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Volumn 17, Issue 8, 2013, Pages 889-903

The promise of CaMKII inhibition for heart disease: Preventing heart failure and arrhythmias

Author keywords

Arrhythmia; CaMKII; Heart failure; Ischemia; Mitochondria

Indexed keywords

ALDOSTERONE ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IVABRADINE; KN 92; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PEPTIDE DERIVATIVE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84880393367     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.809064     Document Type: Review
Times cited : (22)

References (137)
  • 1
    • 3242744450 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
    • DOI 10.1016/j.cardiores.2004.04.026, PII S0008636304001981
    • Zhang T, Brown JH. Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc Res 2004;63:476-86 (Pubitemid 38970192)
    • (2004) Cardiovascular Research , vol.63 , Issue.3 , pp. 476-486
    • Zhang, T.1    Brown, J.H.2
  • 2
    • 77955039883 scopus 로고    scopus 로고
    • Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
    • Rellos P, Pike AC, Niesen FH, et al. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol 2010;8:e1000426
    • (2010) PLoS Biol , vol.8
    • Rellos, P.1    Pike, A.C.2    Niesen, F.H.3
  • 4
    • 0021807380 scopus 로고
    • 2+/calmodulin-dependent protein kinase
    • Kuret J, Schulman H. Mechanism of autophosphorylation of the multifunctional Ca2+/calmodulindependent protein kinase. J Biol Chem 1985;260:6427-33 (Pubitemid 15051783)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.10 , pp. 6427-6433
    • Kuret, J.1    Schulman, H.2
  • 5
    • 0026718175 scopus 로고
    • Calmodulin trapping by calcium-calmodulin-dependent protein kinase
    • Meyer T, Hanson PI, Stryer L, Schulman H. Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science 1992;256:1199-202
    • (1992) Science , vol.256 , pp. 1199-1202
    • Meyer, T.1    Hanson, P.I.2    Stryer, L.3    Schulman, H.4
  • 6
    • 79952772425 scopus 로고    scopus 로고
    • Reactive oxygen species-activated Ca/calmodulin kinase IIdelta is required for late I(Na) augmentation leading to cellular Na and Ca overload
    • Wagner S, Ruff HM, Weber SL, et al. Reactive oxygen species-activated Ca/calmodulin kinase IIdelta is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res 2011;108:555-65
    • (2011) Circ Res , vol.108 , pp. 555-565
    • Wagner, S.1    Ruff, H.M.2    Weber, S.L.3
  • 7
    • 0027340006 scopus 로고
    • 2+/calmodulin-dependent protein kinase II by basal autophosphorylation
    • Colbran RJ. Inactivation of Ca2+/calmodulin-dependent protein kinase II by basal autophosphorylation. J Biol Chem 1993;268:7163-70 (Pubitemid 23105606)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.10 , pp. 7163-7170
    • Colbran, R.J.1
  • 8
    • 77957838101 scopus 로고    scopus 로고
    • A beta (IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
    • Hund TJ, Koval OM, Li J, et al. A beta (IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest 2010;120:3508-19
    • (2010) J Clin Invest , vol.120 , pp. 3508-3519
    • Hund, T.J.1    Koval, O.M.2    Li, J.3
  • 9
    • 64249158777 scopus 로고    scopus 로고
    • Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes
    • El-Haou S, Balse E, Neyroud N, et al. Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circ Res 2009;104:758-69
    • (2009) Circ Res , vol.104 , pp. 758-769
    • El-Haou, S.1    Balse, E.2    Neyroud, N.3
  • 10
    • 49049108214 scopus 로고    scopus 로고
    • The role of calmodulin kinase II in myocardial physiology and disease
    • Couchonnal LF, Anderson ME. The role of calmodulin kinase II in myocardial physiology and disease. Physiology (Bethesda) 2008;23:151-9
    • (2008) Physiology (Bethesda) , vol.23 , pp. 151-159
    • Couchonnal, L.F.1    Anderson, M.E.2
  • 11
    • 84859756212 scopus 로고    scopus 로고
    • Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes predominant by Ca waves or Ca currents?
    • Zhao Z, Wen H, Fefelova N, et al. Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents? Am J Physiol Heart Circ Physiol 2012;302:H1636-44
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Zhao, Z.1    Wen, H.2    Fefelova, N.3
  • 13
    • 78049473869 scopus 로고    scopus 로고
    • Heart Rhythm 2010;7:1686-94
    • (2010) Heart Rhythm , vol.7 , pp. 1686-1694
  • 14
    • 78650125298 scopus 로고    scopus 로고
    • Early afterdepolarizations and cardiac arrhythmias
    • Weiss JN, Garfinkel A, Karagueuzian HS, et al. Early afterdepolarizations and cardiac arrhythmias. Heart Rhythm 2010;7:1891-9
    • (2010) Heart Rhythm , vol.7 , pp. 1891-1899
    • Weiss, J.N.1    Garfinkel, A.2    Karagueuzian, H.S.3
  • 16
    • 0026573866 scopus 로고
    • Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II
    • McCarron JG, McGeown JG, Reardon S, et al. Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II. Nature 1992;357:74-7
    • (1992) Nature , vol.357 , pp. 74-77
    • McCarron, J.G.1    McGeown, J.G.2    Reardon, S.3
  • 17
    • 0027966195 scopus 로고
    • Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase
    • Yuan W, Bers DM. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am J Physiol 1994;267:H982-93
    • (1994) Am J Physiol , vol.267
    • Yuan, W.1    Bers, D.M.2
  • 18
    • 0028171306 scopus 로고
    • Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes
    • Anderson ME, Braun AP, Schulman H, Premack BA. Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes. Circ Res 1994;75:854-61
    • (1994) Circ Res , Issue.75 , pp. 854-861
    • Anderson, M.E.1    Braun, A.P.2    Schulman, H.3    Premack, B.A.4
  • 19
    • 0033781028 scopus 로고    scopus 로고
    • Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
    • Dzhura I, Wu Y, Colbran RJ, et al. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat Cell Biol 2000;2:173-7
    • (2000) Nat Cell Biol , vol.2 , pp. 173-177
    • Dzhura, I.1    Wu, Y.2    Colbran, R.J.3
  • 20
    • 0025124412 scopus 로고
    • Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes
    • Yue DT, Herzig S, Marban E. Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes. Proc Natl Acad Sci USA 1990;87:753-7
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 753-757
    • Yue, D.T.1    Herzig, S.2    Marban, E.3
  • 21
    • 0021182780 scopus 로고
    • Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
    • Hess P, Lansman JB, Tsien RW. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 1984;311:538-44 (Pubitemid 14046377)
    • (1984) Nature , vol.311 , Issue.5986 , pp. 538-544
    • Hess, P.1    Lansman, J.B.2    Tsien, R.W.3
  • 22
  • 25
    • 77950419553 scopus 로고    scopus 로고
    • CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations
    • Koval OM, Guan X, Wu Y, et al. CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc Natl Acad Sci USA 2010;107:4996-5000
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4996-5000
    • Koval, O.M.1    Guan, X.2    Wu, Y.3
  • 26
    • 77953439656 scopus 로고    scopus 로고
    • Facilitation of murine cardiac L-type Ca (v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570
    • Blaich A, Welling A, Fischer S, et al. Facilitation of murine cardiac L-type Ca (v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570. Proc Natl Acad Sci USA 2010;107:10285-9
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10285-10289
    • Blaich, A.1    Welling, A.2    Fischer, S.3
  • 27
    • 79957832166 scopus 로고    scopus 로고
    • Ca2+-calmodulindependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation
    • Ronkainen JJ, Hanninen SL, Korhonen T, et al. Ca2+-calmodulindependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation. J Physiol 2011;589:2669-86
    • (2011) J Physiol , vol.589 , pp. 2669-2686
    • Ronkainen, J.J.1    Hanninen, S.L.2    Korhonen, T.3
  • 28
    • 33845296446 scopus 로고    scopus 로고
    • Altered cardiac myocyte Ca regulation in heart failure
    • DOI 10.1152/physiol.00019.2006
    • Bers DM. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda) 2006;21:380-7 (Pubitemid 44879246)
    • (2006) Physiology , vol.21 , Issue.6 , pp. 380-387
    • Bers, D.M.1
  • 29
    • 33745751387 scopus 로고    scopus 로고
    • Calmodulin kinase II accelerates L-type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2+]i in rat ventricular myocytes
    • Guo J, Duff HJ. Calmodulin kinase II accelerates L-type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2+]i in rat ventricular myocytes. J Physiol 2006;574:509-18
    • (2006) J Physiol , vol.574 , pp. 509-518
    • Guo, J.1    Duff, H.J.2
  • 31
    • 0038643573 scopus 로고    scopus 로고
    • c isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
    • DOI 10.1161/01.RES.0000069686.31472.C5
    • Zhang T, Maier LS, Dalton ND, et al. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res 2003;92:912-19 (Pubitemid 36542533)
    • (2003) Circulation Research , vol.92 , Issue.8 , pp. 912-919
    • Zhang, T.1    Maier, L.S.2    Dalton, N.D.3    Miyamoto, S.4    Ross Jr., J.5    Bers, D.M.6    Brown, J.H.7
  • 32
    • 74249092635 scopus 로고    scopus 로고
    • Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes
    • Aiba T, Hesketh GG, Liu T, et al. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res 2010;85:454-63
    • (2010) Cardiovasc Res , vol.85 , pp. 454-463
    • Aiba, T.1    Hesketh, G.G.2    Liu, T.3
  • 33
    • 69249202387 scopus 로고    scopus 로고
    • Constitutive CaMKII activity regulates Na+ channel in rat ventricular myocytes
    • Yoon JY, Ho WK, Kim ST, Cho H. Constitutive CaMKII activity regulates Na+ channel in rat ventricular myocytes. J Mol Cell Cardiol 2009;47:475-84
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 475-484
    • Yoon, J.Y.1    Ho, W.K.2    Kim, S.T.3    Cho, H.4
  • 34
    • 84867777430 scopus 로고    scopus 로고
    • CaMKII-based regulation of voltagegated Na+ channel in cardiac disease
    • Koval OM, Snyder JS, Wolf RM, et al. CaMKII-based regulation of voltagegated Na+ channel in cardiac disease. Circulation 2012;126:2084-94
    • (2012) Circulation , vol.126 , pp. 2084-2094
    • Koval, O.M.1    Snyder, J.S.2    Wolf, R.M.3
  • 35
    • 84862001882 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites
    • Ashpole NM, Herren AW, Ginsburg KS, et al. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J Biol Chem 2012;287:19856-69
    • (2012) J Biol Chem , vol.287 , pp. 19856-19869
    • Ashpole, N.M.1    Herren, A.W.2    Ginsburg, K.S.3
  • 36
    • 0034640093 scopus 로고    scopus 로고
    • Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel
    • Veldkamp MW, Viswanathan PC, Bezzina C, et al. Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel. Circ Res 2000;86:E91-7
    • (2000) Circ Res , vol.86
    • Veldkamp, M.W.1    Viswanathan, P.C.2    Bezzina, C.3
  • 37
    • 79957698604 scopus 로고    scopus 로고
    • Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation
    • Nerbonne JM. Repolarizing cardiac potassium channels: multiple sites and mechanisms for CaMKII-mediated regulation. Heart Rhythm 2011;8:938-41
    • (2011) Heart Rhythm , vol.8 , pp. 938-941
    • Nerbonne, J.M.1
  • 38
    • 33750915091 scopus 로고    scopus 로고
    • Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents
    • DOI 10.1161/01.RES.0000249369.71709.5c, PII 0000301220061110000011
    • Li J, Marionneau C, Zhang R, et al. Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res 2006;99:1092-9 (Pubitemid 44729933)
    • (2006) Circulation Research , vol.99 , Issue.10 , pp. 1092-1099
    • Li, J.1    Marionneau, C.2    Zhang, R.3    Shah, V.4    Hell, J.W.5    Nerbonne, J.M.6    Anderson, M.E.7
  • 39
    • 54449101791 scopus 로고    scopus 로고
    • Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes
    • Xiao L, Coutu P, Villeneuve LR, et al. Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res 2008;103:733-42
    • (2008) Circ Res , vol.103 , pp. 733-742
    • Xiao, L.1    Coutu, P.2    Villeneuve, L.R.3
  • 40
    • 70349471243 scopus 로고    scopus 로고
    • Ca/calmodulin kinase II differentially modulates potassium currents
    • Wagner S, Hacker E, Grandi E, et al. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol 2009;2:285-94
    • (2009) Circ Arrhythm Electrophysiol , vol.2 , pp. 285-294
    • Wagner, S.1    Hacker, E.2    Grandi, E.3
  • 41
    • 0033572668 scopus 로고    scopus 로고
    • + current diversity in mouse ventricular myocytes
    • Guo W, Xu H, London B, Nerbonne JM. Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol 1999;521 Pt 3:587-99 (Pubitemid 30042774)
    • (1999) Journal of Physiology , vol.521 , Issue.3 , pp. 587-599
    • Guo, W.1    Xu, H.2    London, B.3    Nerbonne, J.M.4
  • 46
    • 0029080486 scopus 로고
    • Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism
    • Lokuta AJ, Rogers TB, Lederer WJ, Valdivia HH. Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism. J Physiol 1995;487(Pt 3):609-22
    • (1995) J Physiol , vol.487 , Issue.PART 3 , pp. 609-622
    • Lokuta, A.J.1    Rogers, T.B.2    Lederer, W.J.3    Valdivia, H.H.4
  • 48
    • 3042763171 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor
    • Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res 2004;94:e61-70
    • (2004) Circ Res , vol.94
    • Wehrens, X.H.1    Lehnart, S.E.2    Reiken, S.R.3    Marks, A.R.4
  • 49
    • 33644865926 scopus 로고    scopus 로고
    • Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes
    • Kohlhaas M, Seidler T, Zibrova D, et al. Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res 2006;98:235-44
    • (2006) Circ Res , vol.98 , pp. 235-244
    • Kohlhaas, M.1    Seidler, T.2    Zibrova, D.3
  • 51
    • 33847058737 scopus 로고    scopus 로고
    • Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase
    • Curran J, Hinton MJ, Rios E, et al. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res 2007;100:391-8
    • (2007) Circ Res , vol.100 , pp. 391-398
    • Curran, J.1    Hinton, M.J.2    Rios, E.3
  • 52
    • 31444444347 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure
    • Ai X, Curran JW, Shannon TR, et al. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res 2005;97:1314-22
    • (2005) Circ Res , vol.97 , pp. 1314-1322
    • Ai, X.1    Curran, J.W.2    Shannon, T.R.3
  • 53
    • 78650701435 scopus 로고    scopus 로고
    • Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure
    • van Oort RJ, McCauley MD, Dixit SS, et al. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation 2010;122:2669-79
    • (2010) Circulation , vol.122 , pp. 2669-2679
    • Van Oort, R.J.1    McCauley, M.D.2    Dixit, S.S.3
  • 54
    • 84861591191 scopus 로고    scopus 로고
    • Role of RyR2 phosphorylation at S2814 during heart failure progression
    • Respress JL, van Oort RJ, Li N, et al. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res 2012;110:1474-83
    • (2012) Circ Res , vol.110 , pp. 1474-1483
    • Respress, J.L.1    Van Oort, R.J.2    Li, N.3
  • 55
    • 77953356086 scopus 로고    scopus 로고
    • Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II
    • Curran J, Brown KH, Santiago DJ, et al. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol 2010;49:25-32
    • (2010) J Mol Cell Cardiol , vol.49 , pp. 25-32
    • Curran, J.1    Brown, K.H.2    Santiago, D.J.3
  • 56
    • 0028172951 scopus 로고
    • Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca( 2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase
    • Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan DH. Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. J Biol Chem 1994;269:26492-6
    • (1994) J Biol Chem , Issue.269 , pp. 26492-26496
    • Toyofuku, T.1    Curotto Kurzydlowski, K.2    Narayanan, N.3    MacLennan, D.H.4
  • 57
    • 0029666260 scopus 로고    scopus 로고
    • The vmax of the Ca2 +-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin-dependent phosphorylation or by interaction with phospholamban
    • Odermatt A, Kurzydlowski K, MacLennan DH. The vmax of the Ca2 +-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin- dependent phosphorylation or by interaction with phospholamban. J Biol Chem 1996;271:14206-13
    • (1996) J Biol Chem , vol.271 , pp. 14206-14213
    • Odermatt, A.1    Kurzydlowski, K.2    MacLennan, D.H.3
  • 58
    • 80052740644 scopus 로고    scopus 로고
    • CaMKIIdeltaB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart
    • Lu YM, Huang J, Shioda N, et al. CaMKIIdeltaB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart. PLoS One 2011;6:e24724
    • (2011) PLoS One , vol.6
    • Lu, Y.M.1    Huang, J.2    Shioda, N.3
  • 59
    • 74149093364 scopus 로고    scopus 로고
    • Beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes
    • Mani SK, Egan EA, Addy BK, et al. Beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol 2010;48:342-51
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 342-351
    • Mani, S.K.1    Egan, E.A.2    Addy, B.K.3
  • 61
    • 74249087588 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure
    • Sag CM, Wadsack DP, Khabbazzadeh S, et al. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail 2009;2:664-75
    • (2009) Circ Heart Fail , vol.2 , pp. 664-675
    • Sag, C.M.1    Wadsack, D.P.2    Khabbazzadeh, S.3
  • 63
    • 79958084460 scopus 로고    scopus 로고
    • Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm
    • Tsuji Y, Hojo M, Voigt N, et al. Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation 2011;123:2192-203
    • (2011) Circulation , vol.123 , pp. 2192-2203
    • Tsuji, Y.1    Hojo, M.2    Voigt, N.3
  • 64
    • 70349446744 scopus 로고    scopus 로고
    • The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    • Qi X, Yeh YH, Chartier D, et al. The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome. Circ Arrhythm Electrophysiol 2009;2:295-304
    • (2009) Circ Arrhythm Electrophysiol , vol.2 , pp. 295-304
    • Qi, X.1    Yeh, Y.H.2    Chartier, D.3
  • 65
    • 84867870977 scopus 로고    scopus 로고
    • Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog
    • Bourgonje VJ, Schoenmakers M, Beekman JD, et al. Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart Rhythm 2012;9:1875-83
    • (2012) Heart Rhythm , vol.9 , pp. 1875-1883
    • Bourgonje, V.J.1    Schoenmakers, M.2    Beekman, J.D.3
  • 66
    • 77949641112 scopus 로고    scopus 로고
    • CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation
    • Neef S, Dybkova N, Sossalla S, et al. CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res 2010;106:1134-44
    • (2010) Circ Res , vol.106 , pp. 1134-1144
    • Neef, S.1    Dybkova, N.2    Sossalla, S.3
  • 67
    • 84856693079 scopus 로고    scopus 로고
    • Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice
    • Li N, Wang T, Wang W, et al. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res 2012;110:465-70
    • (2012) Circ Res , vol.110 , pp. 465-470
    • Li, N.1    Wang, T.2    Wang, W.3
  • 68
    • 68849092129 scopus 로고    scopus 로고
    • Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice
    • Chelu MG, Sarma S, Sood S, et al. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest 2009;119:1940-51
    • (2009) J Clin Invest , vol.119 , pp. 1940-1951
    • Chelu, M.G.1    Sarma, S.2    Sood, S.3
  • 69
    • 84860338741 scopus 로고    scopus 로고
    • Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation
    • Voigt N, Li N, Wang Q, et al. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation 2012;125:2059-70
    • (2012) Circulation , vol.125 , pp. 2059-2070
    • Voigt, N.1    Li, N.2    Wang, Q.3
  • 70
    • 78650819612 scopus 로고    scopus 로고
    • Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia
    • Liu N, Ruan Y, Denegri M, et al. Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia. J Mol Cell Cardiol 2011;50:214-22
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 214-222
    • Liu, N.1    Ruan, Y.2    Denegri, M.3
  • 71
    • 84870440232 scopus 로고    scopus 로고
    • CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome
    • Degrande S, Nixon D, Koval O, et al. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm 2012;9:2034-41
    • (2012) Heart Rhythm , vol.9 , pp. 2034-2041
    • Degrande, S.1    Nixon, D.2    Koval, O.3
  • 72
    • 57749181755 scopus 로고    scopus 로고
    • Proarrhythmic defects in Timothy syndrome require calmodulin kinase II
    • Thiel WH, Chen B, Hund TJ, et al. Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation 2008;118:2225-34
    • (2008) Circulation , vol.118 , pp. 2225-2234
    • Thiel, W.H.1    Chen, B.2    Hund, T.J.3
  • 73
    • 33646028247 scopus 로고    scopus 로고
    • Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart
    • Valverde CA, Mundina-Weilenmann C, Reyes M, et al. Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart. Cardiovasc Res 2006;70:335-45
    • (2006) Cardiovasc Res , vol.70 , pp. 335-345
    • Valverde, C.A.1    Mundina-Weilenmann, C.2    Reyes, M.3
  • 74
    • 0033515617 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium
    • Hoch B, Meyer R, Hetzer R, et al. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res 1999;84:713-21 (Pubitemid 29157339)
    • (1999) Circulation Research , vol.84 , Issue.6 , pp. 713-721
    • Hoch, B.1    Meyer, R.2    Hetzer, R.3    Krause, E.-G.4    Karczewski, P.5
  • 75
    • 84868629814 scopus 로고    scopus 로고
    • CaMKII determines mitochondrial stress responses in heart
    • Joiner ML, Koval OM, Li J, et al. CaMKII determines mitochondrial stress responses in heart. Nature 2012;491:269-73
    • (2012) Nature , vol.491 , pp. 269-273
    • Joiner, M.L.1    Koval, O.M.2    Li, J.3
  • 77
    • 77952669275 scopus 로고    scopus 로고
    • The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury
    • Salas MA, Valverde CA, Sanchez G, et al. The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury. J Mol Cell Cardiol 2010;48:1298-306
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 1298-1306
    • Ma, S.1    Valverde, C.A.2    Sanchez, G.3
  • 78
    • 77956385759 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy
    • Toko H, Takahashi H, Kayama Y, et al. Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation 2010;122:891-9
    • (2010) Circulation , vol.122 , pp. 891-899
    • Toko, H.1    Takahashi, H.2    Kayama, Y.3
  • 79
    • 65249154058 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart
    • Singh MV, Kapoun A, Higgins L, et al. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest 2009;119:986-96
    • (2009) J Clin Invest , vol.119 , pp. 986-996
    • Singh, M.V.1    Kapoun, A.2    Higgins, L.3
  • 80
    • 84875224962 scopus 로고    scopus 로고
    • Ca2+/Calmodulin-dependent protein kinase II delta mediates myocardial ischemia/reperfusion injury through nuclear factor-kappaB
    • Ling H, Gray CB, Zambon AC, et al. Ca2+/Calmodulin-dependent protein kinase II delta mediates myocardial ischemia/reperfusion injury through nuclear factor-kappaB. Circ Res 2013;112:935-44
    • (2013) Circ Res , Issue.112 , pp. 935-944
    • Ling, H.1    Gray, C.B.2    Zambon, A.C.3
  • 82
    • 84856100794 scopus 로고    scopus 로고
    • Oxidation of CaMKII determines the cardiotoxic effects of aldosterone
    • He BJ, Joiner ML, Singh MV, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med 2011;17:1610-18
    • (2011) Nat Med , vol.17 , pp. 1610-1618
    • He, B.J.1    Joiner, M.L.2    Singh, M.V.3
  • 83
    • 0016746520 scopus 로고
    • Precursors of sudden coronary death Factors related to the incidence of sudden death
    • Kannel WB, Doyle JT, McNamara PM, et al. Precursors of sudden coronary death. Factors related to the incidence of sudden death. Circulation 1975;51:606-13
    • (1975) Circulation , vol.51 , pp. 606-613
    • Kannel, W.B.1    Doyle, J.T.2    McNamara, P.M.3
  • 84
    • 0002537440 scopus 로고    scopus 로고
    • Cardiac Hypertrophy: The Good, the Bad, and the Ugly
    • DOI 10.1146/annurev.physiol.65.092101.142243
    • Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 2003;65:45-79 (Pubitemid 38249147)
    • (2003) Annual Review of Physiology , vol.65 , pp. 45-79
    • Frey, N.1    Olson, E.N.2
  • 85
    • 78751647632 scopus 로고    scopus 로고
    • Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling
    • Mishra S, Ling H, Grimm M, et al. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J Cardiovasc Pharmacol 2010;56:598-603
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 598-603
    • Mishra, S.1    Ling, H.2    Grimm, M.3
  • 93
    • 0344874709 scopus 로고    scopus 로고
    • 7 receptors to activation of extracellular-regulated kinase through a protein kinase A-independent pathway that can utilize Epac
    • DOI 10.1046/j.1471-4159.2003.02076.x
    • Lin SL, Johnson-Farley NN, Lubinsky DR, Cowen DS. Coupling of neuronal 5-HT7 receptors to activation of extracellular-regulated kinase through a protein kinase A-independent pathway that can utilize Epac. J Neurochem 2003;87:1076-85 (Pubitemid 37485065)
    • (2003) Journal of Neurochemistry , vol.87 , Issue.5 , pp. 1076-1085
    • Lin, S.L.1    Johnson-Farley, N.N.2    Lubinsky, D.R.3    Cowen, D.S.4
  • 94
    • 0030609163 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes
    • DOI 10.1074/jbc.272.49.31203
    • Ramirez MT, Zhao XL, Schulman H, Brown JH. The nuclear deltaB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes. J Biol Chem 1997;272:31203-8 (Pubitemid 27527572)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.49 , pp. 31203-31208
    • Teresa Ramirez, M.1    Zhao, X.-L.2    Schulman, H.3    Brown, J.H.4
  • 97
    • 33745812011 scopus 로고    scopus 로고
    • CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    • DOI 10.1172/JCI27438
    • Backs J, Song K, Bezprozvannaya S, et al. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest 2006;116:1853-64 (Pubitemid 44033310)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1853-1864
    • Backs, J.1    Song, K.2    Bezprozvannaya, S.3    Chang, S.4    Olson, E.N.5
  • 98
    • 66449097490 scopus 로고    scopus 로고
    • Requirement for Ca2+/calmodulindependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice
    • Ling H, Zhang T, Pereira L, et al. Requirement for Ca2+/ calmodulindependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest 2009;119:1230-40
    • (2009) J Clin Invest , vol.119 , pp. 1230-1240
    • Ling, H.1    Zhang, T.2    Pereira, L.3
  • 99
    • 79960841637 scopus 로고    scopus 로고
    • Crossing signals: Relationships between beta-adrenergic stimulation and CaMKII activation
    • Grimm M, Ling H, Brown JH. Crossing signals: relationships between beta-adrenergic stimulation and CaMKII activation. Heart Rhythm 2011;8:1296-8
    • (2011) Heart Rhythm , vol.8 , pp. 1296-1298
    • Grimm, M.1    Ling, H.2    Brown, J.H.3
  • 100
    • 60549085044 scopus 로고    scopus 로고
    • The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
    • Backs J, Backs T, Neef S, et al. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci USA 2009;106:2342-7
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2342-2347
    • Backs, J.1    Backs, T.2    Neef, S.3
  • 101
    • 79952794188 scopus 로고    scopus 로고
    • Lifetime costs of medical care after heart failure diagnosis
    • Dunlay SM, Shah ND, Shi Q, et al. Lifetime costs of medical care after heart failure diagnosis. Circ Cardiovasc Qual Outcomes 2011;4:68-75
    • (2011) Circ Cardiovasc Qual Outcomes , vol.4 , pp. 68-75
    • Dunlay, S.M.1    Shah, N.D.2    Shi, Q.3
  • 102
    • 33745198418 scopus 로고    scopus 로고
    • Redox regulation of cardiac calcium channels and transporters
    • Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 2006;71:310-21
    • (2006) Cardiovasc Res , vol.71 , pp. 310-321
    • Zima, A.V.1    Blatter, L.A.2
  • 103
    • 0037049977 scopus 로고    scopus 로고
    • Cardiac excitation-contraction coupling
    • DOI 10.1038/415198a
    • Bers DM. Cardiac excitation-contraction coupling. Nature 2002;415:198-205 (Pubitemid 34059525)
    • (2002) Nature , vol.415 , Issue.6868 , pp. 198-205
    • Bers, D.M.1
  • 105
    • 79955451727 scopus 로고    scopus 로고
    • CaMKII regulation of phospholamban and SR Ca2+ load
    • Mattiazzi A, Kranias EG. CaMKII regulation of phospholamban and SR Ca2+ load. Heart Rhythm 2011;8:784-7
    • (2011) Heart Rhythm , vol.8 , pp. 784-787
    • Mattiazzi, A.1    Kranias, E.G.2
  • 107
    • 33846858884 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart
    • DOI 10.1016/j.cardiores.2006.11.005, PII S0008636306004937
    • Maier LS, Bers DM. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res 2007;73:631-40 (Pubitemid 46227343)
    • (2007) Cardiovascular Research , vol.73 , Issue.4 , pp. 631-640
    • Maier, L.S.1    Bers, D.M.2
  • 108
    • 76349084460 scopus 로고    scopus 로고
    • Phospholamban ablation rescues sarcoplasmic reticulum Ca( 2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice
    • Zhang T, Guo T, Mishra S, et al. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res 2010;106:354-62
    • (2010) Circ Res , Issue.106 , pp. 354-362
    • Zhang, T.1    Guo, T.2    Mishra, S.3
  • 109
    • 79251558128 scopus 로고    scopus 로고
    • CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release
    • Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm 2011;8:323-5
    • (2011) Heart Rhythm , vol.8 , pp. 323-325
    • Wehrens, X.H.1
  • 110
    • 77953418093 scopus 로고    scopus 로고
    • Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure
    • Kushnir A, Shan J, Betzenhauser MJ, et al. Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci USA 2010;107:10274-9
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10274-10279
    • Kushnir, A.1    Shan, J.2    Betzenhauser, M.J.3
  • 111
    • 84894892983 scopus 로고    scopus 로고
    • Abstract 18574: Mitochondrial Reprogramming by Camkii{delta} Underlies Gq-induced Cardiomyopathy
    • Westenbrink BD, Ling H, Miyamoto S, et al. Abstract 18574: mitochondrial Reprogramming By Camkii{delta} Underlies Gq-induced Cardiomyopathy. Circulation 2012;126:A18574
    • (2012) Circulation , vol.126
    • Westenbrink, B.D.1    Ling, H.2    Miyamoto, S.3
  • 112
    • 84862296973 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase II: Linking heart failure and arrhythmias
    • Swaminathan PD, Purohit A, Hund TJ, Anderson ME. Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res 2012;110:1661-77
    • (2012) Circ Res , vol.110 , pp. 1661-1677
    • Swaminathan, P.D.1    Purohit, A.2    Hund, T.J.3    Anderson, M.E.4
  • 113
    • 84861657926 scopus 로고    scopus 로고
    • How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project
    • Noble D, Garny A, Noble PJ. How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project. J Physiol 2012;590:2613-28
    • (2012) J Physiol , vol.590 , pp. 2613-2628
    • Noble, D.1    Garny, A.2    Noble, P.J.3
  • 115
    • 2442587536 scopus 로고    scopus 로고
    • Mechanistic systems models of cell signaling networks: A case study of myocyte adrenergic regulation
    • DOI 10.1016/j.pbiomolbio.2004.01.005, PII S0079610704000161
    • Saucerman JJ, McCulloch AD. Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Prog Biophys Mol Biol 2004;85:261-78 (Pubitemid 38629912)
    • (2004) Progress in Biophysics and Molecular Biology , vol.85 , Issue.2-3 , pp. 261-278
    • Saucerman, J.J.1    McCulloch, A.D.2
  • 116
    • 10644295566 scopus 로고    scopus 로고
    • Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: Computational models of whole cells and heterogeneous tissue
    • DOI 10.1161/01.RES.0000150055.06226.4e
    • Saucerman JJ, Healy SN, Belik ME, et al. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circ Res 2004;95:1216-24 (Pubitemid 39648213)
    • (2004) Circulation Research , vol.95 , Issue.12 , pp. 1216-1224
    • Saucerman, J.J.1    Healy, S.N.2    Belik, M.E.3    Puglisi, J.L.4    McCulloch, A.D.5
  • 118
    • 58149280497 scopus 로고    scopus 로고
    • Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes
    • Saucerman JJ, Bers DM. Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J 2008;95:4597-612
    • (2008) Biophys J , vol.95 , pp. 4597-4612
    • Saucerman, J.J.1    Bers, D.M.2
  • 119
    • 77956191808 scopus 로고    scopus 로고
    • Role of CaMKII in RyR leak, EC coupling and action potential duration: A computational model
    • Hashambhoy YL, Greenstein JL, Winslow RL. Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model. J Mol Cell Cardiol 2010;49:617-24
    • (2010) J Mol Cell Cardiol , vol.49 , pp. 617-624
    • Hashambhoy, Y.L.1    Greenstein, J.L.2    Winslow, R.L.3
  • 120
    • 77958154955 scopus 로고    scopus 로고
    • Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling
    • Soltis AR, Saucerman JJ. Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling. Biophys J 2010;99:2038-47
    • (2010) Biophys J , vol.99 , pp. 2038-2047
    • Soltis, A.R.1    Saucerman, J.J.2
  • 121
    • 79953691401 scopus 로고    scopus 로고
    • Local control of beta-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient
    • Heijman J, Volders PG, Westra RL, Rudy Y. Local control of beta-adrenergic stimulation: effects on ventricular myocyte electrophysiology and Ca(2+)-transient. J Mol Cell Cardiol 2011;50:863-71
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 863-871
    • Heijman, J.1    Volders, P.G.2    Westra, R.L.3    Rudy, Y.4
  • 122
    • 84871284029 scopus 로고    scopus 로고
    • Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling
    • Ryall KA, Holland DO, Delaney KA, et al. Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling. J Biol Chem 2012;287:42259-68
    • (2012) J Biol Chem , vol.287 , pp. 42259-42268
    • Ryall, K.A.1    Holland, D.O.2    Delaney, K.A.3
  • 123
    • 15244345086 scopus 로고    scopus 로고
    • Calmodulin kinase signaling in heart: An intriguing candidate target for therapy of myocardial dysfunction and arrhythmias
    • DOI 10.1016/j.pharmthera.2004.11.002
    • Anderson ME. Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias. Pharmacol Ther 2005;106:39-55 (Pubitemid 40386719)
    • (2005) Pharmacology and Therapeutics , vol.106 , Issue.1 , pp. 39-55
    • Anderson, M.E.1
  • 124
    • 80051981571 scopus 로고    scopus 로고
    • Cardiac calmodulin kinase: A potential target for drug design
    • Banyasz T, Szentandrassy N, Toth A, et al. Cardiac calmodulin kinase: a potential target for drug design. Curr Med Chem 2011;18:3707-13
    • (2011) Curr Med Chem , vol.18 , pp. 3707-3713
    • Banyasz, T.1    Szentandrassy, N.2    Toth, A.3
  • 125
    • 0026507736 scopus 로고
    • The Cardiac Arrhythmia Suppression Trial: First CAST. then CAST-II
    • Greene HL, Roden DM, Katz RJ, et al. The Cardiac Arrhythmia Suppression Trial: first CAST. then CAST-II. J Am Coll Cardiol 1992;19:894-8
    • (1992) J Am Coll Cardiol , vol.19 , pp. 894-898
    • Greene, H.L.1    Roden, D.M.2    Katz, R.J.3
  • 126
    • 84864477617 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
    • McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012;14:803-69
    • (2012) Eur J Heart Fail , vol.14 , pp. 803-869
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3
  • 127
    • 84874607556 scopus 로고    scopus 로고
    • Diabetes increases mortality after myocardial infarction by oxidizing CaMKII
    • Luo M, Guan X, Luczak ED, et al. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest 2013;123:1262-74
    • (2013) J Clin Invest , Issue.123 , pp. 1262-1274
    • Luo, M.1    Guan, X.2    Luczak, E.D.3
  • 128
    • 79961015131 scopus 로고    scopus 로고
    • Oxidized CaMKII causes cardiac sinus node dysfunction in mice
    • Swaminathan PD, Purohit A, Soni S, et al. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest 2011;121:3277-88
    • (2011) J Clin Invest , vol.121 , pp. 3277-3288
    • Swaminathan, P.D.1    Purohit, A.2    Soni, S.3
  • 129
    • 84874256463 scopus 로고    scopus 로고
    • Crucial role for Ca2(+)/calmodulindependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation
    • Hamdani N, Krysiak J, Kreusser MM, et al. Crucial role for Ca2(+)/calmodulindependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ Res 2013;112:664-74
    • (2013) Circ Res , vol.112 , pp. 664-674
    • Hamdani, N.1    Krysiak, J.2    Kreusser, M.M.3
  • 130
    • 78349303787 scopus 로고    scopus 로고
    • Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium
    • Sossalla S, Fluschnik N, Schotola H, et al. Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res 2010;107:1150-61
    • (2010) Circ Res , vol.107 , pp. 1150-1161
    • Sossalla, S.1    Fluschnik, N.2    Schotola, H.3
  • 131
    • 77649275550 scopus 로고    scopus 로고
    • L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes
    • Song YH, Cho H, Ryu SY, et al. L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes. J Mol Cell Cardiol 2010;48:773-80
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 773-780
    • Song, Y.H.1    Cho, H.2    Ryu, S.Y.3
  • 132
    • 33645120204 scopus 로고    scopus 로고
    • KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4- chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels
    • Rezazadeh S, Claydon TW, Fedida D. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4- methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J Pharmacol Exp Ther 2006;317:292-9
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 292-299
    • Rezazadeh, S.1    Claydon, T.W.2    Fedida, D.3
  • 133
    • 0026345859 scopus 로고
    • The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
    • Sumi M, Kiuchi K, Ishikawa T, et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun 1991;181:968-75
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 968-975
    • Sumi, M.1    Kiuchi, K.2    Ishikawa, T.3
  • 135
    • 74049097964 scopus 로고    scopus 로고
    • Circ Res 2010;106:102-10
    • (2010) Circ Res , vol.106 , pp. 102-110
  • 136
    • 84856087553 scopus 로고    scopus 로고
    • Location matters: Clarifying the concept of nuclear and cytosolic CaMKII subtypes
    • Mishra S, Gray CB, Miyamoto S, et al. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res 2011;109:1354-62
    • (2011) Circ Res , vol.109 , pp. 1354-1362
    • Mishra, S.1    Gray, C.B.2    Miyamoto, S.3
  • 137
    • 84894893470 scopus 로고    scopus 로고
    • Abstract 18536: CaMKII-{delta} splice variants exert differential effects on heart failure development and myocardial ischemia/reperfusion injury
    • Westenbrink BD, Gray CB, Xiang S, et al. Abstract 18536: CaMKII-{delta} splice variants exert differential effects on heart failure development and myocardial ischemia/reperfusion injury. Circulation 2012;126:A18536
    • (2012) Circulation , vol.126
    • Westenbrink, B.D.1    Gray, C.B.2    Xiang, S.3


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