Hybrid compounds as new Bcr/Abl inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 1965-1968

  Wang, Deping ^a,b   Zhang, Zhang ^a   Lu, Xiaoyun ^a   Feng, Yubing ^a   Luo, Kun ^a   Gan, Jirong ^a   Yingxue, Liu ^a   Wan, Junting ^a   Li, Xiang ^a   Zhang, Fengxiang ^a   Tu, Zhengchao ^a   Cai, Qian ^a   Ren, Xiaomei ^a   Ding, Ke ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

2,4 Disubstituted thiazole; Anticancer; Bcr Abl kinase; Chronic myelogenous leukemia; Hybride compound

Indexed keywords

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; IMATINIB; NILOTINIB; THIAZOLE DERIVATIVE;

AMINOLYSIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; IC 50; LEUKEMIA CELL; MOLECULAR DOCKING; PROTEIN CONFORMATION; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 79952489998     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.029     Document Type: Article

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