The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome

Circulation: Arrhythmia and Electrophysiology

Volumn 2, Issue 3, 2009, Pages 295-304

  Qi, Xiao Yan ^a   Yeh, Yung Hsin ^a,c   Chartier, Denis ^a   Xiao, Ling ^a,b   Tsuji, Yukiomi ^d   Brundel, Bianca J J M ^e   Kodama, Itsuo ^d   Nattel, Stanley ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d NAGOYA UNIVERSITY   (Japan)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Calcium; Electrophysiology; Ion channels; Long QT syndrome; Remodeling

Indexed keywords

CAFFEINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CHANNEL L TYPE; DELAYED RECTIFIER POTASSIUM CHANNEL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THAPSIGARGIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; ATRIOVENTRICULAR BLOCK; AUTOPHOSPHORYLATION; BRADYCARDIA; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HEART DEPOLARIZATION; HEART VENTRICLE; HEART VENTRICLE PACING; IMMUNOBLOTTING; LONG QT SYNDROME; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; SYSTOLE; WHOLE CELL;

ACTION POTENTIALS; ANIMALS; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; LONG QT SYNDROME; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RABBITS; TORSADES DE POINTES;

EID: 70349446744     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.108.815654     Document Type: Article

References (32)

1. Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis. 1988; 31:115-172.
2. Antzelevitch C. Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace. 2007; Suppl 4:iv4 -15.
3. Tsuji Y, Opthof T, Yasui K, Inden Y, Takemura H, Niwa N, Lu Z, Lee JK, Honjo H, Kamiya K, Kodama I. Ionic mechanisms of acquired QT prolongation and torsades de pointes in rabbits with chronic complete atrioventricular block. Circulation. 2002; 106:2012-2018.
4. Vos MA, Verduyn SC, Gorgels AP, Lipcsei GC, Wellens HJ. Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation. 1995; 91:864-872.
5. Tsuji Y, Zicha S, Qi XY, Kodama I, Nattel S. Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayedrectifier changes. Circulation. 2006; 113:345-355.
6. + currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation. 1999; 100:2455-2461.
7. +-induced early afterdepolarizations in Purkinje fibers. J Cardiovasc Electrophysiol. 1994; 5:933-944.
8. Anderson ME. Multiple downstream proarrhythmic targets for calmodulin kinase, II: moving beyond an ion channel-centric focus. Cardiovasc Res. 2007; 73:657- 666.
9. 2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes. Am J Physiol. 2006; 291:H2290-H2300.
10. Brundel BJ, van Gelder IC, Henning RH, Tuinenburg AE, Deelman LE, Tieleman RG, Grandjean JG, van Gilst WH, Crijns HJ. Gene expression of proteins influencing the calcium homeostasis in patients with persistent and paroxysmal atrial fibrillation. Cardiovasc Res. 1999; 42:443- 454.
11. 2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block. J Physiol. 2007; 579:147-160.
12. 2+/calmodulin- dependent protein kinase II activation. Circ Res. 2000; 87:760 -767.
13. 2+ release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis. Circulation. 2000; 102:2137-2144.
14. Verduyn SC, Vos MA, Gorgels AP, van der Zande J, Leunissen JD, Wellens HJ. The effect of flunarizine and ryanodine on acquired torsades de pointes arrhythmias in the intact canine heart. J Cardiovasc Electrophysiol. 1995; 6:189 -200.
15. 2+ current facilitation. J Mol Cell Cardiol. 2007; 42:196 -205.
16. Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J Jr, Bers DM, Brown JH. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003; 92: 912-919.
17. Mazur A, Roden DM, Anderson ME. Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. Circulation. 1999; 100:2437-2442.
18. 2+ current: a cellular mechanism for long Q-T arrhythmias. Am J Physiol. 1999; 276:H2168-H2178.
19. Wu Y, Roden DM, Anderson ME. Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current. Circ Res. 1999; 84:906 -912.
20. 2+/calmodulin kinase II. J Clin Invest. 2003; 111:617- 625.
21. Hothi SS, Gurung IS, Heathcote JC, Zhang Y, Booth SW, Skepper JN, Grace AA, Huang CL. Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart. Pflugers Arch. 2008; 457:253-270.
22. Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 2008; 133:462- 474.
23. Nattel S, Quantz MA. Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovasc Res. 1988; 22:808-817.
24. 2+ channel agonist Bay K 8644. Circ Res. 1988; 62:563-571.
25. 2+ current. Circ Res. 1989; 64: 977-990.
26. Zeng J, Rudy Y. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys J. 1995; 68:949 -964.
27. Hagemann D, Xiao RP. Dual site phospholamban phosphorylation and its physiological relevance in the heart. Trends Cardiovasc Med. 2002; 12: 51-56.
28. Huffaker R, Lamp ST, Weiss JN, Kogan B. Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome. Heart Rhythm. 2004; 1:441- 448.
29. Roden DM, Viswanathan PC. Genetics of acquired long QT syndrome. J Clin Invest. 2005; 115:2025-2032.
30. Kurita T, Ohe T, Marui N, Aihara N, Takaki H, Kamakura S, Matsuhisa M, Shimomura K. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes. Am J Cardiol. 1992; 69:628-633.
31. ++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998; 287:996 -1006.
32. Winckels SK, Thomsen MB, Oosterhoff P, Oros A, Beekman JD, Attevelt NJ, Kretzers L, Vos MA. High-septal pacing reduces ventricular electrical remodeling and proarrhythmia in chronic atrioventricular block dogs. J Am Coll Cardiol. 2007; 50:906 -913.