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Volumn 36, Issue 4, 2013, Pages 595-612

Ammonia toxicity to the brain

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 PHENYLBUTYRIC ACID; AMINO ACID; AMMONIA; ARGININE; BENZOIC ACID; CHOLINE ACETYLTRANSFERASE; CILIARY NEUROTROPHIC FACTOR; CREATINE; CYTOCHROME C OXIDASE; DISACCHARIDE; DIZOCILPINE; GLUCOSE; GLUTAMATE AMMONIA LIGASE; LACTULOSE; LEVACECARNINE; METHIONINE SULFOXIMINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE; NEUROTRANSMITTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ORNITHINE ASPARTATE; ORNITHINE PHENYLACETATE; PHENYLACETIC ACID; PLACEBO; RIFAXIMIN; ROSCOVITINE; UNINDEXED DRUG;

EID: 84880203578     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/s10545-012-9546-2     Document Type: Review
Times cited : (225)

References (202)
  • 1
    • 0342470611 scopus 로고    scopus 로고
    • Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats
    • 10686089 1:CAS:528:DC%2BD3cXht1Ontbo%3D
    • Aguilar MA, Minarro J, Felipo V (2000) Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats. Exp Neurol 161:704-713
    • (2000) Exp Neurol , vol.161 , pp. 704-713
    • Aguilar, M.A.1    Minarro, J.2    Felipo, V.3
  • 2
    • 80053564971 scopus 로고    scopus 로고
    • P38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts
    • 21636647 1:CAS:528:DC%2BC3MXhsV2iurzI
    • Agusti A, Cauli O, Rodrigo R, Llansola M, Hernandez-Rabaza V, Felipo V (2011) p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts. Gut 60:1572-1579
    • (2011) Gut , vol.60 , pp. 1572-1579
    • Agusti, A.1    Cauli, O.2    Rodrigo, R.3    Llansola, M.4    Hernandez-Rabaza, V.5    Felipo, V.6
  • 3
    • 33750608704 scopus 로고    scopus 로고
    • Glutamine: A Trojan horse in ammonia neurotoxicity
    • 17006913 1:CAS:528:DC%2BD28XhtFyqsr%2FI
    • Albrecht J, Norenberg MD (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44:788-794
    • (2006) Hepatology , vol.44 , pp. 788-794
    • Albrecht, J.1    Norenberg, M.D.2
  • 4
    • 77956647974 scopus 로고    scopus 로고
    • Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal
    • 20654582 1:CAS:528:DC%2BC3cXhtFyitb3F
    • Albrecht J, Zielinska M, Norenberg MD (2010) Glutamine as a mediator of ammonia neurotoxicity: a critical appraisal. Biochem Pharmacol 80:1303-1308
    • (2010) Biochem Pharmacol , vol.80 , pp. 1303-1308
    • Albrecht, J.1    Zielinska, M.2    Norenberg, M.D.3
  • 5
    • 2342487336 scopus 로고    scopus 로고
    • Non-absorbable disaccharides for hepatic encephalopathy: Systematic review of randomised trials
    • 1:CAS:528:DC%2BD2cXksleltL8%3D
    • Als-Nielsen B, Gluud LL, Gluud C (2004) Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials. Br Med J 328:1046
    • (2004) Br Med J , vol.328 , pp. 1046
    • Als-Nielsen, B.1    Gluud, L.L.2    Gluud, C.3
  • 6
    • 80053647234 scopus 로고    scopus 로고
    • Interaction between cytokines and ammonia in the mitochondrial permeability transition in cultured astrocytes
    • 21748779 1:CAS:528:DC%2BC3MXht1yktLbM
    • Alvarez VM, Rama Rao KV, Brahmbhatt M, Norenberg MD (2011) Interaction between cytokines and ammonia in the mitochondrial permeability transition in cultured astrocytes. J Neurosci Res 89:2028-2040
    • (2011) J Neurosci Res , vol.89 , pp. 2028-2040
    • Alvarez, V.M.1    Rama Rao, K.V.2    Brahmbhatt, M.3    Norenberg, M.D.4
  • 7
    • 0024341964 scopus 로고
    • A simple animal model of hyperammonemia
    • 2759549 1:CAS:528:DyaL1MXlsFWnsrk%3D
    • Azorin I, Minana MD, Felipo V, Grisolia S (1989) A simple animal model of hyperammonemia. Hepatology 10:311-314
    • (1989) Hepatology , vol.10 , pp. 311-314
    • Azorin, I.1    Minana, M.D.2    Felipo, V.3    Grisolia, S.4
  • 8
    • 0037944015 scopus 로고    scopus 로고
    • Outcome and survival of 88 patients with urea cycle disorders: A retrospective evaluation
    • 12684900
    • Bachmann C (2003) Outcome and survival of 88 patients with urea cycle disorders: a retrospective evaluation. Eur J Pediatr 162:410-416
    • (2003) Eur J Pediatr , vol.162 , pp. 410-416
    • Bachmann, C.1
  • 9
    • 0021235972 scopus 로고
    • Increase of tryptophan and 5-hydroxyindole acetic acid in the brain of ornithine carbamoyltransferase deficient sparse-fur mice
    • 6201810 1:CAS:528:DyaL2cXhsFCqs78%3D
    • Bachmann C, Colombo JP (1984) Increase of tryptophan and 5-hydroxyindole acetic acid in the brain of ornithine carbamoyltransferase deficient sparse-fur mice. Pediatr Res 18:372-375
    • (1984) Pediatr Res , vol.18 , pp. 372-375
    • Bachmann, C.1    Colombo, J.P.2
  • 11
    • 0035577916 scopus 로고    scopus 로고
    • Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes
    • 11746427 1:CAS:528:DC%2BD3MXpt1SgtLk%3D
    • Bai G, Rama Rao KV, Murthy CR, Panickar KS, Jayakumar AR, Norenberg MD (2001) Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes. J Neurosci Res 66:981-991
    • (2001) J Neurosci Res , vol.66 , pp. 981-991
    • Bai, G.1    Rama Rao, K.V.2    Murthy, C.R.3    Panickar, K.S.4    Jayakumar, A.R.5    Norenberg, M.D.6
  • 12
    • 79952255608 scopus 로고    scopus 로고
    • Review article: The design of clinical trials in hepatic encephalopathy-an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement
    • 21306407 1:STN:280:DC%2BC3MvitVyjtw%3D%3D
    • Bajaj JS, Cordoba J, Mullen KD et al (2011) Review article: the design of clinical trials in hepatic encephalopathy-an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Aliment Pharmacol Ther 33:739-747
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 739-747
    • Bajaj, J.S.1    Cordoba, J.2    Mullen, K.D.3
  • 13
    • 84859133780 scopus 로고    scopus 로고
    • Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: A cost-effectiveness analysis
    • 22135042
    • Bajaj JS, Pinkerton SD, Sanyal AJ, Heuman DM (2012) Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis. Hepatology 55:1164-1171
    • (2012) Hepatology , vol.55 , pp. 1164-1171
    • Bajaj, J.S.1    Pinkerton, S.D.2    Sanyal, A.J.3    Heuman, D.M.4
  • 14
    • 77950246404 scopus 로고    scopus 로고
    • Rifaximin treatment in hepatic encephalopathy
    • 20335583 1:CAS:528:DC%2BC3cXjvFyjsrw%3D
    • Bass NM, Mullen KD, Sanyal A et al (2010) Rifaximin treatment in hepatic encephalopathy. N Engl J Med 362:1071-1081
    • (2010) N Engl J Med , vol.362 , pp. 1071-1081
    • Bass, N.M.1    Mullen, K.D.2    Sanyal, A.3
  • 15
    • 0035145334 scopus 로고    scopus 로고
    • Alternative pathway therapy for urea cycle disorders: Twenty years later
    • 11148549 1:CAS:528:DC%2BD3MXhtF2lsL4%3D
    • Batshaw ML, MacArthur RB, Tuchman M (2001) Alternative pathway therapy for urea cycle disorders: twenty years later. J Pediatr 138:S46-S54
    • (2001) J Pediatr , vol.138
    • Batshaw, M.L.1    MacArthur, R.B.2    Tuchman, M.3
  • 16
    • 78651274358 scopus 로고    scopus 로고
    • Synthesis and transport of creatine in the CNS: Importance for cerebral functions
    • 20796169
    • Béard E, Braissant O (2010) Synthesis and transport of creatine in the CNS: importance for cerebral functions. J Neurochem 115:297-313
    • (2010) J Neurochem , vol.115 , pp. 297-313
    • Béard, E.1    Braissant, O.2
  • 17
    • 33845302602 scopus 로고    scopus 로고
    • Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro
    • 16956696
    • Bélanger M, Asashima T, Ohtsuki S, Yamaguchi H, Ito S, Terasaki T (2007) Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem Int 50:95-101
    • (2007) Neurochem Int , vol.50 , pp. 95-101
    • Bélanger, M.1    Asashima, T.2    Ohtsuki, S.3    Yamaguchi, H.4    Ito, S.5    Terasaki, T.6
  • 18
    • 73049161747 scopus 로고
    • Metabolic compartments in vivo. Ammonia and glutamic acid metabolism in brain and liver
    • 13867916 1:CAS:528:DyaF38Xks1Ggurk%3D
    • Berl S, Takagaki G, Clarke DD, Waelsch H (1962) Metabolic compartments in vivo. Ammonia and glutamic acid metabolism in brain and liver. J Biol Chem 237:2562-2569
    • (1962) J Biol Chem , vol.237 , pp. 2562-2569
    • Berl, S.1    Takagaki, G.2    Clarke, D.D.3    Waelsch, H.4
  • 19
    • 0035140623 scopus 로고    scopus 로고
    • Long-term management of patients with urea cycle disorders
    • 11148550 1:CAS:528:DC%2BD3MXhtF2lsL0%3D
    • Berry GT, Steiner RD (2001) Long-term management of patients with urea cycle disorders. J Pediatr 138:S56-S60
    • (2001) J Pediatr , vol.138
    • Berry, G.T.1    Steiner, R.D.2
  • 20
    • 84862791514 scopus 로고    scopus 로고
    • Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure
    • 22300646 1:CAS:528:DC%2BC38XisFKjuro%3D
    • Bosoi CR, Yang X, Huynh J et al (2012) Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure. Free Radic Biol Med 52:1228-1235
    • (2012) Free Radic Biol Med , vol.52 , pp. 1228-1235
    • Bosoi, C.R.1    Yang, X.2    Huynh, J.3
  • 21
    • 77950338275 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of urea cycle disorders
    • 1:CAS:528:DC%2BC3cXks1Shurk%3D
    • Braissant O (2010a) Current concepts in the pathogenesis of urea cycle disorders. Mol Gen Metab 100(Suppl 1):S3-S12
    • (2010) Mol Gen Metab , vol.100 , Issue.SUPPL. 1
    • Braissant, O.1
  • 22
    • 77950339065 scopus 로고    scopus 로고
    • Ammonia toxicity to the brain: Effects on creatine metabolism and transport and protective roles of creatine
    • 20227315 1:CAS:528:DC%2BC3cXks1Shu7Y%3D
    • Braissant O (2010b) Ammonia toxicity to the brain: effects on creatine metabolism and transport and protective roles of creatine. Mol Genet Metab 100(Suppl 1):S53-S58
    • (2010) Mol Genet Metab , vol.100 , Issue.SUPPL. 1
    • Braissant, O.1
  • 23
    • 84863883001 scopus 로고    scopus 로고
    • Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
    • 22252611 1:CAS:528:DC%2BC38XpvVyrsrw%3D
    • Braissant O (2012) Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers. J Inherit Metab Dis 35:655-664
    • (2012) J Inherit Metab Dis , vol.35 , pp. 655-664
    • Braissant, O.1
  • 24
    • 0033020697 scopus 로고    scopus 로고
    • L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: An in situ hybridization study
    • 10407171 1:CAS:528:DyaK1MXkt1agur0%3D
    • Braissant O, Gotoh T, Loup M, Mori M, Bachmann C (1999a) L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study. Mol Brain Res 70:231-241
    • (1999) Mol Brain Res , vol.70 , pp. 231-241
    • Braissant, O.1    Gotoh, T.2    Loup, M.3    Mori, M.4    Bachmann, C.5
  • 25
    • 0033532234 scopus 로고    scopus 로고
    • Hyperammonemia: Regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain
    • 10353334 1:CAS:528:DyaK1MXjtlCktrs%3D
    • Braissant O, Honegger P, Loup M, Iwase K, Takiguchi M, Bachmann C (1999b) Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Neurosci Lett 266:89-92
    • (1999) Neurosci Lett , vol.266 , pp. 89-92
    • Braissant, O.1    Honegger, P.2    Loup, M.3    Iwase, K.4    Takiguchi, M.5    Bachmann, C.6
  • 26
    • 0035854458 scopus 로고    scopus 로고
    • Differential expression of the cationic amino acid transporter 2(B) in the adult rat brain
    • 11457509 1:CAS:528:DC%2BD3MXltFyqsLs%3D
    • Braissant O, Gotoh T, Loup M, Mori M, Bachmann C (2001) Differential expression of the cationic amino acid transporter 2(B) in the adult rat brain. Mol Brain Res 91:189-195
    • (2001) Mol Brain Res , vol.91 , pp. 189-195
    • Braissant, O.1    Gotoh, T.2    Loup, M.3    Mori, M.4    Bachmann, C.5
  • 27
    • 0037112067 scopus 로고    scopus 로고
    • Ammonium-induced impairment of axonal growth is prevented through glial creatine
    • 12427837 1:CAS:528:DC%2BD38XovF2ks7Y%3D
    • Braissant O, Henry H, Villard AM et al (2002) Ammonium-induced impairment of axonal growth is prevented through glial creatine. J Neurosci 22:9810-9820
    • (2002) J Neurosci , vol.22 , pp. 9810-9820
    • Braissant, O.1    Henry, H.2    Villard, A.M.3
  • 28
    • 41549151211 scopus 로고    scopus 로고
    • Ammonium alters creatine transport and synthesis in a 3D-culture of developing brain cells, resulting in secondary cerebral creatine deficiency
    • 18380667
    • Braissant O, Cagnon L, Monnet-Tschudi F et al (2008) Ammonium alters creatine transport and synthesis in a 3D-culture of developing brain cells, resulting in secondary cerebral creatine deficiency. Eur J Neurosci 27:1673-1685
    • (2008) Eur J Neurosci , vol.27 , pp. 1673-1685
    • Braissant, O.1    Cagnon, L.2    Monnet-Tschudi, F.3
  • 29
    • 80052812187 scopus 로고    scopus 로고
    • Creatine deficiency syndromes and the importance of creatine synthesis in the brain
    • 21390529 1:CAS:528:DC%2BC3MXkvFWqtrc%3D
    • Braissant O, Henry H, Beard E, Uldry J (2011) Creatine deficiency syndromes and the importance of creatine synthesis in the brain. Amino Acids 40:1315-1324
    • (2011) Amino Acids , vol.40 , pp. 1315-1324
    • Braissant, O.1    Henry, H.2    Beard, E.3    Uldry, J.4
  • 30
    • 77950341375 scopus 로고    scopus 로고
    • Creatine metabolism and the urea cycle
    • 20304692 1:CAS:528:DC%2BC3cXks1Shu7g%3D
    • Brosnan JT, Brosnan ME (2010) Creatine metabolism and the urea cycle. Mol Genet Metab 100(Suppl 1):S49-S52
    • (2010) Mol Genet Metab , vol.100 , Issue.SUPPL. 1
    • Brosnan, J.T.1    Brosnan, M.E.2
  • 32
    • 0029690198 scopus 로고    scopus 로고
    • Urea cycle disorders: Diagnosis, pathophysiology, and therapy
    • 8794176 1:STN:280:DyaK28zos1ChtA%3D%3D
    • Brusilow SW, Maestri NE (1996) Urea cycle disorders: diagnosis, pathophysiology, and therapy. Adv Pediatr 43:127-170
    • (1996) Adv Pediatr , vol.43 , pp. 127-170
    • Brusilow, S.W.1    Maestri, N.E.2
  • 33
    • 0018597819 scopus 로고
    • New pathways of nitrogen excretion in inborn errors of urea synthesis
    • 89510 1:CAS:528:DyaL3cXls1WgsQ%3D%3D
    • Brusilow SW, Valle DL, Batshaw M (1979) New pathways of nitrogen excretion in inborn errors of urea synthesis. Lancet 2:452-454
    • (1979) Lancet , vol.2 , pp. 452-454
    • Brusilow, S.W.1    Valle, D.L.2    Batshaw, M.3
  • 34
    • 0031879678 scopus 로고    scopus 로고
    • Effects of hyperammonaemia on brain function
    • 9686341
    • Butterworth RF (1998) Effects of hyperammonaemia on brain function. J Inherit Metab Dis 21(Suppl 1):6-20
    • (1998) J Inherit Metab Dis , vol.21 , Issue.SUPPL. 1 , pp. 6-20
    • Butterworth, R.F.1
  • 35
    • 16544385266 scopus 로고    scopus 로고
    • Hepatic encephalopathy
    • 15535452
    • Butterworth RF (2003) Hepatic encephalopathy. Alcohol Res Health 27:240-246
    • (2003) Alcohol Res Health , vol.27 , pp. 240-246
    • Butterworth, R.F.1
  • 36
    • 84861622097 scopus 로고    scopus 로고
    • Brain edema and encephalopathy in acute liver failure: A primary neurogliopathy?
    • 22381564 1:CAS:528:DC%2BC38XksleisLc%3D
    • Butterworth RF (2012) Brain edema and encephalopathy in acute liver failure: a primary neurogliopathy? Neurochem Int 60:661
    • (2012) Neurochem Int , vol.60 , pp. 661
    • Butterworth, R.F.1
  • 37
    • 67149146685 scopus 로고    scopus 로고
    • Experimental models of hepatic encephalopathy: ISHEN guidelines
    • 19638106
    • Butterworth RF, Norenberg MD, Felipo V et al (2009) Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver Int 29:783-788
    • (2009) Liver Int , vol.29 , pp. 783-788
    • Butterworth, R.F.1    Norenberg, M.D.2    Felipo, V.3
  • 38
    • 36048953322 scopus 로고    scopus 로고
    • Hyperammonemia-induced toxicity for the developing central nervous system
    • 17881060 1:CAS:528:DC%2BD2sXhtlalsrvO
    • Cagnon L, Braissant O (2007) Hyperammonemia-induced toxicity for the developing central nervous system. Brain Res Rev 56:183-197
    • (2007) Brain Res Rev , vol.56 , pp. 183-197
    • Cagnon, L.1    Braissant, O.2
  • 39
    • 53749090841 scopus 로고    scopus 로고
    • Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells
    • 18722528 1:CAS:528:DC%2BD1cXht1Kns7bN
    • Cagnon L, Braissant O (2008) Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells. Neurobiol Dis 32:281-292
    • (2008) Neurobiol Dis , vol.32 , pp. 281-292
    • Cagnon, L.1    Braissant, O.2
  • 40
    • 57449084135 scopus 로고    scopus 로고
    • CNTF protects oligodendrocytes from ammonia toxicity: Intracellular signaling pathways involved
    • 18992343 1:CAS:528:DC%2BD1cXhsFags7vL
    • Cagnon L, Braissant O (2009) CNTF protects oligodendrocytes from ammonia toxicity: intracellular signaling pathways involved. Neurobiol Dis 33:133-142
    • (2009) Neurobiol Dis , vol.33 , pp. 133-142
    • Cagnon, L.1    Braissant, O.2
  • 41
    • 0021261278 scopus 로고
    • Clinical features of carbamyl phosphate synthetase-I deficiency in an adult
    • 6465866 1:STN:280:DyaL2c3nvV2htQ%3D%3D
    • Call G, Seay AR, Sherry R, Qureshi IA (1984) Clinical features of carbamyl phosphate synthetase-I deficiency in an adult. Ann Neurol 16:90-93
    • (1984) Ann Neurol , vol.16 , pp. 90-93
    • Call, G.1    Seay, A.R.2    Sherry, R.3    Qureshi, I.A.4
  • 42
    • 77952287099 scopus 로고    scopus 로고
    • Language and motor skills are impaired in infants with biliary atresia before transplantation
    • 20223479
    • Caudle SE, Katzenstein JM, Karpen SJ, McLin VA (2010) Language and motor skills are impaired in infants with biliary atresia before transplantation. J Pediatr 156:936-940
    • (2010) J Pediatr , vol.156 , pp. 936-940
    • Caudle, S.E.1    Katzenstein, J.M.2    Karpen, S.J.3    McLin, V.A.4
  • 43
    • 84867015822 scopus 로고    scopus 로고
    • Developmental assessment of infants with biliary atresia: Differences between males and females
    • Caudle SE, Katzenstein JM, Karpen S, McLin V (2012) Developmental assessment of infants with biliary atresia: Differences between males and females. J Pediatr Gastroenterol Nutr 55(4):384-389
    • (2012) J Pediatr Gastroenterol Nutr , vol.55 , Issue.4 , pp. 384-389
    • Caudle, S.E.1    Katzenstein, J.M.2    Karpen, S.3    McLin, V.4
  • 44
    • 35448962385 scopus 로고    scopus 로고
    • Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors
    • 17727627 1:CAS:528:DC%2BD2sXhtl2jurvK
    • Cauli O, Lopez-Larrubia P, Rodrigues TB, Cerdan S, Felipo V (2007) Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors. J Neurochem 103:1334-1343
    • (2007) J Neurochem , vol.103 , pp. 1334-1343
    • Cauli, O.1    Lopez-Larrubia, P.2    Rodrigues, T.B.3    Cerdan, S.4    Felipo, V.5
  • 45
    • 60449084556 scopus 로고    scopus 로고
    • Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy
    • 19085094 1:CAS:528:DC%2BD1MXhvVOjsrs%3D
    • Cauli O, Rodrigo R, Llansola M et al (2009) Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metab Brain Dis 24:69-80
    • (2009) Metab Brain Dis , vol.24 , pp. 69-80
    • Cauli, O.1    Rodrigo, R.2    Llansola, M.3
  • 46
    • 79251552307 scopus 로고    scopus 로고
    • Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats
    • 20977905 1:CAS:528:DC%2BC3MXhtlSksLg%3D
    • Cauli O, Lopez-Larrubia P, Rodrigo R et al (2011) Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology 140:638-645
    • (2011) Gastroenterology , vol.140 , pp. 638-645
    • Cauli, O.1    Lopez-Larrubia, P.2    Rodrigo, R.3
  • 47
    • 77953023545 scopus 로고    scopus 로고
    • Alternative pathway or diversion therapy for urea cycle disorders now and in the future
    • 20462778 1:CAS:528:DC%2BC3cXntVyrtrc%3D
    • Cederbaum S, Lemons C, Batshaw ML (2010) Alternative pathway or diversion therapy for urea cycle disorders now and in the future. Mol Genet Metab 100:219-220
    • (2010) Mol Genet Metab , vol.100 , pp. 219-220
    • Cederbaum, S.1    Lemons, C.2    Batshaw, M.L.3
  • 48
    • 0034257046 scopus 로고    scopus 로고
    • Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes
    • 10812209 1:CAS:528:DC%2BD3cXksF2gtrk%3D
    • Chan H, Hazell AS, Desjardins P, Butterworth RF (2000) Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes. Neurochem Int 37:243-248
    • (2000) Neurochem Int , vol.37 , pp. 243-248
    • Chan, H.1    Hazell, A.S.2    Desjardins, P.3    Butterworth, R.F.4
  • 50
    • 77949854341 scopus 로고    scopus 로고
    • Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure
    • 19843475 1:CAS:528:DC%2BC3cXlt1Sisbk%3D
    • Chavarria L, Oria M, Romero-Gimenez J, Alonso J, Lope-Piedrafita S, Cordoba J (2010) Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. Gastroenterology 138:1566-1573
    • (2010) Gastroenterology , vol.138 , pp. 1566-1573
    • Chavarria, L.1    Oria, M.2    Romero-Gimenez, J.3    Alonso, J.4    Lope-Piedrafita, S.5    Cordoba, J.6
  • 51
    • 81255166084 scopus 로고    scopus 로고
    • Neuroimaging in acute liver failure
    • 21945201 1:CAS:528:DC%2BC3MXhsFeisrvL
    • Chavarria L, Alonso J, Rovira A, Cordoba J (2011) Neuroimaging in acute liver failure. Neurochem Int 59:1175-1180
    • (2011) Neurochem Int , vol.59 , pp. 1175-1180
    • Chavarria, L.1    Alonso, J.2    Rovira, A.3    Cordoba, J.4
  • 52
    • 33747190865 scopus 로고    scopus 로고
    • Taurine rescues hippocampal long-term potentiation from ammonia-induced impairment
    • 16766203 1:CAS:528:DC%2BD28XotlWnsLs%3D
    • Chepkova AN, Sergeeva OA, Haas HL (2006) Taurine rescues hippocampal long-term potentiation from ammonia-induced impairment. Neurobiol Dis 23:512-521
    • (2006) Neurobiol Dis , vol.23 , pp. 512-521
    • Chepkova, A.N.1    Sergeeva, O.A.2    Haas, H.L.3
  • 53
    • 33645668947 scopus 로고    scopus 로고
    • Two cases of citrullinaemia presenting with stroke
    • 16601887 1:STN:280:DC%2BD287psFSjsw%3D%3D
    • Choi JH, Kim H, Yoo HW (2006) Two cases of citrullinaemia presenting with stroke. J Inherit Metab Dis 29:182-183
    • (2006) J Inherit Metab Dis , vol.29 , pp. 182-183
    • Choi, J.H.1    Kim, H.2    Yoo, H.W.3
  • 54
    • 0027498888 scopus 로고
    • Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency
    • 8433866 1:STN:280:DyaK3s7msFerug%3D%3D
    • Connelly A, Cross JH, Gadian DG, Hunter JV, Kirkham FJ, Leonard JV (1993) Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency. Pediatr Res 33:77-81
    • (1993) Pediatr Res , vol.33 , pp. 77-81
    • Connelly, A.1    Cross, J.H.2    Gadian, D.G.3    Hunter, J.V.4    Kirkham, F.J.5    Leonard, J.V.6
  • 55
    • 0030004892 scopus 로고    scopus 로고
    • Glutamine, myo-inositol, and brain edema in acute liver failure
    • 8621171 1:STN:280:DyaK283gs1Gksg%3D%3D
    • Cordoba J (1996) Glutamine, myo-inositol, and brain edema in acute liver failure. Hepatology 23:1291-1292
    • (1996) Hepatology , vol.23 , pp. 1291-1292
    • Cordoba, J.1
  • 56
    • 0030460773 scopus 로고    scopus 로고
    • Brain edema and hepatic encephalopathy
    • 8989813 1:STN:280:DyaK2s7ktlyjsA%3D%3D
    • Cordoba J, Blei AT (1996) Brain edema and hepatic encephalopathy. Semin Liver Dis 16:271-280
    • (1996) Semin Liver Dis , vol.16 , pp. 271-280
    • Cordoba, J.1    Blei, A.T.2
  • 58
    • 84866867389 scopus 로고    scopus 로고
    • Handling macromolecule signals in the quantification of the neurochemical profile
    • Cudalbu C, Mlynárik V, Gruetter R (2012a) Handling macromolecule signals in the quantification of the neurochemical profile. J Alzh Dis 31:S101-115
    • (2012) J Alzh Dis , vol.31
    • Cudalbu C, M.1
  • 60
    • 0034623174 scopus 로고    scopus 로고
    • Impaired cognitive performance in ornithine transcarbamylase-deficient mice on arginine-free diet
    • 10973586
    • D'Hooge R, Marescau B, Qureshi IA, De Deyn PP (2000) Impaired cognitive performance in ornithine transcarbamylase-deficient mice on arginine-free diet. Brain Res 876:1-9
    • (2000) Brain Res , vol.876 , pp. 1-9
    • D'Hooge, R.1    Marescau, B.2    Qureshi, I.A.3    De Deyn, P.P.4
  • 61
    • 79955646990 scopus 로고    scopus 로고
    • Inhibition of glutamine synthesis induces glutamate dehydrogenase- dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons
    • 21397649 1:CAS:528:DC%2BC3MXhtV2nurrL
    • Dadsetan S, Bak LK, Sørensen M et al (2011) Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons. Neurochem Int 59:482-488
    • (2011) Neurochem Int , vol.59 , pp. 482-488
    • Dadsetan, S.1    Bak, L.K.2    Sørensen, M.3
  • 63
    • 0028139971 scopus 로고
    • Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: An experimental study based on in vivo brain dialysis
    • 7911135
    • de Knegt RJ, Schalm SW, van der Rijt CC, Fekkes D, Dalm E, Hekking-Weyma I (1994) Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. J Hepatol 20:19-26
    • (1994) J Hepatol , vol.20 , pp. 19-26
    • De Knegt, R.J.1    Schalm, S.W.2    Van Der Rijt, C.C.3    Fekkes, D.4    Dalm, E.5    Hekking-Weyma, I.6
  • 64
    • 36849048235 scopus 로고    scopus 로고
    • Contrasting features of urea cycle disorders in human patients and knockout mouse models
    • 17933574 1:CAS:528:DC%2BD2sXhsVCjsb7F
    • Deignan JL, Cederbaum SD, Grody WW (2008) Contrasting features of urea cycle disorders in human patients and knockout mouse models. Mol Genet Metab 93:7-14
    • (2008) Mol Genet Metab , vol.93 , pp. 7-14
    • Deignan, J.L.1    Cederbaum, S.D.2    Grody, W.W.3
  • 65
    • 84861650480 scopus 로고    scopus 로고
    • Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: Role of glutamine redefined
    • 22382077 1:CAS:528:DC%2BC38Xjs1Ghtr0%3D
    • Desjardins P, Du T, Jiang W, Peng L, Butterworth RF (2012) Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochem Int 60:690-696
    • (2012) Neurochem Int , vol.60 , pp. 690-696
    • Desjardins, P.1    Du, T.2    Jiang, W.3    Peng, L.4    Butterworth, R.F.5
  • 66
    • 0038381490 scopus 로고    scopus 로고
    • Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation
    • 12621025 1:CAS:528:DC%2BD3sXjs1Kit78%3D
    • Dolder M, Walzel B, Speer O, Schlattner U, Wallimann T (2003) Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation. J Biol Chem 278:17760-17766
    • (2003) J Biol Chem , vol.278 , pp. 17760-17766
    • Dolder, M.1    Walzel, B.2    Speer, O.3    Schlattner, U.4    Wallimann, T.5
  • 67
    • 0023945506 scopus 로고
    • Severe cerebral damage in ornithine transcarbamylase deficiency
    • 3370859 1:STN:280:DyaL1c3itl2htw%3D%3D
    • Dolman CL, Clasen RA, Dorovini-Zis K (1988) Severe cerebral damage in ornithine transcarbamylase deficiency. Clin Neuropathol 7:10-15
    • (1988) Clin Neuropathol , vol.7 , pp. 10-15
    • Dolman, C.L.1    Clasen, R.A.2    Dorovini-Zis, K.3
  • 68
    • 84857577254 scopus 로고    scopus 로고
    • Rifaximin vs. conventional oral therapy for hepatic encephalopathy: A meta-analysis
    • 22371636 1:CAS:528:DC%2BC38XjslOmu7s%3D
    • Eltawil KM, Laryea M, Peltekian K, Molinari M (2012) Rifaximin vs. conventional oral therapy for hepatic encephalopathy: a meta-analysis. World J Gastroenterol 18:767-777
    • (2012) World J Gastroenterol , vol.18 , pp. 767-777
    • Eltawil, K.M.1    Laryea, M.2    Peltekian, K.3    Molinari, M.4
  • 69
    • 49149086386 scopus 로고    scopus 로고
    • Neurologic damage and neurocognitive dysfunction in urea cycle disorders
    • 18708004
    • Enns GM (2008) Neurologic damage and neurocognitive dysfunction in urea cycle disorders. Semin Pediatr Neurol 15:132-139
    • (2008) Semin Pediatr Neurol , vol.15 , pp. 132-139
    • Enns, G.M.1
  • 70
    • 77950338976 scopus 로고    scopus 로고
    • Nitrogen sparing therapy revisited 2009
    • 20202877 1:CAS:528:DC%2BC3cXks1Sgsrw%3D
    • Enns GM (2010) Nitrogen sparing therapy revisited 2009. Mol Genet Metab 100(Suppl 1):S65-S71
    • (2010) Mol Genet Metab , vol.100 , Issue.SUPPL. 1
    • Enns, G.M.1
  • 71
    • 34249803312 scopus 로고    scopus 로고
    • Survival after treatment with phenylacetate and benzoate for urea-cycle disorders
    • 17538087 1:CAS:528:DC%2BD2sXmtVKku7o%3D
    • Enns GM, Berry SA, Berry GT, Rhead WJ, Brusilow SW, Hamosh A (2007) Survival after treatment with phenylacetate and benzoate for urea-cycle disorders. N Engl J Med 356:2282-2292
    • (2007) N Engl J Med , vol.356 , pp. 2282-2292
    • Enns, G.M.1    Berry, S.A.2    Berry, G.T.3    Rhead, W.J.4    Brusilow, S.W.5    Hamosh, A.6
  • 72
    • 0027276211 scopus 로고
    • Hyperammonemia decreases protein-kinase-C-dependent phosphorylation of microtubule-associated protein 2 and increases its binding to tubulin
    • 8508795 1:CAS:528:DyaK3sXksVKlu70%3D
    • Felipo V, Grau E, Minana MD, Grisolia S (1993) Hyperammonemia decreases protein-kinase-C-dependent phosphorylation of microtubule-associated protein 2 and increases its binding to tubulin. Eur J Biochem 214:243-249
    • (1993) Eur J Biochem , vol.214 , pp. 243-249
    • Felipo, V.1    Grau, E.2    Minana, M.D.3    Grisolia, S.4
  • 73
    • 84856386174 scopus 로고    scopus 로고
    • Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests
    • 21953369
    • Felipo V, Ordono JF, Urios A et al (2012) Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests. Hepatology 55:530-539
    • (2012) Hepatology , vol.55 , pp. 530-539
    • Felipo, V.1    Ordono, J.F.2    Urios, A.3
  • 74
    • 0022619794 scopus 로고
    • Ornithine transcarbamylase deficiency: Neuropathologic changes acquired in utero
    • 3712162 1:STN:280:DyaL283is1ymsg%3D%3D
    • Filloux F, Townsend JJ, Leonard C (1986) Ornithine transcarbamylase deficiency: neuropathologic changes acquired in utero. J Pediatr 108:942-945
    • (1986) J Pediatr , vol.108 , pp. 942-945
    • Filloux, F.1    Townsend, J.J.2    Leonard, C.3
  • 76
    • 0011443093 scopus 로고    scopus 로고
    • Major complications of cirrhosis
    • A.S. Fauci E. Braunwald K.J. Isselbacher J.D. Wilson J.B. Martin D.L. Kasper S.L. Hauser D.L. Longo (eds) 14 McGraw-Hill New-York
    • Flint Beal M, Martin JB (1998) Major complications of cirrhosis. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (eds) Harrison's principles of internal medicine, 14th edn. McGraw-Hill, New-York, pp 2451-2457
    • (1998) Harrison's Principles of Internal Medicine , pp. 2451-2457
    • Flint Beal, M.1    Martin, J.B.2
  • 77
    • 70349215356 scopus 로고    scopus 로고
    • Minimal hepatic encephalopathy in children: Evaluation with proton MR spectroscopy
    • 19509075 1:STN:280:DC%2BD1MnhslSnsA%3D%3D
    • Foerster BR, Conklin LS, Petrou M, Barker PB, Schwarz KB (2009) Minimal hepatic encephalopathy in children: evaluation with proton MR spectroscopy. Am J Neuroradiol 30:1610-1613
    • (2009) Am J Neuroradiol , vol.30 , pp. 1610-1613
    • Foerster, B.R.1    Conklin, L.S.2    Petrou, M.3    Barker, P.B.4    Schwarz, K.B.5
  • 78
    • 55749088032 scopus 로고    scopus 로고
    • Brain cholinergic impairment in liver failure
    • 18772221
    • Garcia-Ayllon MS, Cauli O, Silveyra MX et al (2008) Brain cholinergic impairment in liver failure. Brain 131:2946-2956
    • (2008) Brain , vol.131 , pp. 2946-2956
    • Garcia-Ayllon, M.S.1    Cauli, O.2    Silveyra, M.X.3
  • 79
    • 77950339042 scopus 로고    scopus 로고
    • Brain imaging in urea cycle disorders
    • 20207564 1:CAS:528:DC%2BC3cXks1Shurg%3D
    • Gropman A (2010) Brain imaging in urea cycle disorders. Mol Genet Metab 100(Suppl 1):S20-S30
    • (2010) Mol Genet Metab , vol.100 , Issue.SUPPL. 1
    • Gropman, A.1
  • 80
    • 37449009053 scopus 로고    scopus 로고
    • Neurological implications of urea cycle disorders
    • 18038189 1:CAS:528:DC%2BD2sXhtl2ks7jF
    • Gropman AL, Summar M, Leonard JV (2007) Neurological implications of urea cycle disorders. J Inherit Metab Dis 30:865-879
    • (2007) J Inherit Metab Dis , vol.30 , pp. 865-879
    • Gropman, A.L.1    Summar, M.2    Leonard, J.V.3
  • 81
    • 77958595578 scopus 로고    scopus 로고
    • Diffusion tensor imaging detects areas of abnormal white matter microstructure in patients with partial ornithine transcarbamylase deficiency
    • 20488904 1:STN:280:DC%2BC3cfotFWqtg%3D%3D
    • Gropman AL, Gertz B, Shattuck K et al (2010) Diffusion tensor imaging detects areas of abnormal white matter microstructure in patients with partial ornithine transcarbamylase deficiency. Am J Neuroradiol 31:1719-1723
    • (2010) Am J Neuroradiol , vol.31 , pp. 1719-1723
    • Gropman, A.L.1    Gertz, B.2    Shattuck, K.3
  • 82
    • 33744537598 scopus 로고    scopus 로고
    • Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encephalopathy
    • 16718775 1:CAS:528:DC%2BD28XmtVOntbY%3D
    • Grover VP, Dresner MA, Forton DM et al (2006) Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encephalopathy. World J Gastroenterol 12:2969-2978
    • (2006) World J Gastroenterol , vol.12 , pp. 2969-2978
    • Grover, V.P.1    Dresner, M.A.2    Forton, D.M.3
  • 83
    • 0035999512 scopus 로고    scopus 로고
    • 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
    • 12020614 1:CAS:528:DC%2BD38XjvVejtb0%3D
    • 13C NMR studies of compartmentalized cerebral carbohydrate metabolism. Neurochem Int 41:143-154
    • (2002) Neurochem Int , vol.41 , pp. 143-154
    • Gruetter, R.1
  • 84
    • 33645407403 scopus 로고    scopus 로고
    • Late-onset ornithine transcarbamylase deficiency in male patients: Prognostic factors and characteristics of plasma amino acid profile
    • 16635166 1:CAS:528:DC%2BD28XkslKktrg%3D
    • Harada E, Nishiyori A, Tokunaga Y et al (2006) Late-onset ornithine transcarbamylase deficiency in male patients: prognostic factors and characteristics of plasma amino acid profile. Pediatr Int 48:105-111
    • (2006) Pediatr Int , vol.48 , pp. 105-111
    • Harada, E.1    Nishiyori, A.2    Tokunaga, Y.3
  • 85
    • 0021367838 scopus 로고
    • Ornithine carbamoyl transferase deficiency: A neuropathological study
    • 6734670 1:STN:280:DyaL2c3js1aksA%3D%3D
    • Harding BN, Leonard JV, Erdohazi M (1984) Ornithine carbamoyl transferase deficiency: a neuropathological study. Eur J Pediatr 141:215-220
    • (1984) Eur J Pediatr , vol.141 , pp. 215-220
    • Harding, B.N.1    Leonard, J.V.2    Erdohazi, M.3
  • 86
    • 0025811894 scopus 로고
    • Propionic acidaemia: A neuropathological study of two patients presenting in infancy
    • 1857488 1:STN:280:DyaK3Mzht1Ggug%3D%3D
    • Harding BN, Leonard JV, Erdohazi M (1991) Propionic acidaemia: a neuropathological study of two patients presenting in infancy. Neuropathol Appl Neurobiol 17:133-138
    • (1991) Neuropathol Appl Neurobiol , vol.17 , pp. 133-138
    • Harding, B.N.1    Leonard, J.V.2    Erdohazi, M.3
  • 87
    • 35448998940 scopus 로고    scopus 로고
    • Energy metabolism in brain cells: Effects of elevated ammonia concentrations
    • 17882538 1:CAS:528:DC%2BD2sXht1amur%2FK
    • Hertz L, Kala G (2007) Energy metabolism in brain cells: effects of elevated ammonia concentrations. Metab Brain Dis 22:199-218
    • (2007) Metab Brain Dis , vol.22 , pp. 199-218
    • Hertz, L.1    Kala, G.2
  • 88
    • 25644456056 scopus 로고    scopus 로고
    • + permeability in aquaporin-expressing Xenopus oocytes
    • 15988592 1:CAS:528:DC%2BD2MXhtVajsLnK
    • + permeability in aquaporin-expressing Xenopus oocytes. Pflugers Arch 450:415-428
    • (2005) Pflugers Arch , vol.450 , pp. 415-428
    • Holm, L.M.1    Jahn, T.P.2    Møller, A.L.3
  • 89
    • 0002424997 scopus 로고    scopus 로고
    • Aggregating neural cell culture
    • S. Fedoroff A. Richardson (eds) 3 Humana Press Totowa
    • Honegger P, Monnet-Tschudi F (2001) Aggregating neural cell culture. In: Fedoroff S, Richardson A (eds) Protocols for neural cell culture, 3rd edn. Humana Press, Totowa, pp 199-218
    • (2001) Protocols for Neural Cell Culture , pp. 199-218
    • Honegger, P.1    Monnet-Tschudi, F.2
  • 90
    • 0032557865 scopus 로고    scopus 로고
    • Dendritic alterations in cortical pyramidal cells in the sparse fur mouse
    • 9630607 1:CAS:528:DyaK1cXjvVSmu70%3D
    • Hopkins KJ, McKean J, Mervis RF, Oster-Granite ML (1998) Dendritic alterations in cortical pyramidal cells in the sparse fur mouse. Brain Res 797:167-172
    • (1998) Brain Res , vol.797 , pp. 167-172
    • Hopkins, K.J.1    McKean, J.2    Mervis, R.F.3    Oster-Granite, M.L.4
  • 91
    • 0022458486 scopus 로고
    • Anorexia and altered serotonin metabolism in a patient with argininosuccinic aciduria
    • 2422338 1:STN:280:DyaL287pvFektg%3D%3D
    • Hyman SL, Coyle JT, Parke JC et al (1986) Anorexia and altered serotonin metabolism in a patient with argininosuccinic aciduria. J Pediatr 108:705-709
    • (1986) J Pediatr , vol.108 , pp. 705-709
    • Hyman, S.L.1    Coyle, J.T.2    Parke, J.C.3
  • 92
    • 0023616487 scopus 로고
    • Behavior management of feeding disturbances in urea cycle and organic acid disorders
    • 2443629 1:STN:280:DyaL1c%2FhtVemuw%3D%3D
    • Hyman SL, Porter CA, Page TJ, Iwata BA, Kissel R, Batshaw ML (1987) Behavior management of feeding disturbances in urea cycle and organic acid disorders. J Pediatr 111:558-562
    • (1987) J Pediatr , vol.111 , pp. 558-562
    • Hyman, S.L.1    Porter, C.A.2    Page, T.J.3    Iwata, B.A.4    Kissel, R.5    Batshaw, M.L.6
  • 93
    • 0023478104 scopus 로고
    • Accumulation of large neutral amino acids in the brain of sparse-fur mice at hyperammonemic state
    • 3435685 1:CAS:528:DyaL1cXpt1GrsQ%3D%3D
    • Inoue I, Gushiken T, Kobayashi K, Saheki T (1987) Accumulation of large neutral amino acids in the brain of sparse-fur mice at hyperammonemic state. Biochem Med Metab Biol 38:378-386
    • (1987) Biochem Med Metab Biol , vol.38 , pp. 378-386
    • Inoue, I.1    Gushiken, T.2    Kobayashi, K.3    Saheki, T.4
  • 94
    • 26944437887 scopus 로고    scopus 로고
    • Ammonia-mediated LTP inhibition: Effects of NMDA receptor antagonists and L-carnitine
    • 15935684 1:CAS:528:DC%2BD2MXhtFCjsL7P
    • Izumi Y, Izumi M, Matsukawa M, Funatsu M, Zorumski CF (2005) Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine. Neurobiol Dis 20:615-624
    • (2005) Neurobiol Dis , vol.20 , pp. 615-624
    • Izumi, Y.1    Izumi, M.2    Matsukawa, M.3    Funatsu, M.4    Zorumski, C.F.5
  • 95
    • 34548737013 scopus 로고    scopus 로고
    • L-Ornithine phenylacetate (OP): A novel treatment for hyperammonemia and hepatic encephalopathy
    • 17467190 1:CAS:528:DC%2BD2sXhtVOgs73N
    • Jalan R, Wright G, Davies NA, Hodges SJ (2007) L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy. Med Hypotheses 69:1064-1069
    • (2007) Med Hypotheses , vol.69 , pp. 1064-1069
    • Jalan, R.1    Wright, G.2    Davies, N.A.3    Hodges, S.J.4
  • 96
    • 79961208830 scopus 로고    scopus 로고
    • A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure
    • 21745296 1:CAS:528:DC%2BC3MXht1SrtLjF
    • Jambekar AA, Palma E, Nicolosi L et al (2011) A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure. Liver Int 31:1209-1221
    • (2011) Liver Int , vol.31 , pp. 1209-1221
    • Jambekar, A.A.1    Palma, E.2    Nicolosi, L.3
  • 97
    • 77954142513 scopus 로고    scopus 로고
    • The Na-K-Cl Co-transporter in astrocyte swelling
    • 20336356 1:CAS:528:DC%2BC3cXktlShtLs%3D
    • Jayakumar AR, Norenberg MD (2010) The Na-K-Cl Co-transporter in astrocyte swelling. Metab Brain Dis 25:31-38
    • (2010) Metab Brain Dis , vol.25 , pp. 31-38
    • Jayakumar, A.R.1    Norenberg, M.D.2
  • 98
    • 33646949200 scopus 로고    scopus 로고
    • Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes
    • 16672650 1:CAS:528:DC%2BD28XkvFSgt7c%3D
    • Jayakumar AR, Panickar KS, Murthy C, Norenberg MD (2006) Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. J Neurosci 26:4774-4784
    • (2006) J Neurosci , vol.26 , pp. 4774-4784
    • Jayakumar, A.R.1    Panickar, K.S.2    Murthy, C.3    Norenberg, M.D.4
  • 99
    • 78751570908 scopus 로고    scopus 로고
    • The Na-K-Cl cotransporter in the brain edema of acute liver failure
    • 21056502 1:CAS:528:DC%2BC3MXmsVyksA%3D%3D
    • Jayakumar AR, Valdes V, Norenberg MD (2011) The Na-K-Cl cotransporter in the brain edema of acute liver failure. J Hepatol 54:272-278
    • (2011) J Hepatol , vol.54 , pp. 272-278
    • Jayakumar, A.R.1    Valdes, V.2    Norenberg, M.D.3
  • 100
    • 84863782846 scopus 로고    scopus 로고
    • Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy
    • 22609932 1:CAS:528:DC%2BC38XhtVSls7nO
    • Jayakumar AR, Tong XY, Ospel J, Norenberg MD (2012) Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy. Neuroscience 218:305-316
    • (2012) Neuroscience , vol.218 , pp. 305-316
    • Jayakumar, A.R.1    Tong, X.Y.2    Ospel, J.3    Norenberg, M.D.4
  • 101
    • 33645996033 scopus 로고    scopus 로고
    • Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy
    • 16557540
    • Kale RA, Gupta RK, Saraswat VA et al (2006) Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy. Hepatology 43:698-706
    • (2006) Hepatology , vol.43 , pp. 698-706
    • Kale, R.A.1    Gupta, R.K.2    Saraswat, V.A.3
  • 103
    • 0027351016 scopus 로고
    • 15N NMR study of in vivo cerebral glutamine synthesis in hyperammonemic rats
    • 8096147 1:CAS:528:DyaK3sXksVKltb0%3D
    • 15N NMR study of in vivo cerebral glutamine synthesis in hyperammonemic rats. NMR Biomed 6:21-26
    • (1993) NMR Biomed , vol.6 , pp. 21-26
    • Kanamori, K.1    Parivar, F.2    Ross, B.D.3
  • 104
    • 33747586047 scopus 로고    scopus 로고
    • Characterization of late-onset citrullinemia 1 in a Korean patient: Confirmation by argininosuccinate synthetase gene mutation analysis
    • 16889683 1:CAS:528:DC%2BD28Xotlygs7Y%3D
    • Kim IS, Ki CS, Kim JW, Lee M, Jin DK, Lee SY (2006) Characterization of late-onset citrullinemia 1 in a Korean patient: confirmation by argininosuccinate synthetase gene mutation analysis. J Biochem Mol Biol 39:400-405
    • (2006) J Biochem Mol Biol , vol.39 , pp. 400-405
    • Kim, I.S.1    Ki, C.S.2    Kim, J.W.3    Lee, M.4    Jin, D.K.5    Lee, S.Y.6
  • 105
    • 84857049233 scopus 로고    scopus 로고
    • Clinical features of congenital portosystemic shunt in children
    • 21912894
    • Kim MJ, Ko JS, Seo JK et al (2012) Clinical features of congenital portosystemic shunt in children. Eur J Pediatr 171:395-400
    • (2012) Eur J Pediatr , vol.171 , pp. 395-400
    • Kim, M.J.1    Ko, J.S.2    Seo, J.K.3
  • 106
    • 0031003989 scopus 로고    scopus 로고
    • Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: Results of a placebo-controlled, double-blind study
    • 9185752 1:CAS:528:DyaK2sXlsFOjur0%3D
    • Kircheis G, Nilius R, Held C et al (1997) Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 25:1351-1360
    • (1997) Hepatology , vol.25 , pp. 1351-1360
    • Kircheis, G.1    Nilius, R.2    Held, C.3
  • 107
    • 20544457990 scopus 로고    scopus 로고
    • Mechanisms of ammonia-induced cell death in rat cortical neurons: Roles of NMDA receptors and glutathione
    • 15985217 1:CAS:528:DC%2BD2MXlsl2ktLg%3D
    • Klejman A, Wegrzynowicz M, Szatmari EM, Mioduszewska B, Hetman M, Albrecht J (2005) Mechanisms of ammonia-induced cell death in rat cortical neurons: roles of NMDA receptors and glutathione. Neurochem Int 47:51-57
    • (2005) Neurochem Int , vol.47 , pp. 51-57
    • Klejman, A.1    Wegrzynowicz, M.2    Szatmari, E.M.3    Mioduszewska, B.4    Hetman, M.5    Albrecht, J.6
  • 108
    • 0031460097 scopus 로고    scopus 로고
    • Superoxide production and antioxidant enzymes in ammonia intoxication in rats
    • 9455699 1:CAS:528:DyaK1cXpslWqtA%3D%3D
    • Kosenko E, Kaminsky Y, Kaminsky A et al (1997) Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic Res 27:637-644
    • (1997) Free Radic Res , vol.27 , pp. 637-644
    • Kosenko, E.1    Kaminsky, Y.2    Kaminsky, A.3
  • 109
    • 0031949404 scopus 로고    scopus 로고
    • Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication
    • 9570638 1:CAS:528:DyaK1cXivVWmu7c%3D
    • Kosenko E, Kaminsky Y, Lopata O et al (1998) Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication. Metab Brain Dis 13:29-41
    • (1998) Metab Brain Dis , vol.13 , pp. 29-41
    • Kosenko, E.1    Kaminsky, Y.2    Lopata, O.3
  • 110
    • 0032967196 scopus 로고    scopus 로고
    • Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication
    • 10401599 1:STN:280:DyaK1MzivFynsA%3D%3D
    • Kosenko E, Kaminski Y, Lopata O, Muravyov N, Felipo V (1999) Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication. Free Radic Biol Med 26:1369-1374
    • (1999) Free Radic Biol Med , vol.26 , pp. 1369-1374
    • Kosenko, E.1    Kaminski, Y.2    Lopata, O.3    Muravyov, N.4    Felipo, V.5
  • 111
    • 70149084232 scopus 로고    scopus 로고
    • Intellectual, adaptive, and behavioral functioning in children with urea cycle disorders
    • 19287347 1:CAS:528:DC%2BD1MXnsV2ktr0%3D
    • Krivitzky L, Babikian T, Lee HS, Thomas NH, Burk-Paull KL, Batshaw ML (2009) Intellectual, adaptive, and behavioral functioning in children with urea cycle disorders. Pediatr Res 66:96-101
    • (2009) Pediatr Res , vol.66 , pp. 96-101
    • Krivitzky, L.1    Babikian, T.2    Lee, H.S.3    Thomas, N.H.4    Burk-Paull, K.L.5    Batshaw, M.L.6
  • 112
    • 0037245327 scopus 로고    scopus 로고
    • Magnetic resonance imaging in late-onset ornithine transcarbamylase deficiency
    • 12536032
    • Kurihara A, Takanashi J, Tomita M et al (2003) Magnetic resonance imaging in late-onset ornithine transcarbamylase deficiency. Brain Dev 25:40-44
    • (2003) Brain Dev , vol.25 , pp. 40-44
    • Kurihara, A.1    Takanashi, J.2    Tomita, M.3
  • 113
    • 0022972426 scopus 로고
    • Brain alpha-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors
    • 3760866 1:CAS:528:DyaL2sXitFWk
    • Lai JC, Cooper AJ (1986) Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J Neurochem 47:1376-1386
    • (1986) J Neurochem , vol.47 , pp. 1376-1386
    • Lai, J.C.1    Cooper, A.J.2
  • 116
    • 0035143585 scopus 로고    scopus 로고
    • Long-term correction of urea cycle disorders
    • 11148551 1:CAS:528:DC%2BD3MXhtF2lsLs%3D
    • Lee B, Goss J (2001) Long-term correction of urea cycle disorders. J Pediatr 138:S62-S71
    • (2001) J Pediatr , vol.138
    • Lee, B.1    Goss, J.2
  • 117
    • 0036303636 scopus 로고    scopus 로고
    • Urea cycle disorders
    • 12069536 1:STN:280:DC%2BD38zislOltw%3D%3D
    • Leonard JV, Morris AA (2002) Urea cycle disorders. Semin Neonatol 7:27-35
    • (2002) Semin Neonatol , vol.7 , pp. 27-35
    • Leonard, J.V.1    Morris, A.A.2
  • 118
    • 39049165141 scopus 로고    scopus 로고
    • Hypothesis: Proposals for the management of a neonate at risk of hyperammonaemia due to a urea cycle disorder
    • 17436013
    • Leonard JV, Ward Platt MP, Morris AA (2008) Hypothesis: proposals for the management of a neonate at risk of hyperammonaemia due to a urea cycle disorder. Eur J Pediatr 167:305-309
    • (2008) Eur J Pediatr , vol.167 , pp. 305-309
    • Leonard, J.V.1    Ward Platt, M.P.2    Morris, A.A.3
  • 119
    • 38949087309 scopus 로고    scopus 로고
    • Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasis in vivo
    • 18186079
    • Lichter-Konecki U, Mangin JM, Gordish-Dressman H, Hoffman EP, Gallo V (2008) Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasis in vivo. Glia 56:365-377
    • (2008) Glia , vol.56 , pp. 365-377
    • Lichter-Konecki, U.1    Mangin, J.M.2    Gordish-Dressman, H.3    Hoffman, E.P.4    Gallo, V.5
  • 121
    • 1642581755 scopus 로고    scopus 로고
    • Neonatal citrullinemia: Comparison of conventional MR, diffusion-weighted, and diffusion tensor findings
    • 14729525
    • Majoie CB, Mourmans JM, Akkerman EM, Duran M, Poll-The BT (2004) Neonatal citrullinemia: comparison of conventional MR, diffusion-weighted, and diffusion tensor findings. Am J Neuroradiol 25:32-35
    • (2004) Am J Neuroradiol , vol.25 , pp. 32-35
    • Majoie, C.B.1    Mourmans, J.M.2    Akkerman, E.M.3    Duran, M.4    Poll-The, B.T.5
  • 122
    • 0028894969 scopus 로고
    • Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum
    • 8556324 1:CAS:528:DyaK2MXos1Ggs7c%3D
    • Marcaida G, Minana MD, Grisolia S, Felipo V (1995) Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum. Brain Res 695:146-150
    • (1995) Brain Res , vol.695 , pp. 146-150
    • Marcaida, G.1    Minana, M.D.2    Grisolia, S.3    Felipo, V.4
  • 123
    • 84894885993 scopus 로고    scopus 로고
    • Assessment of cerebral osmotic regulation in a rat model of biliary cirrhosis using MR spectroscopy
    • McLin VA, Braissant O, van de Looij Y, Kunz N, Gruetter R, Cudalbu C (2012) Assessment of cerebral osmotic regulation in a rat model of biliary cirrhosis using MR spectroscopy. J Hepatol 56(Suppl 2):S231-S232
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2
    • McLin, V.A.1    Braissant, O.2    Van De Looij, Y.3    Kunz, N.4    Gruetter, R.5    Cudalbu, C.6
  • 124
    • 67049169082 scopus 로고    scopus 로고
    • MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T
    • 19319893 1:CAS:528:DC%2BD1MXnvVWlur8%3D
    • Mekle R, Mlynarik V, Gambarota G, Hergt M, Krueger G, Gruetter R (2009) MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T. Magn Reson Med 61:1279-1285
    • (2009) Magn Reson Med , vol.61 , pp. 1279-1285
    • Mekle, R.1    Mlynarik, V.2    Gambarota, G.3    Hergt, M.4    Krueger, G.5    Gruetter, R.6
  • 125
    • 77950340268 scopus 로고    scopus 로고
    • Liver, liver cell and stem cell transplantation for the treatment of urea cycle defects
    • 20156696 1:CAS:528:DC%2BC3cXks1Sgsrs%3D
    • Meyburg J, Hoffmann GF (2010) Liver, liver cell and stem cell transplantation for the treatment of urea cycle defects. Mol Genet Metab 100(Suppl 1):S77-S83
    • (2010) Mol Genet Metab , vol.100 , Issue.SUPPL. 1
    • Meyburg, J.1    Hoffmann, G.F.2
  • 126
    • 0030864157 scopus 로고    scopus 로고
    • Ornithine transcarbamylase deficiency: Pathogenesis of the cerebral disorder and new prospects for therapy
    • 9346466 1:CAS:528:DyaK2sXntFSru7Y%3D
    • Michalak A, Butterworth RF (1997) Ornithine transcarbamylase deficiency: pathogenesis of the cerebral disorder and new prospects for therapy. Metab Brain Dis 12:171-182
    • (1997) Metab Brain Dis , vol.12 , pp. 171-182
    • Michalak, A.1    Butterworth, R.F.2
  • 127
    • 52949130629 scopus 로고    scopus 로고
    • 1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: Improvements in quantification of the neurochemical profile
    • 18703364 1:CAS:528:DC%2BD1cXhtF2rsbjF
    • 1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: improvements in quantification of the neurochemical profile. J Magn Reson 194:163-168
    • (2008) J Magn Reson , vol.194 , pp. 163-168
    • Mlynarik, V.1    Cudalbu, C.2    Xin, L.3    Gruetter, R.4
  • 128
    • 37549048204 scopus 로고    scopus 로고
    • Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times
    • 18050343 1:CAS:528:DC%2BD1cXhtleqsLY%3D
    • Mlynarik V, Kohler I, Gambarota G, Vaslin A, Clarke PG, Gruetter R (2008b) Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times. Magn Reson Med 59:52-58
    • (2008) Magn Reson Med , vol.59 , pp. 52-58
    • Mlynarik, V.1    Kohler, I.2    Gambarota, G.3    Vaslin, A.4    Clarke, P.G.5    Gruetter, R.6
  • 129
    • 84861335405 scopus 로고    scopus 로고
    • Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy
    • 22465844
    • Montoliu C, Gonzalez-Escamilla G, Atienza M et al (2012) Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy. NeuroImage 61:1165-1175
    • (2012) NeuroImage , vol.61 , pp. 1165-1175
    • Montoliu, C.1    Gonzalez-Escamilla, G.2    Atienza, M.3
  • 130
    • 77955406067 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinases in the mechanism of oxidant-induced cell swelling in cultured astrocytes
    • 20623534 1:CAS:528:DC%2BC3cXos1GmtLo%3D
    • Moriyama M, Jayakumar AR, Tong XY, Norenberg MD (2010) Role of mitogen-activated protein kinases in the mechanism of oxidant-induced cell swelling in cultured astrocytes. J Neurosci Res 88:2450-2458
    • (2010) J Neurosci Res , vol.88 , pp. 2450-2458
    • Moriyama, M.1    Jayakumar, A.R.2    Tong, X.Y.3    Norenberg, M.D.4
  • 131
    • 0021187612 scopus 로고
    • Neurologic outcome in children with inborn errors of urea synthesis. Outcome of urea-cycle enzymopathies
    • 6717540 1:STN:280:DyaL2c7ptFCjug%3D%3D
    • Msall M, Batshaw ML, Suss R, Brusilow SW, Mellits ED (1984) Neurologic outcome in children with inborn errors of urea synthesis. Outcome of urea-cycle enzymopathies. N Engl J Med 310:1500-1505
    • (1984) N Engl J Med , vol.310 , pp. 1500-1505
    • Msall, M.1    Batshaw, M.L.2    Suss, R.3    Brusilow, S.W.4    Mellits, E.D.5
  • 132
    • 0342313714 scopus 로고    scopus 로고
    • Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro
    • 10823575 1:CAS:528:DC%2BD3cXjt1Gjur4%3D
    • Munoz MD, Monfort P, Gaztelu JM, Felipo V (2000) Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro. Neurochem Res 25:437-441
    • (2000) Neurochem Res , vol.25 , pp. 437-441
    • Munoz, M.D.1    Monfort, P.2    Gaztelu, J.M.3    Felipo, V.4
  • 133
    • 0035888288 scopus 로고    scopus 로고
    • Ammonia-induced production of free radicals in primary cultures of rat astrocytes
    • 11592125 1:CAS:528:DC%2BD3MXnsVykur8%3D
    • Murthy CR, Rama Rao KV, Bai G, Norenberg MD (2001) Ammonia-induced production of free radicals in primary cultures of rat astrocytes. J Neurosci Res 66:282-288
    • (2001) J Neurosci Res , vol.66 , pp. 282-288
    • Murthy, C.R.1    Rama Rao, K.V.2    Bai, G.3    Norenberg, M.D.4
  • 134
    • 3342967877 scopus 로고    scopus 로고
    • Nitric oxide synthesis in ornithine transcarbamylase deficiency: Possible involvement of low NO synthesis in clinical manifestations of urea cycle defect
    • 15289781 1:CAS:528:DC%2BD2cXmt1ChsbY%3D
    • Nagasaka H, Komatsu H, Ohura T et al (2004) Nitric oxide synthesis in ornithine transcarbamylase deficiency: possible involvement of low NO synthesis in clinical manifestations of urea cycle defect. J Pediatr 145:259-262
    • (2004) J Pediatr , vol.145 , pp. 259-262
    • Nagasaka, H.1    Komatsu, H.2    Ohura, T.3
  • 135
    • 29744441816 scopus 로고    scopus 로고
    • Mechanisms of ammonia-induced astrocyte swelling
    • 16382341 1:CAS:528:DC%2BD2MXhtlGhu77N
    • Norenberg MD, Rao KV, Jayakumar AR (2005) Mechanisms of ammonia-induced astrocyte swelling. Metab Brain Dis 20:303-318
    • (2005) Metab Brain Dis , vol.20 , pp. 303-318
    • Norenberg, M.D.1    Rao, K.V.2    Jayakumar, A.R.3
  • 136
    • 0031882282 scopus 로고    scopus 로고
    • Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog
    • 1:STN:280:DyaK1c7pt1ansg%3D%3D
    • Nyberg SL, Cerra FB, Gruetter R (1998) Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog. Liver Transp Surg 4:158-165
    • (1998) Liver Transp Surg , vol.4 , pp. 158-165
    • Nyberg, S.L.1    Cerra, F.B.2    Gruetter, R.3
  • 137
    • 80053648196 scopus 로고    scopus 로고
    • Down-regulation of Kir4.1 in the cerebral cortex of rats with liver failure and in cultured astrocytes treated with glutamine: Implications for astrocytic dysfunction in hepatic encephalopathy
    • 21538466 1:CAS:528:DC%2BC3MXht1yktLbO
    • Obara-Michlewska M, Pannicke T, Karl A et al (2011) Down-regulation of Kir4.1 in the cerebral cortex of rats with liver failure and in cultured astrocytes treated with glutamine: Implications for astrocytic dysfunction in hepatic encephalopathy. J Neurosci Res 89:2018-2027
    • (2011) J Neurosci Res , vol.89 , pp. 2018-2027
    • Obara-Michlewska, M.1    Pannicke, T.2    Karl, A.3
  • 140
    • 83555162585 scopus 로고    scopus 로고
    • Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis
    • 21835138 1:CAS:528:DC%2BC3MXhs1GhsbvJ
    • Oria M, Romero-Giménez J, Arranz JA, Riudor E, Raquer N, Córdoba J (2012) Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis. J Hepatol 56:109-114
    • (2012) J Hepatol , vol.56 , pp. 109-114
    • Oria, M.1    Romero-Giménez, J.2    Arranz, J.A.3    Riudor, E.4    Raquer, N.5    Córdoba, J.6
  • 141
    • 67349210009 scopus 로고    scopus 로고
    • Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake
    • 19428812 1:CAS:528:DC%2BD1MXltVKrsb0%3D
    • Panickar KS, Jayakumar AR, Rao KV, Norenberg MD (2009) Ammonia-induced activation of p53 in cultured astrocytes: role in cell swelling and glutamate uptake. Neurochem Int 55:98-105
    • (2009) Neurochem Int , vol.55 , pp. 98-105
    • Panickar, K.S.1    Jayakumar, A.R.2    Rao, K.V.3    Norenberg, M.D.4
  • 142
    • 0023146757 scopus 로고
    • Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy
    • 3570029 1:CAS:528:DyaL2sXktleitLw%3D
    • Patil DH, Westaby D, Mahida YR et al (1987) Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy. Gut 28:255-259
    • (1987) Gut , vol.28 , pp. 255-259
    • Patil, D.H.1    Westaby, D.2    Mahida, Y.R.3
  • 144
    • 78650793324 scopus 로고    scopus 로고
    • Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic Thrombophilic disorders
    • 21182228
    • Pietrobattista A, Luciani M, Abraldes JG et al (2010) Extrahepatic portal vein thrombosis in children and adolescents: influence of genetic Thrombophilic disorders. World J Gastroenterol 16:6123-6127
    • (2010) World J Gastroenterol , vol.16 , pp. 6123-6127
    • Pietrobattista, A.1    Luciani, M.2    Abraldes, J.G.3
  • 145
    • 0030846740 scopus 로고    scopus 로고
    • Sparse-fur (spf) mouse as a model of hyperammonemia: Alterations in the neurotransmitter systems
    • 9286431 1:CAS:528:DyaK1cXhsVyjsro%3D
    • Qureshi IA, Rao KV (1997) Sparse-fur (spf) mouse as a model of hyperammonemia: alterations in the neurotransmitter systems. Adv Exp Med Biol 420:143-158
    • (1997) Adv Exp Med Biol , vol.420 , pp. 143-158
    • Qureshi, I.A.1    Rao, K.V.2
  • 147
    • 84865797225 scopus 로고    scopus 로고
    • Glutamine in the pathogenesis of acute hepatic encephalopathy
    • 22285152 1:CAS:528:DC%2BC38XisFyjsr0%3D
    • Rama Rao KV, Jayakumar AR, Norenberg MD (2012) Glutamine in the pathogenesis of acute hepatic encephalopathy. Neurochem Int 61:575-580
    • (2012) Neurochem Int , vol.61 , pp. 575-580
    • Rama Rao, K.V.1    Jayakumar, A.R.2    Norenberg, M.D.3
  • 148
    • 25144511007 scopus 로고    scopus 로고
    • Cytotoxic edema is responsible for raised intracranial pressure in fulminant hepatic failure: In vivo demonstration using diffusion-weighted MRI in human subjects
    • 16167196
    • Ranjan P, Mishra AM, Kale R, Saraswat VA, Gupta RK (2005) Cytotoxic edema is responsible for raised intracranial pressure in fulminant hepatic failure: in vivo demonstration using diffusion-weighted MRI in human subjects. Metab Brain Dis 20:181-192
    • (2005) Metab Brain Dis , vol.20 , pp. 181-192
    • Ranjan, P.1    Mishra, A.M.2    Kale, R.3    Saraswat, V.A.4    Gupta, R.K.5
  • 149
    • 0036090597 scopus 로고    scopus 로고
    • Nitric oxide in hepatic encephalopathy and hyperammonemia
    • 12020616 1:CAS:528:DC%2BD38XjvVejtbs%3D
    • Rao VLR (2002) Nitric oxide in hepatic encephalopathy and hyperammonemia. Neurochem Int 41:161-170
    • (2002) Neurochem Int , vol.41 , pp. 161-170
    • Rao, V.L.R.1
  • 150
    • 0032978522 scopus 로고    scopus 로고
    • Reduction in the MK-801 binding sites of the NMDA sub-type of glutamate receptor in a mouse model of congenital hyperammonemia: Prevention by acetyl-L-carnitine
    • 10219976 1:CAS:528:DyaK1MXit1ertrw%3D
    • Rao KV, Qureshi IA (1999) Reduction in the MK-801 binding sites of the NMDA sub-type of glutamate receptor in a mouse model of congenital hyperammonemia: prevention by acetyl-L-carnitine. Neuropharmacology 38:383-394
    • (1999) Neuropharmacology , vol.38 , pp. 383-394
    • Rao, K.V.1    Qureshi, I.A.2
  • 151
    • 0037997376 scopus 로고    scopus 로고
    • Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: Role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion
    • 9086462 1:CAS:528:DyaK2sXhvFWntLk%3D
    • Rao KV, Mawal YR, Qureshi IA (1997) Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion. Neurosci Lett 224:83-86
    • (1997) Neurosci Lett , vol.224 , pp. 83-86
    • Rao, K.V.1    Mawal, Y.R.2    Qureshi, I.A.3
  • 152
    • 0026752613 scopus 로고
    • Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice
    • 1575747 1:CAS:528:DyaK38XisFemtro%3D
    • Ratnakumari L, Qureshi IA, Butterworth RF (1992) Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice. Biochem Biophys Res Commun 184:746-751
    • (1992) Biochem Biophys Res Commun , vol.184 , pp. 746-751
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 153
    • 0028240536 scopus 로고
    • Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency
    • 7914668 1:CAS:528:DyaK2cXltVKjs7c%3D
    • Ratnakumari L, Qureshi IA, Butterworth RF (1994a) Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency. Metab Brain Dis 9:43-51
    • (1994) Metab Brain Dis , vol.9 , pp. 43-51
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 154
    • 0027999155 scopus 로고
    • Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency
    • 7816342 1:CAS:528:DyaK2cXmsFejsL4%3D
    • Ratnakumari L, Qureshi IA, Butterworth RF (1994b) Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency. Neurosci Lett 178:63-65
    • (1994) Neurosci Lett , vol.178 , pp. 63-65
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 155
    • 0029042318 scopus 로고
    • Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: Effect of acetyl-L-carnitine
    • 7616428 1:CAS:528:DyaK2MXntVWltbw%3D
    • Ratnakumari L, Qureshi IA, Maysinger D, Butterworth RF (1995) Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine. J Pharmacol Exp Ther 274:437-443
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 437-443
    • Ratnakumari, L.1    Qureshi, I.A.2    Maysinger, D.3    Butterworth, R.F.4
  • 156
    • 0029933851 scopus 로고    scopus 로고
    • Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency
    • 8798241 1:STN:280:DyaK28zptFalug%3D%3D
    • Ratnakumari L, Qureshi IA, Butterworth RF (1996a) Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency. Pediatr Res 40:25-28
    • (1996) Pediatr Res , vol.40 , pp. 25-28
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 157
    • 0030582438 scopus 로고    scopus 로고
    • Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: Effect of metabolic arginine deficiency
    • 8899736 1:CAS:528:DyaK28XmtlWhtbk%3D
    • Ratnakumari L, Qureshi IA, Butterworth RF, Marescau B, De Deyn PP (1996b) Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: effect of metabolic arginine deficiency. Neurosci Lett 215:153-156
    • (1996) Neurosci Lett , vol.215 , pp. 153-156
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3    Marescau, B.4    De Deyn, P.P.5
  • 158
    • 34247547012 scopus 로고    scopus 로고
    • Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    • 17352382
    • Reinehr R, Gorg B, Becker S et al (2007) Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices. Glia 55:758-771
    • (2007) Glia , vol.55 , pp. 758-771
    • Reinehr, R.1    Gorg, B.2    Becker, S.3
  • 159
    • 0026610373 scopus 로고
    • Brain serotonin2 and serotonin1A receptors are altered in the congenitally hyperammonemic sparse fur mouse
    • 1531355 1:CAS:528:DyaK38XhsV2htr0%3D
    • Robinson MB, Anegawa NJ, Gorry E et al (1992a) Brain serotonin2 and serotonin1A receptors are altered in the congenitally hyperammonemic sparse fur mouse. J Neurochem 58:1016-1022
    • (1992) J Neurochem , vol.58 , pp. 1016-1022
    • Robinson, M.B.1    Anegawa, N.J.2    Gorry, E.3
  • 160
    • 0026660831 scopus 로고
    • Quinolinate in brain and cerebrospinal fluid in rat models of congenital hyperammonemia
    • 1279510 1:CAS:528:DyaK3sXitVChtg%3D%3D
    • Robinson MB, Heyes MP, Anegawa NJ et al (1992b) Quinolinate in brain and cerebrospinal fluid in rat models of congenital hyperammonemia. Pediatr Res 32:483-488
    • (1992) Pediatr Res , vol.32 , pp. 483-488
    • Robinson, M.B.1    Heyes, M.P.2    Anegawa, N.J.3
  • 161
    • 17444422183 scopus 로고    scopus 로고
    • Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in the cerebellum and cortex of patients with liver cirrhosis
    • 15837570 1:CAS:528:DC%2BD2MXjtlajs7Y%3D
    • Rodrigo R, Erceg S, Felipo V (2005) Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in the cerebellum and cortex of patients with liver cirrhosis. Neurobiol Dis 19:150-161
    • (2005) Neurobiol Dis , vol.19 , pp. 150-161
    • Rodrigo, R.1    Erceg, S.2    Felipo, V.3
  • 162
    • 64949120484 scopus 로고    scopus 로고
    • Role of NMDA receptors in acute liver failure and ammonia toxicity: Therapeutical implications
    • 19428814 1:CAS:528:DC%2BD1MXltVKrs74%3D
    • Rodrigo R, Cauli O, Boix J, El Mlili N, Agusti A, Felipo V (2009) Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications. Neurochem Int 55:113-118
    • (2009) Neurochem Int , vol.55 , pp. 113-118
    • Rodrigo, R.1    Cauli, O.2    Boix, J.3    El Mlili, N.4    Agusti, A.5    Felipo, V.6
  • 163
    • 33646824320 scopus 로고    scopus 로고
    • Effect of ammonia on astrocytic glutamate uptake/release mechanisms
    • 16635245 1:CAS:528:DC%2BD28XksVyksb8%3D
    • Rose C (2006) Effect of ammonia on astrocytic glutamate uptake/release mechanisms. J Neurochem 97(Suppl 1):11-15
    • (2006) J Neurochem , vol.97 , Issue.SUPPL. 1 , pp. 11-15
    • Rose, C.1
  • 164
    • 29744437097 scopus 로고    scopus 로고
    • Limited capacity for ammonia removal by brain in chronic liver failure: Potential role of nitric oxide
    • 16382338 1:CAS:528:DC%2BD2MXhtlGhurfL
    • Rose C, Felipo V (2005) Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis 20:275-283
    • (2005) Metab Brain Dis , vol.20 , pp. 275-283
    • Rose, C.1    Felipo, V.2
  • 165
    • 0031852152 scopus 로고    scopus 로고
    • L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: Therapeutic efficacy and mechanism of action
    • 9699922 1:CAS:528:DyaK1cXltlChsb4%3D
    • Rose C, Michalak A, Pannunzio P et al (1998) L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metab Brain Dis 13:147-157
    • (1998) Metab Brain Dis , vol.13 , pp. 147-157
    • Rose, C.1    Michalak, A.2    Pannunzio, P.3
  • 166
    • 20444366546 scopus 로고    scopus 로고
    • Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH
    • 15802262 1:CAS:528:DC%2BD2MXks1emurw%3D
    • Rose C, Kresse W, Kettenmann H (2005) Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH. J Biol Chem 280:20937-20944
    • (2005) J Biol Chem , vol.280 , pp. 20937-20944
    • Rose, C.1    Kresse, W.2    Kettenmann, H.3
  • 167
    • 54249128893 scopus 로고    scopus 로고
    • MR imaging findings in hepatic encephalopathy
    • 18583413 1:STN:280:DC%2BD1cnkvVCmsQ%3D%3D
    • Rovira A, Alonso J, Cordoba J (2008) MR imaging findings in hepatic encephalopathy. Am J Neuroradiol 29:1612-1621
    • (2008) Am J Neuroradiol , vol.29 , pp. 1612-1621
    • Rovira, A.1    Alonso, J.2    Cordoba, J.3
  • 168
    • 0035845671 scopus 로고    scopus 로고
    • Clinical and molecular findings in hyperornithinemia-hyperammonemia-
    • 11552031 1:CAS:528:DC%2BD3MXntFGktrk%3D
    • Salvi S, Santorelli FM, Bertini E et al (2001) Clinical and molecular findings in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. Neurology 57:911-914
    • (2001) Neurology , vol.57 , pp. 911-914
    • Salvi, S.1    Santorelli, F.M.2    Bertini, E.3
  • 169
    • 77950313953 scopus 로고    scopus 로고
    • New insights in nutritional management and amino acid supplementation in urea cycle disorders
    • 20299258 1:CAS:528:DC%2BC3cXks1Sgsro%3D
    • Scaglia F (2010) New insights in nutritional management and amino acid supplementation in urea cycle disorders. Mol Genet Metab 100(Suppl 1):S72-S76
    • (2010) Mol Genet Metab , vol.100 , Issue.SUPPL. 1
    • Scaglia, F.1
  • 170
    • 33646496837 scopus 로고    scopus 로고
    • Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase i deficiency
    • Scaglia F, Lee B (2006) Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency. Am J Med Genet C Semin Med Genet 142:113-120
    • (2006) Am J Med Genet C Semin Med Genet , vol.142 , pp. 113-120
    • Scaglia, F.1    Lee, B.2
  • 171
    • 0036140891 scopus 로고    scopus 로고
    • An integrated approach to the diagnosis and prospective management of partial ornithine transcarbamylase deficiency
    • 11773558
    • Scaglia F, Zheng Q, O'Brien WE et al (2002) An integrated approach to the diagnosis and prospective management of partial ornithine transcarbamylase deficiency. Pediatrics 109:150-152
    • (2002) Pediatrics , vol.109 , pp. 150-152
    • Scaglia, F.1    Zheng, Q.2    O'Brien, W.E.3
  • 172
    • 4744344225 scopus 로고    scopus 로고
    • Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism
    • 15465784 1:CAS:528:DC%2BD2cXosVOjsrY%3D
    • Scaglia F, Brunetti-Pierri N, Kleppe S et al (2004) Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. J Nutr 134:2775S-2782S
    • (2004) J Nutr , vol.134
    • Scaglia, F.1    Brunetti-Pierri, N.2    Kleppe, S.3
  • 173
    • 0036581130 scopus 로고    scopus 로고
    • Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes
    • 11923223 1:CAS:528:DC%2BD38XjsVeqt74%3D
    • Schliess F, Gorg B, Fischer R et al (2002) Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J 16:739-741
    • (2002) FASEB J , vol.16 , pp. 739-741
    • Schliess, F.1    Gorg, B.2    Fischer, R.3
  • 174
    • 0031595306 scopus 로고    scopus 로고
    • 15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain
    • 9778582 1:CAS:528:DyaK1cXntl2ltrg%3D
    • 15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain. Dev Neurosci 20:434-443
    • (1998) Dev Neurosci , vol.20 , pp. 434-443
    • Shen, J.1    Sibson, N.R.2    Cline, G.3    Behar, K.L.4    Rothman, D.L.5    Shulman, R.G.6
  • 175
    • 34249785397 scopus 로고    scopus 로고
    • Alternative-pathway therapy for hyperammonemia
    • 17538092 1:CAS:528:DC%2BD2sXmtVKrsrg%3D
    • Shih VE (2007) Alternative-pathway therapy for hyperammonemia. N Engl J Med 356:2321-2322
    • (2007) N Engl J Med , vol.356 , pp. 2321-2322
    • Shih, V.E.1
  • 178
    • 84858699672 scopus 로고    scopus 로고
    • Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases
    • 22260250 1:CAS:528:DC%2BC38XmsVKltr4%3D
    • Skowronska M, Zielinska M, Wojcik-Stanaszek L et al (2012) Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases. J Neurochem 121:125-134
    • (2012) J Neurochem , vol.121 , pp. 125-134
    • Skowronska, M.1    Zielinska, M.2    Wojcik-Stanaszek, L.3
  • 179
    • 26844455345 scopus 로고    scopus 로고
    • Urea cycle disorders: Clinical presentation outside the newborn period
    • 16227115
    • Smith W, Kishnani PS, Lee B et al (2005) Urea cycle disorders: clinical presentation outside the newborn period. Crit Care Clin 21:S9-S17
    • (2005) Crit Care Clin , vol.21
    • Smith, W.1    Kishnani, P.S.2    Lee, B.3
  • 180
    • 0037096037 scopus 로고    scopus 로고
    • GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats
    • 12111833 1:CAS:528:DC%2BD38XksFGru7g%3D
    • Song G, Dhodda VK, Blei AT, Dempsey RJ, Rao VL (2002) GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats. J Neurosci Res 68:730-737
    • (2002) J Neurosci Res , vol.68 , pp. 730-737
    • Song, G.1    Dhodda, V.K.2    Blei, A.T.3    Dempsey, R.J.4    Rao, V.L.5
  • 181
    • 12244304903 scopus 로고    scopus 로고
    • 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy
    • 12602516 1:CAS:528:DC%2BD3sXislGqsg%3D%3D
    • 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 17:399-413
    • (2002) Metab Brain Dis , vol.17 , pp. 399-413
    • Spahr, L.1    Burkhard, P.R.2    Grotzsch, H.3    Hadengue, A.4
  • 182
    • 0035142619 scopus 로고    scopus 로고
    • Current strategies for the management of neonatal urea cycle disorders
    • 11148547 1:CAS:528:DC%2BD3MXhtF2ls7g%3D
    • Summar M (2001) Current strategies for the management of neonatal urea cycle disorders. J Pediatr 138:S30-S39
    • (2001) J Pediatr , vol.138
    • Summar, M.1
  • 183
    • 0037162369 scopus 로고    scopus 로고
    • Distinctly abnormal brain metabolism in late-onset ornithine transcarbamylase deficiency
    • 12136059 1:CAS:528:DC%2BD38Xmt1Sisbs%3D
    • Takanashi J, Kurihara A, Tomita M et al (2002) Distinctly abnormal brain metabolism in late-onset ornithine transcarbamylase deficiency. Neurology 59:210-214
    • (2002) Neurology , vol.59 , pp. 210-214
    • Takanashi, J.1    Kurihara, A.2    Tomita, M.3
  • 184
    • 0038614744 scopus 로고    scopus 로고
    • Brain MR imaging in neonatal hyperammonemic encephalopathy resulting from proximal urea cycle disorders
    • 12812952
    • Takanashi J, Barkovich AJ, Cheng SF et al (2003) Brain MR imaging in neonatal hyperammonemic encephalopathy resulting from proximal urea cycle disorders. Am J Neuroradiol 24:1184-1187
    • (2003) Am J Neuroradiol , vol.24 , pp. 1184-1187
    • Takanashi, J.1    Barkovich, A.J.2    Cheng, S.F.3
  • 185
    • 0035070667 scopus 로고    scopus 로고
    • Carbamyl phosphate synthetase 1 deficiency: A destructive encephalopathy
    • 11301219 1:STN:280:DC%2BD3MvntlamtA%3D%3D
    • Takeoka M, Soman TB, Shih VE, Caviness VS, Krishnamoorthy KS (2001) Carbamyl phosphate synthetase 1 deficiency: a destructive encephalopathy. Pediatr Neurol 24:193-199
    • (2001) Pediatr Neurol , vol.24 , pp. 193-199
    • Takeoka, M.1    Soman, T.B.2    Shih, V.E.3    Caviness, V.S.4    Krishnamoorthy, K.S.5
  • 186
    • 13544270851 scopus 로고    scopus 로고
    • Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats
    • 15708485 1:CAS:528:DC%2BD2MXhtlent7w%3D
    • Tanigami H, Rebel A, Martin LJ et al (2005) Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats. Neuroscience 131:437-449
    • (2005) Neuroscience , vol.131 , pp. 437-449
    • Tanigami, H.1    Rebel, A.2    Martin, L.J.3
  • 188
    • 70349613203 scopus 로고    scopus 로고
    • 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T
    • 19591201
    • 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T. Magn Reson Med 62:868-879
    • (2009) Magn Reson Med , vol.62 , pp. 868-879
    • Tkác, I.1    Oz, G.2    Adriany, G.3    Ugurbil, K.4    Gruetter, R.5
  • 189
    • 46749144467 scopus 로고    scopus 로고
    • Cross-sectional multicenter study of patients with urea cycle disorders in the United States
    • 18562231 1:CAS:528:DC%2BD1cXosVOntb0%3D
    • Tuchman M, Lee B, Lichter-Konecki U et al (2008) Cross-sectional multicenter study of patients with urea cycle disorders in the United States. Mol Genet Metab 94:397-402
    • (2008) Mol Genet Metab , vol.94 , pp. 397-402
    • Tuchman, M.1    Lee, B.2    Lichter-Konecki, U.3
  • 190
    • 0031926212 scopus 로고    scopus 로고
    • Neurodevelopmental outcome of long-term therapy of urea cycle disorders in Japan
    • 9686352
    • Uchino T, Endo F, Matsuda I (1998) Neurodevelopmental outcome of long-term therapy of urea cycle disorders in Japan. J Inherit Metab Dis 21(Suppl 1):151-159
    • (1998) J Inherit Metab Dis , vol.21 , Issue.SUPPL. 1 , pp. 151-159
    • Uchino, T.1    Endo, F.2    Matsuda, I.3
  • 191
    • 0023663546 scopus 로고
    • The molecular basis of the sparse fur mouse mutation
    • 3603027 1:CAS:528:DyaL1cXhslShtQ%3D%3D
    • Veres G, Gibbs RA, Scherer SE, Caskey CT (1987) The molecular basis of the sparse fur mouse mutation. Science 237:415-417
    • (1987) Science , vol.237 , pp. 415-417
    • Veres, G.1    Gibbs, R.A.2    Scherer, S.E.3    Caskey, C.T.4
  • 192
    • 69249202553 scopus 로고    scopus 로고
    • Ammonia toxicity and its prevention in inherited defects of the urea cycle
    • 19531057 1:CAS:528:DC%2BD1MXhtFyqt7bN
    • Walker V (2009) Ammonia toxicity and its prevention in inherited defects of the urea cycle. Diabetes Obes Metab 11:823-835
    • (2009) Diabetes Obes Metab , vol.11 , pp. 823-835
    • Walker, V.1
  • 193
    • 0035081701 scopus 로고    scopus 로고
    • Arginine metabolism and the synthesis of nitric oxide in the nervous system
    • 11275358 1:CAS:528:DC%2BD3MXitF2mtrk%3D
    • Wiesinger H (2001) Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol 64:365-391
    • (2001) Prog Neurobiol , vol.64 , pp. 365-391
    • Wiesinger, H.1
  • 194
    • 0030062478 scopus 로고    scopus 로고
    • Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat
    • 9053810 1:CAS:528:DyaK28XhsVGnu7g%3D
    • Willard-Mack CL, Koehler RC, Hirata T et al (1996) Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat. Neuroscience 71:589-599
    • (1996) Neuroscience , vol.71 , pp. 589-599
    • Willard-Mack, C.L.1    Koehler, R.C.2    Hirata, T.3
  • 195
    • 84856642184 scopus 로고    scopus 로고
    • Reduction in hyperammonaemia by ornithine phenylacetate prevents lipopolysaccharide-induced brain edema and coma in cirrhotic rats
    • 22151131 1:CAS:528:DC%2BC38XkvVCjsbg%3D
    • Wright G, Vairappan B, Stadlbauer V, Mookerjee RP, Davies NA, Jalan R (2012) Reduction in hyperammonaemia by ornithine phenylacetate prevents lipopolysaccharide-induced brain edema and coma in cirrhotic rats. Liver Int 32:410-419
    • (2012) Liver Int , vol.32 , pp. 410-419
    • Wright, G.1    Vairappan, B.2    Stadlbauer, V.3    Mookerjee, R.P.4    Davies, N.A.5    Jalan, R.6
  • 196
    • 77249119654 scopus 로고    scopus 로고
    • Encephalopathy assessment in children with extra-hepatic portal vein obstruction with MR, psychometry and critical flicker frequency
    • 20137823
    • Yadav SK, Srivastava A, Thomas MA et al (2010) Encephalopathy assessment in children with extra-hepatic portal vein obstruction with MR, psychometry and critical flicker frequency. J Hepatol 52:348-354
    • (2010) J Hepatol , vol.52 , pp. 348-354
    • Yadav, S.K.1    Srivastava, A.2    Thomas, M.A.3
  • 197
    • 0036125033 scopus 로고    scopus 로고
    • An autopsy case of ornithine transcarbamylase deficiency
    • 11891099
    • Yamanouchi H, Yokoo H, Yuhara Y et al (2002) An autopsy case of ornithine transcarbamylase deficiency. Brain Dev 24:91-94
    • (2002) Brain Dev , vol.24 , pp. 91-94
    • Yamanouchi, H.1    Yokoo, H.2    Yuhara, Y.3
  • 198
    • 29744452133 scopus 로고    scopus 로고
    • Mechanisms of ischemic neuroprotection by acetyl-L-carnitine
    • 16179519 1:CAS:528:DC%2BD28XotlKksQ%3D%3D
    • Zanelli SA, Solenski NJ, Rosenthal RE, Fiskum G (2005) Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann N Y Acad Sci 1053:153-161
    • (2005) Ann N y Acad Sci , vol.1053 , pp. 153-161
    • Zanelli, S.A.1    Solenski, N.J.2    Rosenthal, R.E.3    Fiskum, G.4
  • 200
    • 84865792376 scopus 로고    scopus 로고
    • (+)LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes
    • 22401943 1:CAS:528:DC%2BC38Xkt1GmsLg%3D
    • (+)LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes. Neurochem Int 61:531-535
    • (2012) Neurochem Int , vol.61 , pp. 531-535
    • Zielinska, M.1    Skowronska, M.2    Fresko, I.3    Albrecht, J.4
  • 201
    • 35448961690 scopus 로고    scopus 로고
    • The anaplerotic flux and ammonia detoxification in hepatic encephalopathy
    • 17823857 1:CAS:528:DC%2BD2sXht1amur%2FE
    • Zwingmann C (2007) The anaplerotic flux and ammonia detoxification in hepatic encephalopathy. Metab Brain Dis 22:235-249
    • (2007) Metab Brain Dis , vol.22 , pp. 235-249
    • Zwingmann, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.