First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2078-2081

  Bastien, Dominic ^a   Leblanc, Valérie ^a   Asselin, Éric ^a   Bérubé, Gervais ^a  

^a UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

Author keywords

Androgen receptor; Dimers; Prostate cancer; Testosterone

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 7ALPHA ALLYLTESTOSTERONE; CYPROTERONE ACETATE; DIMER; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CATALYST; CELL ASSAY; CIS ISOMER; CONTROLLED STUDY; CYTOTOXICITY; DIMERIZATION; DRUG SYNTHESIS; GEOMETRY; HUMAN; HUMAN CELL; ISOMER; MALE; PROSTATE CANCER; TRANS ISOMER; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ANDROGEN ANTAGONISTS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOMERISM; MALE; MODELS, MOLECULAR; PROSTATIC NEOPLASMS; TESTOSTERONE;

EID: 77949541879     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.077     Document Type: Article

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