Camkiiδb mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic Constriction-Induced failing heart

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Lu, Ying Mei ^b,c   Huang, Jiyun ^a   Shioda, Norifumi ^c   Fukunaga, Kohji ^c   Shirasaki, Yasufumi ^d   Li, Xiao ming ^b   Han, Feng ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TOHOKU UNIVERSITY   (Japan)

^d DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II DELTA B; CALMODULIN INHIBITOR; DY 9836; HISTONE DEACETYLASE; MYOCYTE ENHANCER FACTOR 2; PLACEBO; PROTEIN NCX1; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; CALCIUM; NCX1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; GENETIC TRANSFECTION; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE CELL; HEART WEIGHT; IMMUNOBLOTTING; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM; SHAM PROCEDURE; SIGNAL TRANSDUCTION; TIBIA; ANIMAL; AORTA DISEASE; GENETICS; HEART; IMMUNOHISTOCHEMISTRY; LUNG; METABOLISM; ORGAN SIZE; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALIA; MUS;

ANIMALS; AORTIC DISEASES; BLOTTING, WESTERN; BODY WEIGHT; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; HEART; HEART FAILURE; IMMUNOHISTOCHEMISTRY; LUNG; MALE; MICE; ORGAN SIZE; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER;

EID: 80052740644     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024724     Document Type: Article

References (31)

1. Yang D, Zhu WZ, Xiao B, Brochet DX, Chen SR, et al. (2007) Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res 100: 399-407.
2. Ling H, Zhang T, Pereira L, Means CK, Cheng H, et al. (2009) Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest 119: 1230-1240.
3. Bodi I, Mikala G, Koch SE, Akhter SA, Schwartz A, (2005) The L-type calcium channel in the heart: the beat goes on. J Clin Invest 115: 3306-3317.
4. Petrashevskaya NN, Bodi I, Rubio M, Molkentin JD, Schwartz A, (2002) Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse. Cardiovasc Res 54: 117-132.
5. Ramirez MT, Zhao XL, Schulman H, Brown JH, (1997) The nuclear deltaB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes. J Biol Chem 272: 31203-31208.
6. Zhang T, Johnson EN, Gu Y, Morissette MR, Sah VP, et al. (2002) The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem 277: 1261-1267.
7. Bers DM, (2002) Cardiac excitation-contraction coupling. Nature 415: 198-205.
8. Kent RL, Rozich JD, McCollam PL, McDermott DE, Thacker UF, et al. (1993) Rapid expression of the Na+-Ca2+ exchanger in response to cardiac pressure overload. Am J Physiol 265: H1024-H1029.
9. Hasenfuss G, Reinecke H, Studer R, Meyer M, Pieske B, et al. (1994) Relation between myocardial function and expression of sarcoplasmic reticulum Ca2+-ATPase in failing and nonfailing human myocardium. Circ Res 75: 434-442.
10. Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM, (2001) Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 88: 1159-1167.
11. Hobai IA, O'Rourke B, (2001) Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation 103: 1577-1584.
12. Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, et al. (2009) Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol 47: 180-187.
13. Anwar A, Schlüter KD, Heger J, Piper HM, Euler G, (2008) Enhanced SERCA2A expression improves contractile performance of ventricular cardiomyocytes of rat under adrenergic stimulation. Pflugers Arch- Eur J Physiol 457: 485-491.
14. Menick DR, Barnes KV, Thacker UF, Dawson MM, McDermott DE, et al. (1996) The exchanger and cardiac hypertrophy. Ann N Y Acad Sci 779: 489-501.
15. Müller JG, Isomatsu Y, Koushik SV, O'Quinn M, Xu L, et al. (2002) Cardiac-specific expression and hypertrophic upregulation of the feline Na+-Ca2+ exchanger gene H1-promoter in a transgenic mouse model. Circ Res 90: 158-164.
16. Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, et al. (2010) Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice. J Pharmacol Exp Ther 332: 421-428.
17. Lu YM, Shioda N, Han F, Moriguchi S, Kasahara J, et al. (2007) Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes. Biochem Pharmacol 74: 1727-1737.
18. Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, et al. (2006) Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med 12: 181-189.
19. Lu YM, Shioda N, Yamamoto Y, Han F, Fukunaga K, (2010) Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes. Biochim Biophys Acta 1799: 429-441.
20. Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, et al. (2009) Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist. Mol Pharmacol 75: 101-112.
21. Kohlhaas M, Zhang T, Seidler T, Zibrova D, Dybkova N, et al. (2006) Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res 98: 235-244.
22. Little GH, Bai Y, Williams T, Poizat C, (2007) Nuclear Calcium/Calmodulin-dependent Protein Kinase II Preferentially Transmits Signals to Histone Deacetylase 4 in Cardiac Cells. J Biol Chem 282: 7219-7231.
23. McKinsey TA, Zhang CL, Lu J, Olson EN, (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408: 106-111.
24. Youn HD, Grozinger CM, Liu JO, (2000) Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. J Biol Chem 275: 22563-22567.
25. Cheng G, Hagen TP, Dawson ML, Barnes KV, Menick DR, (1999) The role of GATA, CArG, E-box, and a novel element in the regulation of cardiac expression of the Na+-Ca2+ exchanger gene. J Biol Chem 274: 12819-12826.
26. Menick DR, Renaud L, Buchholz A, Müller JG, Zhou H, et al. (2007) Regulation of Ncx1 gene expression in the normal and hypertrophic heart. Ann N Y Acad Sci 1099: 195-203.
27. Randriamboavonjy V, Pistrosch F, Bölck B, Schwinger RH, Dixit M, et al. (2008) Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. Circulation 117: 52-60.
28. Li XM, Ma YT, Yang YN, Liu F, Chen Bd, et al. (2009) Downregulation of survival signalling pathways and increased apoptosis in the transition of pressure overload-induced cardiac hypertrophy to heart failure. Clin Exp Pharmacol Physiol 36: 1054-1061.
29. Moorjani N, Ahmad M, Catarino P, Brittin R, Trabzuni D, et al. (2006) Activation of apoptotic caspase cascade during the transition to pressure overload-induced heart failure. J Am Coll Cardiol 48: 1451-1458.
30. Xu A, Hawkins C, Narayanan N, (1993) Phosphorylation and activation of the Ca2+-pumping ATPase of cardiac sarcoplasmic reticulum by Ca2+/calmodulin-dependent protein kinase. J Biol Chem 268: 8394-8397.
31. Toyofuku T, Curotto KK, Narayanan N, MacLennan DH, (1994) Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca2+-ATPase that is phosphorylated by Ca2+/calmodulindependent protein kinase. J Biol Chem 269: 26492-26496.