Design, synthesis, and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents

Chemistry - A European Journal

Volumn 15, Issue 23, 2009, Pages 5799-5813

  Matsuya, Yuji ^a   Kobayashi, Yuta ^a   Kawaguchi, Takanori ^a   Hori, Ayana ^a   Watanabe, Yuka ^a   Ishihara, Kentaro ^a   Ahmed, Kanwal ^a   Wei, Zheng Li ^a   Yu, Da Yong ^a   Zhao, Qing Li ^a   Kondo, Takashi ^a   Nemoto, Hideo ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Anticancer agents apoptosis; Epothilones macrosphelides; Metathesis

Indexed keywords

ANTICANCER AGENTS APOPTOSIS; APOPTOSIS; BIOLOGICAL EVALUATION; EPOTHILONE; EPOTHILONES MACROSPHELIDES; HYBRID COMPOUNDS; LYMPHOMA CELLS; MACRO-CYCLIZATION; METATHESIS; RING CLOSING METATHESIS; SIDE CHAINS; STRUCTURE ACTIVITY RELATIONSHIPS;

CELL DEATH; CYTOTOXICITY;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; EPOTHILONE DERIVATIVE; THIAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CYCLIZATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; EPOTHILONES; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 66249088013     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200802661     Document Type: Article

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