Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure

Circulation

Volumn 122, Issue 25, 2010, Pages 2669-2679

  Van Oort, Ralph J ^a   McCauley, Mark D ^a   Dixit, Sayali S ^a   Pereira, Laetitia ^b   Yang, Yi ^b   Respress, Jonathan L ^a   Wang, Qiongling ^a   De Almeida, Angela C ^a   Skapura, Darlene G ^a   Anderson, Mark E ^c   Bers, Donald M ^b   Wehrens, Xander H T ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

arrhythmia; calcium; calcium calmodulin dependent protein kinase type 2; heart failure; ryanodine receptor calcium release channel; sarcoplasmic reticulum

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; RYANODINE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE ACTIVATION; HEART FAILURE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; SUDDEN DEATH;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DEATH, SUDDEN, CARDIAC; ELECTRIC STIMULATION; HEART FAILURE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PHOSPHORYLATION; RISK FACTORS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR;

EID: 78650701435     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.982298     Document Type: Article

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