Second generation transition state analogue inhibitors of human 5′-methylthioadenosine phosphorylase

Journal of Medicinal Chemistry

Volumn 48, Issue 14, 2005, Pages 4679-4689

  Evans, Gary B ^a   Furneaux, Richard H ^a   Lenz, Dirk H ^a   Painter, Gavin F ^a   Schramm, Vern L ^b   Singh, Vipender ^b   Tyler, Peter C ^a  

^a CALLAGHAN INNOVATION   (New Zealand)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTHIO ALPHA DEXTRO RIBOSE 1 PHOSPHATE; 5' METHYLTHIOADENOSINE; 5' METHYLTHIOADENOSINE PHOSPHORYLASE; ADENINE; CARBENOID; GLYCOSYLTRANSFERASE INHIBITOR; POLYAMINE; PURINE; RIBOOXOCARBENIUM ION; S ADENOSYLMETHIONINE; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISSOCIATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITOR INTERACTION; EQUILIBRIUM CONSTANT; HUMAN; MOLECULAR MIMICRY; NONHUMAN; PRECURSOR;

ADENINE; HUMANS; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22244445554     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050269z     Document Type: Article

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