CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome

Heart Rhythm

Volumn 9, Issue 12, 2012, Pages 2034-2041

  Degrande, Sean ^a,b   Nixon, Derek ^a   Koval, Olha ^b   Curran, Jerald W ^a   Wright, Patrick ^a   Wang, Qiongling ^c   Kashef, Farshid ^a   Chiang, David ^c   Li, Na ^c   Wehrens, Xander H T ^c   Anderson, Mark E ^b   Hund, Thomas J ^a,d,e   Mohler, Peter J ^a,d  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Division of Cardiovascular Medicine   (United States)

^e Ohio State University   (United States)

Author keywords

Ankyrin; Arrhythmia; CaMKII; Ryanodine receptor; Spectrin

Indexed keywords

ANKYRIN; ANKYRIN B; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II INHIBITORY PEPTIDE; INHIBITOR PROTEIN; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; RYANODINE RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MODEL; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART PROARRHYTHMIA; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SUDDEN DEATH; SYMPATHETIC TONE;

ANIMALS; ANKYRINS; ARRHYTHMIAS, CARDIAC; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHENOTYPE; VENTRICULAR FIBRILLATION;

EID: 84870440232     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.08.026     Document Type: Article

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