Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system

Investigational New Drugs

Volumn 29, Issue 1, 2011, Pages 9-21

  Kruczynski, Anna ^a   Vandenberghe, Isabelle ^a   Pillon, Arnaud ^a   Pesnel, Sabrina ^b   Goetsch, Liliane ^a   Barret, Jean Marc ^a   Guminski, Yves ^a   Le Pape, Alain ^b   Imbert, Thierry ^a   Bailly, Christian ^a   Guilbaud, Nicolas ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b TAAM CIPA   (France)

Author keywords

Fluorophor labeled spermine probes; In vivo antitumor activity; Polyamine transport system; Spermine drug conjugate; Targeted cytotoxic agent

Indexed keywords

ANTINEOPLASTIC AGENT; F 14512; FLUORESCENT DYE; POLYAMINE; SPERMINE; UNCLASSIFIED DRUG;

AMINE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOMA; BURKITT LYMPHOMA; CANCER REGRESSION; CELL DEATH; CELL LABELING; COLON ADENOCARCINOMA; COLON CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG INTERMITTENT THERAPY; DRUG MECHANISM; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IMAGING; FLUOROPHOTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LARGE CELL CARCINOMA; LUNG CANCER; LUNG CARCINOMA; MALE; MELANOMA; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; PROSTATE CARCINOMA; SARCOMA;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL DEATH; CELL LINE, TUMOR; FLOW CYTOMETRY; FLUORESCENCE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; PODOPHYLLOTOXIN; POLYAMINES; SPERMINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79151481154     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9328-3     Document Type: Article

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