The combi-targeting concept: Mechanism of action of the pleiotropic combi-molecule RB24 and discovery of a novel cell signaling-based combination principle

Cellular Signalling

Volumn 23, Issue 4, 2011, Pages 630-640

  Banerjee, Ranjita ^a   Huang, Ying ^a   Qiu, Qiyu ^a   Mcnamee, James P ^b   Belinsky, Gina ^a   Jean Claude, Bertrand J ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b HEALTH CANADA   (Canada)

Author keywords

Cell signaling; Combi molecule; DNA damage and repair; EGFR

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MITOGEN ACTIVATED PROTEIN KINASE P38; NSC 741279; PROTEIN BAD; RB 10; RB 24; TEMOZOLOMIDE; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DNA REPAIR; DRUG POTENCY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; PLEIOTROPY; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BUTADIENES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DACARBAZINE; DNA DAMAGE; DNA METHYLATION; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRIAZENES;

EID: 79151483335     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2010.11.014     Document Type: Article

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