메뉴 건너뛰기




Volumn 116, Issue 7, 2006, Pages 1853-1864

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 4; PROTEIN KINASE (CALCIUM,CALMODULIN) II; UNCLASSIFIED DRUG;

EID: 33745812011     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI27438     Document Type: Article
Times cited : (431)

References (50)
  • 2
    • 0036008097 scopus 로고    scopus 로고
    • Deacetylase enzymes: Biological functions and the use of small-molecule inhibitors
    • Grozinger, C.M., and Schreiber, S.L. 2002. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem. Biol. 9:3-16.
    • (2002) Chem. Biol. , vol.9 , pp. 3-16
    • Grozinger, C.M.1    Schreiber, S.L.2
  • 3
    • 33644837326 scopus 로고    scopus 로고
    • Control of cardiac growth by histone acetylation/deacetylation
    • Backs, J., and Olson, E.N. 2006. Control of cardiac growth by histone acetylation/deacetylation. Circ. Res. 98:15-24.
    • (2006) Circ. Res. , vol.98 , pp. 15-24
    • Backs, J.1    Olson, E.N.2
  • 4
    • 0037406061 scopus 로고    scopus 로고
    • Class II histone deacetylases: Versatile regulators
    • Verdin, E., Dequiedt, F., and Kasler, H.G. 2003. Class II histone deacetylases: versatile regulators. Trends Genet. 19:286-293.
    • (2003) Trends Genet. , vol.19 , pp. 286-293
    • Verdin, E.1    Dequiedt, F.2    Kasler, H.G.3
  • 5
    • 0034608955 scopus 로고    scopus 로고
    • Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
    • Grozinger, C.M., and Schreiber, S.L. 2000. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl. Acad. Sci. U. S. A. 97:7835-7840.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 7835-7840
    • Grozinger, C.M.1    Schreiber, S.L.2
  • 6
    • 0034597816 scopus 로고    scopus 로고
    • Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    • McKinsey, T.A., Zhang, C.L., Lu, J., and Olson, E.N. 2000. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 408:106-111.
    • (2000) Nature , vol.408 , pp. 106-111
    • McKinsey, T.A.1    Zhang, C.L.2    Lu, J.3    Olson, E.N.4
  • 7
    • 0035724044 scopus 로고    scopus 로고
    • Identification of a signal-responsive nuclear export sequence in class II histone deacetylases
    • McKinsey, T.A., Zhang, C.L., and Olson, E.N. 2001. Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. Mol. Cell. Biol. 21:6312-6321.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6312-6321
    • McKinsey, T.A.1    Zhang, C.L.2    Olson, E.N.3
  • 8
    • 0028279115 scopus 로고
    • Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
    • Edmondson, D.G., Lyons, G.E., Martin, J.F., and Olson, E.N. 1994. Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development. 120:1251-1263.
    • (1994) Development , vol.120 , pp. 1251-1263
    • Edmondson, D.G.1    Lyons, G.E.2    Martin, J.F.3    Olson, E.N.4
  • 9
    • 19244386873 scopus 로고    scopus 로고
    • CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
    • Passier, R., et al. 2000. CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. J. Clin. Invest. 105:1395-1406.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1395-1406
    • Passier, R.1
  • 10
    • 0033010960 scopus 로고    scopus 로고
    • Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene
    • Naya, F.J., Wu, C., Richardson, J.A., Overbeek, P., and Olson, E.N. 1999. Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. Development. 126:2045-2052.
    • (1999) Development , vol.126 , pp. 2045-2052
    • Naya, F.J.1    Wu, C.2    Richardson, J.A.3    Overbeek, P.4    Olson, E.N.5
  • 11
    • 0033568028 scopus 로고    scopus 로고
    • HDAC4 deacetylase associates with and represses the MEF2 transcription factor
    • Miska, E.A., et al. 1999. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 18:5099-5107.
    • (1999) EMBO J. , vol.18 , pp. 5099-5107
    • Miska, E.A.1
  • 12
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • Zhang, C.L., et al. 2002. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 110:479-488.
    • (2002) Cell , vol.110 , pp. 479-488
    • Zhang, C.L.1
  • 13
    • 4544358659 scopus 로고    scopus 로고
    • Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
    • Chang, S., et al. 2004. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol. Cell. Biol. 24:8467-8476.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8467-8476
    • Chang, S.1
  • 14
    • 8344261349 scopus 로고    scopus 로고
    • Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    • Vega, R.B., et al. 2004. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 119:555-566.
    • (2004) Cell , vol.119 , pp. 555-566
    • Vega, R.B.1
  • 15
    • 0034687741 scopus 로고    scopus 로고
    • Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
    • McKinsey, T.A., Zhang, C.L., and Olson, E.N. 2000. Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc. Natl. Acad. Sci. U. S. A. 97:14400-14405.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 14400-14405
    • McKinsey, T.A.1    Zhang, C.L.2    Olson, E.N.3
  • 16
    • 4544315655 scopus 로고    scopus 로고
    • Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5
    • Vega, R.B., et al. 2004. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol. Cell. Biol. 24:8374-8385.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8374-8385
    • Vega, R.B.1
  • 17
    • 15444375044 scopus 로고    scopus 로고
    • Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis
    • Dequiedt, F., et al. 2005. Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J. Exp. Med. 201:793-804.
    • (2005) J. Exp. Med. , vol.201 , pp. 793-804
    • Dequiedt, F.1
  • 18
    • 33646161306 scopus 로고    scopus 로고
    • Regulation of cardiac stress signaling by protein kinase d1
    • Harrison, B.C., et al. 2006. Regulation of cardiac stress signaling by protein kinase d1. Mol. Cell. Biol. 26:3875-3888.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3875-3888
    • Harrison, B.C.1
  • 19
    • 0037805720 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy
    • Davis, F.J., Gupta, M., Camoretti-Mercado, B., Schwartz, R.J., and Gupta, M.P. 2003. Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy. J. Biol. Chem. 278:20047-20058.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20047-20058
    • Davis, F.J.1    Gupta, M.2    Camoretti-Mercado, B.3    Schwartz, R.J.4    Gupta, M.P.5
  • 20
    • 0035860735 scopus 로고    scopus 로고
    • The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking
    • Zhao, X., et al. 2001. The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J. Biol. Chem. 276:35042-35048.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35042-35048
    • Zhao, X.1
  • 21
    • 15444378007 scopus 로고    scopus 로고
    • Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle
    • Liu, Y., Randall, W.R., and Schneider, M.F. 2005. Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle. J. Cell Biol. 168:887-897.
    • (2005) J. Cell. Biol. , vol.168 , pp. 887-897
    • Liu, Y.1    Randall, W.R.2    Schneider, M.F.3
  • 22
    • 26844518082 scopus 로고    scopus 로고
    • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death
    • Bolger, T.A., and Yao, T.P. 2005. Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J. Neurosci. 25:9544-9553.
    • (2005) J. Neurosci. , vol.25 , pp. 9544-9553
    • Bolger, T.A.1    Yao, T.P.2
  • 23
    • 0028085454 scopus 로고
    • Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus
    • Srinivasan, M., Edman, C.F., and Schulman, H. 1994. Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus. J. Cell Biol. 126:839-852.
    • (1994) J. Cell. Biol. , vol.126 , pp. 839-852
    • Srinivasan, M.1    Edman, C.F.2    Schulman, H.3
  • 24
    • 0032584671 scopus 로고    scopus 로고
    • Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting
    • Heist, E.K., Srinivasan, M., and Schulman, H. 1998. Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting. J. Biol. Chem. 273:19763-19771.
    • (1998) J. Biol. Chem. , vol.273 , pp. 19763-19771
    • Heist, E.K.1    Srinivasan, M.2    Schulman, H.3
  • 25
    • 20444420893 scopus 로고    scopus 로고
    • An expression screen reveals modulators of class II histone deacetylase phosphorylation
    • Chang, S., Bezprozvannaya, S., Li, S., and Olson, E.N. 2005. An expression screen reveals modulators of class II histone deacetylase phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 102:8120-8125.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 8120-8125
    • Chang, S.1    Bezprozvannaya, S.2    Li, S.3    Olson, E.N.4
  • 26
    • 0031596835 scopus 로고    scopus 로고
    • The role of Ca2+/calmodulin-dependent protein kinases within the nucleus
    • Heist, E.K., and Schulman, H. 1998. The role of Ca2+/calmodulin-dependent protein kinases within the nucleus. Cell Calcium. 23:103-114.
    • (1998) Cell Calcium , vol.23 , pp. 103-114
    • Heist, E.K.1    Schulman, H.2
  • 27
    • 0036702526 scopus 로고    scopus 로고
    • Calcium, calmodulin, and calcium-calmodulin kinase II: Heartbeat to heartbeat and beyond
    • Maier, L.S., and Bers, D.M. 2002. Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J. Mol. Cell. Cardiol. 34:919-939.
    • (2002) J. Mol. Cell. Cardiol. , vol.34 , pp. 919-939
    • Maier, L.S.1    Bers, D.M.2
  • 28
    • 33644641253 scopus 로고    scopus 로고
    • Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitationtranscription coupling
    • doi:10.1172/JCI27374
    • Wu, X., et al. 2006. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitationtranscription coupling. J. Clin. Invest. 116:675-682. doi:10.1172/JCI27374.
    • (2006) J. Clin. Invest. , vol.116 , pp. 675-682
    • Wu, X.1
  • 29
    • 19944427655 scopus 로고    scopus 로고
    • ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle
    • Xu, X., et al. 2005. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell. 120:59-72.
    • (2005) Cell , vol.120 , pp. 59-72
    • Xu, X.1
  • 30
    • 0037315106 scopus 로고    scopus 로고
    • Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo
    • Colomer, J.M., Mao, L., Rockman, H.A., and Means, A.R. 2003. Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Mol. Endocrinol. 17:183-192.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 183-192
    • Colomer, J.M.1    Mao, L.2    Rockman, H.A.3    Means, A.R.4
  • 31
    • 0037097022 scopus 로고    scopus 로고
    • Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
    • Hudmon, A., and Schulman, H. 2002. Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem. J. 364:593-611.
    • (2002) Biochem. J. , vol.364 , pp. 593-611
    • Hudmon, A.1    Schulman, H.2
  • 32
    • 0345303850 scopus 로고    scopus 로고
    • Organization and evolution of multifunctional Ca(2+)/CaM-dependent protein kinase genes
    • Tombes, R.M., Faison, M.O., and Turbeville, J.M. 2003. Organization and evolution of multifunctional Ca(2+)/CaM-dependent protein kinase genes. Gene. 322:17-31.
    • (2003) Gene , vol.322 , pp. 17-31
    • Tombes, R.M.1    Faison, M.O.2    Turbeville, J.M.3
  • 34
    • 0032185669 scopus 로고    scopus 로고
    • KAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle
    • Bayer, K.U., Harbers, K., and Schulman, H. 1998. alphaKAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle. EMBO J. 17:5598-5605.
    • (1998) EMBO J. , vol.17 , pp. 5598-5605
    • Bayer, K.U.1    Harbers, K.2    Schulman, H.3
  • 35
    • 2242425422 scopus 로고    scopus 로고
    • Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin
    • Leonard, A.S., et al. 2002. Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin. J. Biol. Chem. 277:48441-48448.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48441-48448
    • Leonard, A.S.1
  • 36
    • 3242744450 scopus 로고    scopus 로고
    • Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
    • Zhang, T., and Brown, J.H. 2004. Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc. Res. 63:476-486.
    • (2004) Cardiovasc. Res. , vol.63 , pp. 476-486
    • Zhang, T.1    Brown, J.H.2
  • 37
    • 0033515617 scopus 로고    scopus 로고
    • Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium
    • Hoch, B., Meyer, R., Hetzer, R., Krause, E.G., and Karczewski, P. 1999. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ. Res. 84:713-721.
    • (1999) Circ. Res. , vol.84 , pp. 713-721
    • Hoch, B.1    Meyer, R.2    Hetzer, R.3    Krause, E.G.4    Karczewski, P.5
  • 38
    • 20244362095 scopus 로고    scopus 로고
    • Calmodulin kinase II inhibition protects against structural heart disease
    • Zhang, R., et al. 2005. Calmodulin kinase II inhibition protects against structural heart disease. Nat. Med. 11:409-417.
    • (2005) Nat. Med. , vol.11 , pp. 409-417
    • Zhang, R.1
  • 39
    • 0030609163 scopus 로고    scopus 로고
    • The nuclear deltaB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes
    • Ramirez, M.T., Zhao, X.L., Schulman, H., and Brown, J.H. 1997. The nuclear deltaB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes. J. Biol. Chem. 272:31203-31208.
    • (1997) J. Biol. Chem. , vol.272 , pp. 31203-31208
    • Ramirez, M.T.1    Zhao, X.L.2    Schulman, H.3    Brown, J.H.4
  • 40
    • 0034463866 scopus 로고    scopus 로고
    • Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression
    • Colomer, J.M., and Means, A.R. 2000. Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression. Mol. Endocrinol. 14:1125-1136.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1125-1136
    • Colomer, J.M.1    Means, A.R.2
  • 41
    • 0034685545 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy
    • Zhu, W., et al. 2000. Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J. Biol. Chem. 275:15239-15245.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15239-15245
    • Zhu, W.1
  • 42
    • 0027234582 scopus 로고
    • Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice
    • Gruver, C.L., DeMayo, F., Goldstein, M.A., and Means, A.R. 1993. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice. Endocrinology. 133:376-388.
    • (1993) Endocrinology , vol.133 , pp. 376-388
    • Gruver, C.L.1    DeMayo, F.2    Goldstein, M.A.3    Means, A.R.4
  • 43
    • 0037059791 scopus 로고    scopus 로고
    • The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin- dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity
    • Zhang, T., et al. 2002. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J. Biol. Chem. 277:1261-1267.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1261-1267
    • Zhang, T.1
  • 44
    • 0038643573 scopus 로고    scopus 로고
    • The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
    • Zhang, T., et al. 2003. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92:912-919.
    • (2003) Circ. Res. , vol.92 , pp. 912-919
    • Zhang, T.1
  • 46
    • 0037728615 scopus 로고    scopus 로고
    • HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
    • Dequiedt, F., et al. 2003. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 18:687-698.
    • (2003) Immunity , vol.18 , pp. 687-698
    • Dequiedt, F.1
  • 47
    • 0037379709 scopus 로고    scopus 로고
    • Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5
    • Chawla, S., Vanhoutte, P., Arnold, F.J., Huang, C.L., and Bading, H. 2003. Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J. Neurochem. 85:151-159.
    • (2003) J. Neurochem. , vol.85 , pp. 151-159
    • Chawla, S.1    Vanhoutte, P.2    Arnold, F.J.3    Huang, C.L.4    Bading, H.5
  • 48
    • 0142135022 scopus 로고    scopus 로고
    • Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival
    • Linseman, D.A., et al. 2003. Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival. J. Biol. Chem. 278:41472-41481.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41472-41481
    • Linseman, D.A.1
  • 49
    • 0035808460 scopus 로고    scopus 로고
    • Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor
    • Zhang, C.L., McKinsey, T.A., Lu, J.R., and Olson, E.N. 2001. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J. Biol. Chem. 276:35-39.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35-39
    • Zhang, C.L.1    McKinsey, T.A.2    Lu, J.R.3    Olson, E.N.4
  • 50
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    • Molkentin, J.D., et al. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93:215-228.
    • (1998) Cell , vol.93 , pp. 215-228
    • Molkentin, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.