KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)-amino-N-(4- chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 1, 2006, Pages 292-299

  Rezazadeh, Saman ^a   Claydon, Thomas W ^a   Fedida, David ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b 2350 Health Sciences Mall ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 [N (4 METHOXYBENZENESULFONYL)]AMINO N (4 CHLOROCINNAMYL) N METHYLBENZYLAMINE PHOSPHATE; ARGININE; CYSTEINE; KN 92; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE INHIBITOR; THREONINE; UNCLASSIFIED DRUG; VALINE; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; KINETICS; PRIORITY JOURNAL;

BENZYLAMINES; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CLONING, MOLECULAR; HUMANS; MEMBRANE POTENTIALS; POINT MUTATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN KINASE INHIBITORS; SULFONAMIDES;

EID: 33645120204     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.097618     Document Type: Article

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