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Volumn 8, Issue 8, 2013, Pages 1029-1047

Advances in the development of hybrid anticancer drugs

Author keywords

Anticancer agents; Combi molecules; Drug design; Drug targeting; Hybrids

Indexed keywords

5,11 DIKETOINDENOISOQUINOLINE; ACRONINE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; BEXAROTENE; CAMPTOTHECIN; CHALCONE; CHLORAMBUCIL; CHLORMETHINE; COUMARIN; DASATINIB; DAUNORUBICIN; DICTYOSTATIN; DISCODERMOLIDE; DOXORUBICIN; ENTINOSTAT; FLUOROURACIL; IMATINIB; INDOLO[2,3 B]QUINOLINE; MELPHALAN; NEO TANSHINLACTONE; NILOTINIB; PROPAFENONE; PSOROSPERMIN; QUINOLINE; RESVERATROL; TRIAZINE; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

EID: 84880729529     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2013.798296     Document Type: Review
Times cited : (206)

References (69)
  • 1
    • 72949087797 scopus 로고    scopus 로고
    • Promise and challenges in drug discovery and development of hybrid anticancer drugs
    • Gediya LK, Njar VC. Promise and challenges in drug discovery and development of hybrid anticancer drugs. Expert Opin Drug Discov 2009;4(11):1099-111
    • (2009) Expert Opin Drug Discov , vol.4 , Issue.11 , pp. 1099-1111
    • Gediya, L.K.1    Njar, V.C.2
  • 2
    • 34547484265 scopus 로고    scopus 로고
    • Molecular hybridization: A useful tool in the design of new drug prototypes
    • Viegas-Junior C, Danuello A, da Silva Bolzani V, et al. Molecular hybridization: A useful tool in the design of new drug prototypes. Curr Med Chem 2007;14(17):1829-52
    • (2007) Curr Med Chem , vol.14 , Issue.17 , pp. 1829-1852
    • Viegas-Junior, C.1    Danuello, A.2    Da Silva Bolzani, V.3
  • 3
    • 0038155266 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of cytotoxic 11-Alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline- camptothecin hybrids
    • Fox BM, Xiao X, Antony S, et al. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids. J Med Chem 2003;46(15):3275-82
    • (2003) J Med Chem , vol.46 , Issue.15 , pp. 3275-3282
    • Fox, B.M.1    Xiao, X.2    Antony, S.3
  • 4
    • 65249126902 scopus 로고    scopus 로고
    • Antitumor psoropermum xanthones and sarcomelicope acridones: Privileged structures implied in DNA alkylation
    • Nguyen HT, Lallemand MC, Boutefnouchet S, et al. Antitumor psoropermum xanthones and sarcomelicope acridones: Privileged structures implied in DNA alkylation. J Nat Prod 2009;72(3):527-39
    • (2009) J Nat Prod , vol.72 , Issue.3 , pp. 527-539
    • Nguyen, H.T.1    Lallemand, M.C.2    Boutefnouchet, S.3
  • 5
    • 79952489998 scopus 로고    scopus 로고
    • Hybrid compounds as new Bcr/Abl inhibitors
    • Wang D, Zhang Z, Lu X, et al. Hybrid compounds as new Bcr/Abl inhibitors. Bioorg Med Chem Lett 2011;21(7):1965-8
    • (2011) Bioorg Med Chem Lett , vol.7 , Issue.21 , pp. 1965-1968
    • Wang, D.1    Zhang, Z.2    Lu, X.3
  • 6
    • 33750690149 scopus 로고    scopus 로고
    • Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells
    • Lee KW, Kim JH, Park JH, et al. Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells. Anticancer Res 2006;26(5 A):3429-38
    • (2006) Anticancer Res , vol.26 , pp. 3429-3438
    • Lee, K.W.1    Kim, J.H.2    Park, J.H.3
  • 7
    • 41749125906 scopus 로고    scopus 로고
    • Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
    • Florence GJ, Gardner NM, Paterson I. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin. Nat Prod Rep 2008;25(2):342-75
    • (2008) Nat Prod Rep , vol.25 , Issue.2 , pp. 342-375
    • Florence, G.J.1    Gardner, N.M.2    Paterson, I.3
  • 8
    • 75649147768 scopus 로고    scopus 로고
    • Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol discodermolide and dictyostatin
    • Paterson I, Naylor GJ, Fujita T, et al. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin. Chem Commun 2010;46(2):261-3
    • (2010) Chem Commun , vol.46 , Issue.2 , pp. 261-263
    • Paterson, I.1    Naylor, G.J.2    Fujita, T.3
  • 9
    • 52649167707 scopus 로고    scopus 로고
    • Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide
    • Paterson I, Naylor GJ, Wright AE. Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. Chem Commun 2008(38):4628-30
    • (2008) Chem Commun , vol.38 , pp. 4628-4630
    • Paterson, I.1    Naylor, G.J.2    Wright, A.E.3
  • 10
    • 38949125112 scopus 로고    scopus 로고
    • Hybrid molecules with a dual mode of action: Dream or reality?
    • Meunier B. Hybrid molecules with a dual mode of action: Dream or reality? Acc Chem Res 2008;41(1):69-77
    • (2008) Acc Chem Res , vol.41 , Issue.1 , pp. 69-77
    • Meunier, B.1
  • 11
    • 33748757218 scopus 로고    scopus 로고
    • Studies of interactions between uracil-based hybrid molecules and P-glycoprotein-search for multidrug resistance modulators
    • Singh P, Paul K. Studies of interactions between uracil-based hybrid molecules and P-glycoprotein-search for multidrug resistance modulators. Bioorg Med Chem 2006;14(21):7183-6
    • (2006) Bioorg Med Chem , vol.14 , Issue.21 , pp. 7183-7186
    • Singh, P.1    Paul, K.2
  • 12
    • 77953134777 scopus 로고    scopus 로고
    • Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents
    • Belluti F, Fontana G, Bo LD, et al. Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents. Bioorg Med Chem 2010;18(10):3543-50
    • (2010) Bioorg Med Chem , vol.18 , Issue.10 , pp. 3543-3550
    • Belluti, F.1    Fontana, G.2    Bo, L.D.3
  • 13
    • 0032856051 scopus 로고    scopus 로고
    • Effects of psychotropic drugs on cell proliferation and differentiation
    • Nordenberg J, Fenig E, Landau M, et al. Effects of psychotropic drugs on cell proliferation and differentiation. Biochem Pharmacol 1999;58(8):1229-36
    • (1999) Biochem Pharmacol , vol.58 , Issue.8 , pp. 1229-1236
    • Nordenberg, J.1    Fenig, E.2    Landau, M.3
  • 14
    • 51349102050 scopus 로고    scopus 로고
    • Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents
    • Guandalini L, Cellai C, Laurenzana A, et al. Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. Bioorg Med Chem Lett 2008;18(18):5071-4
    • (2008) Bioorg Med Chem Lett , vol.18 , Issue.18 , pp. 5071-5074
    • Guandalini, L.1    Cellai, C.2    Laurenzana, A.3
  • 15
    • 46149115894 scopus 로고    scopus 로고
    • Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist
    • Tavera-Mendoza LE, Quach TD, Dabbas B, et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc Natl Acad Sci USA 2008;105(24):8250-5
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.24 , pp. 8250-8255
    • Tavera-Mendoza, L.E.1    Quach, T.D.2    Dabbas, B.3
  • 16
    • 77953129939 scopus 로고    scopus 로고
    • Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids
    • Lamblin M, Dabbas B, Spingarn R, et al. Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids. Bioorg Med Chem 2010;18(11):4119-37
    • (2010) Bioorg Med Chem , vol.18 , Issue.11 , pp. 4119-4137
    • Lamblin, M.1    Dabbas, B.2    Spingarn, R.3
  • 17
    • 84865462213 scopus 로고    scopus 로고
    • Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
    • Fischer J, Wang TT, Kaldre D, et al. Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition. Chem Biol 2012;19(8):963-71
    • (2012) Chem Biol , vol.19 , Issue.8 , pp. 963-971
    • Fischer, J.1    Wang, T.T.2    Kaldre, D.3
  • 18
    • 78449312762 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth
    • Mizuno CS, Paul S, Suh N, et al. Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth. Bioorg Med Chem Lett 2010;20(24):7385-7
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.24 , pp. 7385-7387
    • Mizuno, C.S.1    Paul, S.2    Suh, N.3
  • 19
    • 78449284852 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents
    • Sashidhara KV, Kumar A, Kumar M, et al. Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents. Bioorg Med Chem Lett 2010;20(24):7205-11
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.24 , pp. 7205-7211
    • Sashidhara, K.V.1    Kumar, A.2    Kumar, M.3
  • 20
    • 33645464536 scopus 로고    scopus 로고
    • 1H and 13C NMR data for indolo [ 2,3-b]quinoline-aminoglycoside hybrids, a novel potent anticancer drug family
    • Bednarek E, Bocian W, Sitkowski J, et al. 1H and 13C NMR data for indolo [2,3-b]quinoline-aminoglycoside hybrids, a novel potent anticancer drug family. Magn Reson Chem 2006;44(4):459-62
    • (2006) Magn Reson Chem , vol.44 , Issue.4 , pp. 459-462
    • Bednarek, E.1    Bocian, W.2    Sitkowski, J.3
  • 21
    • 77950862822 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity evaluation of (tetrahydro-beta-carboline)-1,3, 5-triazine hybrids as anticancer agents
    • Kumar R, Gupta L, Pal P, et al. Synthesis and cytotoxicity evaluation of (tetrahydro-beta-carboline)-1,3,5-triazine hybrids as anticancer agents. Eur J Med Chem 2010;45(6):2265-76
    • (2010) Eur J Med Chem , vol.45 , Issue.6 , pp. 2265-2276
    • Kumar, R.1    Gupta, L.2    Pal, P.3
  • 22
    • 84866072432 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity studies of bifunctional hybrids of nitrogen mustards with potential enzymes inhibitors based on melamine framework
    • Kolesinska B, Barszcz K, Kaminski ZJ, et al. Synthesis and cytotoxicity studies of bifunctional hybrids of nitrogen mustards with potential enzymes inhibitors based on melamine framework. J Enzyme Inhib Med Chem 2012;27(5):619-27
    • (2012) J Enzyme Inhib Med Chem , vol.27 , Issue.5 , pp. 619-627
    • Kolesinska, B.1    Barszcz, K.2    Kaminski, Z.J.3
  • 23
    • 84857665235 scopus 로고    scopus 로고
    • Biosyn thesis, synthesis, and biological activities of pyrrolobenzodiazepines
    • Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev 2012;32(2):254-93
    • (2012) Med Res Rev , vol.32 , Issue.2 , pp. 254-293
    • Gerratana, B.1
  • 24
    • 33144473207 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of pyrrolo 2,1-c][ 1,4] benzodiazepine and indole conjugates as anticancer agents
    • Wang JJ, Shen YK, Hu WP, et al. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4] benzodiazepine and indole conjugates as anticancer agents. J Med Chem 2006;49(4):1442-9
    • (2006) J Med Chem , vol.49 , Issue.4 , pp. 1442-1449
    • Wang, J.J.1    Shen, Y.K.2    Hu, W.P.3
  • 25
    • 77955552068 scopus 로고    scopus 로고
    • Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity
    • Ismail MMF, Rateb HS, Hussein MMM. Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity. Eur J Med Chem 2010;45(9):3950-9
    • (2010) Eur J Med Chem , vol.45 , Issue.9 , pp. 3950-3959
    • Ismail, M.M.F.1    Rateb, H.S.2    Hussein, M.M.M.3
  • 26
    • 58349099435 scopus 로고    scopus 로고
    • Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain
    • Ahmed K, Matsuya Y, Nemoto H, et al. Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain. Chem Biol Interact 2009;177(3):218-26
    • (2009) Chem Biol Interact , vol.177 , Issue.3 , pp. 218-226
    • Ahmed, K.1    Matsuya, Y.2    Nemoto, H.3
  • 27
    • 66249088013 scopus 로고    scopus 로고
    • Design synthesis and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents
    • Matsuya Y, Kobayashi Y, Kawaguchi T, et al. Design, synthesis, and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents. Chem Eur J 2009;15(23):5799-813
    • (2009) Chem Eur J , vol.15 , Issue.23 , pp. 5799-5813
    • Matsuya, Y.1    Kobayashi, Y.2    Kawaguchi, T.3
  • 28
    • 80051483748 scopus 로고    scopus 로고
    • Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates
    • Havrylyuk D, Kovach N, Zimenkovsky B, et al. Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates. Arch Pharm 2011;344(8):514-22
    • (2011) Arch Pharm , vol.344 , Issue.8 , pp. 514-522
    • Havrylyuk, D.1    Kovach, N.2    Zimenkovsky, B.3
  • 29
    • 84868234211 scopus 로고    scopus 로고
    • Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation
    • Kumar K, Sagar S, Esau L, et al. Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation. Eur J Med Chem 2012;58:153-9
    • (2012) Eur J Med Chem , Issue.58 , pp. 153-159
    • Kumar, K.1    Sagar, S.2    Esau, L.3
  • 30
    • 84865717991 scopus 로고    scopus 로고
    • Azide-alkyne cycloaddition en route to novel 1H-1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation
    • Singh P, Sharma P, Anand A, et al. Azide-alkyne cycloaddition en route to novel 1H-1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation. Eur J Med Chem 2012;55:455-61
    • (2012) Eur J Med Chem , Issue.55 , pp. 455-461
    • Singh, P.1    Sharma, P.2    Anand, A.3
  • 31
    • 79151475531 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents
    • Kamal A, Bharathi EV, Reddy JS, et al. Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. Eur J Med Chem 2011;46(2):691-703
    • (2011) Eur J Med Chem , vol.46 , Issue.2 , pp. 691-703
    • Kamal, A.1    Bharathi, E.V.2    Reddy, J.S.3
  • 32
    • 80053968888 scopus 로고    scopus 로고
    • The application of tandem aza-wittig reaction to synthesize artemisinin-guanidine hybrids and their anti-tumor activity
    • Xie L, Zhao Y, Zhai X, et al. The application of tandem aza-wittig reaction to synthesize artemisinin-guanidine hybrids and their anti-tumor activity. Arch Pharm 2011;344(10):631-8
    • (2011) Arch Pharm , vol.344 , Issue.10 , pp. 631-638
    • Xie, L.1    Zhao, Y.2    Zhai, X.3
  • 33
    • 77949541879 scopus 로고    scopus 로고
    • First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells
    • Bastien D, Leblanc V, Asselin E, et al. First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells. Bioorg Med Chem Lett 2010;20(7):2078-81
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.7 , pp. 2078-2081
    • Bastien, D.1    Leblanc, V.2    Asselin, E.3
  • 34
    • 33745123646 scopus 로고    scopus 로고
    • The combi-targeting concept: Synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR
    • Domarkas J, Dudouit F, Williams C, et al. The combi-targeting concept: Synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR). J Med Chem 2006;49(12):3544-52
    • (2006) J Med Chem , vol.49 , Issue.12 , pp. 3544-3552
    • Domarkas, J.1    Dudouit, F.2    Williams, C.3
  • 35
    • 79961128455 scopus 로고    scopus 로고
    • A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR-DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity
    • Golabi N, Brahimi F, Huang Y, et al. A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR-DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity. J Pharm Biomed Anal 2011;56(3):592-9
    • (2011) J Pharm Biomed Anal , vol.56 , Issue.3 , pp. 592-599
    • Golabi, N.1    Brahimi, F.2    Huang, Y.3
  • 36
    • 84895069237 scopus 로고    scopus 로고
    • The concept of divergent targeting through the activation and inhibition of receptors as a novel chemotherapeutic strategy: Signaling responses to strong DNA-reactive combinatorial mimicries
    • Watt HL, Rachid Z, Jean-Claude BJ. The concept of divergent targeting through the activation and inhibition of receptors as a novel chemotherapeutic strategy: Signaling responses to strong DNA-reactive combinatorial mimicries. J Signal Transduct 2012;2012:282050
    • (2012) J Signal Transduct , Issue.2012 , pp. 282050
    • Watt, H.L.1    Rachid, Z.2    Jean-Claude, B.J.3
  • 37
    • 84864285448 scopus 로고    scopus 로고
    • Combi-targeting mitozolomide: Conferring novel signaling inhibitory properties to an abandoned DNA alkylating agent in the treatment of advanced prostate cancer
    • Fang Y, Qiu Q, Domarkas J, et al. "Combi-targeting" mitozolomide: Conferring novel signaling inhibitory properties to an abandoned DNA alkylating agent in the treatment of advanced prostate cancer. Prostate 2012;72(12):1273-85
    • (2012) Prostate , vol.72 , Issue.12 , pp. 1273-1285
    • Fang, Y.1    Qiu, Q.2    Domarkas, J.3
  • 38
    • 34250219551 scopus 로고    scopus 로고
    • Novel nitrogen mustard-armed combimolecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: Discovery of an unusual structure-activity relationship
    • Rachid Z, Brahimi F, Qiu Q, et al. Novel nitrogen mustard-armed combimolecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: Discovery of an unusual structure-activity relationship. J Med Chem 2007;50(11):2605-8
    • (2007) J Med Chem , vol.50 , Issue.11 , pp. 2605-2608
    • Rachid, Z.1    Brahimi, F.2    Qiu, Q.3
  • 39
    • 84856071595 scopus 로고    scopus 로고
    • Characterization of the potency of epidermal growth factor (EGFR)- DNA targeting combi-molecules containing a hydrolabile carbamate at the 3-position of the triazene chain
    • MacPhee M, Rachid Z, Todorova M, et al. Characterization of the potency of epidermal growth factor (EGFR)- DNA targeting combi-molecules containing a hydrolabile carbamate at the 3-position of the triazene chain. Invest New Drugs 2011;29(5):833-45
    • (2011) Invest New Drugs , vol.29 , Issue.5 , pp. 833-845
    • MacPhee, M.1    Rachid, Z.2    Todorova, M.3
  • 40
    • 79954556455 scopus 로고    scopus 로고
    • In vitro and in vivo biodistribution of ZRS1, a stabilized type I N-acetoxymethyl carbamate-containing combi-molecule
    • Golabi N, Rachid Z, Qiu Q, et al. In vitro and in vivo biodistribution of ZRS1, a stabilized type I N-acetoxymethyl carbamate-containing combi-molecule. Drug Metab Lett 2011;5(2):141-9
    • (2011) Drug Metab Lett , vol.5 , Issue.2 , pp. 141-149
    • Golabi, N.1    Rachid, Z.2    Qiu, Q.3
  • 41
    • 79952842273 scopus 로고    scopus 로고
    • MGMT is a molecular determinant for potency of the DNA-EGFR-combimolecule ZRS1
    • Huang Y, Rachid Z, Jean-Claude BJ. MGMT is a molecular determinant for potency of the DNA-EGFR-combimolecule ZRS1. Mol Cancer Res 2011;9(3):320-31
    • (2011) Mol Cancer Res , vol.9 , Issue.3 , pp. 320-331
    • Huang, Y.1    Rachid, Z.2    Jean-Claude, B.J.3
  • 42
    • 34447103009 scopus 로고    scopus 로고
    • Optimization of novel combimolecules: Identification of balanced and mixed bcr-abl/DNA targeting properties
    • Rachid Z, Katsoulas A, Williams C, et al. Optimization of novel combimolecules: Identification of balanced and mixed bcr-abl/DNA targeting properties. Bioorg Med Chem Lett 2007;17(15):4248-53
    • (2007) Bioorg Med Chem Lett , vol.17 , Issue.15 , pp. 4248-4253
    • Rachid, Z.1    Katsoulas, A.2    Williams, C.3
  • 43
    • 80955122676 scopus 로고    scopus 로고
    • Inhibition of DNA synthesis by a platinum-acridine hybrid agent leads to potent cell kill in nonsmall cell lung cancer
    • Smyre CL, Saluta G, Kute TE, et al. Inhibition of DNA synthesis by a platinum-acridine hybrid agent leads to potent cell kill in nonsmall cell lung cancer. ACS Med Chem Lett 2011;2(11):870-4
    • (2011) ACS Med Chem Lett , vol.2 , Issue.11 , pp. 870-874
    • Smyre, C.L.1    Saluta, G.2    Kute, T.E.3
  • 44
    • 84855800613 scopus 로고    scopus 로고
    • 1 2,3-Triazole tethered b-lactam-Chalcone bifunctional hybrids: Synthesis and anticancer evaluation
    • Singh P, Raj R, Kumar V, et al. 1,2,3-Triazole tethered b-lactam-Chalcone bifunctional hybrids: Synthesis and anticancer evaluation. Eur J Med Chem 2012;47(1):594-600
    • (2012) Eur J Med Chem , vol.47 , Issue.1 , pp. 594-600
    • Singh, P.1    Raj, R.2    Kumar, V.3
  • 45
    • 84864414558 scopus 로고    scopus 로고
    • Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
    • Mourad MAE, Abdel-Aziz M, Abuo-Rahma GEDAA, et al. Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids. Eur J Med Chem 2012;54:907-13
    • (2012) Eur J Med Chem , Issue.54 , pp. 907-913
    • Mourad, M.A.E.1    Abdel-Aziz, M.2    Abuo-Rahma, G.E.D.A.A.3
  • 46
    • 0346729862 scopus 로고    scopus 로고
    • Synthesis and antitumour activity of pyrene-linked pyrrolo [ 2,1-c][ 1,4] benzodiazepine hybrids
    • Kamal A, Ramesh G, Srinivas O, et al. Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids. Bioorg Med Chem Lett 2004;14(2):471-4
    • (2004) Bioorg Med Chem Lett , vol.14 , Issue.2 , pp. 471-474
    • Kamal, A.1    Ramesh, G.2    Srinivas, O.3
  • 47
    • 3042553996 scopus 로고    scopus 로고
    • Synthesis of C8-linked pyrrolo[ 2,1-c] [ 1,4]benzodiazepine-acridone/ acridine hybrids as potential DNA-binding agents
    • Kamal A, Srinivas O, Ramulu P, et al. Synthesis of C8-linked pyrrolo[2,1-c] [1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents. Bioorg Med Chem Lett 2004;14(15):4107-11
    • (2004) Bioorg Med Chem Lett , vol.14 , Issue.15 , pp. 4107-4111
    • Kamal, A.1    Srinivas, O.2    Ramulu, P.3
  • 48
    • 84869745043 scopus 로고    scopus 로고
    • Targeting the estrogen receptor using steroid-therapeutic drug conjugates (hybrids)
    • Dao KL, Hanson RN. Targeting the estrogen receptor using steroid-therapeutic drug conjugates (hybrids). Bioconjug Chem 2012;23(11):2139-58
    • (2012) Bioconjug Chem , vol.23 , Issue.11 , pp. 2139-2158
    • Dao, K.L.1    Hanson, R.N.2
  • 49
    • 46749149988 scopus 로고    scopus 로고
    • Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta
    • Descôteaux C, Leblanc V, Bélanger G, et al. Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta. Steroids 2008;73(11):1077-89
    • (2008) Steroids , vol.73 , Issue.11 , pp. 1077-1089
    • Descôteaux, C.1    Leblanc, V.2    Bélanger, G.3
  • 50
    • 72549095564 scopus 로고    scopus 로고
    • VP-128, a novel oestradiolplatinum( II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo
    • Van Themsche C, Parent S, Leblanc V, et al. VP-128, a novel oestradiolplatinum( II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo. Endocr Relat Cancer 2009;16(4):1185-95
    • (2009) Endocr Relat Cancer , vol.16 , Issue.4 , pp. 1185-1195
    • Van Themsche, C.1    Parent, S.2    Leblanc, V.3
  • 51
    • 84855990242 scopus 로고    scopus 로고
    • Synthesis, antiproliferative activity and estrogen receptor a affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues
    • Saha P, Descoteaux C, Brasseur K, et al. Synthesis, antiproliferative activity and estrogen receptor a affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues. Eur J Med Chem 2012;48:385-90
    • (2012) Eur J Med Chem , Issue.48 , pp. 385-390
    • Saha, P.1    Descoteaux, C.2    Brasseur, K.3
  • 52
    • 74049106561 scopus 로고    scopus 로고
    • Hybrid anticancer agents: Isothiocyanate-progesterone conjugates as chemotherapeutic agents and insights into their cytotoxicities
    • Adsule S, Banerjee S, Ahmed F, et al. Hybrid anticancer agents: Isothiocyanate-progesterone conjugates as chemotherapeutic agents and insights into their cytotoxicities. Bioorg Med Chem Lett 2010;20(3):1247-51
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.3 , pp. 1247-1251
    • Adsule, S.1    Banerjee, S.2    Ahmed, F.3
  • 53
    • 84865514941 scopus 로고    scopus 로고
    • Design synthesis, cytocidal activity and estrogen receptor a affinity of doxorubicin conjugates at 16a-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer
    • Saha P, Fortin S, Leblanc V, et al. Design, synthesis, cytocidal activity and estrogen receptor a affinity of doxorubicin conjugates at 16a-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer. Steroids 2012;77(11):1113-22
    • (2012) Steroids , vol.77 , Issue.11 , pp. 1113-1122
    • Saha, P.1    Fortin, S.2    Leblanc, V.3
  • 54
    • 23744448112 scopus 로고    scopus 로고
    • Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma
    • Trafalis DTP, Camoutsis C, Papageorgiou A. Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma. Melanoma Res 2005;15:273-81
    • (2005) Melanoma Res , vol.15 , pp. 273-281
    • Trafalis, D.T.P.1    Camoutsis, C.2    Papageorgiou, A.3
  • 55
    • 84858343513 scopus 로고    scopus 로고
    • Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine ovarian and breast cancer cell lines
    • Descôteaux C, Brasseur K, Leblanc V, et al. Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. Steroids 2012;77(5):403-12
    • (2012) Steroids , vol.77 , Issue.5 , pp. 403-412
    • Descôteaux, C.1    Brasseur, K.2    Leblanc, V.3
  • 56
    • 79955634152 scopus 로고    scopus 로고
    • Preclinical investigation of tolerance and antitumour activity of new fluorodeoxyglucose-coupled chlorambucil alkylating agents
    • Miot-Noirault E, Reux B, Debiton E, et al. Preclinical investigation of tolerance and antitumour activity of new fluorodeoxyglucose-coupled chlorambucil alkylating agents. Invest New Drugs 2011;29(3):424-33
    • (2011) Invest New Drugs , vol.29 , Issue.3 , pp. 424-433
    • Miot-Noirault, E.1    Reux, B.2    Debiton, E.3
  • 57
    • 84866740975 scopus 로고    scopus 로고
    • Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: In vitro and in vivo preclinical studies
    • Peyrode C, Weber V, David E, et al. Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: In vitro and in vivo preclinical studies. Invest New Drugs 2012;30(4):1782-90
    • (2012) Invest New Drugs , vol.30 , Issue.4 , pp. 1782-1790
    • Peyrode, C.1    Weber, V.2    David, E.3
  • 58
    • 80555131125 scopus 로고    scopus 로고
    • Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase I.I
    • Brel V, Annereau JP, Vispe S, et al. Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II. Biochem Pharmacol 2011;82(12):1843-52
    • (2011) Biochem Pharmacol , vol.82 , Issue.12 , pp. 1843-1852
    • Brel, V.1    Annereau, J.P.2    Vispe, S.3
  • 59
    • 57149094031 scopus 로고    scopus 로고
    • F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system
    • Barret JM, Kruczynski A, Vispe S, et al. F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system. Cancer Res 2008;68(23):9845-53
    • (2008) Cancer Res , vol.68 , Issue.23 , pp. 9845-9853
    • Barret, J.M.1    Kruczynski, A.2    Vispe, S.3
  • 60
    • 79151481154 scopus 로고    scopus 로고
    • Preclinical activity of F14512 designed to target tumors expressing an active polyamine transport system
    • Kruczynski A, Vandenberghe I, Pillon A, et al. Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system. Invest New Drugs 2011;29(1):9-21
    • (2011) Invest New Drugs , vol.29 , Issue.1 , pp. 9-21
    • Kruczynski, A.1    Vandenberghe, I.2    Pillon, A.3
  • 61
    • 78549292799 scopus 로고    scopus 로고
    • Synthesis, physical properties, and cytotoxicity of Nitroxyl-Aziridine hybrid
    • Kumamoto T, Suzuki K, Kim SK, et al. Synthesis, physical properties, and cytotoxicity of Nitroxyl-Aziridine hybrid. Helv Chim Acta 2010;93(11):2109-14
    • (2010) Helv Chim Acta , vol.93 , Issue.11 , pp. 2109-2114
    • Kumamoto, T.1    Suzuki, K.2    Kim, S.K.3
  • 62
    • 44949103190 scopus 로고    scopus 로고
    • Evaluation of radiolabeled (hetero) aromatic analogues of N-(2- diethylaminoethyl)-4-iodobenzamide for imaging and targeted radionuclide therapy of melanoma
    • Chezal JM, Papon J, Labarre P, et al. Evaluation of radiolabeled (hetero) aromatic analogues of N-(2- diethylaminoethyl)-4-iodobenzamide for imaging and targeted radionuclide therapy of melanoma. J Med Chem 2008;51(11):3133-44
    • (2008) J Med Chem , vol.51 , Issue.11 , pp. 3133-3144
    • Chezal, J.M.1    Papon, J.2    Labarre, P.3
  • 63
    • 49149095748 scopus 로고    scopus 로고
    • Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma
    • Desbois N, Gardette M, Papon J, et al. Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma. Bioorg Med Chem 2008;16(16):7671-90
    • (2008) Bioorg Med Chem , vol.16 , Issue.16 , pp. 7671-7690
    • Desbois, N.1    Gardette, M.2    Papon, J.3
  • 64
    • 84856060113 scopus 로고    scopus 로고
    • Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using 125I an Auger electron emitter
    • Gardette M, Papon J, Bonnet M, et al. Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using 125I, an Auger electron emitter. Invest New Drugs 2011;29(6):1253-63
    • (2011) Invest New Drugs , vol.29 , Issue.6 , pp. 1253-1263
    • Gardette, M.1    Papon, J.2    Bonnet, M.3
  • 65
    • 79151483335 scopus 로고    scopus 로고
    • The combi-targeting concept: Mechanism of action of the pleiotropic combi-molecule RB24 and discovery of a novel cell signaling-based combination principle
    • Banerjee R, Huang Y, Qiu Q, et al. The combi-targeting concept: Mechanism of action of the pleiotropic combi-molecule RB24 and discovery of a novel cell signaling-based combination principle. Cell Signal 2011;23(4):630-40
    • (2011) Cell Signal , vol.23 , Issue.4 , pp. 630-640
    • Banerjee, R.1    Huang, Y.2    Qiu, Q.3
  • 66
    • 80052950320 scopus 로고    scopus 로고
    • Synthesis, characterization and anticancer studies of mixed ligand dithiocarbamate palladium(II) complexes
    • Khan H, Badshah A, Murtaz G, et al. Synthesis, characterization and anticancer studies of mixed ligand dithiocarbamate palladium(II) complexes. Eur J Med Chem 2011;46(9):4071-7
    • (2011) Eur J Med Chem , vol.46 , Issue.9 , pp. 4071-4077
    • Khan, H.1    Badshah, A.2    Murtaz, G.3
  • 67
    • 84863410726 scopus 로고    scopus 로고
    • Enhancement of the cytotoxic potential of the mixed EGFR and DNA-targeting combi-molecule ZRBA1 against human solid tumour cells by a bis-quinazoline-based drug design approach
    • Al-Safadi S, Domarkas J, Han Y, et al. Enhancement of the cytotoxic potential of the mixed EGFR and DNA-targeting combi-molecule ZRBA1 against human solid tumour cells by a bis-quinazoline-based drug design approach. Anticancer Drugs 2012;23(5):483-93
    • (2012) Anticancer Drugs , vol.23 , Issue.5 , pp. 483-493
    • Al-Safadi, S.1    Domarkas, J.2    Han, Y.3
  • 68
    • 84868031063 scopus 로고    scopus 로고
    • Biological effects of AL622 a molecule rationally designed to release an EGFR and a c-Src kinase inhibitor
    • Larroque-Lombard AL, Ning N, Rao S, et al. Biological effects of AL622, a molecule rationally designed to release an EGFR and a c-Src kinase inhibitor. Chem Biol Drug Des 2012;80(6):981-91
    • (2012) Chem Biol Drug Des , vol.80 , Issue.6 , pp. 981-991
    • Larroque-Lombard, A.L.1    Ning, N.2    Rao, S.3


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