The application of tandem aza-wittig reaction to synthesize artemisinin-guanidine hybrids and their anti-tumor activity

Archiv der Pharmazie

Volumn 344, Issue 10, 2011, Pages 631-638

  Xie, Lijun ^a   Zhao, Yanfang ^a   Zhai, Xin ^a   Li, Peng ^a   Liu, Chun ^a   Li, Yangxiong ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti tumor activity; Artemisinin; aza Wittig reaction; Guanidine

Indexed keywords

2 (2,4 DICHLOROPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 (3 BROMOPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 (3 BROMOPHENYL) 3 [2 (10BETA DIHYDROARTEMISINOXY)ETHYL]DIETHYLGUANIDINE; 2 (3 CHLOROPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 (3 CHLOROPHENYL) 3 [2 (10BETA DIHYDROARTEMISINOXY)ETHYL]DIETHYLGUANIDINE; 2 (3 FLUOROPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 (4 CHLOROPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 (4 TRIFLUOROMETHOXYPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 (4 TRIFLUOROMETHYLPHENYL) 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 2 [2 CHLORO 5 (TRIFLUOROMETHYL)PHENYL] 1,3 BIS[2 (10BETA DIHYDROARTEMISINOXY)ETHYL]GUANIDINE; 3 (10ALPHA DEOXOARTEMISININ) 2 [4 (TRIFLUOROMETHOXY)PHENYL]DIETHYLGUANIDINE; ANTINEOPLASTIC AGENT; ARTEMISININ DERIVATIVE; DIHYDROARTEMISININ; GUANIDINE; N (10ALPHA DEOXOARTEMISININ) N' [4 (TRIFLUOROMETHOXY)PHENYL]MORPHOLINE 4 CARBOXAMIDINE; N (10ALPHA DEOXOARTEMISININ) N' [4 (TRIFLUOROMETHOXY)PHENYL]PIPERIDINE 1 CARBOXAMIDINE; N (10BETA DEOXOARTEMISININ) N' [2 CHLORO 5 (TRIFLUOROMETHYL)PHENYL]PYRROLIDINE 1 CARBOXAMIDINE; N (10BETA DEOXOARTEMISININ) N' [4 (TRIFLUOROMETHOXY)PHENY]MORPHOLINE 4 CARBOXAMIDINE; N (10BETA DEOXOARTEMISININ) N' [4 (TRIFLUOROMETHOXY)PHENYL]PIPERIDINE 1 CARBOXAMIDINE; N' (3 BROMOPHENYL) N [2 (10BETA DIHYDROARTEMISINOXY)ETHYL]MORPHOLINE 4 CARBOXAMIDINE; N' (3 CHLOROPHENYL) N [2 (10BETA DIHYDROARTEMISINOXY)ETHYL] 4 METHYLPIPERAZINE 1 CARBOXAMIDINE; N' 4 (TRIFLUOROMETHYL)PHENYL) N [2 (10BETA DIHYDROARTEMISINOXY]PYRROLIDINE 1 CARBOXAMIDINE; N' [3 (TRIFLUOROMETHYL)PHENYL] N [2 (10BETA DIHYDROARTERMISINOXY)ETHYL]PIPERADINE 1 CARBOXAMIDINE; N' [4 (TRIFLUOROMETHOXY)PHENYL] N [2 (10BETA DIHYDROARTEMISINOXY)ETHYL]PIPERIDINE 1 CARBOXAMIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AZA WITTIG REACTION; CELL LINE; CELL STRAIN HT29; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ARTEMISININS; AZA COMPOUNDS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GUANIDINE; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053968888     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000363     Document Type: Article

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