HYDROXYMETHYLPYRROLIDINE; 1 [(9 DEAZAGUANIN 9 YL)METHYL] 3 HYDROXY 4 HYDROXYMETHYLPYRROLIDINE; 1 [(9 DEAZAHYPOXANTHIN 9 YL)METHYL] 3 HYDROXY 4 HYDROXYMETHYLPYRROLIDINE; DRUG ANALOG; IMMUCILLIN G; IMMUCILLIN H; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; EQUILIBRIUM CONSTANT;

ENZYME INHIBITORS; GUANINE; HUMANS; HYPOXANTHINE; HYPOXANTHINES; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242691662     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030305z     Document Type: Article

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