Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II

Biochemical Pharmacology

Volumn 82, Issue 12, 2011, Pages 1843-1852

  Brel, Viviane ^a   Annereau, Jean Philippe ^a   Vispé, Stéphane ^a   Kruczynski, Anna ^a   Bailly, Christian ^a   Guilbaud, Nicolas ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Apoptosis; Etoposide; F14512; Polyamines; Senescence; Topoisomerase II

Indexed keywords

ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; CASPASE 3; CASPASE 7; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; F 14512; GYRASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE S PHASE; CELL DEATH; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVITY; FLOW CYTOMETRY; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL CYCLE; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; ETOPOSIDE; HUMANS; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; POLYAMINES; TOPOISOMERASE II INHIBITORS;

EID: 80555131125     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.08.028     Document Type: Article

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