Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

Medicinal Research Reviews

Volumn 32, Issue 2, 2012, Pages 254-293

  Gerratana, Barbara ^a  

^a University of Maryland   (United States)

Author keywords

Anthramycin; Anticancer; Biosynthesis; DNA alkylation; DSB 120; Lincomycin; Pyrrolobenzodiazepines; Sibiromycin; SJG 136; Tomaymycin

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ABBEYMYCIN; ANTHRAMYCIN; ANTIBIOTIC AGENT; BENZODIAZEPINE DERIVATIVE; CHICAMYCIN A; CIRCUMDATIN; CIRCUMDATIN A; CIRCUMDATIN B; DNA; DNA BINDING PROTEIN; LIMAZEPINE; LIMAZEPINE A; LIMAZEPINE C; LIMAZEPINE E; LIMAZEPINE F; MAZETHRAMYCIN; METHIONINE; NEOTHRAMYCIN; NEOTHRAMYCIN A; NEOTHRAMYCIN B; OXOTOMAYMYCIN; POROTHRAMYCIN; PROTHRACARCIN; RK 1441 A; RK 1441 B; SIBANOMICIN; SIBIROMYCIN; TOMAYMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CYCLIZATION; CYTOTOXICITY; DNA ALKYLATION; DNA BINDING; DRUG DESIGN; DRUG DETERMINATION; DRUG ISOLATION; DRUG MECHANISM; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; GLYCOSYLATION; HUMAN; HYDROLYSIS; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MICROCOCCUS; NONHUMAN; PROTEIN METHYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STREPTOMYCES; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ACTINOBACTERIA; AMINOGLYCOSIDES; ANTHRAMYCIN; ANTINEOPLASTIC AGENTS, ALKYLATING; BENZODIAZEPINES; DNA; MODELS, MOLECULAR; MULTIGENE FAMILY; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857665235     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.20212     Document Type: Article

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