Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication

Free Radical Biology and Medicine

Volumn 26, Issue 11-12, 1999, Pages 1369-1374

  Kosenko, Elena ^b   Kaminski, Yuri ^a   Lopata, Oksana ^a   Muravyov, Nikolay ^a   Felipo, Vicente ^b  

^a INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Ammonia toxicity; Free radicals; Glutamate receptors; Glutathione; Hepatic encephalopathy; Hyperammonemia; Neurotoxicity; Nitric oxide; NMDA receptor

Indexed keywords

AMMONIA; DIZOCILPINE; FREE RADICAL; GLUTAMATE RECEPTOR; GLUTATHIONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SUPEROXIDE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN MITOCHONDRION; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; HYPERAMMONEMIA; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ACUTE DISEASE; AMMONIA; ANIMALS; ANTIOXIDANTS; BRAIN; CATALASE; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SUPEROXIDE DISMUTASE; SUPEROXIDES;

ANIMALIA;

EID: 0032967196     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00339-6     Document Type: Article

References (39)

1. Hahn M., Massen O., Nencki M., Pavlov I. Die Eck'sche Fistel zwischen der unteren Hohlvene und der Pfortader und ihre Folgen für den Organisms. Archiv fur Experimentelle Pathologie und Pharmakologie. 32:1893;161-210.
2. Hindfelt B., Siesjö B.K. Cerebral effects of acute ammonia intoxication. Scand. J. Clin. Lab. Invest. 28:1971;365-374.
3. Hawkins R.A., Miller A.L., Nielsen R.C., Veech R.L. The acute action of ammonia on rat brain metabolism in vivo. Biochem. J. 134:1973;1001-1008.
4. Hindfelt B., Plum F., Duffy T.E. Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts. J. Clin. Invest. 59:1977;386-396.
5. Kosenko E., Kaminsky Y., Felipo V., Miñana M.D., Grisolía S. Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonia intoxication. Biochim. Biophys. Acta. 1180:1993;321-326.
6. Schenker S., McCandless D.W., Brophy E., Lewis M.S. Studies on intracerebral toxicity of ammonia. J. Clin. Invest. 46:1967;838-848.
7. +-ATPase. J. Neurochem. 63:1994;2172-2178.
8. Marcaida G., Felipo V., Hermenegildo C., Miñana M.D., Grisolía S. Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors. FEBS Lett. 296:1992;67-68.
9. Hermenegildo C., Marcaida G., Montoliu C., Grisolia S., Miñana M.D., Felipo V. NMDA receptor antagonists prevent acute ammonia toxicity in mice. Neurochem. Res. 21:1996;1237-1244.
10. Choi D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7:1987;369-379.
11. Novelli A., Reilly J.A., Lysko P.G., Henneberry R.C. Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451:1988;205-212.
12. Miñana M.D., Hermenegildo C., Llansola M., Montoliu C., Grisolía S., Felipo V. Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons. J. Pharmacol. Exp. Ther. 279:1996;194-199.
13. Marcaida G., Miñana M.D., Grisolía S., Felipo V. Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum. Brain Res. 695:1995;146-150.
14. +-ATPase that results in its activation in cerebellar neurons in culture. J. Neurochem. 66:1996;99-104.
15. Kosenko E., Felipo V., Miñana M.D., Grisolia S., Kaminsky Y. Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria. Metab. Brain Dis. 12:1997;69-82.
16. Dawson V.L., Dawson T.M. Free radicals and neuronal cell death. Cell Death Differ. 3:1996;71-78.
17. Kosenko E., Kaminski Y., Kaminski A., Valencia M., Lee L., Hermenegildo C., Felipo V. Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic. Res. 27:1997;637-644.
18. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
19. Bindokas V.P., Jordán J., Lee C.C., Miller R.J. Superoxide production in rat hippocampal neurons selective imaging with hydroethidine . J. Neurosci. 15:1996;1324-1336.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
21. Golderg D.M., Spooner R.J. Glutathione reductase. Bergmeyer H.U. Methods of enzymatic analysis. Vol. 3:1984;259-265 Wiley, New York.
22. Lawrence R.A., Burk R.F. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71:1976;952-958.
23. Aebi H.E. Catalase. Bergmeyer H.U. Methods of enzymatic analysis. Vol. 3:1984;273-286 Wiley, New York.
24. Cohen G., Dembiec D., Marcus J. Measurement of catalase activity in tissue extracts. Anal. Biochem. 34:1970;30-38.
25. Beauchamp C., Fridovich I. Improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 44:1971;276-287.
26. Deutsch J. Glucose-6-phosphate dehydrogenase. Bergmeyer H.U. Methods of enzymatic analysis. Vol. 3:1983;190-196 Verlag Chemie, Weinheim.
27. Forman H.J., Kennedy J. Dihidroorotate-dependent superoxide production in rat brain and liver. A function of the primary dehydrogenase. Arch. Biochem. Biophys. 173:1976;219-224.
28. Ohkawa H., Ohishi N., Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:1979;351-358.
29. Anderson M. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113:1985;548-552.
30. Weisiger R.A., Fridovich I. Superoxide dismutase. Organelle specificity. J. Biol. Chem. 248:1973;3582-3592.
31. Noack H., Lindenau J., Rothe F., Asayama K., Wolf G. Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxicity mediated neurodegeneration relation to oxidative and nitrergic stress . Glia. 23:1998;285-297.
32. 2-associated relaxation. Am. J. Physiol. 271:1996;H1900-H1906.
33. Farias-Eisner R., Chaudhuri G., Aeberhard E., Fukuto J.M. The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistance/susceptibility. J. Biol. Chem. 271:1996;6144-6151.
34. Brown G.C. Reversible binding and inhibition of catalase by nitric oxide. Eur. J. Biochem. 232:1995;188-191.
35. Asahi M., Fujii J., Suzuki K., Seo H.G., Kuzuya T., Hori M., Tada M., Fujii S., Taniguchi N. Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity. J. Biol. Chem. 270:1995;21035-21039.
36. Bolaños J.P., Peuchen S., Heales S.J., Land J.M., Clark J.B. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J. Neurochem. 63:1994;910-916.
37. Luperchio S., Tamir S., Tannembaum S.R. NO-induced oxidative stress and glutathione metabolism in rodent and human cells. Free Radic. Biol. Med. 21:1996;513-519.
38. Kosenko E., Kaminsky Y., Lopata O., Muravyov N., Kaminsky A., Hermenegildo C., Felipo V. Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication. Metab. Brain. Dis. 13:1998;29-41.
39. Kosenko, E.; Kaminsky, Y.; Grau, E.; Miñana, M. D.; Grisolía, S.; Felipo, V. N-arginine, an inhibitor of nitric oxide synthase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism. Neurochem. Res. 20:451-456; 1995.