Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

Journal of Medicinal Chemistry

Volumn 46, Issue 15, 2003, Pages 3275-3282

  Fox, Brian M ^a   Xiao, Xiangshu ^a   Antony, Smitha ^b   Kohlhagen, Glenda ^b   Pommier, Yves ^b   Staker, Bart L ^c   Stewart, Lance ^c   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c DeCODE Chemistry & Biostructures   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11 (3' AMINOPROPYLIDENE) 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 11 (4' BROMOBUTYLIDENE) 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 11 (4' CHLOROBUTYLIDENE) 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 11 (4' IODOBUTYLIDENE) 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 11 (5' BROMOPENTYLIDENE) 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 11 (6' BROMOHEXYLIDENE) 5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 12H 5,11A DIAZADIBENZO[B,H]FLUOREN 11 ONE; 8,9 DIMETHOXY 12H 5,11A DIAZADIBENZO[B,H]FLUOREN 11 ONE; ALDEHYDE; ALKENE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; INDENOISOQUINOLINE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; GEOMETRY; HALOGENATION; HUMAN; HUMAN CELL; HYBRID; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0038155266     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0300476     Document Type: Article

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