Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

Biochemistry

Volumn 42, Issue 19, 2003, Pages 5694-5705

  Sauve, Anthony A ^a   Cahill, Sean M ^a   Zech, Stephan G ^b   Basso, Luiz A ^c   Lewandowicz, Andrzej ^a   Santos, Diogenes S ^c   Grubmeyer, Charles ^d   Evans, Gary B ^e   Furneaux, Richard H ^e   Tyler, Peter C ^e   McDermott, Ann ^b   Girvin, Mark E ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL BONDS; COMPLEXATION; ENZYMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUBSTRATES;

IONIC STABILIZATION;

BIOCHEMISTRY;

ALPHA DEXTRO RIBOSE; GUANOSINE; GUANOSINE PHOSPHATE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMINO ACID; IMINORIBITOL; IMMUCILLIN H; IMMUCILLIN H 5' PHOSPHATE; ION; N RIBOSYLTRANSFERASE; OXACARBENIUM; PHOSPHATE; PROTEIN; PURINE NUCLEOSIDE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; PURINE NUCLEOTIDE; PYROPHOSPHATE; RIBITOL; RIBOSE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ELECTRICITY; ENERGY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; GEOMETRY; IONIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTON TRANSPORT; SOLID STATE;

5'-GUANYLIC ACID; CATALYTIC DOMAIN; GUANOSINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IONS; KINETICS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0038290447     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034003a     Document Type: Article

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